The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38α Mitogen-activated Protein Kinase (p38αMAPK)
Open accessAbstract
A novel ribosomal S6 kinase (RSK) family member, RSK-B, was identified in a p38alphaMAPK-baited intracellular interaction screen. RSK-B presents two catalytic domains typical for the RSK family. The protein kinase C-like N-terminal and the calcium/calmodulin kinase-like C-terminal domains both contain conserved ATP-binding and activation consensus sequences. RSK-B is a p38alphaMAPK substrate, and activated by p38alphaMAPK and, more weakly, by ERK1. RSK-B phosphorylates the cAMP response element-binding protein (CREB) and c-Fos peptides. In intracellular assays, RSK-B drives cAMP response element- and AP1-dependent reporter expression. RSK-B locates to the cell nucleus and co-translocates p38alphaMAPK. In conclusion, RSK-B is a novel CREB kinase under dominant p38alphaMAPK control, also phosphorylating additional substrates.
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Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
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Cited by
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274
Chen, Z., Gibson, T. B., Robinson, F., Silvestro, L., Pearson, G., Xu, B.-E., Wright, A., Vanderbilt, C., & Cobb, M. H. (2001) · Chemical Reviews · doi:10.1021/cr000241p · Cited by 788
The RSK family of kinases: emerging roles in cellular signalling
Anjum, R., & Blenis, J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2509 · Cited by 777
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction
Frödin, M., & Gammeltoft, S. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00061-1 · Cited by 716
Nuclear RNA-seq of single neurons reveals molecular signatures of activation
Lacar, B., Linker, S. B., Jaeger, B. N., Krishnaswami, S. R., Barron, J. J., Kelder, M. J. E., Parylak, S. L., Paquola, A. C. M., Venepally, P., Novotny, M., et al. (2016) · Nature Communications · doi:10.1038/ncomms11022 · Cited by 405
Metadata
- Authors
- Pierrat, B., Correia, J. D. S., Mary, J.-L., Tomás-Zuber, M., & Lesslauer, W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 273
- Issue
- 45
- Pages
- 29661-29671
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1964887620
- Cited by
- 163
- References
- 5
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38α Mitogen-activated Protein Kinase (p38αMAPK). https://app.cochat.ai/papers/10.1074/jbc.273.45.29661
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- Pierrat, B., Correia, J. D. S., Mary, J.-L., Tomás-Zuber, M., & Lesslauer, W. (1998). RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38α Mitogen-activated Protein Kinase (p38αMAPK). Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.45.29661
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
