Creation of a Stress-activated p90 Ribosomal S6 Kinase

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,396 · see citing works

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., & Saltiel, A. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7686 · Cited by 2,679 · see citing works

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R., & Lee, J. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00357-f · Cited by 2,086 · see citing works

Mitogen‐ and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Deák, M., Clifton, A. D., Lucocq, J. M., & Alessi, D. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4426 · Cited by 992 · see citing works

Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

Waskiewicz, A. J., Flynn, A., Proud, C. G., & Cooper, J. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1909 · Cited by 951 · see citing works

MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

Fukunaga, R., & Hunter, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1921 · Cited by 666 · see citing works

pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167

Joel, P. B., Smith, J. A., Sturgill, T. W., Fisher, T. L., Blenis, J., & Lannigan, D. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.1978 · Cited by 345 · see citing works

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

Ben-Levy, R., Hooper, S., Wilson, R., Paterson, H. F., & Marshall, C. J. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70442-7 · Cited by 338 · see citing works

Differential targeting of MAP kinases to the ETS‐domain transcription factor Elk‐1

Yang, S., Whitmarsh, A. J., Davis, R. J., & Sharrocks, A. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1740 · Cited by 299 · see citing works

Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

Smith, J. A., Poteet-Smith, C. E., Malarkey, K., & Sturgill, T. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2893 · Cited by 283 · see citing works

Evidence for Two Catalytically Active Kinase Domains in pp90 rsk

Fisher, T. L., & Blenis, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1212 · Cited by 196 · see citing works

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

Stokoe, D., Caudwell, B., Cohen, P., & Cohen, P. T. W. (1993) · Biochemical Journal · doi:10.1042/bj2960843 · Cited by 190 · see citing works

Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes

Adams, P. D., Li, X., Sellers, W. R., Baker, K., Leng, X., Harper, J. W., Taya, Y., & Kaelin, W. G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1068 · Cited by 185 · see citing works

RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38α Mitogen-activated Protein Kinase (p38αMAPK)

Pierrat, B., Correia, J. D. S., Mary, J., Tomás-Zuber, M., & Lesslauer, W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29661 · Cited by 163 · see citing works

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

Gavin, A.-C., & Nebreda, A. R. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80120-1 · Cited by 158 · see citing works

Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm

Zúñiga, Á., Torres, J., Úbeda, J., & Pulido, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21900 · Cited by 131 · see citing works

Comparison of the specificities of p70 S6 kinase and MAPKAP kinase‐1 identifies a relatively specific substrate for p70 S6 kinase: the N‐terminal kinase domain of MAPKAP kinase‐1 is essential for peptide phosphorylation

Leighton, I. A., Dalby, K. N., Caudwell, F. B., Cohen, P. T. W., & Cohen, P. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01170-j · Cited by 126 · see citing works

Divergent Functional Roles for p90 Kinase Domains

Bj⊘rbæk, C., Zhao, Y., & Moller, D. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18848 · Cited by 105 · see citing works

Generation of Constitutively Active p90 Ribosomal S6 Kinasein Vivo

Poteet-Smith, C. E., Smith, J. A., Lannigan, D. A., Freed, T. A., & Sturgill, T. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22135 · Cited by 67 · see citing works

Nerve growth factor-induced phosphorylation cascade in PC12 pheochromocytoma cells. Association of S6 kinase II with the microtubule-associated protein kinase, ERK1.

Scimeca, J., Nguyen, T. T., Filloux, C., & OBBERGHEN, E. V. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41935-7 · Cited by 51 · see citing works

Nerve growth factor-induced phosphorylation cascade in PC12 pheochromocytoma cells. Association of S6 kinase II with the microtubule-associated protein kinase, ERK1.

