TSC1 Stabilizes TSC2 by Inhibiting the Interaction between TSC2 and the HERC1 Ubiquitin Ligase

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

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The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

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Rare coding variants in ten genes confer substantial risk for schizophrenia

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IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway

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The TSC-mTOR pathway regulates macrophage polarization

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The role of ubiquitination and deubiquitination in cancer metabolism

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The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

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Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

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A Mouse Model of Tuberous Sclerosis: Neuronal Loss of Tsc1 Causes Dysplastic and Ectopic Neurons, Reduced Myelination, Seizure Activity, and Limited Survival

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mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

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Nutrient signaling to mTOR and cell growth

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The tuberous sclerosis complex

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Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

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mTOR signaling and its roles in normal and abnormal brain development

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TSC1 controls macrophage polarization to prevent inflammatory disease

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A Strategy for Modulation of Enzymes in the Ubiquitin System

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Mechanisms maintaining the dormancy and survival of mammalian primordial follicles

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Regulation of Imaginal Disc Growth by Tumor-Suppressor Genes in Drosophila

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Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities

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Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles

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Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia

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Genetically engineered human cortical spheroid models of tuberous sclerosis

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Stress-Responsive Sestrins Link p53 with Redox Regulation and Mammalian Target of Rapamycin Signaling

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Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

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mTOR signaling in stem and progenitor cells

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Critical Role for Hypothalamic mTOR Activity in Energy Balance

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iLIR database: A web resource for LIR motif-containing proteins in eukaryotes

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mTOR pathway as a target in tissue hypertrophy

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WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1–CUL4–ROC1 ligasePreprint

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TSC1 and TSC2 gene mutations and their implications for treatment in Tuberous Sclerosis Complex: a review

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Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners

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The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling

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Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

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From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis

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HCMV Targets the Metabolic Stress Response through Activation of AMPK Whose Activity Is Important for Viral Replication

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Genetics and Molecular Biology of Tuberous Sclerosis Complex

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Functional and pathological relevance of HERC family proteins: a decade later

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TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1–TSC2 complex

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GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

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Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle

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Pam (Protein associated with Myc) functions as an E3 Ubiquitin ligase and regulates TSC/mTOR signaling

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mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level

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FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

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The Role of Tuberous Sclerosis Complex 1 in Regulating Innate Immunity

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The E3 Ubiquitin Protein Ligase HERC2 Modulates the Activity of Tumor Protein p53 by Regulating Its Oligomerization

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miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma

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From genes to cognition in tuberous sclerosis: Implications for mTOR inhibitor-based treatment approaches

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Tuberous Sclerosis Complex Proteins 1 and 2 Control Serum-Dependent Translation in a TOP-Dependent and -Independent Manner

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Progressive Purkinje Cell Degeneration in tambaleante Mutant Mice Is a Consequence of a Missense Mutation in HERC1 E3 Ubiquitin Ligase

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Smooth Muscle–like Cells in Pulmonary Lymphangioleiomyomatosis

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E3 ubiquitin ligase E6AP‐mediated TSC2 turnover in the presence and absence of HPV16 E6

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Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson’s disease

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Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances

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Intracellular signalling during female gametogenesis

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NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth

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Akt regulates nuclear/cytoplasmic localization of tuberin

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Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin

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The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo

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Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

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Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms

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mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy

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TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice

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Functional assessment of TSC1 missense variants identified in individuals with tuberous sclerosis complex

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Pulmonary lymphangioleiomyomatosis (LAM): Progress and current challenges

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TSC1 involvement in bladder cancer: diverse effects and therapeutic implications

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Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila

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Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM

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The Tuberous Sclerosis Complex Regulates Trafficking of Glucose Transporters and Glucose Uptake

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