Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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The Hallmarks of Aging

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mTOR Signaling in Growth, Metabolism, and Disease

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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mTOR Signaling in Growth, Metabolism, and Disease.

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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A C. elegans mutant that lives twice as long as wild type

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Physical activity/exercise and diabetes: A position statement of the American Diabetes Association

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The genetics of ageing

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daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

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FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

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Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

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Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>

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HOMOCYSTEINE METABOLISM

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Mechanism of Human SIRT1 Activation by Resveratrol

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Influence of TOR kinase on lifespan in C. elegans

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Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

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The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

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A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

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Overexpression of Atg5 in mice activates autophagy and extends lifespan

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Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

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Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

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AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in <i>C. elegans</i>

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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

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Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

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Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

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The GH/IGF-1 axis in ageing and longevity

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Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

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Homocysteine, B Vitamins, and Cognitive Impairment

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AMPK in skeletal muscle function and metabolism

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Exercise Promotes Healthy Aging of Skeletal Muscle

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Autophagic cell death restricts chromosomal instability during replicative crisis

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Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

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Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

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High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study

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High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study

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Metformin slows down aging and extends life span of female SHR mice

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Metformin Alleviates Hepatosteatosis by Restoring SIRT1-Mediated Autophagy Induction via an AMP-Activated Protein Kinase-Independent Pathway

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Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

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Polymorphic Variants of Insulin-Like Growth Factor I (IGF-I) Receptor and Phosphoinositide 3-Kinase Genes Affect IGF-I Plasma Levels and Human Longevity: Cues for an Evolutionarily Conserved Mechanism of Life Span Control

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Insulin Resistance with Aging

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Myostatin decreases with aerobic exercise and associates with insulin resistance

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SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans

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Exercise induces autophagy in peripheral tissues and in the brain

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Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

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Pharmacologic agents targeting autophagy

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Exercise Training Promotes SIRT1 Activity in Aged Rats

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The influence of skeletal muscle on systemic aging and lifespan

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Autophagy and genomic integrity

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METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice

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Endurance Exercise Training Reduces Glucose-Stimulated Insulin Levels in 60- to 70-Year-Old Men and Women

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Autophagy in stem cells: repair, remodelling and metabolic reprogramming

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Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway

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The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes

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Exercise-Training in Young Drosophila melanogaster Reduces Age-Related Decline in Mobility and Cardiac Performance

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AMPK: a cellular energy sensor primarily regulated by AMP

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Effects of Aging on Insulin Secretion

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<scp>TOR</scp>‐mediated regulation of metabolism in aging

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Autophagy and the immune function in aging

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Metabolic effects of resveratrol: Addressing the controversies

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The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle

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Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

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Longevity effect of IGF ‐1 R +/− mutation depends on genetic background‐specific receptor activation

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Growth hormone and aging: A challenging controversy

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Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians’ offspring

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Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study

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Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH–INS genes

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The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice

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Effects of Aerobic Exercises on Serum Levels of Myonectin and Insulin Resistance in Obese and Overweight Women

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