Low Reserve of Cytochrome c Oxidase Capacity in Vivo in the Respiratory Chain of a Variety of Human Cell Types

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167 · see citing works

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

Yang, J., Liu, X., Bhalla, K. N., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X. (1997) · Science · doi:10.1126/science.275.5303.1129 · Cited by 4,913 · see citing works

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715 · see citing works

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

Rizzuto, R., Pinton, P., Carrington, W., Fay, F. S., Fogarty, K. E., Lifshitz, L. M., Tuft, R. A., & Pozzan, T. (1998) · Science · doi:10.1126/science.280.5370.1763 · Cited by 2,257 · see citing works

Human Cells Lacking mtDNA: Repopulation with Exogenous Mitochondria by Complementation

King, M. P., & Attardi, G. M. (1989) · Science · doi:10.1126/science.2814477 · Cited by 1,659 · see citing works

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

Heinrich, R., & Rapoport, T. A. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03318.x · Cited by 1,400 · see citing works

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

(1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90040-d · Cited by 1,386 · see citing works

Diseases of the mitochondrial DNA

Wallace, D. C. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.005523 · Cited by 1,319 · see citing works

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

Aden, D. P., Fogel, A., Plotkin, S. A., Damjanov, I., & Knowles, B. B. (1979) · Nature · doi:10.1038/282615a0 · Cited by 1,317 · see citing works

Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

Biedler, J. L., Helson, L., & Spengler, B. A. (1973) · PubMed · Cited by 1,295 · see citing works

A continuous tumor‐cell line from a human lung carcinoma with properties of type II alveolar epithelial cells

Lieber, M. M., Todaro, G. J., Smith, B., Szakal, A. K., & Nelson‐Rees, W. A. (1976) · International Journal of Cancer · doi:10.1002/ijc.2910170110 · Cited by 1,284 · see citing works

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD‐specific caspase activation and independently of mitochondrial transmembrane depolarization

Bossy‐Wetzel, E., Newmeyer, D. D., & Green, D. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.37 · Cited by 1,225 · see citing works

Quantification of the contribution of various steps to the control of mitochondrial respiration.

Groen, A. K., Wanders, R. J. A., Westerhoff, H. V., van der Meer, R., & Tager, J. M. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81026-8 · Cited by 629 · see citing works

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

Brown, G. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00763-y · Cited by 540 · see citing works

Mitochondrial DNA Mutations and Pathogenesis

Schon, E. A., Bonilla, E., & DiMauro, S. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022685929755 · Cited by 421 · see citing works

Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.

Olsson, L., & Kaplan, H. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5429 · Cited by 380 · see citing works

Energy Thresholds in Brain Mitochondria

Davey, G. P., Peuchen, S., & Clark, J. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.12753 · Cited by 361 · see citing works

Mitochondrial Oxygen Affinity, Respiratory Flux Control And Excess Capacity Of Cytochrome c Oxidase

Gnaiger, E., Lassnig, B., Kuznetsov, A. V., Rieger, G. E., & Margreiter, R. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.8.1129 · Cited by 318 · see citing works

Cell Respiration is Controlled by ATP, an Allosteric Inhibitor of Cytochrome‐c Oxidase

Arnold, S., & Kadenbach, B. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.t01-1-00350.x · Cited by 240 · see citing works

Threshold Effects and Control of Oxidative Phosphorylation in Nonsynaptic Rat Brain Mitochondria

Davey, G. P., & Clark, J. B. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66041617.x · Cited by 209 · see citing works

In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells

Villani, G., & Attardi, G. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1166 · Cited by 199 · see citing works

Control of cellular respiration in vivo by mitochondrial outer membrane and by Creatine Kinase. A new speculative hypothesis: possible involvement of mitochondrial-cytoskeleton interactions

Saks, V. A., Kuznetsov, A. V., Khuchua, Z. A., Vasilyeva, E. V., BELIKOVA, J., Kesvatera, T., & Tiivel, T. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(08)80056-9 · Cited by 164 · see citing works

Widespread tissue distribution of mitochondrial DNA deletions in Kearns‐Sayre syndrome

Shanske, S., Moraes, C. T., Lombès, A., Miranda, A. F., Bonilla, E., Lewis, P., Whelan, M. A., Ellsworth, C. A., & DiMauro, S. (1990) · Neurology · doi:10.1212/wnl.40.1.24 · Cited by 151 · see citing works

The kinetic basis of threshold effects observed in mitochondrial diseases: a systemic approach

