Receptor Activator of NF-κB and Osteoprotegerin Expression by Human Microvascular Endothelial Cells, Regulation by Inflammatory Cytokines, and Role in Human Osteoclastogenesis

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

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Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

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Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

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VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.

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Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesis in Vitro1

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Understanding the Molecular and Cellular Changes Behind Aortic Valve Stenosis

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Interleukin 1β and tumor necrosis factor α promote hFOB1.19 cell viability via activating AP1.

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Deletion of a Distal RANKL Gene Enhancer Delays Progression of Atherosclerotic Plaque Calcification in Hypercholesterolemic Mice

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A polymorphism near osteoprotegerin gene confer risk of obesity in Uyghurs

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Effects of high glucose on expression of OPG and RANKL in rat aortic vascular smooth muscle cells

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Bone mineral density, bone remodeling and osteoprotegerin in patients with acute coronary syndrome

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Decreased serum osteoprotegerin levels in patients with cardiac syndrome X

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Integrins and Other Adhesion Molecules

Helfrich, M., & Horton, M. A. (2006) · Elsevier eBooks · doi:10.1016/b978-012088562-6/50009-1 · Cited by 8

Unbalanced RANKL/RANK pathway in aortic valve sclerosis

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Arthritis and Osteoporosis

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Osteoprotegerin Serum Levels in Rheumatoid Arthritis

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Modulation of the hepatic RANK-RANKL-OPG axis by combined C5 and CD14 inhibition in a long-term polytrauma model

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Osteoprotegerin in T urner syndrome – relationship to aortic diameter

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Delineating the role of osteoprotegerin as a marker of breast cancer risk among women with a BRCA1 mutation

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Associations between bone mineral density and subclinical peripheral arterial disease in elderly men with type 2 diabetes mellitus

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Effects of Aldosterone, Osteoprotegerin and Fibroblast Growth Factor-23 and Some Biochemical Markers in Chronic Kidney Disease Patients (Stage II-IV) among Patients with or without Cardiovascular Events

Ameen, Z. A., & Ali, S. H. (2018) · Iraqi Journal of Pharmaceutical Sciences · doi:10.31351/vol27iss2pp150-158 · Cited by 5

Values of osteoprotegerin in aortic valve tissue in patients with significant aortic stenosis depend on the existence of concomitant coronary artery disease

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An Evidence-Based Review of Micro-CT Assessments of the Postmenopausal Osteoporosis Rat Model

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Bone Turnover Following Autologous Transplantation in Multiple Myeloma

Clark, R. E., & Fraser, W. D. (2002) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190290011985 · Cited by 5

Membrane-bound or soluble, mesenchymal or myeloid: which RANKL drives osteoclastogenesis?

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Glucocorticoids, Inflammation, and Bone

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Osteoprotegerin and soluble receptor activator of nuclear factor-kappa B ligand in exudative age-related macular degeneration.

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Receptor Activator of Nuclear Factor-Kappa B Ligand, Osteoprotegerin and Interleukin-17 Levels in GCF of Chronic, Aggressive Periodontitis and Type 2 Diabetes

Ibrahim, R. O. (2013) · Cited by 4

Hydrogen Sulfide

Kurabayashi, M. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303072 · Cited by 4

Osteoprotegerin: A Promising Biomarker in the Metabolic Syndrome - New Perspectives

de Ciriza, C. P. (2016) · Biochemistry & Analytical Biochemistry · doi:10.4172/2161-1009.1000289 · Cited by 3

Bone Cell Biology

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The Immunomodulatory effect of Vitamin D in Osteoimmunology

Hossein‐Nezhad, A., Ahangari, G., Behzadi, H., Maghbooli, Z., & Larijani, B. A. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 3

CULTURES OF FIBROBLAST-LIKE SYNOVIAL CELLS FROM PATIENTS WITH RHEUMATOID ARTHRITIS: PROPERTIES AND OPPORTUNITIES

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Targeting MAPK/MKP Signaling as a Therapeutic Axis in Periodontal Disease

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Metabolism of Subchondral Bone Tissue in Posttraumatic Osteoarthrosis in Rats

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Decreased level of soluble receptor activator of nuclear factor-κβ ligand (sRANKL) in overweight and obese children

Erazmus, M., Rumińska, M., Witkowska–Sędek, E., Kucharská, A., Stelmaszczyk‐Emmel, A., Majcher, A., & Pyrżak, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.963467 · Cited by 2

Functional Genetic and Genomic Analysis of Modeled Arthritis

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Implication of bone regulatory factors in human coronary artery calcification

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Primitive and bone metastatic renal carcinoma cells promote osteoclastogenesis through endothelial cells.

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Calcific Uremic Arteriolopathy (Calciphylaxis)

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Bones, blood vessels, and the immune system: what's the link?

