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Failure to Cleave Sterol Regulatory Element-binding Proteins (SREBPs) Causes Cholesterol Auxotrophy in Chinese Hamster Ovary Cells with Genetic Absence of SREBP Cleavage-activating Protein
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The phenotype of SPRINGKO cells is highly reminiscent of cells lacking SCAP and liver-specific Scap knockout mice.
“This is highly reminiscent of what is observed in cells lacking SCAP45 and in liver-specific Scap knockout mice46.”
From Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism (2020) · cites this paper as [45]
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Metadata
- Authors
- Rawson, R. B., DeBose-Boyd, R., Goldstein, J. L., & Brown, M. S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 274
- Issue
- 40
- Pages
- 28549-28556
- ISSN
- 0021-9258
- Cited by
- 160
- References
- 0
- Language
- en
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