Letellier, T., Heinrich, R., Malgat, M., & Mazat, J. (1994) · Biochemical Journal · doi:10.1042/bj3020171 · Cited by 134 · see citing works

Study of regulation of mitochondrial respiration in vivo

Kay, L., Li, Z., Mericskay, M., Olivares, J., Tranqui, L., Fontaine, E. M., Tiivel, T., Sikk, P., Käämbre, T., Samuel, J.-L., et al. (1997) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00071-6 · Cited by 129 · see citing works

Control of oxidative phosphorylation in rat muscle mitochondria: implications for mitochondrial myopathies

Letellier, T., Malgat, M., & Mazat, J. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90189-m · Cited by 118 · see citing works

Threshold Effects in Synaptosomal and Nonsynaptic Mitochondria from Hippocampal CA1 and Paramedian Neocortex Brain Regions

Davey, G. P., Canevari, L., & Clark, J. B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062564.x · Cited by 117 · see citing works

Functional characterization of mitochondrial oxidative phosphorylation in saponin-skinned human muscle fibers

Kunz, W. S., Kuznetsov, A. V., Schulze, W., Eichhorn, K., Schild, L., Striggow, F., Bohnensack, R., Neuhof, S., Graßhoff, H., Neumann, H. W., et al. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90029-f · Cited by 112 · see citing works

Mitochondria and Ageing

Müller‐Höcker, J. (1992) · Brain Pathology · doi:10.1111/j.1750-3639.1992.tb00683.x · Cited by 103 · see citing works

Oxygen dependence of mitochondrial function in isolated rat cardiac myocytes

Kennedy, F. G., & Jones, D. P. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.250.3.c374 · Cited by 98 · see citing works

Functional Imaging of Mitochondria in Saponin-permeabilized Mice Muscle Fibers

Kuznetsov, A. V., Mayboroda, O. A., Kunz, D., Winkler, K., SCHUBERT, W. J., & Kunz, W. S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.5.1091 · Cited by 88 · see citing works

The cytochrome chain of mitochondria exhibits variable H+/e− stoichiometry

Papa, S., Capitanio, N., Capitanio, G., Nitto, E. D., & Minuto, M. N. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81030-c · Cited by 73 · see citing works

The control of mitochondrial oxidations by complex III in rat muscle and liver mitochondria. Implications for our understanding of mitochondrial cytopathies in man.

Taylor, R. W., Birch-Machin, M., Bartlett, K., Lowerson, S. A., & Turnbull, D. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41894-1 · Cited by 73 · see citing works

Factors Affecting the H+/e- Stoichiometry in Mitochondrial Cytochrome c Oxidase: Influence of the Rate of Electron Flow and Transmembrane ΔpH

Capitanio, N., Capitanio, G., Demarinis, D. A., Nitto, E. D., Massari, S., & Papa, S. (1996) · Biochemistry · doi:10.1021/bi9606509 · Cited by 70 · see citing works

Mechanistic Stoichiometry of Yeast Mitochondrial Oxidative Phosphorylation

Fitton‐Ouhabi, V., Rigoulet, M., Ouhabi, R., & Guérin, B. (1994) · Biochemistry · doi:10.1021/bi00198a039 · Cited by 67 · see citing works

H+/e− stoichiometry of mitochondrial cytochrome complexes reconstituted in liposomes Rate‐dependent changes of the stoichiometry in the cytochrome c oxidase vesicles

Capitanio, N., Capitanio, G., Nitto, E. D., Villani, G., & Papa, S. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81029-8 · Cited by 63 · see citing works

Application of inhibitor titrations for the detection of oxidative phosphorylation defects in saponin-skinned muscle fibers of patients with mitochondrial diseases

Kuznetsov, A. V., Winkler, K., Kirches, E., Lins, H., Feistner, H., & Kunz, W. S. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(96)00072-5 · Cited by 62 · see citing works

Regulation of mitochondrial energy generation in health and disease

Kadenbach, B., Barth, J., Akgün, R., Freund, R., Linder, D., & Possekel, S. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00016-w · Cited by 60 · see citing works

Fluxes of Nicotinamide Adenine Dinucleotides through Mitochondrial Membranes in Human Cultured Cells

Rustin, P., Parfait, B., Chrétien, D., Bourgeron, T., Djouadi, F., Bastin, J., Rötig, A., & Münnich, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.14785 · Cited by 54 · see citing works

Increase of Flux Control of Cytochrome c Oxidase in Copper-deficient Mottled Brindled Mice

