From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Epidemiological Surveys of Autism and Other Pervasive Developmental Disorders: An Update

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White matter in learning, cognition, and psychiatric disorders

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Phosphorylation and Functional Inactivation of TSC2 by Erk

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Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

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Reversal of Neurological Defects in a Mouse Model of Rett Syndrome

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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Tuberous sclerosis

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Correction of Fragile X Syndrome in Mice

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Translational control of long-lasting synaptic plasticity and memory

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Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis

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Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

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A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

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Epidemiology of Tuberous Sclerosis

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A complex interplay between Akt, TSC2 and the two mTOR complexes

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

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Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

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Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

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The NF1 tumor suppressor critically regulates TSC2 and mTOR

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Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity

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Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways

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Control of Dendritic Arborization by the Phosphoinositide-3′-Kinase–Akt–Mammalian Target of Rapamycin Pathway

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory

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The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

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Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

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Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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Pharmacological Rescue of Synaptic Plasticity, Courtship Behavior, and Mushroom Body Defects in a Drosophila Model of Fragile X Syndrome

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A Mouse Model of Tuberous Sclerosis: Neuronal Loss of Tsc1 Causes Dysplastic and Ectopic Neurons, Reduced Myelination, Seizure Activity, and Limited Survival

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Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites

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Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

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A pilot open label, single dose trial of fenobam in adults with fragile X syndrome

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Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

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Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites

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Tuberous sclerosis complex proteins control axon formationPreprint

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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

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Behavioral and Cognitive Aspects of Tuberous Sclerosis Complex

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MORBIDITY ASSOCIATED WITH TUBEROUS SCLEROSIS: A POPULATION STUDY

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Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome

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Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse

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Sirolimus Therapy in Tuberous Sclerosis or Sporadic Lymphangioleiomyomatosis

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Autism and Tuberous Sclerosis

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Reversing Neurodevelopmental Disorders in Adults

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Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory

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Cognitive prognosis of patients with tuberous sclerosis complex

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Psychiatric comorbid conditions in a clinic population of 241 patients with tuberous sclerosis complex

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Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1

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Glutamatergic Regulation of the p70S6 Kinase in Primary Mouse Neurons*

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Epileptogenesis and Reduced Inward Rectifier Potassium Current in Tuberous Sclerosis Complex‐1–Deficient Astrocytes

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Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex

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ERK and mTOR Signaling Couple β-Adrenergic Receptors to Translation Initiation Machinery to Gate Induction of Protein Synthesis-dependent Long-term Potentiation

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Impaired synaptic plasticity in a rat model of tuberous sclerosis

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