Telomeres and immunological diseases of aging.

Andrews, Nicolas P.; Fujii, Hiroshi; Goronzy, Jörg J.; Weyand, Cornelia M.

doi:10.1159/000268620

Cited by 109Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsNuclear Structure and Function

Telomeres and immunological diseases of aging.

Open access

Andrews, Nicolas P., Fujii, Hiroshi, Goronzy, Jörg J., Weyand, Cornelia M.·2010·Gerontology

DOI 10.1159/000268620PMC PMC2917738

Open this paper in CoChat — free account

Abstract

A defining feature of the eukaryotic genome is the presence of linear chromosomes. This arrangement, however, poses several challenges with regard to chromosomal replication and maintenance. To prevent the loss of coding sequences and to suppress gross chromosomal rearrangements, linear chromosomes are capped by repetitive nucleoprotein structures, called telomeres. Each cell division results in a progressive shortening of telomeres that, below a certain threshold, promotes genome instability, senescence, and apoptosis. Telomeric erosion, maintenance, and repair take center stage in determining cell fate. Cells of the immune system are under enormous proliferative demand, stressing telomeric intactness. Lymphocytes are capable of upregulating telomerase, an enzyme that can elongate telomeric sequences and, thus, prolong cellular lifespan. Therefore, telomere dynamics are critical in preserving immune function and have become a focus for studies of immunosenescence and autoimmunity. In this review, we describe the role of telomeric nucleoproteins in shaping telomere architecture and in suppressing DNA damage responses. We summarize new insights into the regulation of telomerase activity, hereditary disorders associated with telomere dysfunction, the role of telomere loss in immune aging, and the impact of telomere dysfunction in chronic inflammatory disease.

Integrity signals

Registry

Crossref · 10.1159/000268620

Cites

148 of 148 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

T cells can reactivate telomerase, elongate telomeres, and thereby extend their life span.
“In contrast to most other somatic cells, they have the ability to reactivate telomerase, elongate telomeres and thus lengthen their life span [13].”
From T-cell aging in rheumatoid arthritis (2014) · cites this paper as [13]
HIV-associated inflammation and/or exposure to nucleoside analogues have been associated with changes in telomere-related and other key biologic pathways.
“HIV-associated inflammation and/or exposure to nucleoside analogues have been associated with changes in these and other key biologic pathways (33–40).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [37]