Kuznetsov, A. V., Clark, J. F., Winkler, K., & Kunz, W. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.283 · Cited by 54 · see citing works

Hemoprotein quantitation in isolated hepatocytes

Jones, D. P., Orrenius, S., & Mason, H. S. (1979) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(79)90480-x · Cited by 39 · see citing works

Oxygen dependence of flux control of cytochrome c oxidase – implications for mitochondrial diseases

Wiedemann, F. R., & Kunz, W. S. (1998) · FEBS Letters · doi:10.1016/s0014-5793(97)01586-x · Cited by 32 · see citing works

The Sum of Flux Control Coefficients in the Electron‐Transport Chain of Mitochondria

Brand, M. D., Vallis, B. P. S., & Kesseler, A. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.00819.x · Cited by 28 · see citing works

The Consequences of a Mild Respiratory Chain Deficiency on Substrate Competitive Oxidation in Human Mitochondria

Géromel, V., Parfait, B., von Kleist-Retzow, J., Chrétien, D., Münnich, A., Rötig, A., & Rustin, P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7024 · Cited by 25 · see citing works

Oxygraphic Evaluation of Mitochondrial Function in Digitonin-Permeabilized Mononuclear Cells and Cultured Skin Fibroblasts of Patients with Chronic Progressive External Ophthalmoplegia

Kunz, D., Luley, C. H., Fritz, S., Bohnensack, R., Winkler, K., Kunz, W. S., & Wallesch, C. W. (1995) · Biochemical and Molecular Medicine · doi:10.1006/bmme.1995.1015 · Cited by 25 · see citing works

Generation of High δɛ in Respiring Submitochondrial Particles by Steady‐State Accumulation of Oxidized N,N,N′,N′‐Tetramethyl‐p‐phenylenediamine

Sagi‐Eisenberg, R., & Gutman, M. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb13093.x · Cited by 11 · see citing works

Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

Kuznetsov, A. V., Veksler, V., Gellerich, F. N., Saks, V. A., Margreiter, R., & Kunz, W. S. (2008) · Nature Protocols · doi:10.1038/nprot.2008.61 · Cited by 805 · see citing works

Mitochondrial threshold effects

Rossignol, R., Faustin, B., Rocher, C., Malgat, M., Mazat, J., & Letellier, T. (2003) · Biochemical Journal · doi:10.1042/bj20021594 · Cited by 802 · see citing works

The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance

Cooper, C. E., & Brown, G. C. (2008) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-008-9166-6 · Cited by 724 · see citing works

AIF deficiency compromises oxidative phosphorylation

Vahsen, N., Candé, C., Brière, J.-J., Bénit, P., Joza, N. A., Larochette, N., Mastroberardino, P. G., Péquignot, M. O., Casares, N., Lazar, V., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600461 · Cited by 622 · see citing works

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC‐to‐EpiSC/hESC transition

Zhou, W., Choi, M. P., Margineantu, D. H., Margaretha, L., Hesson, J., Cavanaugh, C., Blau, C. A., Horwitz, M. S., Hockenbery, D. M., Ware, C. B., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.71 · Cited by 555 · see citing works

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis

Hüttemann, M., Pecina, P., Rainbolt, M., Sanderson, T. H., Kagan, V. E., Samavati, L., Doan, J. W., & Lee, I. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.01.010 · Cited by 522 · see citing works

Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation

Acín‐Pérez, R., Salazar, E., Kamenetsky, M., Buck, J., Levin, L. R., & Manfredi, G. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.012 · Cited by 465 · see citing works

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

Lin, M. T. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.2.133 · Cited by 366 · see citing works

Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex

Li, Y.-F., Park, J.-S., Deng, J., & Bai, Y. (2006) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-006-9052-z · Cited by 342 · see citing works

Molecular Mechanisms and Therapeutic Effects of (−)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration

Shay, J., Elbaz, H. A., Lee, I., Zielske, S. P., Malek, M. H., & Hüttemann, M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/181260 · Cited by 282 · see citing works

Natural selection and the evolution of mtDNA-encoded peptides: evidence for intergenomic co-adaptation

Blier, P. U. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02338-1 · Cited by 269 · see citing works

Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase

Kadenbach, B., Hüttemann, M., Arnold, S., Lee, I., & Bender, E. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00305-1 · Cited by 268 · see citing works

In vivo and in organello assessment of OXPHOS activities

Barrientos, A. (2002) · Methods · doi:10.1016/s1046-2023(02)00036-1 · Cited by 266 · see citing works

