Growth Control Under Stress: mTOR Regulation through the REDD1-TSC Pathway

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

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Dysregulation of the TSC-mTOR pathway in human disease

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Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

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AMP‐activated protein kinase: the energy charge hypothesis revisited

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

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Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, <i>RTP801</i> , Involved in Apoptosis

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.Preprint

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REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species

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A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets

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Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1

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TSC2: filling the GAP in the mTOR signaling pathway

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The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in DrosophilaPreprint

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Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP Activity

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The Stress-inducted Proteins RTP801 and RTP801L Are Negative Regulators of the Mammalian Target of Rapamycin Pathway

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Dexamethasone-induced Gene 2 (dig2) Is a Novel Pro-survival Stress Gene Induced Rapidly by Diverse Apoptotic Signals

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REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase

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TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

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Targeting the mTOR signaling network in cancer

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Insulin/TOR signaling in growth and homeostasis: A view from the fly world

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The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

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The role of mTOR in the management of solid tumors: An overview

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Autophagy Signaling and the Cogwheels of Cancer

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Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

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The Role of Chronic Inflammation in Obesity-Associated Cancers

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Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle

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Biochemistry of proinflammatory macrophage activation

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Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling

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Transcriptional regulation of the stress response by mTOR

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Rapid Turnover of the mTOR Complex 1 (mTORC1) Repressor REDD1 and Activation of mTORC1 Signaling following Inhibition of Protein Synthesis

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Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues

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REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids

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RTP801/REDD1 Regulates the Timing of Cortical Neurogenesis and Neuron Migration

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DDIT4/REDD1/RTP801 Is a Novel Negative Regulator of Schwann Cell Myelination

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Ezrin Inhibition Up-regulates Stress Response Gene Expression

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REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumorsPreprint

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REDD1 Protects Osteoblast Cells from Gamma Radiation-Induced Premature Senescence

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The Leukemia-Specific Fusion Gene ETV6/RUNX1 Perturbs Distinct Key Biological Functions Primarily by Gene Repression

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PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease

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A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network

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PI3K inhibitors protect against glucocorticoid-induced skin atrophy

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Acute Alcohol Intoxication Increases REDD1 in Skeletal Muscle

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Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma

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Novel Target Genes Responsive to Apoptotic Activity byOcimum gratissimumin Human Osteosarcoma Cells

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Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation

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Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats

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REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization

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Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid Atrophy

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Evidence of molecular links between PKR and mTOR signalling pathways in Aβ neurotoxicity: Role of p53, Redd1 and TSC2

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RTP801 is a critical factor in the neurodegeneration process of A53T α‐synuclein in a mouse model of Parkinson's disease under chronic restraint stress

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The Stress-Response Gene redd1 Regulates Dorsoventral Patterning by Antagonizing Wnt/β-catenin Activity in Zebrafish

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PKR, a cognitive decline biomarker, can regulate translation <i>via</i> two consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients

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Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas

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The mTOR Signaling Pathway is an Emerging Therapeutic Target in Multiple Myeloma

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Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125

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Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway

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Amino Acid- and Insulin-Induced Activation of mTORC1 in Neonatal Piglet Skeletal Muscle Involves Sestrin2-GATOR2, Rag A/C-mTOR, and RHEB-mTOR Complex Formation

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