The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Rac/Cdc42 and p65PAK Regulate the Microtubule-destabilizing Protein Stathmin through Phosphorylation at Serine 16
Open accessAbstract
We have identified a rapid protein phosphorylation event at residue serine 16 of stathmin using two-dimensional gel electrophoresis coupled to matrix-assisted laser desorption/ionization mass spectrometry in combination with post-source decay analysis, which is induced by the epidermal growth factor receptor. Phosphorylation is specifically mediated by the small GTPases Rac and Cdc42 and their common downstream target, the serine/threonine kinase p65PAK. Both GTPases have previously been shown to regulate the dynamics of actin polymerization. Because stathmin destabilizes microtubules, and this process is inhibited by phosphorylation at residue 16, Rac and Cdc42 can potentially regulate both F-actin and microtubule dynamics.
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Cites
Rho GTPases and the Actin Cytoskeleton
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Self-citationA Role for Cdc42 in Macrophage Chemotaxis
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p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts
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RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Self-citationCell migration: Rho GTPases lead the way
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Self-citationConserved microtubule–actin interactions in cell movement and morphogenesis
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Rho and Ras GTPases in axon growth, guidance, and branching
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Self-citationThe oncoprotein 18/stathmin family of microtubule destabilizers
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Metadata
- Authors
- Daub, H., Gevaert, K., Vandekerckhove, J., Sobel, A., & Hall, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 276
- Issue
- 3
- Pages
- 1677-1680
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2017328399
- Cited by
- 295
- References
- 20
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Daub, H., Gevaert, K., Vandekerckhove, J., Sobel, A., & Hall, A. (2001). Rac/Cdc42 and p65PAK Regulate the Microtubule-destabilizing Protein Stathmin through Phosphorylation at Serine 16. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.c000635200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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