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RANK Ligand and Osteoprotegerin

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Vitamin D and Bone Health; Potential Mechanisms

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The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts.

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A Physical Mechanism for Coupling Bone Resorption and Formation in Adult Human Bone

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Increased Osteoprotegerin Serum Levels in Men with Coronary Artery Disease

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Osteoprotegerin, vascular calcification and atherosclerosis

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Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification

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Stromal Cell-Derived Factor-1 (SDF-1) Recruits Osteoclast Precursors by Inducing Chemotaxis, Matrix Metalloproteinase-9 (MMP-9) Activity, and Collagen Transmigration

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Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair

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Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts

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RANK Signaling Is Not Required for TNFα-Mediated Increase in CD11bhi Osteoclast Precursors but Is Essential for Mature Osteoclast Formation in TNFα-Mediated Inflammatory Arthritis

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CCR1 Chemokines Promote the Chemotactic Recruitment, RANKL Development, and Motility of Osteoclasts and Are Induced by Inflammatory Cytokines in Osteoblasts

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Apoptotic Bodies Convey Activity Capable of Initiating Osteoclastogenesis and Localized Bone Destruction

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Circulating Osteoprotegerin and Receptor Activator for Nuclear Factor κB Ligand: Clinical Utility in Metabolic Bone Disease Assessment

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TNF-Related Activation-Induced Cytokine Enhances Leukocyte Adhesiveness: Induction of ICAM-1 and VCAM-1 via TNF Receptor-Associated Factor and Protein Kinase C-Dependent NF-κB Activation in Endothelial Cells

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OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

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Systemic tumor necrosis factor α mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor α–transgenic mice

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High levels of osteoprotegerin and soluble receptor activator of nuclear factor κB ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor α treatment.

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Osteoclasts are important for bone angiogenesis

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Localization of Osteoprotegerin, Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand, and Receptor Activator of Nuclear Factor-κB Ligand in Monckeberg’s Sclerosis and Atherosclerosis

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In vitro Models of Bone Remodelling and Associated Disorders

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Pathogenesis of calciphylaxis: Hans Selye to nuclear factor κ-B

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Cancer and the Microenvironment

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Runx2-Upregulated Receptor Activator of Nuclear Factor κB Ligand in Calcifying Smooth Muscle Cells Promotes Migration and Osteoclastic Differentiation of Macrophages

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Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities?

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Osteoprotegerin (OPG) is localized to the Weibel‐Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor

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NF-κB p50 and p52 Expression Is Not Required for RANK-Expressing Osteoclast Progenitor Formation but Is Essential for RANK- and Cytokine-Mediated Osteoclastogenesis

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Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

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Control of RANKL gene expression

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RANK–RANKL signalling in cancer

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Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: expression of receptor activator NFκB, RANK ligand and osteoprotegerin

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Root resorption and the OPG/RANKL/RANK system: a mini review

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Adenoviral VEGF‐A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues

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An Increased Osteoprotegerin Serum Release Characterizes the Early Onset of Diabetes Mellitus and May Contribute to Endothelial Cell Dysfunction

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Recent advances in multifactorial regulation of vascular calcification

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(Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis

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Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis

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RANKL Stimulates Inducible Nitric-oxide Synthase Expression and Nitric Oxide Production in Developing Osteoclasts

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Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo

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EGFL6 Promotes Endothelial Cell Migration and Angiogenesis through the Activation of Extracellular Signal-regulated Kinase

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Pathophysiological roles of osteoprotegerin (OPG)

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VEGF and bone cell signalling: an essential vessel for communication?

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The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology

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Murine and Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response to BMP2

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Influence of the TGF-β Superfamily on Osteoclasts/Osteoblasts Balance in Physiological and Pathological Bone Conditions

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In situ expression of RANKL, RANK, osteoprotegerin and cytokines in osteoclasts of rat periodontal tissue

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TNF-related Activation-induced Cytokine (TRANCE) Induces Angiogenesis through the Activation of Src and Phospholipase C (PLC) in Human Endothelial Cells

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Novel Aspects on RANK Ligand and Osteoprotegerin in Osteoporosis and Vascular Disease

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Estrogens in rheumatoid arthritis; the immune system and bone

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Vascular Endothelial Growth Factor Up-regulates Expression of Receptor Activator of NF-κB (RANK) in Endothelial Cells

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Human Microvascular Endothelial Cell Activation by IL-1 and TNF-α Stimulates the Adhesion and Transendothelial Migration of Circulating Human CD14+ Monocytes That Develop With RANKL Into Functional Osteoclasts

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Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement

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Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption

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Basic Fibroblast Growth Factor Stimulates Osteoclast Recruitment, Development, and Bone Pit Resorption in Association With Angiogenesis In Vivo on the Chick Chorioallantoic Membrane and Activates Isolated Avian Osteoclast Resorption In Vitro

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New Perspective in Osteoarthritis: The OPG and RANKL System as a Potential Therapeutic Target?