Ceramide Interaction with the Respiratory Chain of Heart Mitochondria

Di Paola, M., Cocco, T., & Lorusso, M. (2000) · Biochemistry · doi:10.1021/bi9924415 · Cited by 262 · see citing works

Mitochondrial Respiration and ATP Production Are Significantly Impaired in Striatal Cells Expressing Mutant Huntingtin

Milakovic, T., & Johnson, G. V. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504749200 · Cited by 259 · see citing works

Evaluation of the Mitochondrial Respiratory Chain and Oxidative Phosphorylation System Using Polarography and Spectrophotometric Enzyme Assays

Barrientos, A., Fontanesi, F., & Díaz, F. (2009) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg1903s63 · Cited by 251 · see citing works

Cytochrome c Oxidase and the Regulation of Oxidative Phosphorylation

Ludwig, B., Bender, E., Arnold, S., Hüttemann, M., Lee, I., & Kadenbach, B. (2001) · ChemBioChem · doi:10.1002/1439-7633(20010601)2:6 · Cited by 246 · see citing works

The subunit composition and function of mammalian cytochrome c oxidase

Kadenbach, B., & Hüttemann, M. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.07.002 · Cited by 244 · see citing works

Mitochondrial dysregulation and oxidative stress in patients with chronic kidney disease

Granata, S., Zaza, G., Simone, S., Villani, G., Latorre, D., Pontrelli, P., Carella, M., Schena, F. P., Grandaliano, G., & Pertosa, G. B. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-388 · Cited by 242 · see citing works

The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseases

Kadenbach, B., Arnold, S., Lee, I., & Hüttemann, M. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2003.06.005 · Cited by 235 · see citing works

Tissue‐specific regulation of cytochrome c by post‐translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis

Kalpage, H. A., Bazylianska, V., Recanati, M., Fite, A., Liu, J., Wan, J., Mantena, N., Malek, M. H., Podgorski, I., Heath, E., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201801417r · Cited by 226 · see citing works

Complex IV – The regulatory center of mitochondrial oxidative phosphorylation

Kadenbach, B. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.10.004 · Cited by 212 · see citing works

Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress

Schneider, L. E., Giordano, S. S., Zelickson, B. R., Johnson, M. S., Benavides, G. A., Ouyang, X., Fineberg, N. S., Darley-Usmar, V. M., & Zhang, J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.030 · Cited by 210 · see citing works

Characterization of Mitochondrial and Extra-mitochondrial Oxygen Consuming Reactions in Human Hematopoietic Stem Cells

Piccoli, C., Ria, R., Scrima, R., Cela, O., D'Aprile, A., Boffoli, D., Falzetti, F., Tabilio, A., & Capitanio, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500047200 · Cited by 209 · see citing works

cAMP-dependent Tyrosine Phosphorylation of Subunit I Inhibits Cytochrome c Oxidase Activity

Lee, I., Salomon, A. R., Ficarro, S. B., Mathes, I., Lottspeich, F., Grossman, L. I., & Hüttemann, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411335200 · Cited by 204 · see citing works

Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity

D'Erchia, A. M., Atlante, A., Gadaleta, G., Pavesi, G., Chiara, M., De Virgilio, C., Manzari, C., Mastropasqua, F., Prazzoli, G. M., Picardi, E., et al. (2015) · Mitochondrion · doi:10.1016/j.mito.2014.10.005 · Cited by 197 · see citing works

Sequential Serum-dependent Activation of CREB and NRF-1 Leads to Enhanced Mitochondrial Respiration through the Induction of Cytochrome c

Herzig, R. P., Scacco, S., & Scarpulla, R. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.13134 · Cited by 197 · see citing works

Tissue-specific differences in mitochondrial activity and biogenesis

Fernández‐Vizarra, E., Enrı́quez, J. A., Martos, A. P., Montoya, J., & Fernández‐Silva, P. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.09.011 · Cited by 195 · see citing works

Acquisition of Temozolomide Chemoresistance in Gliomas Leads to Remodeling of Mitochondrial Electron Transport Chain

Oliva, C. R., Nozell, S. E., Diers, A. R., McClugage, S. G., Sarkaria, J. N., Markert, J. M., Darley-Usmar, V. M., Bailey, S. M., Gillespie, G. Y., Landar, A. L., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.147504 · Cited by 192 · see citing works

Protein Phosphorylation and Prevention of Cytochrome Oxidase Inhibition by ATP: Coupled Mechanisms of Energy Metabolism Regulation

Acin-Perez, R., Gatti, D. L., Bai, Y., & Manfredi, G. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.024 · Cited by 190 · see citing works