1 retracted

Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
Akiyama, M., Hideshima, T., Hayashi, T., Tai, Y., Mitsiades, C. S., Mitsiades, N., Chauhan, D., Richardson, P. G. G., Munshi, N. C., & Anderson, K. C. (2003) · PubMed · Cited by 212 · see citing works
Retracted
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1× · see citing works
“Regulation of Telomerase ActivityIn the process of carcinogenesis, cells escape senescence through the mutation of tumor suppressor genes and survive crisis through telomerase upregulation. Thus, approximately 90p of tumor cells are positive for telomerase activity [”
Background
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056 · see citing works
Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524 · see citing works
Mammalian Telomeres End in a Large Duplex Loop
Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447 · see citing works
Estimates of the worldwide incidence of 25 major cancers in 1990
Parkin, D. M., Pisani, P., & Ferlay, J. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990315)80:6 · Cited by 2,013 · see citing works
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802 · see citing works
ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex
Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works
Obesity, cigarette smoking, and telomere length in women
Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66630-5 · Cited by 1,363 · see citing works
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066157 · Cited by 1,357 · see citing works
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
Hemann, M. T., Strong, M. A., Hao, L.-Y., & Greider, C. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00504-9 · Cited by 1,219 · see citing works
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193 · see citing works
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086 · see citing works
Requirement of the MRN complex for ATM activation by DNA damage
Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075 · see citing works
The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder
Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060 · see citing works
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works
Ageing and infection
Gavazzi, G., & Krause, K.-H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00437-1 · Cited by 990 · see citing works
X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions
Heiss, N. S., Knight, S. W., Vulliamy, T. J., Klauck, S. M., Wiemann, S., Mason, P. J., Poustka, A., & Dokal, I. (1998) · Nature Genetics · doi:10.1038/ng0598-32 · Cited by 976 · see citing works
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., & Dokal, I. (2001) · Nature · doi:10.1038/35096585 · Cited by 960 · see citing works
DNA Repair, Genome Stability, and Aging
Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944 · see citing works
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
Lavin, M. F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2514 · Cited by 901 · see citing works
Human Telomerase and Its Regulation
Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898 · see citing works
Direct activation of TERT transcription by c-MYC
Wu, K.-J., Grandori, C., Amacker, M., Simon-Vermot, N., Polack, A., Lingner, J., & Dalla-Favera, R. (1999) · Nature Genetics · doi:10.1038/6010 · Cited by 893 · see citing works
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880 · see citing works
Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M. A., Shay, J. W., Ishioka, S., & Yamakido, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.8.3711 · Cited by 853 · cited 1× · see citing works
“Lymphocytes have a unique requirement for clonal expansion that necessitates robust proliferative capacity. To circumvent growth arrest due to replication-associated telomere loss, immune cells maintain their chromosome ends via telomerase induction during entry into the cell cycle. Early studies described very low to…”
Background
Genetic determination of telomere size in humans: a twin study of three age groups.
Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 741 · see citing works
Telomerase maintains telomere structure in normal human cells
Kenichi, M., Yu, E. Y., Shilagardi, K., Ben‐Porath, I., Currier, J. L., Metz, G. B., Brooks, M. W., Kaneko, S., Seishi, M., DeCaprio, J. A., et al. (2006) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 738 · see citing works
Senescence and immortalization: role of telomeres and telomerase
Shay, J. W., & Wright, W. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh296 · Cited by 729 · see citing works
Mutations in <i>TERT,</i> the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia
Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042980 · Cited by 723 · see citing works
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709 · see citing works
The rate of telomere sequence loss in human leukocytes varies with age
Frenck, R. W., Blackburn, E. H., & Shannon, K. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5607 · Cited by 675 · see citing works
HIF-1α induces cell cycle arrest by functionally counteracting Myc
Koshiji, M., Kageyama, Y., Pete, E. A., Horikawa, I., Barrett, J. C., & Huang, L. E. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600196 · Cited by 652 · see citing works
Telomere Length as an Indicator of Biological Aging
Bénétos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., Labat, C., Bean, K., & Aviv, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.381 · Cited by 621 · see citing works
DNA methylation: past, present and future directions
Robertson, K. D., & Jones, P. A. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.461 · Cited by 609 · see citing works
Dyskeratosis congenita in all its forms
Dokal, I. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02109.x · Cited by 575 · see citing works
Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes.
Liuzzo, G., Goronzy, J. J., Yang, H., Kopecky, S. L., Holmes, D. R., Frye, R. L., & Weyand, C. M. (2000) · Circulation · doi:10.1161/01.cir.101.25.2883 · Cited by 552 · see citing works
Self-citation
T‐loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang
Stansel, R. M., de Lange, T., & Griffith, J. D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5532 · Cited by 529 · see citing works
Genomic 5-methyldeoxycytidine decreases with age.
Wilson, V. L., Smith, R. A., Ma, S., & Cutler, R. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61057-9 · Cited by 521 · see citing works
Telomere Length in the Newborn
Okuda, K., Bardeguez, A., Gardner, J. P., Rodriguez, P., Ganesh, V., Kimura, M., Skurnick, J., Awad, G., & Aviv, A. (2002) · Pediatric Research · doi:10.1203/00006450-200209000-00012 · Cited by 507 · see citing works
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)
Kyo, S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.3.669 · Cited by 494 · see citing works
CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.
Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118638 · Cited by 482 · see citing works
Self-citation
Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit
Kang, S. S., Kwon, T., Kwon, D. Y., & Do, S.-I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13085 · Cited by 480 · see citing works
T cell homeostasis in patients with rheumatoid arthritis
Koetz, K., Bryl, E., Spickschen, K., O’Fallon, W. M., Goronzy, J. J., & Weyand, C. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9203 · Cited by 467 · see citing works
Self-citation
Replication and protection of telomeres
Verdun, R. E., & Karlseder, J. (2007) · Nature · doi:10.1038/nature05976 · Cited by 463 · see citing works
Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC
Vulliamy, T., Marrone, A., Szydlo, R., Walne, A., Mason, P. J., & Dokal, I. (2004) · Nature Genetics · doi:10.1038/ng1346 · Cited by 461 · see citing works
Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis
Effros, R. B., Allsopp, R., Chiu, C.-P., Hausner, M. A., Hirji, K., Wang, L., Harley, C. B., Villeponteau, B., West, M. D., & Giorgi, J. V. (1996) · AIDS · doi:10.1097/00002030-199607000-00001 · Cited by 457 · see citing works
The molecular inflammatory process in aging
Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., & Yu, B. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.572 · Cited by 437 · see citing works
Site‐specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening
Oikawa, S., & Kawanishi, S. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00748-6 · Cited by 435 · see citing works
Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts
Petersen, S., Saretzki, G., & Zglinicki, T. V. (1998) · Experimental Cell Research · doi:10.1006/excr.1997.3893 · Cited by 427 · see citing works
TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita
Savage, S. A., Giri, N., Baerlocher, G. M., Orr, N., Lansdorp, P. M., & Alter, B. P. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.10.004 · Cited by 414 · see citing works
Accelerated Telomere Erosion Is Associated with a Declining Immune Function of Caregivers of Alzheimer’s Disease Patients
Damjanovic, A. K., Yang, Y., Glaser, R., Kiecolt‐Glaser, J. K., Nguyen, H., Laskowski, B. F., Zou, Y., Beversdorf, D. Q., & Weng, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4249 · Cited by 413 · see citing works
Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.
Horikawa, I., Cable, P. L., Afshari, C. A., & Barrett, J. C. (1999) · PubMed · Cited by 395 · see citing works
Molecular mechanisms of aging-associated inflammation.
Sarkar, D., & Fisher, P. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.04.009 · Cited by 379 · see citing works
Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence
Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · cited 1× · see citing works
“which provides indirect evidence that telomere erosion negatively affects the maintenance of a functional memory T-cell pool in elderly individuals. T-Lymphocyte Senescence Is Associated with Low Telomerase Activity Loss of the co-stimulatory molecule CD28 on T cells is considered the best marker of T-lymphocyte aging…”
Background
Reduced telomerase activity in human T lymphocytes exposed to cortisol
Choi, J., Fauce, S. R., & Effros, R. B. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.004 · Cited by 352 · see citing works
Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation
Vulliamy, T., Marrone, A., Knight, S. W., Walne, A. J., Mason, P. J., & Dokal, I. S. (2005) · Blood · doi:10.1182/blood-2005-07-2622 · Cited by 343 · see citing works
The bath ankylosing spondylitis radiology index (BASRI): A new, validated approach to disease assessment
Mackay, K., Mack, C., Brophy, S. T., & Călin, A. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199812)41:12 · Cited by 327 · see citing works
Self-citation
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease
Engel, P., Eck, M. J., & Terhorst, C. (2003) · Nature reviews. Immunology · doi:10.1038/nri1202 · Cited by 325 · see citing works
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells
