Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

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WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.

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A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

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Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

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Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

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The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

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The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

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A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

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Identification of a Cytoplasmic-Retention Sequence in ERK2

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Protein modification: Docking sites for kinases

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Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

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The N-terminal ERK-binding Site of MEK1 Is Required for Efficient Feedback Phosphorylation by ERK2 in Vitro and ERK Activation in Vivo

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MEKK1 interacts with ?-actinin and localizes to stress fibers and focal adhesions

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Deuterium Exchange Mass Spectrometry as a Probe of Protein Kinase Activation. Analysis of Wild-Type and Constitutively Active Mutants of MAP Kinase Kinase-1

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The MEK1 Proline-rich Insert Is Required for Efficient Activation of the Mitogen-activated Protein Kinases ERK1 and ERK2 in Mammalian Cells

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Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases

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Biochemical and Biological Functions of the N-Terminal, Noncatalytic Domain of Extracellular Signal-Regulated Kinase 2

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Creation of a Stress-activated p90 Ribosomal S6 Kinase

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The JNK signal transduction pathway

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The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions

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The ERK Cascade: A Prototype of MAPK Signaling

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A walk-through of the yeast mating pheromone response pathway

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Molecular basis of MAP kinase regulation

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Molecular recognitions in the MAP kinase cascades

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Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

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Nucleocytoplasmic shuttling of signal transducers

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The roles of MAPKs in disease

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Rac-PAK Signaling Stimulates Extracellular Signal-Regulated Kinase (ERK) Activation by Regulating Formation of MEK1-ERK Complexes

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Mechanisms of MAPK signalling specificity

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An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors

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Regulatory mechanisms of mitogen-activated kinase signaling

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The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

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Regulation of WNK1 by an Autoinhibitory Domain and Autophosphorylation

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Docking Interactions Induce Exposure of Activation Loop in the MAP Kinase ERK2

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Interaction with MEK Causes Nuclear Export and Downregulation of Peroxisome Proliferator-Activated Receptor γ

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Docking interactions in the mitogen-activated protein kinase cascades

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Regulatory Mechanisms and Function of ERK MAP Kinases

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Regulation of MAP kinases by docking domains

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LynIs a Target Gene for Prostate Cancer

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A mitochondrial kinase complex is essential to mediate an ERK1/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis

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Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

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Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs

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Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1

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Spatiotemporal regulation of the p42/p44 MAPK pathway

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Docking Interactions in the c-Jun N-terminal Kinase Pathway

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MEK genomics in development and disease

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Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in β-cells

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Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation

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Features of the Catalytic Domains and C Termini of the MAPK Signal-integrating Kinases Mnk1 and Mnk2 Determine Their Differing Activities and Regulatory Properties

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PEA-15 Binding to ERK1/2 MAPKs Is Required for Its Modulation of Integrin Activation

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Activation of ERK Induces Phosphorylation of MAPK Phosphatase-7, a JNK Specific Phosphatase, at Ser-446

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Peptides Targeting Protein Kinases: Strategies and Implications

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Binding of JNK/SAPK to MEKK1 Is Regulated by Phosphorylation

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Type I interferon-mediated pathway interacts with peroxisome proliferator activated receptor-γ (PPAR-γ): At the cross-road of pancreatic cancer cell proliferation

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Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking

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Oxysterols Inhibit Phosphatidylcholine Synthesis via ERK Docking and Phosphorylation of CTP:Phosphocholine Cytidylyltransferase

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Interfering with MAP Kinase Docking Interactions: Implications and Perspectives for the p38 Route

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Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif

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The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

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Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo

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The Transcriptional ETS2 Repressor Factor Associates with Active and Inactive Erks through Distinct FXF Motifs

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Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro

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Two Clusters of Residues at the Docking Groove of Mitogen-activated Protein Kinases Differentially Mediate Their Functional Interaction with the Tyrosine Phosphatases PTP-SL and STEP

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Vasoactive Intestinal Peptide Transactivates the Androgen Receptor through a Protein Kinase A-Dependent Extracellular Signal-Regulated Kinase Pathway in Prostate Cancer LNCaP Cells

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Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals

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Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2

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GIT1 is a novel MEK1–ERK1/2 scaffold that localizes to focal adhesions

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ERK2 Shows a Restrictive and Locally Selective Mechanism of Recognition by Its Tyrosine Phosphatase Inactivators Not Shared by Its Activator MEK1

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Charged residues at protein interaction interfaces: Unexpected conservation and orchestrated divergence

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The RGG Domain of Npl3p Recruits Sky1p Through Docking Interactions

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Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

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Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors

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An Essential Function of Yeast Cyclin-dependent Kinase Cdc28 Maintains Chromosome Stability

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Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells

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The Dysregulation of the Monocyte/Macrophage Effector Function Induced by Isopropanol Is Mediated by the Defective Activation of Distinct Members of the AP-1 Family of Transcription Factors

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Different Domains of the Mitogen-activated Protein Kinases ERK3 and ERK2 Direct Subcellular Localization and Upstream Specificityin Vivo

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Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress

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Specific cellular microenvironments for spatiotemporal regulation of StAR and steroid synthesis

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Keratins regulate Hsp70-mediated nuclear localization of p38 mitogen-activated protein kinase

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Controlling Assembly of Hybrid DNA Nanostructures into Higher‐Order Structures via Hydrophobicity

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Two Hydrophobic Residues Can Determine the Specificity of Mitogen-activated Protein Kinase Docking Interactions

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Docking Sites on MEKs, MAP Kinase Phosphatases, and the Elk-1 Transcription Factor Compete for Binding to ERK2 and are Crucial for Enzymatic Activity

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