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Extension of the frontal sinus into the roof of the optic canal: a cadaveric case report

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Systemic Melatonin Supplementation as an Adjunct to Non-Surgical Periodontal Treatment in Obese Patients with Periodontitis

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Association between dietary inflammatory index and all-cause mortality in patients with osteoporosis: data from NHANES

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OX40L in endothelial cells promotes temporomandibular joint subchondral bone angiogenesis and osteoclastogenesis in mice

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TNFRSF11B (tumor necrosis factor receptor superfamily, member 11b)

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Osteoprotegerin and ST Segment Myocardial Infarction: A Novel Risk Marker but Not for Routine Use at Present

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Insulin-Like Growth Factor-1 and Osteocalcin Are Correlated with Markers of Osteoporosis in Postmenopausal Women with Type-2 Diabetes

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Reversal of Inflammation-Induced Bone Loss and Vascular Pathology by Dried Plum's Polyphenols

Rendina-Ruedy, E. (2009) · SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University) · Cited by 1

The role of IL-33 and IL-17 family cytokines in periodontal disease

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Osteoprotegerin (OPG) and its ligands RANKL and TRAIL in falciparum, vivax and knowlesi malaria: correlations with disease severity, and B cell production of OPGPreprint

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On the Role of Osteoprotegerin/RANK/RANKL System in the Interaction between Prostate Cancer and Bone

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Receptor activator of nuclear factor кB ligand (RANKL) versus osteoprotegerin (OPG): the yin and yang of joint integrity

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Bedeutung von RANK-Ligand und Osteoprotegerin für den Knochenstoffwechsel

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Bone Metabolism and Inflammatory Bowel Disease

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RANKL, RANK, and OPG

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Estrogen and raloxifene in experimental arthritis and osteoporosis

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Serum Osteoprotegerin, a Potential Novel Marker of Systemic Inflammation: The Influence of Obesity, Insulin Sensitivity and Oral Glucose Loading on its Circulating Concentrations

Ashley, D. T. (2010) · Dublin City University Open Access Institutional Repository (Dublin City University)

Consecuencias clínicas de la persistencia de actividad inflamatoria en la arteritis de células gigantes. Estudio de factores implicados

Martínez, A. G. (2010) · TDX (Tesis Doctorals en Xarxa)

The Effect of Phytoestrogens on Bone and T Cells Differentiation and Activity

Karieb, S. S. (2012) · PEARL (University of Plymouth) · doi:10.24382/1814

The Phytoestrogens, Calcitonin and Thyroid Hormones: Effects on Bone Tissue

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Ciblage thérapeutique des tumeurs osseuses primitives par transfert de gène

Lamoureux, F. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)

Identification and Characterisation of a Putative Osteoprotegerin Receptor on Pulmonary Arterial Smooth Muscle Cells

Dawson, S. (2014) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

819 LOW CAROTID CALCIUM SCORE IS ASSOCIATED WITH HIGHER LEVELS OF GLYCOSAMINOGLYCANS TNF-ALPHA AND PTH IN HUMAN CAROTID PLAQUES

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Osteoporosis and Vascular Calcification: Lesson from OPG KO Mice

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Inmunopatología de la artritis reumatoide

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Osteoprotegerin: a pathological role in human abdominal aortic aneurysm

Moran, C. S. (2025) · ResearchOnline at James Cook University (James Cook University) · doi:10.25903/j9h2-9r90

Force-induced bone growth and adaptation: A system theoretical approach to understanding bone mechanotransduction

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TNFRSF11B polymorphisms are associated with metabolic traits in Uyghur and Han ethnic groups

Jiang, X., Cai, J., Wang, H., Li, X., Chen, Y., Wang, J., & Lin, R. (2013) · Endocrine Research · doi:10.3109/07435800.2013.797433

Arthritis and immune-mediated bone loss - role of estrogen signalling pathways

Engdahl, C. (2012) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Knochenstoffwechsel bei entzündlich-rheumatischen Erkrankungen

Peichl, P. (2015) · Journal für Kardiologie (Krause & Pachernegg GmbH)

Post-translational and therapy-induced modifications in rheumatoid arthritis

Makrygiannakis, D. (2008) · Figshare

Editorial Inflammatory cells and bone loss in rheumatoid arthritis

Haynes, D. R. (2007)

The RANKL system and the development of tumor-induced bone disease: lessons from pre-clinical models.

Croucher, P. I. (2004) · PubMed

The Roles of Lipid Oxidation Products and Receptor Activator of Nuclear Factor-B Signaling in Atherosclerotic Calcification

Towler, D. A. (2011)

Muscular Strength Training Modifies Regulation of Bone Remodeling: Inferences from Serum Biomarkers in Young Women

Mardock, M. A. (2003) · VTechWorks (Virginia Tech)

Receptor Activator of Nuclear Factor Kappa B (RANK) as a determinant of peri-implantitis Receptor aktivatora nuklearnog faktora kapa B kao činioc periimplantitisa

Raki, M., Struillou, X., Petkovi, A., Stamatovi, N., Mati, S., Aleksi, Z., Vasili, D., Lekovi, V., & Vojvodi, D. (2013)

Mecanismos de calcificación vascular asociados a la uremia y al tratamiento con Calcitriol.