Xu, D., Popov, N., Hou, M., Wang, Q., Björkholm, M., Gruber, A., Menkel, A. R., & Arsenian‐Henriksson, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043198 · Cited by 324 · see citing works
Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10
Walne, A. J., Vulliamy, T., Marrone, A., Beswick, R., Kirwan, M., Masunari, Y., Al-Qurashi, F.-H., Aljurf, M., & Dokal, I. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm111 · Cited by 316 · see citing works
Telomeres in T and B cells
Hodes, R. J., Hathcock, K. S., & Weng, N. (2002) · Nature reviews. Immunology · doi:10.1038/nri890 · Cited by 315 · see citing works
Expansion of unusual CD4+ T cells in severe rheumatoid arthritis
Martens, P. B., Goronzy, J. J., Schaid, D. J., & Weyand, C. M. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400615 · Cited by 290 · see citing works
Self-citation
Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart Study
Aviv, A., Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., & Berenson, G. S. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn338 · Cited by 290 · see citing works
Telomere Length of Circulating Leukocytes Is Decreased in Patients With Chronic Heart Failure
van der Harst, P., van der Steege, G., de Boer, R. A., Voors, A. A., Hall, A. S., Mulder, M. J., van Gilst, W. H., & van Veldhuisen, D. J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.027 · Cited by 281 · see citing works
Perturbation of the T cell repertoire in rheumatoid arthritis
Wagner, U. G., Koetz, K., Weyand, C. M., & Goronzy, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14447 · Cited by 278 · see citing works
Self-citation
Why females live longer than males? Importance of the upregulation of longevity‐associated genes by oestrogenic compounds
Viña, J., Borrás, C., Gambini, J., Sastre, J., & Pallardó, F. V. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.090 · Cited by 271 · see citing works
The many facets of H/ACA ribonucleoproteins
Meier, U. T. (2005) · Chromosoma · doi:10.1007/s00412-005-0333-9 · Cited by 269 · see citing works
Divergent Telomerase and CD28 Expression Patterns in Human CD4 and CD8 T Cells Following Repeated Encounters with the Same Antigenic Stimulus
Valenzuela, H. (2002) · Clinical Immunology · doi:10.1006/clim.2002.5271 · Cited by 254 · see citing works
Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks
Digweed, M., & Sperling, K. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.004 · Cited by 250 · see citing works
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes
Liu, K., Schoonmaker, M. M., Levine, B. L., June, C. H., Hodes, R. J., & Weng, N.-P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5147 · Cited by 233 · see citing works
T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection
Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.002 · Cited by 223 · see citing works
Self-citation
The loss of telomerase activity in highly differentiated CD8+CD28−CD27− T cells is associated with decreased Akt (Ser473) phosphorylation
Plunkett, F. J., Franzese, O., Finney, H. M., Fletcher, J. M., Belaramani, L. L., Salmon, M., Dokal, I., Webster, D., Lawson, A. D. G., & Akbar, A. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7710 · Cited by 222 · see citing works
Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.
Kanaya, T., Kyo, S., Hamada, K., Takakura, M., Kitagawa, Y., Harada, H., & Inoue, M. (2000) · PubMed · Cited by 222 · see citing works
Shortened telomere length in white blood cells of patients with IDDM.
Jeanclos, E., Krolewski, A., Skurnick, J., Kimura, M., Aviv, H., Warram, J. H., & Aviv, A. (1998) · Diabetes · doi:10.2337/diabetes.47.3.482 · Cited by 217 · see citing works
Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages
Schönland, S. O., Lopez, C., Widmann, T., Zimmer, J., Bryl, E., Goronzy, J. J., & Weyand, C. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233561100 · Cited by 216 · see citing works
Self-citation
IL-7-Dependent Extrathymic Expansion of CD45RA+ T Cells Enables Preservation of a Naive Repertoire
Soares, M. V. D., Soares, D., Borthwick, N., Maini, M. K., Janossy, G., Salmon, M., & Akbar, A. N. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.5909 · Cited by 216 · see citing works
Hypoxia-Inducible Factor 1 Mediates Upregulation of Telomerase (hTERT)
Nishi, H., Nakada, T., Kyo, S., Inoue, M., Shay, J. W., & Isaka, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.6076-6083.2004 · Cited by 213 · see citing works
Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene
Renaud, S., Loukinov, D. I., Abdullaev, Z., Guilleret, I., Bosman, F. T., Lobanenkov, V. V., & Benhattar, J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1125 · Cited by 204 · see citing works
Telomere length and heredity: Indications of paternal inheritance
Nordfjäll, K., Larefalk, Å., Lindgren, P., Holmberg, D., & Roos, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501724102 · Cited by 201 · see citing works
Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenitaPreprint
Wong, J. M. Y., & Collins, K. (2006) · Genes & Development · doi:10.1101/gad.1476206 · Cited by 201 · see citing works
Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age
Son, N. H., Murray, S., Yanovski, J., Hodes, R. J., & Weng, N.-P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1191 · Cited by 200 · see citing works
Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer Cells
Li, H., Zhao, L., Funder, J. W., & Liu, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16729 · Cited by 199 · see citing works
Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation.
Goronzy, J. J., & Weyand, C. M. (2003) · Arthritis Research · doi:10.1186/ar974 · Cited by 199 · see citing works
Self-citation
Transfer of the human telomerase reverse transcriptase(TERT) gene into T lymphocytes results in extension of replicative potential
Rufer, N., Migliaccio, M., Antonchuk, J., Humphries, R. K., Roosnek, E. E., & Lansdorp, P. M. (2001) · Blood · doi:10.1182/blood.v98.3.597 · Cited by 180 · see citing works
Sp1 and Sp3 Recruit Histone Deacetylase to Repress Transcription of Human Telomerase Reverse Transcriptase (hTERT) Promoter in Normal Human Somatic Cells
Won, J., Yim, J., & Kim, T. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206064200 · Cited by 180 · see citing works
DNA damage response at functional and dysfunctional telomeresPreprint
Longhese, M. P. (2008) · Genes & Development · doi:10.1101/gad.1626908 · Cited by 180 · see citing works
Paternal age at birth is an important determinant of offspring telomere length
Meyer, T. D., Rietzschel, E. R., Buyzere, M. D., Bacquer, D. D., Criekinge, W. V., Backer, G. D., Gillebert, T. C., Oostveldt, P. V., Bekaert, S., & on behalf of the Asklepios investigators (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm271 · Cited by 176 · see citing works
Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
Effros, R. B. (1997) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(97)00027-x · Cited by 175 · see citing works
Telomerase insufficiency in rheumatoid arthritis
Fujii, H., Shao, L., Colmegna, I., Goronzy, J. J., & Weyand, C. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811332106 · Cited by 172 · see citing works
Self-citation
Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes
Fauce, S. R., Jamieson, B. D., Chin, A. C., Mitsuyasu, R. T., Parish, S. T., Ng, H. L., Ramirez, C. M., Yang, O. O., Harley, C. B., & Effros, R. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7400 · Cited by 170 · see citing works
Identification of Mad as a repressor of the human telomerase (hTERT) gene
Oh, S., Song, Y., Yim, J., & Kim, T. K. (2000) · Oncogene · doi:10.1038/sj.onc.1203439 · Cited by 161 · see citing works
Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.
Goronzy, J. J., Bartz‐Bazzanella, P., Hu, W. T., Jendro, M. C., Walser-Kuntz, D. R., & Weyand, C. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117561 · Cited by 156 · see citing works
Self-citation
Histone Deacetylation Is Involved in the Transcriptional Repression of hTERT in Normal Human Cells
Cong, Y., & Bacchetti, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000637200 · Cited by 150 · see citing works
The Wilms' Tumor 1 Tumor Suppressor Gene Represses Transcription of the Human Telomerase Reverse Transcriptase Gene
Oh, S., Song, Y., Yim, J., & Kim, T. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37473 · Cited by 148 · see citing works
Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study
Andriollo-Sanchez, M., Hininger‐Favier, I., Meunier, N., Venneria, E., O’Connor, J. M., Maiani, G., Coudray, C., & Roussel, A. M. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602300 · Cited by 140 · see citing works
Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells
Moosig, F., Csernok, E., Wang, G., & Gross, W. L. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00695.x · Cited by 138 · see citing works
CTCF binds the proximal exonic region of hTERT and inhibits its transcription
Renaud, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki989 · Cited by 137 · see citing works
Will telomere erosion lead to a loss of T-cell memory?
Akbar, A. N., Beverley, P. C. L., & Salmon, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1440 · Cited by 135 · see citing works
Telomerase levels control the lifespan of human T lymphocytes
Röth, A., Yssel, H., Pène, J., Chavez, E. A., Schertzer, M., Lansdorp, P. M., Spits, H., & Luiten, R. M. (2003) · Blood · doi:10.1182/blood-2002-07-2015 · Cited by 133 · see citing works
HIF-1-mediated activation of telomerase in cervical cancer cells
Yatabe, N., Kyo, S., Maida, Y., Nishi, H., Nakamura, M., Kanaya, T., Tanaka, M., Isaka, K., Ogawa, S., & Inoue, M. (2004) · Oncogene · doi:10.1038/sj.onc.1207460 · Cited by 132 · see citing works
Dyskeratosis congenita: The diverse clinical presentation of mutations in the telomerase complex
Vulliamy, T., & Dokal, I. S. (2007) · Biochimie · doi:10.1016/j.biochi.2007.07.017 · Cited by 126 · see citing works
Transforming Growth Factor β Suppresses Human Telomerase Reverse Transcriptase (hTERT) by Smad3 Interactions with c-Myc and the hTERT Gene
Li, H., Xu, D., Li, J., Berndt, M. C., & Liu, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602381200 · Cited by 123 · see citing works
Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT
Fujimoto, K., Kyo, S., Takakura, M., Kanaya, T., Kitagawa, Y., Itoh, H., Takahashi, M., & Inoue, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2557 · Cited by 116 · see citing works
Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT
Lv, J., Liu, H., Wang, Q., Tang, Z., Hou, L., & Zhang, B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.235 · Cited by 115 · see citing works
Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor
Goueli, B. S., & Janknecht, R. (2003) · Oncogene · doi:10.1038/sj.onc.1206847 · Cited by 115 · see citing works
Effect of Long-Term Hormone Therapy on Telomere Length in Postmenopausal Women