Tumor Necrosis Factor α Inhibits Oxidative Phosphorylation through Tyrosine Phosphorylation at Subunit I of Cytochrome c Oxidase

Samavati, L., Lee, I., Mathes, I., Lottspeich, F., & Hüttemann, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801954200 · Cited by 183 · see citing works

Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation

Tarasenko, T. N., Pacheco, S. E., Koenig, M. K., Gómez‐Rodríguez, J., Kapnick, S. M., Díaz, F., Zerfas, P. M., Barca, E., Sudderth, J., DeBerardinis, R. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.007 · Cited by 177 · see citing works

Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a metabolic regulator of intestinal epithelial cell fate

D’Errico, I., Salvatore, L., Murzilli, S., Sasso, G. L., Latorre, D., Martelli, N., Egorova, A. V., Polishuck, R. S., Madeyski-Bengtson, K., Lelliott, C. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016354108 · Cited by 175 · see citing works

Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects

Goldsmith, R., Joanisse, D. R., Gallagher, D., Pavlovich, K., Shamoon, E., Leibel, R. L., & Rosenbaum, M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00053.2009 · Cited by 171 · see citing works

Human Skin Keloid Fibroblasts Display Bioenergetics of Cancer Cells

Vincent, A. S., Phan, T. T., Mukhopadhyay, A., Lim, H. Y., Halliwell, B. B., & Wong, K. P. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701107 · Cited by 170 · see citing works

Tissue-specific changes of mitochondrial functions in aged rats: Effect of a long-term dietary treatment with N-acetylcysteine

Cocco, T., Sgobbo, P., Clemente, M. T., Lopriore, B., Grattagliano, I., Paola, M. D., & Villani, G. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.034 · Cited by 157 · see citing works

Mitochondrial response to nutrient availability and its role in metabolic disease

Gao, A. W., Cantó, C., & Houtkooper, R. H. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303782 · Cited by 148 · see citing works

Activation of Peroxisome Proliferator-Activated Receptor Pathway Stimulates the Mitochondrial Respiratory Chain and Can Correct Deficiencies in Patients’ Cells Lacking Its Components

Bastin, J., Aubey, F., Rötig, A., Münnich, A., & Djouadi, F. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1701 · Cited by 142 · see citing works

Evaluation of Mitochondrial Respiratory Function in Small Biopsies of Liver

Kuznetsov, A. V., Strobl, D., Ruttmann, E., Königsrainer, A., Margreiter, R., & Gnaiger, E. (2002) · Analytical Biochemistry · doi:10.1006/abio.2002.5658 · Cited by 137 · see citing works

In vivo control of respiration by cytochrome c oxidase in human cells

Villani, G., & Attardi, G. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00303-8 · Cited by 127 · see citing works

Marked aging‐related decline in efficiency of oxidative phosphorylation in human skin fibroblasts

Gréco, M., Villani, G., Mazzucchelli, F., Bresolin, N., Papa, S., & Attardi, G. M. (2003) · The FASEB Journal · doi:10.1096/fj.02-1009fje · Cited by 122 · see citing works

MITOCHONDRIAL DNA VARIATION IS ASSOCIATED WITH MEASURABLE DIFFERENCES IN LIFE-HISTORY TRAITS AND MITOCHONDRIAL METABOLISM IN DROSOPHILA SIMULANS

Ballard, J. W. O., Melvin, R. G., Katewa, S. D., & Maas, K. (2007) · Evolution · doi:10.1111/j.1558-5646.2007.00133.x · Cited by 122 · see citing works

High-resolution respirometry–a modern tool in aging research

Hütter, E., Unterluggauer, H., Garedew, A., Jansen‐Dürr, P., & Gnaiger, E. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.09.011 · Cited by 121 · see citing works

Polarographic Oxygen Sensors, the Oxygraph, and High‐Resolution Respirometry to Assess Mitochondrial Function

Gnaiger, E. (2008) · doi:10.1002/9780470372531.ch12 · Cited by 121 · see citing works

Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson's disease

Pacelli, C., Rasmo, D. D., Signorile, A., Grattagliano, I., Tullio, G. D., D’Orazio, A., Nico, B., Comi, G. P., Ronchi, D., Ferranini, E., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.022 · Cited by 119 · see citing works

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK

Thomas, D. A., Scorrano, L., Putcha, G. V., Korsmeyer, S. J., & Ley, T. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261581498 · Cited by 120 · see citing works