Scimeca, E., Ballotti, R., Scimeca, J., Nguyen, T. J., Filloux, C., & OBBERGHEN, E. V. (1992) · HAL · Cited by 47 · see citing works

Identification of structurally altered estrogen receptors in human breast cancer by site-directed monoclonal antibodies

Traish, A. M., AlFadhli, S. M., Klinge, C. M., Kounine, M., & Quick, T. C. (1995) · Steroids · doi:10.1016/0039-128x(95)00061-t · Cited by 17 · see citing works

Binding of site-directed monoclonal antibodies to an epitope located in the A/B region (amino acids 140–154) of human estrogen receptor-induced conformational changes in an epitope in the DNA-binding domain

Traish, A. M., & Pavao, M. (1996) · Steroids · doi:10.1016/s0039-128x(96)00109-2 · Cited by 14 · see citing works

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274 · see citing works

ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

Roux, P. P., & Blenis, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.2.320-344.2004 · Cited by 2,494 · see citing works

Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

BIONDI, R. M., & NEBREDA, A. R. (2003) · Biochemical Journal · doi:10.1042/bj20021641 · Cited by 334 · see citing works

Molecular recognitions in the MAP kinase cascades

Tanoue, T., & Nishida, E. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(02)00112-2 · Cited by 318 · see citing works

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

Heo, Y., Kim, S., Seo, C. I., Kim, Y. K., Sung, B., Lee, H. S., Lee, J. I., Park, S., Kim, J. H., Hwang, K. Y., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600212 · Cited by 275 · see citing works

Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

Garai, Á., Zeke, A., Gógl, G., Törő, I., Fördős, F., Blankenburg, H., Bárkai, T., Varga, J., Alexa, A., Emig, D., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2003004 · Cited by 177 · see citing works

Mining for protein S-sulfenylation in Arabidopsis uncovers redox-sensitive sites

Huang, J., Willems, P. J., Wei, B., Tian, C., Ferreira, R. B., Bodra, N., Gache, S. A. M., Wahni, K., Liu, K., Vertommen, D., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906768116 · Cited by 167 · see citing works

MSK1 activity is controlled by multiple phosphorylation sites

McCoy, C. E., CAMPBELL, D. G., Deák, M., Bloomberg, G. B., & Arthur, J. S. C. (2005) · Biochemical Journal · doi:10.1042/bj20041501 · Cited by 160 · see citing works

Protein phosphatases in MAPK signalling: we keep learning from yeast

Martı́n, H., Flández, M., Nombela, C., & Molina, M. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04822.x · Cited by 159 · see citing works

Docking interactions in the mitogen-activated protein kinase cascades

Tanoue, T., & Nishida, E. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00188-2 · Cited by 134 · see citing works

Protein–Protein Interactions in the Regulation of the Extracellular Signal-Regulated Kinase

Chuderland, D., & Seger, R. (2005) · Molecular Biotechnology · doi:10.1385/mb:29:1:57 · Cited by 127 · see citing works

Molecular basis of MAPK-activated protein kinase 2:p38 assembly

White, A., Pargellis, C. A., Studts, J. M., Werneburg, B. G., & Farmer, B. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701679104 · Cited by 111 · see citing works

The N and C Termini of the Splice Variants of the Human Mitogen-Activated Protein Kinase-Interacting Kinase Mnk2 Determine Activity and Localization

Scheper, G. C., Parra-Palau, J. L., Wilson, M., van Kollenburg, B., Vertegaal, A. C. O., Han, Z., & Proud, C. G. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5692-5705.2003 · Cited by 109 · see citing works

Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking

Xu, B.-E., Stippec, S., Robinson, F. L., & Cobb, M. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102769200 · Cited by 91 · see citing works

Modular Structure of a Docking Surface on MAPK Phosphatases

Tanoue, T., Yamamoto, T., & Nishida, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202096200 · Cited by 78 · see citing works

Features of the Catalytic Domains and C Termini of the MAPK Signal-integrating Kinases Mnk1 and Mnk2 Determine Their Differing Activities and Regulatory Properties

