The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
TRAAK Is a Mammalian Neuronal Mechano-gated K+Channel
Open accessAbstract
The novel structural class of mammalian channels with four transmembrane segments and two pore regions comprise background K+ channels (TWIK-1, TREK-1, TRAAK, TASK, and TASK-2) with unique physiological functions (1-6). Unlike its counterparts, TRAAK is only expressed in neuronal tissues, including brain, spinal cord, and retina (1). This report shows that TRAAK, which was known to be activated by arachidonic acid (3), is also opened by membrane stretch. Mechanical activation of TRAAK is induced by a convex curvature of the plasma membrane and can be mimicked by the amphipathic membrane crenator trinitrophenol. Cytoskeletal elements are negative tonic regulators of TRAAK. Membrane depolarization and membrane crenation synergize with stretch-induced channel opening. Finally, TRAAK is reversibly blocked by micromolar concentrations of gadolinium, a well known blocker of stretch-activated channels. Mechanical activation of TRAAK in the central nervous system may play an important role during growth cone motility and neurite elongation.
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Cites
Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions
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THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS
Sadoshima, J., & Izumo, S. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.551 · Cited by 864
Morris, C. E. (1990) · The Journal of Membrane Biology · doi:10.1007/bf01872883 · Cited by 715
A mammalian two pore domain mechano-gated S-like K+ channel
Patel, A. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4283 · Cited by 641
TASK, a human background K+ channel to sense external pH variations near physiological pH
Duprat, F. (1997) · The EMBO Journal · doi:10.1093/emboj/16.17.5464 · Cited by 636
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
Lesage, F., Guillemare, E., Fink, M., Duprat, F., Lazdunski, M., Romey, G., & Barhanin, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00437.x · Cited by 560
Self-citationFink, M., Duprat, F., Lesage, F., Reyes, R., Romey, G., Heurteaux, C., & Lazdunski, M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01077.x · Cited by 503
Self-citationMechanosensitive ion channels of E. coli activated by amphipaths
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A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids
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Cited by
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Mechanically Activated Ion Channels
Ranade, S. S., Syeda, R., & Patapoutian, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.032 · Cited by 652
TREK-1, a K+ channel involved in neuroprotection and general anesthesia
Heurteaux, C., Guy, N., Laigle, C., Blondeau, N., Duprat, F., Mazzuca, M., Lang‐Lazdunski, L., Widmann, C., Zanzouri, M., Romey, G., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600234 · Cited by 534
Self-citationDavis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
The TREK K2P channels and their role in general anaesthesia and neuroprotection
Franks, N. P., & Honoré, E. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.09.003 · Cited by 214
Metadata
- Authors
- Maingret, F., Fosset, M., Lesage, F., Lazdunski, M., & Honoré, E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 274
- Issue
- 3
- Pages
- 1381-1387
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2019129862
- Cited by
- 375
- References
- 22
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Maingret, F., Fosset, M., Lesage, F., Lazdunski, M., & Honoré, E. (1999). TRAAK Is a Mammalian Neuronal Mechano-gated K+Channel. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.3.1381
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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