Cited by 603Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative MechanismsSelenium in Biological Systems

Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides

Open access
Rhee, Sue Goo, Woo, Hyun Ae, Kil, In Sup, Bae, Soo Han·2012·Journal of Biological Chemistry

Abstract

Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H(2)O(2). Mammalian cells express six Prx isoforms that are localized to various cellular compartments. The oxidized active site cysteine of Prx can be reduced by a cellular thiol, thus enabling Prx to function as a locally constrained peroxidase. Regulation of Prx via phosphorylation in response to extracellular signals allows the local accumulation of H(2)O(2) and thereby enables its messenger function. The fact that the oxidation state of the active site cysteine of Prx can be transferred to other proteins that are less intrinsically susceptible to H(2)O(2) also allows Prx to function as an H(2)O(2) sensor.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1074/jbc.r111.283432

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Rhee, S. G., Woo, H. A., Kil, I. S., & Bae, S. H.
Affiliations
Ewha Womans University (KR)
Corresponding author
Rhee, Sue Goo
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2012-02
Volume
287
Issue
7
Pages
4403-4410
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2089818796
Cited by
603
References
88
Citations by year
2026: 34 · 2025: 39 · 2024: 25 · 2023: 41 · 2022: 35 · 2021: 35 · 2020: 40 · 2019: 31 · 2018: 40 · 2017: 60 · 2016: 57 · 2015: 59 · 2014: 59 · 2013: 32 · 2012: 15
FWCI
3.11
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Research Foundation
  • National Research Foundation of Korea
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Keywords
peroxiredoxin, peroxidase activity, hydrogen peroxide, thiol reduction, phosphorylation, redox regulation
MeSH terms
Animals, Cysteine, Humans, Hydrogen Peroxide, Isoenzymes, Peroxidase, Oxidation-Reduction, Phosphorylation, Second Messenger Systems, Catalytic Domain, Peroxiredoxins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review