Bioenergetics and cell death

Kushnareva, Y., & Newmeyer, D. D. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05633.x · Cited by 116 · see citing works

Loss of LRPPRC causes ATP synthase deficiency

Mourier, A., Ruzzenente, B., Brandt, T., Kühlbrandt, W., & Larsson, N. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt652 · Cited by 117 · see citing works

The power of life—Cytochrome c oxidase takes center stage in metabolic control, cell signalling and survival

Arnold, S. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.05.003 · Cited by 117 · see citing works

ANT2 Isoform Required for Cancer Cell Glycolysis

Chevrollier, A., Loiseau, D., Chabi, B., Rénier, G., Douay, O., Malthièry, Y., & Stepien, G. (2005) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-005-8642-5 · Cited by 116 · see citing works

Tight Control of Respiration by NADH Dehydrogenase ND5 Subunit Gene Expression in Mouse Mitochondria

Bai, Y., Shakeley, R. M., & Attardi, G. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.805-815.2000 · Cited by 115 · see citing works

Phosphorylations and Acetylations of Cytochrome c Control Mitochondrial Respiration, Mitochondrial Membrane Potential, Energy, ROS, and Apoptosis

Morse, P. T., Arroum, T., Wan, J., Pham, L., Vaishnav, A., Bell, J., Pavelich, L., Malek, M. H., Sanderson, T. H., Edwards, B. F. P., et al. (2024) · Cells · doi:10.3390/cells13060493 · Cited by 111 · see citing works

Phosphorylation and Kinetics of Mammalian Cytochrome c Oxidase

Helling, S., Vogt, S. K., Rhiel, A., Ramzan, R., Wen, L., Marcus, K., & Kadenbach, B. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800137-mcp200 · Cited by 107 · see citing works

Phosphorylation of Mammalian Cytochrome c and Cytochrome c Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease

Hüttemann, M., Lee, I., Grossman, L. I., Doan, J. W., & Sanderson, T. H. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3573-0_10 · Cited by 106 · see citing works

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

Peserico, A., Chiacchiera, F., Grossi, V., Matrone, A., Latorre, D., Simonatto, M., Fusella, A., Ryall, J. G., Finley, L. W. S., Haigis, M. C., et al. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1244-6 · Cited by 103 · see citing works

New Control of Mitochondrial Membrane Potential and ROS Formation A Hypothesis

Lee, I., Bender, E., Arnold, S., & Kadenbach, B. (2001) · Biological Chemistry · doi:10.1515/bc.2001.198 · Cited by 105 · see citing works

Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers

Lemieux, H., Blier, P. U., & Gnaiger, E. (2017) · Scientific Reports · doi:10.1038/s41598-017-02789-8 · Cited by 101 · see citing works

Genetic defects of cytochrome c oxidase assembly

Pecina, P., Houšt'ková, H., Zeman, J., & Houštěk, J. (2004) · Physiological Research · doi:10.33549/physiolres.930000.53.s213 · Cited by 100 · see citing works

Mitochondrial dysfunction in a neural cell model of spinal muscular atrophy

Acsádi, G., Lee, I., Li, X., Khaidakov, M., Pecinová, A., Parker, G. C., & Hüttemann, M. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22106 · Cited by 98 · see citing works

The role of the electron transport chain in immunity

Yin, M., & O’Neill, L. A. J. (2021) · The FASEB Journal · doi:10.1096/fj.202101161r · Cited by 94 · see citing works

Flux Control of Cytochrome c Oxidase in Human Skeletal Muscle

Kunz, W. S., Kudin, A. P., Vielhaber, S., Elger, C. E., Attardi, G. M., & Villani, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004833200 · Cited by 96 · see citing works

Mitochondria in the human heart

Lemieux, H., & Hoppel, C. L. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9211-0 · Cited by 93 · see citing works

Control by cytochromecoxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state

Piccoli, C., Scrima, R., Boffoli, D., & Capitanio, N. (2006) · Biochemical Journal · doi:10.1042/bj20060077 · Cited by 92 · see citing works

Low micromolar concentrations of the superoxide probe MitoSOX uncouple neural mitochondria and inhibit complex IV

Roelofs, B. A., Ge, S. X., Studlack, P. E., & Polster, B. M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.032 · Cited by 92 · see citing works

Two independent respiratory chains adapt OXPHOS performance to glycolytic switch

Fernández‐Vizarra, E., López-Calcerrada, S., Sierra‐Magro, A., Pérez‐Pérez, R., Formosa, L. E., Hock, D. H., Illescas, M., Peñas, A., Brischigliaro, M., Ding, S., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.005 · Cited by 91 · see citing works