Lee, D., Im, J., Kim, J., Lee, H.-R., & Shim, J. (2005) · Yonsei Medical Journal · doi:10.3349/ymj.2005.46.4.471 · Cited by 114 · see citing works
Telomere Erosion in Memory T Cells Induced by Telomerase Inhibition at the Site of Antigenic Challenge In Vivo
Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M., Soares, M. V. D., Cook, J. E., Orteu, C. H., Jackson, S. E., Birch, K. E., Foster, G. R., Salmon, M., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040178 · Cited by 111 · see citing works
Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis.
Colmegna, I., Diaz‐Borjon, A., Fujii, H., Schaefer, L., Goronzy, J. J., & Weyand, C. M. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23287 · Cited by 108 · see citing works
Self-citation
Telomerase Activity Is Induced in Human Peripheral B Lymphocytes by the Stimulation to Antigen Receptor
Igarashi, H., & Sakaguchi, N. (1997) · Blood · doi:10.1182/blood.v89.4.1299 · Cited by 108 · see citing works
Function of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene (<i>TERT</i>) in Human and Mouse Cells
Takakura, M., Kyo, S., Inoue, M., Wright, W. E., & Shay, J. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8037-8043.2005 · Cited by 107 · see citing works
Telomere and adaptive immunity
Weng, N.-P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.11.005 · Cited by 99 · see citing works
Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia
Callén, E. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.4.439 · Cited by 98 · see citing works
Telomerase Activity Is Increased and Telomere Length Shortened in T Cells from Blood of Patients with Atopic Dermatitis and Psoriasis
Wu, K., Higashi, N., Hansen, E. R., Lund, M., Bang, K., & Thestrup‐Pedersen, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4742 · Cited by 95 · see citing works
Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey
Starr, J. M., Shiels, P. G., Harris, S. E., Pattie, A., Pearce, M. S., Relton, C. L., & Deary, I. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.09.020 · Cited by 95 · see citing works
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks
Helmink, B. A., Bredemeyer, A. L., Lee, B.-S., Huang, C., Sharma, G. G., Walker, L. M., Bednarski, J. J., Lee, W.-L., Pandita, T. K., Bassing, C. H., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081326 · Cited by 95 · see citing works
Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration
Steer, S. E., Williams, F. M. K., Kato, B. S., Gardner, J. P., Norman, P. J., Hall, M. A., Kimura, M., Vaughan, R., Aviv, A., & Spector, T. D. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.059188 · Cited by 94 · see citing works
Unregulated inflammation shortens human functional longevity
Brod, S. A. (2000) · Inflammation Research · doi:10.1007/s000110050632 · Cited by 91 · see citing works
Quantitative changes in T cell DNA methylation occur during differentiation and ageing
Golbus, J., Palella, T. D., & Richardson, B. C. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200836 · Cited by 91 · see citing works
Telomere Shortening and Decreased Replicative Potential, Contrasted by Continued Proliferation of Telomerase-Positive CD8+CD28lo T Cells in Patients with Systemic Lupus Erythematosus
Honda, M., Mengesha, E., Albano‐Aluquin, S., Nichols, W. S., Wallace, D. J., Al, M., Klinenberg, J. R., & Linker‐Israeli, M. (2001) · Clinical Immunology · doi:10.1006/clim.2001.5023 · Cited by 90 · see citing works
Prolonged exposure of naïve CD8+ T cells to interleukin‐7 or interleukin‐15 stimulates proliferation without differentiation or loss of telomere length
Wallace, D. L., Berard, M., Soares, M. V. D., Oldham, J. E., Cook, J. E., Akbar, A. N., Tough, D. F., & Beverley, P. C. L. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02429.x · Cited by 79 · see citing works
Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT
Matsubara, Y., Murata, M., Yoshida, T., Watanabe, K., Saito, I., Miyaki, K., Omae, K., & Ikeda, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.163 · Cited by 75 · see citing works
The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome
Plunkett, F. J., Franzese, O., Belaramani, L. L., Fletcher, J. M., Gilmour, K. C., Sharifi, R., Khan, N., Hislop, A. D., Cara, A., Salmon, M., et al. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.006 · Cited by 74 · see citing works
Premature aging of the immune system in children with juvenile idiopathic arthritis
Prelog, M., Schwarzenbrunner, N., Sailer‐Höck, M., Kern, H., Klein‐Franke, A., Ausserlechner, M. J., Koppelstaetter, C., Brunner, A., Duftner, C., Dejaco, C., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23599 · Cited by 74 · see citing works
Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
Williams, E. S., Klingler, R., Ponnaiya, B., Hardt, T., Schröck, E., Lees‐Miller, S. P., Meek, K., Ullrich, R. L., & Bailey, S. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2854 · Cited by 73 · see citing works
The many faces of telomerase: emerging extratelomeric effects
Bollmann, F. M. (2008) · BioEssays · doi:10.1002/bies.20793 · Cited by 72 · see citing works
TNFα induces rapid activation and nuclear translocation of telomerase in human lymphocytes
Akiyama, M., Yamada, O., Hideshima, T., Yanagisawa, T., Yokoi, K., Fujisawa, K., Eto, Y., Yamada, H., & Anderson, K. C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.080 · Cited by 71 · see citing works
TELOMERE REDUCTION IN SCLERODERMA PATIENTS: A POSSIBLE CAUSE FOR CHROMOSOMAL INSTABILITY
Artlett, C. M., Black, C. M., Briggs, D., STEVENS, C. O., & Welsh, K. I. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.8.732 · Cited by 71 · see citing works
Telomere Length Profiles in Humans: All Ends are Not Equal
Gilson, É., & Londoño‐Vallejo, A. (2007) · Cell Cycle · doi:10.4161/cc.6.20.4798 · Cited by 53 · see citing works
hTERT −1327T/C polymorphism is not associated with age-related telomere attrition in peripheral blood
Nordfjäll, K., Osterman, P., Melander, O., Nilsson, P. M., & Roos, G. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.099 · Cited by 49 · see citing works
Association between telomere length and heart disease in a narrow age cohort of older people
Starr, J., McGurn, B., HARRIS, S., Whalley, L. J., Deary, I. J., & Shiels, P. G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.12.002 · Cited by 49 · see citing works
Shortening of telomeres: Evidence for replicative senescence of T cells derived from patients with Wegener's granulomatosis
Vogt, S., Iking‐Konert, C., Hug, F., Andrássy, K., & Hänsch, G. M. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00037.x · Cited by 48 · see citing works
Premature telomere shortening in polymorphonuclear neutrophils from patients with systemic lupus erythematosus is related to the lupus disease activity
Wu, C.-H., Hsieh, S., Li, K., Lu, M., & Yu, C.-L. (2007) · Lupus · doi:10.1177/0961203307077155 · Cited by 47 · see citing works
A major role of PKC θ and NFκB in the regulation of hTERT in human T lymphocytes
Sheng, W.-Y., Chen, Y.-R., & Wang, T. V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.11.044 · Cited by 43 · see citing works
Telomerase activity and telomere length of peripheral blood mononuclear cells in SLE patients
Kurosaka, D., Yasuda, J., Yoshida, K., Yokoyama, T., Ozawa, Y., Obayashi, Y., Kingetsu, I., Saitô, S., & Yamada, A. (2003) · Lupus · doi:10.1191/0961203303lu426oa · Cited by 43 · see citing works
The Opposing Effect of Hypoxia-Inducible Factor-2α on Expression of Telomerase Reverse Transcriptase
Lou, F., Chen, X., Jalink, M., Zhu, Q., Ge, N., Zhao, S., Fang, X., Fan, Y., Björkholm, M., Liu, Z., et al. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0065 · Cited by 43 · see citing works
Stable telomere length and telomerase expression from naıve to memory B-lymphocyte differentiation
Son, N. H., Joyce, B. R., Hieatt, A., Chrest, F. J., Yanovski, J. A., & Weng, N. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00018-6 · Cited by 38 · see citing works
Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells
Anno, K., Hayashi, A., Takahashi, T., Mitsui, Y., Ide, T., & Tahara, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.112 · Cited by 37 · see citing works
Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes
Schreurs, M. W. J., Hermsen, M. A. J. A., Geltink, R. I. K., Scholten, K. B. J., Brink, A. A. T. P., Taanman-Kueter, E. W., Tijssen, M., Meijer, C. J. L. M., Ylstra, B., Meijer, G. A., et al. (2005) · Blood · doi:10.1182/blood-2004-09-3742 · Cited by 37 · see citing works
Mechanisms Regulating the Proliferative Potential of Human CD8+ T Lymphocytes Overexpressing Telomerase
Menzel, O., Migliaccio, M., Goldstein, D. R., Dahoun, S. P., Delorenzi, M., & Rufer, N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3657 · Cited by 37 · see citing works
Telomerase activity in connective tissue diseases: elevated in rheumatoid arthritis, but markedly decreased in systemic sclerosis
Tarhan, E. F., Vural, F., Kosova, B., Aksu, K., Çoğulu, Ö., Keser, G., Gündüz, C., Tombuloğlu, M., Öder, G., Karaca, E., et al. (2007) · Rheumatology International · doi:10.1007/s00296-007-0472-9 · Cited by 36 · see citing works
Reversible Conversion of Immortal Human Cells from Telomerase-Positive to Telomerase-Negative Cells
Kumakura, S., Tsutsui, T. W., Yagisawa, J., Barrett, J. C., & Tsutsui, T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1819 · Cited by 35 · see citing works
An Analysis of Telomere Length in Sarcoidosis
Guan, J. Z., Maeda, T., Sugano, M., Oyama, J.-I., Higuchi, Y., Suzuki, T., & Makino, N. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.11.1199 · Cited by 34 · see citing works
Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion
MacIntyre, A., Brouilette, S., Lamb, K. E., Radhakrishnan, K., McGlynn, L. M., Chee, M. M., Parkinson, E. K., Freeman, D. W., Madhok, R., & Shiels, P. G. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.086652 · Cited by 34 · see citing works
Telomere length analysis in monocytes and lymphocytes from patients with systemic lupus erythematosus using multi-color flow-FISH
Beier, F., Balabanov, S., Amberger, C., Hartmann, U., Manger, K., Dietz, K., Kötter, I., & Brümmendorf, T. H. (2007) · Lupus · doi:10.1177/0961203307084299 · Cited by 27 · see citing works
Differences in telomerase expression by the CD1a + cells in Langerhans cell histiocytosis reflect the diverse clinical presentation of the disease
da Costa, C., Egeler, R. M., Hoogeboom, M., Szuhai, K., Forsyth, R. G., Niesters, M., de Krijger, R. R., Tazi, A., Hogendoorn, P. C. W., & Annels, N. E. (2007) · The Journal of Pathology · doi:10.1002/path.2167 · Cited by 24 · see citing works
T Cell Activation as Starter and Motor of Rheumatic Inflammation
Skapenko, A., Lipsky, P. E., & Schulze‐Koops, H. (2006) · Springer eBooks · doi:10.1007/3-540-29714-6_10 · Cited by 23 · see citing works
Telomere length shortening in Langerhans cell histiocytosis
Bechan, G. I., Meeker, A. K., Marzo, A. M. D., Racke, F. K., Jaffe, R., Sugar, E. A., & Arceci, R. J. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06904.x · Cited by 23 · see citing works