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The role of interleukin-1 in bone resorption in rheumatoid arthritis

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Osteoprotegerin (OPG)—a potential new role in the regulation of endothelialcell phenotype and tumour angiogenesis?

Cross, S. S., Yang, Z., Brown, N. J., Balasubramanian, S. P., Evans, C. A., Woodward, J. K. L., Neville-Webbe, H. L., Down, J. M., Reed, M., Coleman, R. E., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21606 · Cited by 108

Receptor activator of nuclear factor (NF)–κB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice

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Rationale for the role of osteoclast‐like cells in arterial calcification

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RANKL Enhances Macrophage Paracrine Pro-Calcific Activity in High Phosphate-Treated Smooth Muscle Cells: Dependence on IL-6 and TNF-α

Deuell, K. A., Callegari, A., Giachelli, C. M., Rosenfeld, M. E., & Scatena, M. (2012) · Journal of Vascular Research · doi:10.1159/000341216 · Cited by 104

Metabolic Acidosis Stimulates RANKL RNA Expression in Bone Through a Cyclo-oxygenase-Dependent Mechanism

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Aortic valve calcification: basic science to clinical practice

Akat, K. M., Borggrefe, M. M., & Kaden, J. J. (2008) · Heart · doi:10.1136/hrt.2007.134783 · Cited by 106

The role of osteoprotegerin in cardiovascular disease

Montagnana, M., Lippi, G., Danese, E., & Guidi, G. C. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.727019 · Cited by 99

RANKL regulates endothelial cell survival through the phosphatidylinositol 3′‐kinase/Akt signal transduction pathway

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HIV-1 Vpr enhances production of receptor of activated NF-κB ligand (RANKL) via potentiation of glucocorticoid receptor activity

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Osteoclast diseases

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Role of the RANK/RANKL/OPG and Wnt/β-Catenin Systems in CKD Bone and Cardiovascular Disorders

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Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Gannagé‐Yared, M., Yaghi, C., Habre, B., Khalifé, S., Noun, R. J., Germanos-Haddad, M., & Trak-Smayra, V. E. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0797 · Cited by 93

The capability of plasma osteoprotegerin as a predictor of cardiovascular disease: a systematic literature review

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Role of RANKL inhibition in osteoporosis

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Serum levels of osteoprotegerin and RANKL in patients with ST elevation acute myocardial infarction

Crisafulli, A., Micari, A., Altavilla, D., Saporito, F., Sardella, A., Passaniti, M., Raffa, S., D'Anneo, G., Lucà, F., Mioni, C., et al. (2005) · Clinical Science · doi:10.1042/cs20050058 · Cited by 92

Osteoprotegerin Is Associated With Silent Coronary Artery Disease in High-Risk but Asymptomatic Type 2 Diabetic Patients

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Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis

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Osteoprotegerin and RANKL differentially regulate angiogenesis and endothelial cell function

McGonigle, J. S., Giachelli, C. M., & Scatena, M. (2008) · Angiogenesis · doi:10.1007/s10456-008-9127-z · Cited by 90

Inhibition of interleukin‐1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant arthritis

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Inhibition of p38 Mitogen-Activated Protein Kinase Prevents Inflammatory Bone Destruction

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Transforming Growth Factor-β Induces Expression of Receptor Activator of NF-κB Ligand in Vascular Endothelial Cells Derived from Bone

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Morphometric evaluation of the frontal sinus in relation to age

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Distinct gene expression of receptor activator of nuclear factor-κB and rank ligand in the inflammatory response to variant morphologies of UHMWPE particles

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Increased AP-1 and NF-κB activation and recruitment with the combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes

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Causes of Age-Related Bone Loss and Bone Fragility: An Alternative View

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Interleukin-4 and Interleukin-13 Stimulate the Osteoclast Inhibitor Osteoprotegerin by Human Endothelial Cells Through the STAT6 Pathway

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Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology

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Human Microvascular Endothelial Cell Activation by IL-1 and TNF-α Stimulates the Adhesion and Transendothelial Migration of Circulating Human CD14+ Monocytes That Develop With RANKL Into Functional Osteoclasts

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The Effect of Paricalcitol on Osteoprotegerin Production by Human Peripheral Blood Mononuclear Cells

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VEGF-C, a Lymphatic Growth Factor, Is a RANKL Target Gene in Osteoclasts That Enhances Osteoclastic Bone Resorption through an Autocrine Mechanism

Zhang, Q., Guo, R., Lu, Y., Zhao, L., Zhou, Q., Schwarz, E. M., Huang, J. L., Chen, D., Jin, Z., Boyce, B. F., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708055200 · Cited by 89