Mitochondrial respiration and membrane potential are regulated by the allosteric ATP-inhibition of cytochrome c oxidase

Ramzan, R., Staniek, K., Kadenbach, B., & Vogt, S. K. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.06.005 · Cited by 91 · see citing works

Knockdown of Human Oxa1l Impairs the Biogenesis of F1Fo-ATP Synthase and NADH:Ubiquinone Oxidoreductase

Stibůrek, L., Fornůsková, D., Wenchich, L., Pejznochová, M., Hansíková, H., & Zeman, J. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.09.044 · Cited by 91 · see citing works

The oxidative damage theory of aging

Lin, M. T., & Flint Beal, M. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00007-0 · Cited by 89 · see citing works

T3 increases mitochondrial ATP production in oxidative muscle despite increased expression of UCP2 and -3

Short, K. R., Nygren, J., Barazzoni, R., Levine, J. A., & Nair, K. S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e761 · Cited by 90 · see citing works

Molecular evolution of aerobic energy metabolism in primates.

Grossman, L. I., Schmidt, T. R., Wildman, D. E., & Goodman, M. (2001) · Molecular Phylogenetics and Evolution · doi:10.1006/mpev.2000.0890 · Cited by 86 · see citing works

A second mechanism of respiratory control

Kadenbach, B., & Arnold, S. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00229-x · Cited by 86 · see citing works

What do mitochondrial diseases teach us about normal mitochondrial functions... that we already knew: threshold expression of mitochondrial defects

Mazat, J., Rossignol, R., Malgat, M., Rocher, C., Faustin, B., & Letellier, T. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00236-x · Cited by 85 · see citing works

PGC-1s in the Spotlight with Parkinson’s Disease

Piccinin, E., Sardanelli, A. M., Seibel, P., Moschetta, A., Cocco, T., & Villani, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073487 · Cited by 83 · see citing works

Regulation of mitochondrial oxidative phosphorylation through tight control of cytochrome c oxidase in health and disease – Implications for ischemia/reperfusion injury, inflammatory diseases, diabetes, and cancer

Pham, L., Arroum, T., Wan, J., Pavelich, L., Bell, J., Morse, P. T., Lee, I., Grossman, L. I., Sanderson, T. H., Malek, M. H., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103426 · Cited by 83 · see citing works

Control of Respiration by Cytochrome c Oxidase in Intact Cells

Dalmonte, M. E., Forte, E., Genova, M. L., Giuffrè, A., Sarti, P., & Lenaz, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.050146 · Cited by 81 · see citing works

Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: A possible explanation for hypoxic vasodilation

Palacios‐Callender, M., Hollis, V., Mitchison, M., Frakich, N., Unitt, D. C., & Moncada, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709440104 · Cited by 80 · see citing works

An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA

Acín‐Pérez, R. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg021 · Cited by 78 · see citing works

Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients

Winkler‐Stuck, K., Wiedemann, F. R., Wallesch, C., & Kunz, W. S. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.02.003 · Cited by 77 · see citing works

Cytochrome c oxidase subunit 4 isoform 2‐knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

Hüttemann, M., Lee, I., Gao, X., Pecina, P., Pecinová, A., Liu, J., Aras, S., Sommer, N., Sanderson, T. H., Tost, M., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-203273 · Cited by 76 · see citing works

Lactate oxidation in human skeletal muscle mitochondria

Jacobs, R. A., Meinild, A., Nordsborg, N. B., & Lundby, C. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00476.2012 · Cited by 77 · see citing works

Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection

Arnold, S. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3573-0_13 · Cited by 75 · see citing works

In Vivo Regulation of Oxidative Phosphorylation in Cells Harboring a Stop-codon Mutation in Mitochondrial DNA-encoded Cytochrome c Oxidase Subunit I

D’Aurelio, M., Pallotti, F., Barrientos, A., Gajewski, C. D., Kwong, J. Q., Bruno, C., Beal, M. F., & Manfredi, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106429200 · Cited by 71 · see citing works

Transcription of mammalian cytochrome c oxidase subunit IV‐2 is controlled by a novel conserved oxygen responsive element

Hüttemann, M., Lee, I., Liu, J., & Grossman, L. I. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06093.x · Cited by 69 · see citing works

Dinitrophenol-induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells

Desquiret‐Dumas, V., Loiseau, D., Jacques, C., Douay, O., Malthièry, Y., Ritz, P., & Roussel, D. (2005) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2005.11.005 · Cited by 69 · see citing works