Flagged first, then by citations

Sorted by citations

Understanding immunosenescence to improve responses to vaccines
Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2588 · Cited by 827 · see citing works
Self-citation
Aging of the Immune System. Mechanisms and Therapeutic Targets
Weyand, C. M., & Goronzy, J. J. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-095aw · Cited by 554 · see citing works
Self-citation
The risk of infections associated with rheumatoid arthritis, with its comorbidity and treatment
Listing, J., Gerhold, K., & Zink, A. (2013) · Rheumatology · doi:10.1093/rheumatology/kes305 · Cited by 541 · see citing works
HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522 · see citing works
Self-citation
Ageing and the telomere connection: An intimate relationship with inflammation
Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., & Sethi, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.006 · Cited by 386 · see citing works
Aging and Immune Function: Molecular Mechanisms to Interventions
Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339 · see citing works
Telomeres and early-life stress: an overview
Price, L. H., Kao, H.-T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.025 · Cited by 339 · see citing works
IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma
Yang, Z., Grote, D. M., Ziesmer, S. C., Niki, T., Hirashima, M., Novak, A. J., Witzig, T. E., & Ansell, S. M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59806 · Cited by 309 · see citing works
Chronic Kidney Disease: A Clinical Model of Premature Aging
Stenvinkel, P., & Larsson, T. E. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.11.051 · Cited by 298 · see citing works
Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms
Hardeland, R. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12090 · Cited by 285 · see citing works
Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes
Moro‐García, M. A., Mayo, J. C., Sainz, R. M., & Alonso‐Arias, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00339 · Cited by 232 · see citing works
When aging reaches CD4+ T-cells: phenotypic and functional changes
Moro‐García, M. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00107 · Cited by 212 · see citing works
T-cell aging in rheumatoid arthritis
Weyand, C. M., Yang, Z., & Goronzy, J. J. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000011 · Cited by 164 · see citing works
Self-citation
Telomere length measurement as a clinical biomarker of aging and disease
Fasching, C. L. (2018) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2018.1504274 · Cited by 166 · see citing works
Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study
Daubenmier, J., Lin, J., Blackburn, E., Hecht, F. M., Kristeller, J., Maninger, N., Kuwata, M., Bacchetti, P., Havel, P. J., & Epel, E. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.10.008 · Cited by 157 · see citing works
mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription
Pont, A. R., Sadri, N., Hsiao, S. J., Smith, S. H., & Schneider, R. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.019 · Cited by 156 · see citing works
The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?
Kordinas, V., Ioannidis, A., & Chatzipanagiotou, S. (2016) · Genes · doi:10.3390/genes7090060 · Cited by 139 · see citing works
Telomere dysfunction, autoimmunity and aging.
(2011) · Europe PMC (PubMed Central) · Cited by 138 · see citing works
Self-citation
Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment
Goronzy, J. J., Li, G., Yu, M., & Weyand, C. M. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.003 · Cited by 134 · see citing works
Self-citation
Telomere Shortening and Alzheimer’s Disease
Cai, Z., Yan, L., & Ratka, A. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8207-9 · Cited by 120 · see citing works
Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
Liu, X., Hoft, D. F., & Peng, G. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133679 · Cited by 113 · see citing works
Telomere Length in Interstitial Lung Diseases
Snetselaar, R., van Moorsel, C. H. M., Kazemier, K. M., van der Vis, J. J., Zanen, P., van Oosterhout, M. F. M., & Grutters, J. C. (2015) · CHEST Journal · doi:10.1378/chest.14-3078 · Cited by 112 · see citing works
Telomeres, Telomerase and Ageing
Saretzki, G. C. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_9 · Cited by 114 · see citing works
Analysis of sperm telomere length in men with idiopathic infertility
Thilagavathi, J., Kumar, M., Mishra, S. S., Venkatesh, S., Kumar, R., & Dada, R. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2632-8 · Cited by 101 · see citing works
Immune Aging and Rheumatoid Arthritis
Goronzy, J. J., Shao, L., & Weyand, C. M. (2010) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2010.03.001 · Cited by 99 · see citing works
Self-citation
Cellular Aging and Restorative Processes: Subjective Sleep Quality and Duration Moderate the Association between Age and Telomere Length in a Sample of Middle-Aged and Older Adults
Cribbet, M. R., Carlisle, M., Cawthon, R. M., Uchino, B. N., Williams, P. G., Smith, T. W., Gunn, H. E., & Light, K. C. (2014) · Sleep · doi:10.5665/sleep.3308 · Cited by 93 · see citing works
Telomere length: how the length makes a difference
Lulkiewicz, M., Bajsert, J., Kopczynski, P., Barczak, W., & Rubiś, B. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05551-y · Cited by 89 · see citing works
Chronic and acute effects of endurance training on telomere length
Borghini, A., Giardini, G., Tonacci, A., Mastorci, F., Mercuri, A., Mrakic‐Sposta, S., Moretti, S., Andreassi, M. G., & Pratali, L. (2015) · Mutagenesis · doi:10.1093/mutage/gev038 · Cited by 85 · see citing works
Molecular Mechanisms Involved in the Aging of the T-cell Immune Response
Moro‐García, M. A., Alonso‐Arias, R., & López‐Larrea, C. (2012) · Current Genomics · doi:10.2174/138920212803759749 · Cited by 85 · see citing works
Telomeres and immune competency
Weng, N.-P. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.05.001 · Cited by 87 · see citing works
DNA repair: the link between primary immunodeficiency and cancer
de Miranda, N. F. C. C., Björkman, A., & Pan‐Hammarström, Q. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06322.x · Cited by 86 · see citing works
The Role and Mechanism of Metformin in Inflammatory Diseases
Lin, H., Ao, H., Guo, G., & Liu, M. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s436147 · Cited by 92 · see citing works
Discrimination, mental health, and leukocyte telomere length among African American men
Chae, D. H., Epel, E. S., Nuru‐Jeter, A., Lincoln, K. D., Taylor, R. J., Lin, J., Blackburn, E. H., & Thomas, S. B. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.001 · Cited by 79 · see citing works
Meditation as a Therapeutic Intervention for Adults at Risk for Alzheimerâ€™s Disease â€“ Potential Benefits and Underlying Mechanisms
Innes, K. E., & Selfe, T. K. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00040 · Cited by 72 · see citing works
Mechanisms of immunosenescence: lessons from models of accelerated immune aging
Saux, S. L., Weyand, C. M., & Goronzy, J. J. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06297.x · Cited by 75 · see citing works
Self-citation
The effect of mindfulness-based interventions on immunity-related biomarkers: a comprehensive meta-analysis of randomised controlled trials
Dunn, T. J., & Dimolareva, M. (2022) · Clinical Psychology Review · doi:10.1016/j.cpr.2022.102124 · Cited by 69 · see citing works
Telomere, aging and age-related diseases
Huang, X., Li, C., Ren, F., Zhang, H., & Zhang, L. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0021-1 · Cited by 57 · see citing works
Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults
Chen, S. H., Epel, E. S., Mellon, S. H., Lin, J., Reus, V. I., Rosser, R., Kupferman, E., Burke, H., Mahan, L., Blackburn, E. H., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.07.035 · Cited by 55 · see citing works
Telomeres and Telomerase in Renal Health
Wills, L. P., & Schnellmann, R. G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010060662 · Cited by 42 · see citing works
Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease
Fazzini, F., Lamina, C., Raschenberger, J., Schultheiss, U. T., Kotsis, F., Schönherr, S., Weissensteiner, H., Forer, L., Steinbrenner, I., Meiselbach, H., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.02.034 · Cited by 38 · see citing works
Vascular Calcification in Uremia: New-Age Concepts about an Old-Age Problem
Smith, E. R. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3353-2_13 · Cited by 38 · see citing works
T-cell senescence: A crucial player in autoimmune diseases
Lu, Y., Ruan, Y., Pan, H., Rui, K., Liu, Q., Wang, S., & Cui, D. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109202 · Cited by 37 · see citing works
Telomere length in Chernobyl accident recovery workers in the late period after the disaster
Reste, J., Zvigule, G., Zvagule, T., Kurjāne, N., Eglīte, M., Gabruševa, N., Bērziņa, D., Plonis, J., & Miklaševičs, E. (2014) · Journal of Radiation Research · doi:10.1093/jrr/rru060 · Cited by 37 · see citing works
Association between telomere length and complete blood count in US adults
Mazidi, M., Penson, P. E., & Banach, M. (2017) · Archives of Medical Science · doi:10.5114/aoms.2017.67281 · Cited by 37 · see citing works
Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis
Ashouri, J., Hsu, L.-Y., Yu, S., Rychkov, D., Chen, Y., Cheng, D. A., Sirota, M., Hansen, E. N., Lattanza, L. L., Zikherman, J., et al. (2018) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1904271116 · Cited by 36 · see citing works
Use of Telomere Length as a Biomarker for Aging and Age-Related Disease
Fossel, M. (2012) · Current Translational Geriatrics and Experimental Gerontology Reports · doi:10.1007/s13670-012-0013-6 · Cited by 32 · see citing works
Down syndrome: is it really characterized by precocious immunosenescence?
Kusters, M., Verstegen, R. H. J., & de Vries, E. (2011) · Europe PMC (PubMed Central) · Cited by 30 · see citing works
Immunosenescence and age-related viral diseases
Ma, Y. C., & Fang, M. (2013) · Science China Life Sciences · doi:10.1007/s11427-013-4478-0 · Cited by 31 · see citing works
Telomere dysfunction-related serological markers and oxidative stress markers in rheumatoid arthritis patients: correlation with diseases activity
Gamal, R. M., Hammam, N., Zakary, M. M., Abdelaziz, M. M., Razek, M. R. A., Mohamed, M. S. E., Emad, Y., Elnaggar, M. G., & Fürst, D. E. (2018) · Clinical Rheumatology · doi:10.1007/s10067-018-4318-5 · Cited by 30 · see citing works
Physical activity and telomere length in early stage breast cancer survivors
Garland, S. N., Johnson, F. B., Palmer, C., Speck, R. M., Donelson, M. L., Xie, S. X., DeMichele, A. M., & Mao, J. J. J. (2014) · Breast Cancer Research · doi:10.1186/preaccept-5894383411626386 · Cited by 27 · see citing works
A Nested Case-Controlled Comparison of Telomere Length and Psychological Functioning in Breast Cancer Survivors with and without Insomnia Symptoms
Garland, S. N., Palmer, C., Donelson, M. L., Gehrman, P., Johnson, F. B., & Mao, J. J. J. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1586 · Cited by 25 · see citing works
Study of the association of total and differential white blood cell counts with geriatric conditions, cardio-vascular diseases, seric IL-6 levels and telomere length
Compté, N., Bailly, B., Breucker, S. D., Goriely, S., & Pepersack, T. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.11.016 · Cited by 22 · see citing works
The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging
Germann, C. B. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109406 · Cited by 20 · see citing works
Shorter telomere length of T-cells in peripheral blood of patients with lung cancer
Yang, L., Qian, Y., Ding, T., Wei, L., & Cao, S. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s98488 · Cited by 18 · see citing works
Targets of Immune Regeneration in Rheumatoid Arthritis
Hohensinner, P. J., Goronzy, J. J., & Weyand, C. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.01.020 · Cited by 17 · see citing works
Self-citation
Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial
Doherty, J. A., Grieshober, L., Houck, J. R., Barnett, M. J., Tapsoba, J. D. D., Thornquist, M. D., Wang, C., Goodman, G. E., & Chen, C. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0075-0 · Cited by 16 · see citing works
Telomere dysfunction in peripheral blood mononuclear cells from patients with primary biliary cirrhosis
Invernizzi, P., Bernuzzi, F., Lleò, A., Pozzoli, V., Bignotto, M., Zermiani, P., Crosignani, A., Battezzati, P. M., Zuin, M. G., Podda, M., et al. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.11.008 · Cited by 14 · see citing works
Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study
Törn, C., Liu, X., Önengüt-Gümüşcü, S., Counts, K., Moreno, J. L., Remedios, C. L., Chen, W., LeFaive, J., Butterworth, M. D., Akolkar, B., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08058-7 · Cited by 14 · see citing works
The association of circulating systemic inflammation with premature death and the protective role of the Mediterranean diet: a large prospective cohort study of UK biobank
Liu, S., Yang, R., Zuo, Y., Qiao, C., Jiang, W., Cheng, W., Wei, W., Liu, Z., Geng, Y., & Dong, Y. X. (2024) · BMC Public Health · doi:10.1186/s12889-024-18888-x · Cited by 14 · see citing works
Shelterin dysfunction promotes CD4+ T cell senescence in Behçet’s disease
Shi, J., Zhang, M., Zhang, L., Yu, X., Sun, L., Liu, J., Zhao, Y., & Zheng, W. (2023) · Lara D. Veeken · doi:10.1093/rheumatology/kead703 · Cited by 12 · see citing works
Genetic association of leukocyte telomere length with Graves’ disease in Biobank Japan: A two-sample Mendelian randomization study
Ye, M., Wang, Y., & Zhan, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.998102 · Cited by 11 · see citing works
The Catalytic Subunit of Human Telomerase Is a Unique Caspase-6 and Caspase-7 Substrate
Soares, J., Lowe, M. M., & Jarstfer, M. B. (2011) · Biochemistry · doi:10.1021/bi2010398 · Cited by 11 · see citing works
Potent telomerase activators from a novel sapogenin via biotransformation utilizing Camarosporium laburnicola, an endophytic fungus
Küçüksolak, M., Yılmaz, S., Ballar, P., & Bedіr, E. (2023) · Microbial Cell Factories · doi:10.1186/s12934-023-02069-3 · Cited by 10 · see citing works
The Role of Telomeres in Musculoskeletal Diseases
Li, D., Yuan, Q., & Wang, W. (2012) · Journal of International Medical Research · doi:10.1177/147323001204000403 · Cited by 10 · see citing works
Targeting of AUF1 to vascular endothelial cells as a novel anti-aging therapy.
He, J., Jiang, Y., Liu, L., Wang, D.-J., Wei, W., Ji, P., Huang, Y.-C., Song, H., Lü, X., & Zhao, Y. (2017) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2017.08.005 · Cited by 10 · see citing works
The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer
Hagstrom, A. D., & Denham, J. (2018) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk3010009 · Cited by 10 · see citing works
Individual telomere length decay in patients with spondyloarthritis
Tamayo, M., Pértega-Díaz, S., Mosquera, A., Rodríguez, M., Blanco, F. J., FERNÁNDEZ-SUEIRO, J. L., Gosálvez, J., & Fernández, J. L. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.04.006 · Cited by 9 · see citing works
T-cell senescence: Unlocking the tumor immune “Dark Box” - A multidimensional analysis from mechanism to tumor immunotherapeutic intervention
