Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

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Signal Transduction through MAP Kinase Cascades

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Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

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Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

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A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

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A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

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Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase.

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Docking domains and substrate-specificity determination for MAP kinases

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

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Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

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Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

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Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

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Distinct Binding Determinants for ERK2/p38α and JNK MAP Kinases Mediate Catalytic Activation and Substrate Selectivity of MAP Kinase Phosphatase-1

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Two co‐existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer

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The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

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Applications of peptide arrays prepared by the SPOT-technology

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Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors

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ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases

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Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

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Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism

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JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extensionPreprint

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ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

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Docking Sites on Substrate Proteins Direct Extracellular Signal-regulated Kinase to Phosphorylate Specific Residues

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An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors

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A Conserved Docking Site in MEKs Mediates High-affinity Binding to MAP Kinases and Cooperates with a Scaffold Protein to Enhance Signal Transmission

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Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7

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A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

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The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity

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Identification of a Cytoplasmic-Retention Sequence in ERK2

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Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3

Miller, W. E., McDonald, P. H., Cai, S. F., Field, M. E., Davis, R. J., & Lefkowitz, R. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102264200 · Cited by 145 · see citing works

Inhibition of T Cell Signaling by Mitogen-activated Protein Kinase-targeted Hematopoietic Tyrosine Phosphatase (HePTP)

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The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases

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Measurement of kinase activation in single mammalian cells

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Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm

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A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

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Protein modification: Docking sites for kinases

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Regulation of MAP kinases by docking domains

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Solution Structure of ERK2 Binding Domain of MAPK Phosphatase MKP-3

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Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2

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Discordance between the Binding Affinity of Mitogen-activated Protein Kinase Subfamily Members for MAP Kinase Phosphatase-2 and Their Ability to Activate the Phosphatase Catalytically

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Regulation of MAPK Function by Direct Interaction with the Mating-Specific Gα in Yeast

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Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1

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Selective Targeting of MAPKs to the ETS Domain Transcription Factor SAP-1

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A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

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Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking

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Modular Structure of a Docking Surface on MAPK Phosphatases

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Biochemical and Biological Functions of the N-Terminal, Noncatalytic Domain of Extracellular Signal-Regulated Kinase 2

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Extracellular Signal-Regulated Kinase Binds to TFII-I and Regulates Its Activation of the c-fosPromoter

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A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinasePreprint

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Two Clusters of Residues at the Docking Groove of Mitogen-activated Protein Kinases Differentially Mediate Their Functional Interaction with the Tyrosine Phosphatases PTP-SL and STEP

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Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase

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Mitogen-Activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-Breaking Tale

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A walk-through of the yeast mating pheromone response pathway

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The ERK Cascade: A Prototype of MAPK Signaling

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A walk-through of the yeast mating pheromone response pathway

Bardwell, L. (2004) · Peptides · doi:10.1016/j.peptides.2004.10.002 · Cited by 335 · see citing works

Ets ternary complex transcription factors

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Mechanisms of MAPK signalling specificity

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Specific Inactivation and Nuclear Anchoring of Extracellular Signal-Regulated Kinase 2 by the Inducible Dual-Specificity Protein Phosphatase DUSP5

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Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

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Molecular Analysis of the Rice MAP Kinase Gene Family in Relation to Magnaporthe grisea Infection

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The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

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Protein phosphatases in MAPK signalling: we keep learning from yeast

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Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3

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Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry

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Selectivity of Docking Sites in MAPK Kinases

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Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases

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Protein–Protein Interactions in the Regulation of the Extracellular Signal-Regulated Kinase

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A mitochondrial kinase complex is essential to mediate an ERK1/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis

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A Docking Site in MKK4 Mediates High Affinity Binding to JNK MAPKs and Competes with Similar Docking Sites in JNK Substrates

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Crystal Structure of the P38α-MAPKAP Kinase 2 Heterodimer

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Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs

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Noonan and cardio-facio-cutaneous syndromes: two clinically and genetically overlapping disorders

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Competing Docking Interactions can Bring About Bistability in the MAPK Cascade

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A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates

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Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors

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The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation

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Genome-wide identification of mitogen-activated protein kinase gene family in Gossypium raimondii and the function of their corresponding orthologs in tetraploid cultivated cotton

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Substrate-dependent control of MAPK phosphorylation in vivo

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A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1

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MAPK Substrate Competition Integrates Patterning Signals in the Drosophila Embryo

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ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species‐mediated induction of osteopontin gene expression by angiotensin II and interleukin‐1β in adult rat cardiac fibroblasts

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Docking Interactions in the c-Jun N-terminal Kinase Pathway

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Interacting JNK-docking Sites in MKK7 Promote Binding and Activation of JNK Mitogen-activated Protein Kinases

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Evolutionary History of the Vertebrate Mitogen Activated Protein Kinases Family

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The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase Phosphatase 1 Directs Nuclear Targeting and Serum Response Element Transcriptional Regulation

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The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2

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Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

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Modularity of MAP kinases allows deformation of their signalling pathways

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The Anti-Apoptotic Protein PEA-15 Is a Tight Binding Inhibitor of ERK1 and ERK2, Which Blocks Docking Interactions at the D-Recruitment Site

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Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis

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Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo

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The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer

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Characterization of an ERK-binding Domain in Microphthalmia-associated Transcription Factor and Differential Inhibition of ERK2-mediated Substrate Phosphorylation

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Use of Docking Peptides to Design Modular Substrates with High Efficiency for Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase

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Two Hydrophobic Residues Can Determine the Specificity of Mitogen-activated Protein Kinase Docking Interactions

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Substrate-Dependent Control of ERK Phosphorylation Can Lead to Oscillations

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Paradoxical Results in Perturbation-Based Signaling Network Reconstruction

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p38 kinase mediates nitric oxide-induced apoptosis of chondrocytes through the inhibition of protein kinase C ζ by blocking autophosphorylation

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Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice

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ERK2 Shows a Restrictive and Locally Selective Mechanism of Recognition by Its Tyrosine Phosphatase Inactivators Not Shared by Its Activator MEK1

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Molecular Determinants of Substrate Recognition in Hematopoietic Protein-tyrosine Phosphatase

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MAPKs in development: insights from Dictyostelium signaling pathways

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Epitope-Guided Engineering of Monobody Binders for in Vivo Inhibition of Erk-2 Signaling

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Mitogen-activated protein kinase regulation of the phosphodiesterase RegA in early Dictyostelium development

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Application of a peptide-based assay to characterize inhibitors targeting protein kinases from yeast

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Molecular cloning of Ebitein1: A novel extracellular signal-regulated kinase 2-binding protein in testis

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Identification of ERK2-binding domain of EBITEIN1, a novel ERK2-binding protein

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Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates

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Arginase 1 promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner

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Two faces of competition: target‐mediated reverse signalling in microRNA and mitogen‐activated protein kinase regulatory networks

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Regulation of Sp2 DNA-Binding Activity and trans-Activation

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Stimuli That Activate MSK in Cells and the Molecular Mechanism

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Development and validation of kinase activity reporters for the dynamical study of cell response modalities by microscopy : Role of the Mitogen-Activated Protein Kinase / Extracellular signal-Regulated Kinase in necroptosis

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Modulação de MAPKs em celulas de leucemia humana induzidas a apoptose e diferenciação

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Docking Sites on MEKs, MAP Kinase Phosphatases, and the Elk-1 Transcription Factor Compete for Binding to ERK2 and are Crucial for Enzymatic Activity

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

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A Conserved Docking Site in MEKs Mediates High-affinity Binding to MAP Kinases and Cooperates with a Scaffold Protein to Enhance Signal Transmission

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Selectivity of Docking Sites in MAPK Kinases

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