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TOR controls translation initiation and early G1 progression in yeast.

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RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

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TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

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Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

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When is a lipid kinase not a lipid kinase? When it is a protein kinase

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TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

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mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

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The TOR Kinases Link Nutrient Sensing to Cell Growth

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TOR Deficiency in C. elegans Causes Developmental Arrest and Intestinal Atrophy by Inhibition of mRNA Translation

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Therapy for Osteosarcoma

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Roles of Glutamate Receptors and the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Activity-dependent Dendritic Protein Synthesis in Hippocampal Neurons

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Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

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TOR Signaling

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BMPs signal alternately through a SMAD or FRAP–STAT pathway to regulate fate choice in CNS stem cells

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FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

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mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

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Cloning of a Novel Phosphatidylinositol Kinase-related Kinase

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Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages.

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The Mammalian Target of Rapamycin Regulates C2C12 Myogenesis via a Kinase-independent Mechanism

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Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

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mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR

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Large FK506-binding proteins shape the pharmacology of rapamycin

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Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

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The Rapamycin-binding Domain of the Protein Kinase Mammalian Target of Rapamycin Is a Destabilizing Domain

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mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression

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