Cited by 743Cell death mechanisms and regulationNF-κB Signaling PathwaysImmune Response and Inflammation

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Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

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Inohara, Naohiro, Koseki, Takeyoshi, del Peso, Luis, Hu, Yuanming, Yee, Christina, Chen, Shu, Carrio, Roberto, Merino, Jesus, Liu, Ding, Ni, Jian, Núñez, Gabriel·1999·Journal of Biological Chemistry

DOI 10.1074/jbc.274.21.14560

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Abstract

Ced-4 and Apaf-1 belong to a major class of apoptosis regulators that contain caspase-recruitment (CARD) and nucleotide-binding oligomerization domains. Nod1, a protein with an NH2-terminal CARD-linked to a nucleotide-binding domain and a COOH-terminal segment with multiple leucine-rich repeats, was identified. Nod-1 was found to bind to multiple caspases with long prodomains, but specifically activated caspase-9 and promoted caspase-9-induced apoptosis. As reported for Apaf-1, Nod1 required both the CARD and P-loop for function. Unlike Apaf-1, Nod1 induced activation of nuclear factor-kappa-B (NF-kappaB) and bound RICK, a CARD-containing kinase that also induces NF-kappaB activation. Nod1 mutants inhibited NF-kappaB activity induced by RICK, but not that resulting from tumor necrosis factor-alpha stimulation. Thus, Nod1 is a leucine-rich repeat-containing Apaf-1-like molecule that can regulate both apoptosis and NF-kappaB activation pathways.

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Authors: Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., & Núñez, G.
Affiliations: University of Michigan (US)
Human Genome Sciences (United States) (US)
ORCID: Inohara, Naohiro
Koseki, Takeyoshi
Yee, Christina
Chen, Shu
Ni, Jian
Núñez, Gabriel
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1999-05
Volume: 274
Issue: 21
Pages: 14560-14567
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.274.21.14560
OpenAlex: W2119502087
Cited by: 742
References: 55
Citations by year: 2026: 8 · 2025: 7 · 2024: 15 · 2023: 9 · 2022: 25 · 2021: 18 · 2020: 19 · 2019: 28 · 2018: 17 · 2017: 24 · 2016: 22 · 2015: 18 · 2014: 35 · 2013: 28 · 2012: 37
FWCI: 12.35
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7831 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: University of Michigan (T32GM07863)
Japan Science and Technology Corporation
National Institutes of Health (5r01ca064556-10, 5k04ca064421-03)
National Cancer Institute (K04-CA64421, R01 CA64556)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: NOD1, Apaf-1, caspase-9, apoptosis, NF-κB activation, caspase recruitment domain, nucleotide-binding domain, leucine-rich repeats, cards, P-loop, TNF-α, innate immunity
MeSH terms: Amino Acid Sequence, Carrier Proteins, Chromosome Mapping, Humans, Molecular Sequence Data, Mutation, Proteins, NF-kappa B, Apoptosis, Caspases, Adaptor Proteins, Signal Transducing, Caspase 9, Nod1 Signaling Adaptor Protein, Apoptotic Protease-Activating Factor 1

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Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

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