García, S. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Rola RANK/RANKL i OPG w szpiczaku plazmocytowym* The role of RANK/RANKL and OPG in multiple myeloma

Kandefer‐Szerszeń, M. (2006)

Ocena stężenia osteoprotegeryny i wybranych markerów stanu zapalnego u pacjentów z samoistnym nadciśnieniem tętniczym Evaluation of osteoprotegerin level and selected inflammatory markers in patients with essential hypertension

Miller‐Kasprzak, E., Pupek‐Musialik, D., & Jabłecka, A. (2010)

Przebudowa strukturalna tętnic u kobiet z otyłością prostą a stężenie osteoprotegeryny w surowicy krwi

Mizia­‐Stec, K., Gąsior, Z., Holecki, M. T., Mizia, M., Haberka, M., Janowska, J., Gieszczyk-Strózik, K., & Zahorska‐Markiewicz, B. (2009) · Via Medica Journals

Wybrane czynniki proapoptotyczne i antyapoptotyczne w młodzieńczym idiopatycznym zapaleniu stawów

Adamczak, K. (2014)

Elucidating Differences in Osteoclast Activation Mechanisms: Looking for Targets to Prevent Pathological Bone Resorption

Trebec‐Reynolds, D. P. (2010) · TSpace (University of Toronto)

RANK-L is a Potential Therapeutic Target in Homogeneous Atherosclerotic Plaques

Galfo, F., Zito, C., Caridi, G. D., Longobardob, L., Massara, M., Carerj, S., Piccione, M. C., Altavilla, D., Squadrito, F., & Bitto, A. (2018) · Journal of Clinical & Experimental Cardiology · doi:10.4172/2155-9880.1000574

Berberine Chloride and Hyperthermia Promote Osterix Expression and Suppress Cell Cycle Genes in Osteosarcoma Cells

Nashiry, M. A., Al-Khateeb, A., & Froemming, G. R. A. (2018) · Yemeni Journal For Medical Sciences · doi:10.20428/yjms.12.1.a5

Regulation of Breast Cancer Cells’ Bone-Metastatic Potential by Mechanically Stimulated Osteocytes

Ma, Y.-H. V. (2019) · TSpace (University of Toronto)

The role of haptoglobin in osteoclastogenesis

진원종 (2017) · Seoul National University Open Repository (Seoul National University)

Metabolism of subchondral bone tissue in posttraumatic osteoarthrosis in rats

Андреевич, З. Р., Sv, B., & Ulyanov, V. Y. (2021) · Bulletin of Experimental Biology and Medicine · doi:10.47056/0365-9615-2021-172-8-240-243

Calciphylaxis

Sartori‐Valinotti, J. C., & Davis, M. D. P. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2395-3_10

Calciphylaxis

Lee, D. T., & Owen, R. P. (2016) · Springer eBooks · doi:10.1007/978-3-319-26794-4_32

Immunopathologie de la polyarthrite rhumatoïde

Morel, J., Miossec, P., & Combe, B. G. (2006) · EMC - Appareil locomoteur · doi:10.1016/s0246-0521(04)35153-3

Berberine Chloride and Hyperthermia Promote Osterix Expression and Suppress Cell Cycle Genes in Osteosarcoma Cells

Nashiry, M. A., AL-Khateeb, A. R. R., & Froemming, G. R. A. (2018) · Yemeni Journal For Medical Sciences · doi:10.20428/yjms.12.1.7

Berberine Chloride and Hyperthermia Promote Osterix Expression and Suppress Cell Cycle Genes in Osteosarcoma Cells

Nashiry, M. A., AL-Khateeb, A. R. R., & Froemming, G. R. A. (2018) · Yemeni Journal For Medical Sciences · doi:10.20428/yjms.v12i1.1403

Osteoclast exosomes pre-stimulate pulmonary endothelial cells to aggravate sepsis-induced acute lung injury

Sun, X., Zhou, Z., Li, Y., Guo, F., & Yi, L. (2024) · Medical Hypotheses · doi:10.1016/j.mehy.2024.111420

A Mathematical Model for Fibrous Dysplasia: The Role of the Flow of Mutant Cells

Soloviova, M., Beltran-Vargas, J. C., de Castro, L. F., Belmonte-Beitia, J., Pérez‐García, V. M., & Caballero, M. (2024) · Bulletin of Mathematical Biology · doi:10.1007/s11538-024-01336-7

Osteoprotegerin and its ligands RANKL and TRAIL in falciparum, vivax, and knowlesi malaria

Nair, A. S., Woodford, J., Loughland, J. R., Andrew, D. W., Piera, K. A., Amante, F. H., William, T., Grigg, M. J., McCarthy, J. S., Anstey, N. M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112768

Infection-Induced Acute Respiratory Failure: Differences Based on Biomarkers and Non-Infectious EtiologiesPreprint

Ren, K., Xu, J., Wang, Y., Li, Y., & Zhu, H. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5334915

Targeted IL-1 inhibition

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in vitro and in vivo Osteoprotegerin increases leukocyte adhesion to endothelial cells both

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