A CMC1‐knockout reveals translation‐independent control of human mitochondrial complex IV biogenesis

Bourens, M., & Barrientos, A. (2017) · EMBO Reports · doi:10.15252/embr.201643103 · Cited by 69 · see citing works

Oxygen Tolerance and Coupling of Mitochondrial Electron Transport

Campian, J. L., Qian, M., Gao, X., & Eaton, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406685200 · Cited by 69 · see citing works

The C57Bl/6 mouse serves as a suitable model of human skeletal muscle mitochondrial function

Jacobs, R. A., Díaz, V., Meinild, A., Gassmann, M., & Lundby, C. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.070037 · Cited by 68 · see citing works

Metabolic consequences of a novel missense mutation of the mtDNA CO I gene

Varlamov, D. A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.16.1797 · Cited by 68 · see citing works

Regulation of Mammalian 13-Subunit Cytochrome c Oxidase and Binding of other Proteins: Role of NDUFA4

Kadenbach, B. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.09.003 · Cited by 68 · see citing works

Cytoskeleton and regulation of mitochondrial function: the role of beta-tubulin II

Kuznetsov, A. V., Javadov, S. A., Guzun, R., Grimm, M. F., & Saks, V. A. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00082 · Cited by 67 · see citing works

Betaine is a positive regulator of mitochondrial respiration

Lee, I. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.12.005 · Cited by 66 · see citing works

PGC-1α/β upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations

Srivastava, S., Barrett, J. N., & Moraes, C. T. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm045 · Cited by 63 · see citing works

A comparative assessment of mitochondrial function in epimastigotes and bloodstream trypomastigotes of Trypanosoma cruzi

Gonçalves, R. L. S., Barreto, R. F. S. M., Polycarpo, C. R., Gadelha, F. R., de Castro, S. L., & de Oliveira, M. F. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9398-8 · Cited by 60 · see citing works

Thermal sensitivity of mitochondrial functions in permeabilized muscle fibers from two populations of Drosophila simulans with divergent mitotypes

Pichaud, N., Ballard, J. W. O., Tanguay, R. M., & Blier, P. U. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00542.2010 · Cited by 58 · see citing works

Does apoptosis‐inducing factor (AIF) have both life and death functions in cells?

Porter, A. G., & Urbano, A. (2006) · BioEssays · doi:10.1002/bies.20444 · Cited by 58 · see citing works

Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons

Misiak, M., Beyer, C., & Arnold, S. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.009 · Cited by 55 · see citing works

Mitochondrial Outer Membrane Permeability Change and Hypersensitivity to Digitonin Early in Staurosporine-induced Apoptosis

Duan, S., Hájek, P., Lin, C. P., Shin, S. K., Attardi, G. M., & Chomyn, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209269200 · Cited by 55 · see citing works

The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease

Zeitlow, K., Charlambous, L., Ng, I., Gagrani, S., Mihovilovic, M., Luo, S., Rock, D. L., Saunders, A. M., Roses, A. D., & Gottschalk, W. K. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.031 · Cited by 54 · see citing works

Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome

Pecina, P., Čapková, M., Chowdhury, S. R., Drahota, Z., Dubot, A., Pecinová, A., Hansíková, H., Houšt'ková, H., Zeman, J., Godinot, C., et al. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(03)00127-3 · Cited by 54 · see citing works

Tight control of mitochondrial membrane potential by cytochrome c oxidase

Pacelli, C., Latorre, D., Cocco, T., Capuano, F., Kukat, C., Seibel, P., & Villani, G. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.12.004 · Cited by 53 · see citing works

In vivo control of respiration by cytochrome c oxidase in human cells

Villani, G., & Attardi, G. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00303-8 · Cited by 127 · see citing works

In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells

Villani, G., & Attardi, G. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1166 · Cited by 199 · see citing works

Polarographic Assays of Respiratory Chain Complex Activity*

Villani, G., & Attardi, G. M. (2007) · Methods in cell biology · doi:10.1016/s0091-679x(06)80005-1 · Cited by 22 · see citing works

Flux Control of Cytochrome c Oxidase in Human Skeletal Muscle

Kunz, W. S., Kudin, A. P., Vielhaber, S., Elger, C. E., Attardi, G. M., & Villani, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004833200 · Cited by 96 · see citing works

Mitochondrial respiration at low levels of oxygen and cytochrome c

Gnaiger, E., & Kuznetsov, A. V. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300252 · Cited by 138 · see citing works