Parra-Palau, J. L., Buxadé, M., & Proud, C. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508356200 · Cited by 69 · see citing works

Breaking the DNA damage response to improve cervical cancer treatment

Wieringa, H. W., van der Zee, A. G. J., de Vries, E. G. E., & van Vugt, M. A. T. M. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.11.008 · Cited by 65 · see citing works

The MAP kinase ERK5 binds to and phosphorylates p90 RSK

Ranganathan, A., Pearson, G. W., Chrestensen, C. A., Sturgill, T. W., & Cobb, M. H. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.02.023 · Cited by 60 · see citing works

Fibroblast Growth Factor Receptor 3 Associates with and Tyrosine Phosphorylates p90 RSK2, Leading to RSK2 Activation That Mediates Hematopoietic Transformation

Kang, S., Elf, S., Dong, S., Hitosugi, T., Lythgoe, K., Guo, A., Ruan, H., Lonial, S., Khoury, H. J., Williams, I. R., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00998-08 · Cited by 56 · see citing works

Transient Protein-Protein Interactions and a Random-ordered Kinetic Mechanism for the Phosphorylation of a Transcription Factor by Extracellular-regulated Protein Kinase 2

Waas, W. F., & Dalby, K. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110523200 · Cited by 48 · see citing works

Understanding the molecular basis of MK2–p38α signaling complex assembly: insights into protein–protein interaction by molecular dynamics and free energy studies

Yang, Y., Liu, H., & Yao, X. (2012) · Molecular BioSystems · doi:10.1039/c2mb25042j · Cited by 48 · see citing works

Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif

Åberg, E., Torgersen, K. M., Johansen, B., Keyse, S. M., Perander, M., & Seternes, O. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.023283 · Cited by 43 · see citing works

Mitogen‐activated protein kinase‐activated protein kinase‐2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer

Morgan, D., Berggren, K. L., Spiess, C., Smith, H. M., Tejwani, A., Weir, S. J., Lominska, C. E., Thomas, S. M., & Gan, G. N. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23348 · Cited by 42 · see citing works

Structural assembly of the signaling competent ERK2–RSK1 heterodimeric protein kinase complex

Alexa, A., Gógl, G., Glatz, G., Garai, Á., Zeke, A., Varga, J. M., Dudás, E. F., Jeszenői, N., Bodor, A., Hetényi, C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417571112 · Cited by 39 · see citing works

Understanding the specificity of a docking interaction between JNK1 and the scaffolding protein JIP1

Yan, C., Kaoud, T., Lee, S., Dalby, K. N., & Ren, P. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp1073522 · Cited by 36 · see citing works

Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1

Asp, E., & Sunnerhagen, P. (2003) · Molecular Genetics and Genomics · doi:10.1007/s00438-002-0786-y · Cited by 37 · see citing works

Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells

Tamgüney, T., Zhang, C., Fiedler, D., Shokat, K. M., & Stokoe, D. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.04.006 · Cited by 33 · see citing works

The Third Conformation of p38α MAP Kinase Observed in Phosphorylated p38α and in Solution

Akella, R., Min, X., Wu, Q., Gardner, K. H., & Goldsmith, E. J. (2010) · Structure · doi:10.1016/j.str.2010.09.015 · Cited by 31 · see citing works

Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2

Katz, S., & Aronheim, A. (2002) · Biochemical Journal · doi:10.1042/bj20021127 · Cited by 31 · see citing works

Peptides as Signaling Inhibitors for Mammalian MAP Kinase Cascades

Gaestel, M., & Kracht, M. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788682299 · Cited by 25 · see citing works

Regulatory Mechanisms of Natural Active Ingredients and Compounds on Keratinocytes and Fibroblasts in Mitigating Skin Photoaging

Hu, X., Chen, M., Nawaz, J., & Duan, X. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s478666 · Cited by 19 · see citing works

