Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?

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Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

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Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

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Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma

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Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

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Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

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Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States

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Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

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Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

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Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

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PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

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Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

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Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

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Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta‐analysis

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The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

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Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

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Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects

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A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

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Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team

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Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States

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Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

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Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

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Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes*

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Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

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Regulation of gene expression by insulin

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Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

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FoxO1 Regulates Multiple Metabolic Pathways in the Liver

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Adipokines in liver diseases #

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Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

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CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

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Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

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Hormonal regulation of hepatic glucose production in health and disease

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The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

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Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

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CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

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Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/laser-treated retinopathy in type 2 diabetic patients

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Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

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TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

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PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

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Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

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Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study.

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Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis

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Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

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Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans

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The role of the lipogenic pathway in the development of hepatic steatosis

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Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

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Variant in the glucokinase regulatory protein ( GCKR ) gene is associated with fatty liver in obese children and adolescents

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PNPLA3 I148M polymorphism and progressive liver disease

Dongiovanni, P. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i41.6969 · Cited by 252 · see citing works

Nonalcoholic Fatty Liver Disease Is a Risk Factor for Type 2 Diabetes in Middle-Aged Japanese Men

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Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins

Smagris, E., Gilyard, S., BasuRay, S., Cohen, J. C., & Hobbs, H. H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719955 · Cited by 226 · see citing works

Combined Influence of Insulin Resistance, Overweight/Obesity, and Fatty Liver as Risk Factors for Type 2 Diabetes

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Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression

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Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

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Effects of nonalcoholic fatty liver disease on the development of metabolic disorders

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Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors

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New Insights into mTOR Signaling: mTORC2 and Beyond

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