Cheng, J., Zheng, J., Ma, C., Li, Y., & Hao, H. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.05.010 · Cited by 8 · see citing works
Declined hTERT expression of peripheral blood CD 4+ T cells in oral lichen planus correlated with clinical parameter
Zhang, J., Wei, M., Lü, R., Du, G., & Zhou, G. (2015) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12399 · Cited by 8 · see citing works
Development of software and modification of Q-FISH protocol for estimation of individual telomere length in immunopathology
Barkovskaya, M. S., Bogomolov, A. G., Knauer, N., Рубцов, Н. Б., & Va, K. (2016) · Journal of Bioinformatics and Computational Biology · doi:10.1142/s0219720016500414 · Cited by 8 · see citing works
Immunosenescence and its potential modulation: lessons from mouse models
Boldizsár, F., Mikecz, K., & Glant, T. T. (2010) · Expert Review of Clinical Immunology · doi:10.1586/eci.10.16 · Cited by 7 · see citing works
Promoter Polymorphism in the Serotonin Transporter (5-HTT) Gene Is Significantly Associated with Leukocyte Telomere Length in Han Chinese
Li, P., Liu, T., Liu, J., Zhang, Q., Lou, F., Kong, F., Cheng, G., Björkholm, M., Zheng, C., & Xu, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094442 · Cited by 7 · see citing works
Platelet-Rich Plasma Proteome of Mares Susceptible to Persistent-Breeding-Induced Endometritis Differs from Resistant Mares
Novello, G., de Souza, F. F., & Canisso, I. F. (2024) · Animals · doi:10.3390/ani14142100 · Cited by 6 · see citing works
Telomere length distribution on individual chromosome arms in patients with bronchial asthma
Barkovskaya, M. S., Blinova, E. A., Konyahina, J. V., Leonova, M. I., Nepomniashchikch, V. M., Демина, Д. В., Kozhevnikov, V. S., & Va, K. (2019) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2019-1-164-174 · Cited by 6 · see citing works
Anti-mutated citrullinated vimentin antibodies in rheumatoid arthritis; diagnostic utility and association with deformities and disease activity
Mohammed, H., Ahmed, G. H., Tawfik, N., Sayed, S., & Ahmed, A. (2023) · Egyptian journal of Immunology · doi:10.55133/eji.300111 · Cited by 6 · see citing works
Stem Cells Targeting Inflammation as Potential Anti-aging Strategies and Therapies
Gonzalez, Woynarowski, D., & Geffner, L. (2015) · Cell & Tissue Transplantation & Therapy · doi:10.4137/cttt.s19477 · Cited by 6 · see citing works
What is causing my arthritis, doctor? A glimpse beyond the usual suspects in the pathogenesis of rheumatoid arthritis
Pieringer, H., & Studnicka-Benke, A. (2012) · QJM · doi:10.1093/qjmed/hcs205 · Cited by 5 · see citing works
Length Does Not Matter
Goodman, W. A., & Jain, M. K. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.220343 · Cited by 5 · see citing works
Integration of Telomere Length Dynamics into Systems Biology Framework: A Review
Nersisyan, L. (2016) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s39836 · Cited by 4 · see citing works
Telomerase Dysfunction in the Tumorigenesis of Genetic Disorders.
Aql, M. M. F., Bahget, S. A.-E. G., Kholoussi, N. M., Abdel‐Salam, G. M. H., Raouf, H. A., Eid, M. M., & Esmail, R. E.-B. (2021) · PubMed Central · doi:10.22088/ijmcm.bums.10.1.56 · Cited by 3 · see citing works
Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations
Qi, Y., Liu, X., He, Y.-X., Zhou, M., Ning, X., Zhai, Y., Zhang, X., Wang, X., Zhao, Y., Cui, Y., et al. (2021) · Journal of Immunology Research · doi:10.1155/2021/7079359 · Cited by 3 · see citing works
Analyses of Mitochondrial DNA and Immune Phenotyping Suggest Accelerated T-Cell Turnover in Treated HIV
Massanella, M., Karris, M., Pérez‐Santiago, J., Yek, C., Vitomirov, A., & Mehta, S. R. (2018) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001824 · Cited by 2 · see citing works
Measurement of paraoxonase and telomerase enzymes and HDL (high density lipoprotein) values and research of their possible relationships with each other in bloodserum of obese cats
DAĞ, T., & Şahinduran, Ş. (2021) · Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi · doi:10.24880/maeuvfd.920578 · Cited by 2 · see citing works
T Cell Senescence and Tumor Immunotherapy
Liu, X., & Peng, G. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_136-1 · Cited by 2 · see citing works
Telomere Length is Not a Main factor for the Development of Islet Autoimmunity and Type 1 Diabetes in the TEDDY StudyPreprint
Parikh, H. M., Törn, C., Liu, X., Önengüt-Gümüşcü, S., Counts, K., Moreno, J., Remedios, C. L., Chen, W., LeFaive, J., Butterworth, M. D., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1018251/v1 · Cited by 2 · see citing works
Assortative breeding experiment in a songbird suggests telomere length is determined during early life rather than at conception
Xiong, Y., Melgar, J., Tobler, M., & Hasselquist, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-23517-7 · Cited by 1 · see citing works
Telomere length in leukocyte as biomarker for diagnosis of primary Sjögren’s syndrome: a cross-sectional study
Fang, H., Gao, R., Fan, H., Pu, J., Yang, L., Wang, Y., Song, J., Li, C., Wang, Y., Tang, J., et al. (2025) · Clinical Rheumatology · doi:10.1007/s10067-025-07804-2 · Cited by 1 · see citing works
T Cell Senescence and Tumor Immunotherapy
Liu, X., & Peng, G. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_136 · Cited by 1 · see citing works
A short story: senescence in an annual reptile, Labord’s chameleon (Furcifer labordi)
Eckhardt, F. S. (2020) · doi:10.53846/goediss-8355 · Cited by 1 · see citing works
Efeitos da meditação e da sugestão hipnótica na atividade da telomerase nas células mononucleadas do sangue periférico
Santos, A. J. C. D. P. (2020) · doi:10.11606/t.47.2020.tde-21012021-003640 · Cited by 1 · see citing works
TELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
Zinnatova, E. V., Borisov, V. I., Kozhevnikov, V. S., Сизиков, А. Э., & Козлов, В. А. (2014) · Medical Immunology (Russia) · doi:10.15789/1563-0625-2011-2-3-151-156
Innate Immune Responses in the Geriatric Population
Compt, N., & Goriely, S. (2012) · InTech eBooks · doi:10.5772/37878
Models of Immune Aging
O’Connor, J., Herrera, G., Jávega, B., & Martínez‐Romero, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00058-0
Telomere Length and Senescence in a Long-lived Fish (Ictiobus cyprinellus)
Sauer, D. J. (2019) · NDSU Repository (North Dakota State University)
Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men
Shin, Y.-A., Kim, C., Lee, S.-H., Lee, Y.-W., Kim, J.-S., & Park, D. (2021) · Exercise Science · doi:10.15857/ksep.2021.00437
A story of a paper tiger
Charley, J. (1988)
Das Immunsystem
Rensing, L., & Rippe, V. (2013) · Springer eBooks · doi:10.1007/978-3-642-37733-4_7
Telomerase Reverse Transcriptase Enzyme (hTERT) expression in bronchial mucosa inversely correlates with the severity of airway obstruction in patients with chronic airway obstructive diseasesPreprint
Moermans, C., Medard, L., Graff, S., Njock, M., Bougard, N., Schleich, F., Guiot, J., Corhay, J. L., & Louis, R. E. (2022) · medRxiv · doi:10.1101/2022.12.08.22283249
Additional file 6 of The association of circulating systemic inflammation with premature death and the protective role of the Mediterranean diet: a large prospective cohort study of UK biobank
Liu, S., Yang, R., Zuo, Y., Qiao, C., Jiang, W., Cheng, W., Wei, W., Liu, Z., Geng, Y., & Dong, Y. X. (2024) · Figshare · doi:10.6084/m9.figshare.26758844
Additional file 2 of The association of circulating systemic inflammation with premature death and the protective role of the Mediterranean diet: a large prospective cohort study of UK biobank
Liu, S., Yang, R., Zuo, Y., Qiao, C., Jiang, W., Cheng, W., Wei, W., Liu, Z., Geng, Y., & Dong, Y. X. (2024) · Figshare · doi:10.6084/m9.figshare.26758832