Selective Mitogen Activated Protein Kinase Activity Sensors through the Application of Directionally Programmable D Domain Motifs

Peterson, L. B., Yaffe, M. B., & Imperiali, B. (2014) · Biochemistry · doi:10.1021/bi500862c · Cited by 19 · see citing works

MAP Kinase Mediated Activation of RSK1 and MK2 Substrate Kinases

Sok, P., Gógl, G., Kumar, G. S., Alexa, A., Singh, N., Kirsch, K., Sebő, A., Drahos, L., Gáspári, Z., Peti, W., et al. (2020) · Structure · doi:10.1016/j.str.2020.06.007 · Cited by 20 · see citing works

The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo

Parra-Palau, J. L., Scheper, G. C., HARPER, D. E., & Proud, C. G. (2005) · Biochemical Journal · doi:10.1042/bj20040769 · Cited by 13 · see citing works

Kinetic analysis of RSK2 and Elk‐1 interaction on the serum response element and implications for cellular engineering

Kurnaz, I. A. (2004) · Biotechnology and Bioengineering · doi:10.1002/bit.20322 · Cited by 8 · see citing works

Intracellular Signaling

Schulman, H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397179-1.00004-x · Cited by 3 · see citing works

Degradation of Saccharomyces cervisiae Rck2 upon exposure of cells to high levels of zinc is dependent on Pep4

Swaminathan, S., & Sunnerhagen, P. (2005) · Molecular Genetics and Genomics · doi:10.1007/s00438-005-1151-8 · Cited by 3 · see citing works

MK2/p38/p53 Suppress Basal IL-1β and Non-Canonical NF-κB Signaling in Macrophages

Herr, S. M., Stalkopf, D., Padaszus, S., Herbst, L. A., Dörrie, A., Niedenthal, R. K., Ronkina, N., Yakovleva, T. V., Kotlyarov, A., & Gaestel, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073232 · Cited by 1 · see citing works

Intracellular Signaling

Schulman, H. (2004) · Elsevier eBooks · doi:10.1016/b978-012148660-0/50013-5 · Cited by 1 · see citing works

Anti‐Inflammatory/Analgesics: An In‐Depth Look at p 38 MAP Kinases

Brown, K. L. (2011) · Wiley eBooks · doi:10.1002/9780470571224.pse446

MK2/p38/p53 suppress basal IL-1β and non-canonical NF-κB signalingPreprint

Herr, S. M., Stalkopf, D., Padaszus, S., Herbst, L. A., Doerrie, A., Niedenthal, R. K., Ronkina, N., Yakovleva, T. V., Kotlyarov, A., & Gaestel, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.30.679163

Rôle de la kinase MK2 dans la résistance au stress oxydatif des tumeurs hépatobiliaires

Nguyen, H., & Hương, T. (2014) · doi:10.70675/94ab24b3z7dd0z43d7z8e51z9908b59c4c06

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

Gavin, A.-C., & Nebreda, A. R. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80120-1 · Cited by 158 · see citing works

The carboxyl-terminal tail of the MAPKAPs dictates the signal transduction pathway in which they function: Creation of a stress-activated p90 ribosomal S6 kinase

Smith, J. L., Poteet-Smith, C. E., Lannigan, D. A., Freed, T. A., Zoltoski, A. J., & Sturgill, T. W. (2000)

Generation of constitutively active p90 ribosomal S6 kinase in vivo: Implications for the MAP kinase-activated protein kinase family

Poteet-Smith, C. E., Smith, J. H., Lannigan, D. A., Freed, T. A., & Sturgill, T. W. (1999)

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK

Dalby, K. N., MORRICE, N. A., Caudwell, F. B., Avruch, J., & Cohen, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1496 · Cited by 373 · see citing works

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

Tanoue, T., Maeda, R., Adachi, M., & Nishida, E. (2001) · The EMBO Journal · doi:10.1093/emboj/20.3.466 · Cited by 285 · see citing works