The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins
Open accessAbstract
Detergent-stable multimers of alpha-synuclein have been found specifically in the brains of patients with Parkinson's disease and other neurodegenerative diseases. Here we show that recombinant alpha-synuclein forms multimers in vitro upon exposure to vesicles containing certain polyunsaturated fatty acid (PUFA) acyl groups, including arachidonoyl and docosahexaenoyl. This process occurs at physiological concentrations and much faster than in aqueous solution. PUFA-induced aggregation involves physical association with the vesicle surface via the large apolipoprotein-like lipid-binding domain that constitutes the majority of the protein. beta- and gamma-synucleins, as well as the Parkinson's disease-associated alpha-synuclein variants A30P and A53T, show similar tendencies to multimerize in the presence of PUFAs. Multimerization does not require the presence of any tyrosine residues in the sequence. The membrane-based interaction of the synucleins with specific long chain polyunsaturated phospholipids may be relevant to the protein family's physiological functions and may also contribute to the aggregation of alpha-synuclein observed in neurodegenerative disease.
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Cites
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Cited by
Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729
-Synuclein in Parkinson's Disease
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Neuropathology, biochemistry, and biophysics of α‐synuclein aggregation
Uversky, V. N. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04764.x · Cited by 567
Lipid Droplet Binding and Oligomerization Properties of the Parkinson's Disease Protein α-Synuclein
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Metadata
- Authors
- Perrin, R. J., Woods, W. S., Clayton, D. F., & George, J. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 276
- Issue
- 45
- Pages
- 41958-41962
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2076163606
- Cited by
- 279
- References
- 8
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Perrin, R. J., Woods, W. S., Clayton, D. F., & George, J. M. (2001). Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m105022200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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