Authors: Andrews, N. P., Fujii, H., Goronzy, J. J., & Weyand, C. M.
Affiliations: Emory University (US)
ORCID: Fujii, Hiroshi
Goronzy, Jörg J.
Weyand, Cornelia M.
Venue: Gerontology
Publisher: S. Karger AG
Published: 2009-12-17
Volume: 56
Issue: 4
Pages: 390-403
ISSN: 0304-324X (ISSN-L)
1423-0003
DOI: 10.1159/000268620
PMC: PMC2917738
OpenAlex: W1981392889
Cited by: 108
References: 148
Citations by year: 2025: 3 · 2024: 12 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 2 · 2016: 5 · 2015: 7 · 2014: 12 · 2013: 8 · 2012: 15
FWCI: 0.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Gerontology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American College of Rheumatology Research and Education Foundation
Rheumatology Research Foundation
National Institutes of Health
National Institute on Aging (R01AG015043, R01AG15043)
National Heart, Lung, and Blood Institute (R01HL117913)
National Eye Institute (R01EY011916, R01 EY 11916)
National Institute of Allergy and Infectious Diseases (R01AI044142, U19-AI57266, R01AI44142, R01AI108906, R56AI044142, U19AI057266)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR041974, R01 AR 41974, R01AR042527, R01AR42527)
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: telomeres, immunosenescence, autoimmunity, telomerase, telomere dysfunction, lymphocytes, telomere maintenance, DNA damage response, chronic inflammatory diseases, genomic instability, cellular senescence, apoptosis
MeSH terms: Aging, Animals, Humans, Immune System Diseases, Inflammation, Models, Biological, T-Lymphocytes, Gene Expression Regulation, Enzymologic, Telomere, Cellular Senescence, Telomerase, Aging, Premature

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Telomeres and immunological diseases of aging.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks