Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works

Histone deacetylases (HDACs): characterization of the classical HDAC family

RUIJTER, A. J. M. D., GENNIP, A. H. V., CARON, H. N., KEMP, S., & KUILENBURG, A. B. P. V. (2003) · Biochemical Journal · doi:10.1042/bj20021321 · Cited by 3,114 · see citing works

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,889 · see citing works

Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101287200 · Cited by 1,758 · see citing works

Amyloid Precursor Protein Trafficking, Processing, and Function

Thinakaran, G., & Koo, E. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800019200 · Cited by 1,141 · see citing works

HDAC family: What are the cancer relevant targets?

Witt, O., Deubzer, H. E., Milde, T., & Oehme, I. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.08.016 · Cited by 1,069 · see citing works

Amyloid β-Protein and the Genetics of Alzheimer's Disease

Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18295 · Cited by 798 · see citing works

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

Lagger, G., O'Carroll, D., Rembold, M., Khier, H., Tischler, J., Weitzer, G., Schuettengruber, B., Hauser, C., Brunmeir, R., Jenuwein, T., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2672 · Cited by 760 · see citing works

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

Sisodia, S. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6075 · Cited by 738 · see citing works

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Khan, N., Jeffers, M., Kumar, S., Hackett, C., Boldog, F., Khramtsov, N., Qian, X., Mills, E., Berghs, S. C., Carey, N., et al. (2008) · Biochemical Journal · doi:10.1042/bj20070779 · Cited by 713 · see citing works

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

Selkoe, D. J., Podlisny, M. B., Joachim, C. L., Vickers, E., Lee, G. S., Fritz, L. C., & Oltersdorf, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7341 · Cited by 579 · see citing works

Analysis of Heterogeneous βA4 Peptides in Human Cerebrospinal Fluid and Blood by a Newly Developed Sensitive Western Blot Assay

Ida, N., Hartmann, T., Pantel, J., Schrüder, J., Zerfaß, R., Fürstl, H., Sandbrink, R., Masters, C. L., & Beyreuther, K. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22908 · Cited by 476 · see citing works

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

Saitoh, T., Sundsmo, M. P., Roch, J., Kimura, N., Cole, G. M., Schubert, D. A., Oltersdorf, T., & Schenk, D. B. (1989) · Cell · doi:10.1016/0092-8674(89)90096-2 · Cited by 471 · see citing works

Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation

Gurvich, N., Tsygankova, O. M., Meinkoth, J. L., & Klein, P. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-0799 · Cited by 460 · see citing works

The amyloid precursor protein: beyond amyloid.

Zheng, H., & Koo, E. H. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-5 · Cited by 403 · see citing works

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

Wasco, W., Gurubhagavatula, S., Paradis, M. D., Romano, D., Sisodia, S. S., Hyman, B. T., Neve, R. L., & Tanzi, R. E. (1993) · Nature Genetics · doi:10.1038/ng0993-95 · Cited by 392 · see citing works

Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone

Caillé, I., Allinquant, B., Dupont, E., Bouillot, C., Langer, A., Müller, U., & Prochiantz, A. (2004) · Development · doi:10.1242/dev.01103 · Cited by 388 · see citing works

A Critical Function for β-Amyloid Precursor Protein in Neuronal Migration Revealed by <i>In Utero</i> RNA Interference

Young-Pearse, T. L., Bai, J., Chang, R., Zheng, J. B., LoTurco, J. J., & Selkoe, D. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4701-07.2007 · Cited by 369 · see citing works

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

Qing, H., He, G., Ly, P. T. T., Fox, C. J., Staufenbiel, M., Cai, F., Zhang, Z., Wei, S., Sun, X., Chen, C.-H., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081588 · Cited by 365 · see citing works

Valproic acid as epigenetic cancer drug: Preclinical, clinical and transcriptional effects on solid tumors

Dueñas‐González, A., Candelaria, M., Pérez‐Plasencia, C., Pérez‐Cárdenas, E., la Cruz-Hernández, E. N. D., & Herrera, L. A. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2007.11.003 · Cited by 356 · see citing works

Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells.

Radinsky, R., Risin, S. A., Fan, D., Dong, Z., Bielenberg, D. R., Bucana, C. D., & Fidler, I. J. (1995) · PubMed · Cited by 321 · see citing works

Cancer linked to Alzheimer disease but not vascular dementia

Roe, C. M., Fitzpatrick, A. L., Xiong, C., Sieh, W., Kuller, L. H., Miller, J. P., Williams, M. M., Kopan, R., Behrens, M. I., & Morris, J. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c91873 · Cited by 288 · see citing works

Anti‐tumor mechanisms of valproate: A novel role for an old drug

Blaheta, R. A., & Cinatl, J. J. (2002) · Medicinal Research Reviews · doi:10.1002/med.10017 · Cited by 270 · see citing works

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.

Roch, J., Masliah, E., Roch‐Levecq, A., Sundsmo, M. P., Otero, D. A., Veinbergs, I., & Saitoh, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7450 · Cited by 255 · see citing works

Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.

Mobley, W. C., Neve, R. L., Prusiner, S. B., & McKinley, M. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9811 · Cited by 254 · see citing works

Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation

Senese, S., Zaragoza, K., Minardi, S. P., Muradore, I., Ronzoni, S., Passafaro, A., Bernard, L., Draetta, G. F., Alcalay, M., Seiser, C., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00494-07 · Cited by 253 · see citing works

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.

Parker, M. W., Rossjohn, J., Cappai, R., Feil, S. C., Henry, A., McKinstry, W. J., Galatis, D., Hesse, L., Multhaup, G., Beyreuther, K. T., et al. (1999) · Nature Structural Biology · doi:10.1038/7562 · Cited by 242 · see citing works

Role of Class I and Class II histone deacetylases in carcinoma cells using siRNA

Glaser, K. B., Li, J., Staver, M. J., Wei, R.-Q., Albert, D. H., & Davidsen, S. K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.043 · Cited by 220 · see citing works

Evolving anticancer drug valproic acid: Insights into the mechanism and clinical studies

Blaheta, R. A., Michaelis, M., Driever, P. H., & Cinatl, J. J. (2005) · Medicinal Research Reviews · doi:10.1002/med.20027 · Cited by 200 · see citing works

Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension

Jin, L., Ninomiya, H., Roch, J., Schubert, D. A., Masliah, E., Otero, D. A., & Saitoh, T. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05461.1994 · Cited by 198 · see citing works

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling

Roßner, S. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00044-6 · Cited by 195 · see citing works

Cleavage of Alzheimer's Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway

Tomita, S., Kirino, Y., & Suzuki, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6277 · Cited by 188 · see citing works

The Chaperone BiP/GRP78 Binds to Amyloid Precursor Protein and Decreases Aβ40 and Aβ42 Secretion

Yang, Y., Turner, R. S., & Gaut, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25552 · Cited by 179 · see citing works

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

Belyaev, N. D., Nalivaeva, N. N., Makova, N. Z., & Turner, A. J. (2008) · EMBO Reports · doi:10.1038/embor.2008.222 · Cited by 177 · see citing works

Copper inhibits β -amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

Borchardt, T., Camakaris, J., Cappai, R., Masters, C. L., Beyreuther, K. T., & Multhaup, G. (1999) · Biochemical Journal · doi:10.1042/bj3440461 · Cited by 174 · see citing works

Key Factors in Alzheimer's Disease: β‐amyloid Precursor Protein Processing, Metabolism and Intraneuronal Transport

Bayer, T. A., Wirths, O., Majtényi, K., Hartmann, T., Multhaup, G., Beyreuther, K. T., & Czech, C. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00376.x · Cited by 172 · see citing works

Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I

Beher, D., Hesse, L., Masters, C. L., & Multhaup, G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1613 · Cited by 170 · see citing works

The in Vivo Brain Interactome of the Amyloid Precursor Protein

Bai, Y., Markham, K. A., Chen, F., Weerasekera, R., Watts, J. C., Horne, P., Wakutani, Y., Bagshaw, R., Mathews, P. M., Fraser, P. E., et al. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700077-mcp200 · Cited by 169 · see citing works

Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines

Chávez-Blanco, A. D., Pérez‐Plasencia, C., Pérez‐Cárdenas, E., Legleu, C. E. C., Rangel‐López, E., Segura-Pacheco, B. A., Taja‐Chayeb, L., Trejo‐Becerril, C., González‐Fierro, A., Candelaria, M., et al. (2006) · Cancer Cell International · doi:10.1186/1475-2867-6-2 · Cited by 142 · see citing works

Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth.

Ninomiya, H., Roch, J., Sundsmo, M. P., Otero, D. A., & Saitoh, T. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.4.879 · Cited by 140 · see citing works

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers

Gralle, M., Caarls, M. B., & Wouters, F. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808755200 · Cited by 138 · see citing works

Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11.

Hilbich, C., Mönning, U., Grund, C., Masters, C. L., & Beyreuther, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74350-6 · Cited by 137 · see citing works

Pharmacological evaluation of various metabolites and analogues of valproic acidAnticonvulsant and toxic potencies in mice

Löscher, W., & Nau, H. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90028-0 · Cited by 135 · see citing works

Amyloid Precursor Protein Is a Primary Androgen Target Gene That Promotes Prostate Cancer Growth

Takayama, K., Tsutsumi, S., Suzuki, T., Horie‐Inoue, K., Ikeda, K., Kaneshiro, K., Fujimura, T., Kumagai, J., Urano, T., Sakaki, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-3633 · Cited by 128 · see citing works

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells

Stockhausen, M.-T., Sjölund, J., Manetopoulos, C., & Axelson, H. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602309 · Cited by 128 · see citing works

The Search for α-Secretase and its Potential as a Therapeutic Approach to Alzheimer's Disease

Hooper, N. M., & Turner, A. J. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023370121 · Cited by 127 · see citing works

Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

Christensen, D. Z., Kraus, S. L., Flohr, A., Cotel, M.-C., Wirths, O., & Bayer, T. A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0451-6 · Cited by 126 · see citing works

The History of Valproate in Clinical Neuroscience

Henry, T. R., & Schmahl, C. G. (2015) · Psychopharmacology Bulletin · doi:10.64719/pb.7071 · Cited by 124 · see citing works

Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide*[boxs]

Tamboli, I. Y., Prager, K., Barth, E., Heneka, M. T., Sandhoff, K., & Walter, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414525200 · Cited by 122 · see citing works

Chronic Administration of Valproic Acid Inhibits Prostate Cancer Cell Growth In vitro and In vivo

Xia, Q., Sung, J., Chowdhury, W. H., Chen, C., Höti, N., Shabbeer, S., Carducci, M. A., & Rodríguez, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-0487 · Cited by 121 · see citing works

Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation.

Hansel, D. E., Rahman, A., Wehner, S., Herzog, V., Yeo, C. J., & Maitra, A. (2003) · PubMed · Cited by 116 · see citing works

Endoplasmic reticulum chaperones inhibit the production of amyloid-β peptides

Hoshino, T., Nakaya, T., Araki, W., Suzuki, K., Suzuki, T., & Mizushima, T. (2007) · Biochemical Journal · doi:10.1042/bj20061318 · Cited by 115 · see citing works

It all sticks together—the APP-related family of proteins and Alzheimer's disease

Bayer, T. A., Cappai, R., Masters, C. L., Beyreuther, K. T., & Multhaup, G. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000552 · Cited by 114 · see citing works

A Closer Look at α-Secretase

Postina, R. (2008) · Current Alzheimer Research · doi:10.2174/156720508783954668 · Cited by 110 · see citing works

Sodium valproate inhibits in vivo growth of human neuroblastoma cells

Cinatl, J. J., Činátl, J., Driever, P. H., Kotchetkov, R., POUCKOVA, P., Kornhuber, B., & Schwabe, D. (1997) · Anti-Cancer Drugs · doi:10.1097/00001813-199711000-00007 · Cited by 108 · see citing works

Inhibition of Histone Deacetylase Activity by Valproic Acid Blocks Adipogenesis

Lagace, D. C., & Nachtigal, M. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312795200 · Cited by 106 · see citing works

Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: Implications for therapy

Khabele, D., Son, D., Parl, A. K., Goldberg, G. L., Augenlicht, L. H., Mariadason, J. M., & Rice, V. M. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.5.4007 · Cited by 99 · see citing works

Differential Display PCR Reveals Novel Targets for the Mood-Stabilizing Drug Valproate Including the Molecular Chaperone GRP78

Wang, J., Bown, C. D., & Young, L. T. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12177-3 · Cited by 96 · see citing works

From differentiation to proliferation: The secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells

Pietrzik, C. U., Hoffmann, J., Stoeber, K., Chen, C., Bauer, C. R., Otero, D. A. C., Roch, J., & Herzog, V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1770 · Cited by 90 · see citing works

Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor–induced apoptosis

Baumeister, P., Dong, D., Fu, Y., & Lee, A. S. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1166 · Cited by 89 · see citing works

The relevance of estrogen receptor-β expression to the antiproliferative effects observed with histone deacetylase inhibitors and phytoestrogens in prostate cancer treatment

Stettner, M., Kaulfuß, S., Burfeind, P., Schweyer, S., Strauß, A., Ringert, R.-H., & Thelen, P. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0197 · Cited by 81 · see citing works

A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation

Hoffmann, J., Twiesselmann, C., Kummer, M. P., Romagnoli, P., & Herzog, V. (2000) · European Journal of Cell Biology · doi:10.1078/0171-9335-00117 · Cited by 79 · see citing works

Valproic acid induces apoptosis, p16INK4Aupregulation and sensitization to chemotherapy in human melanoma cells

Valentini, A., Gravina, P., Federici, G., & Bernardini, S. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.2.3578 · Cited by 74 · see citing works

Amyloid beta protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivo.

Meng, J. Y., Kataoka, H., Itoh, H., & Koono, M. (2001) · PubMed · Cited by 73 · see citing works

Increased expression of amyloid precursor protein in oral squamous cell carcinoma

Ko, S., Lin, S., Chang, K., Wong, Y., Liu, C., Chi, C., & Liu, T. (2004) · International Journal of Cancer · doi:10.1002/ijc.20328 · Cited by 71 · see citing works

Neurite-Outgrowth Regulating Functions of the Amyloid Protein Precursor of Alzheimer's Disease

Small, D. H., Clarris, H. L., Williamson, T. G., Reed, G., Key, B., Mok, S. S., Beyreuther, K. T., Masters, C. L., & Nurcombe, V. (1999) · Journal of Alzheimer s Disease · doi:10.3233/jad-1999-14-508 · Cited by 66 · see citing works

Current Insights into Molecular Mechanisms of Alzheimer Disease and Their Implications for Therapeutic Approaches

Broeck, B. V., Broeckhoven, C. V., & Kumar‐Singh, S. (2007) · Neurodegenerative Diseases · doi:10.1159/000105156 · Cited by 65 · see citing works

Amyloid β protein precursor is involved in the growth of human colon carcinoma cellin vitro andin vivo

Meng, J.-Y., Kataoka, H., Itoh, H., & Koono, M. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(200102)9999:9999 · Cited by 64 · see citing works

Altered localization of amyloid precursor protein under endoplasmic reticulum stress

Kudo, T., Okumura, M., Imaizumi, K., Araki, W., Morihara, T., Tanimukai, H., Kamagata, E., Tabuchi, N., Kimura, R., Kanayama, D., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.173 · Cited by 58 · see citing works

The survival of rat cerebral cortical neurons in the presence of trophic APP peptides

Yamamoto, K., Miyoshi, T., Yae, T., Kawashima, K., Araki, H., Hanada, K., Otero, D. A. C., Roch, J., & Saitoh, T. (1994) · Journal of Neurobiology · doi:10.1002/neu.480250510 · Cited by 58 · see citing works

Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells

Sondag, C. M., & Combs, C. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313747200 · Cited by 56 · see citing works

Teratogenesis of sodium valproate

Duncan, S. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32805866fb · Cited by 54 · see citing works

Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro.

Knüpfer, M. M., Driever, P. H., Poppenborg, H., Wolff, J. E. A., & Cinatl, J. J. (1998) · PubMed · Cited by 52 · see citing works

Epidermal Growth Factor Receptor Signaling Is Up-regulated in Human Colonic Aberrant Crypt Foci

Cohen, G., Mustafi, R., Chumsangsri, A., Little, N., Nathanson, J., Cerda, S., Jagadeeswaran, S., Dougherty, U., Joseph, L. J., Hart, J., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-0308 · Cited by 50 · see citing works

Valproic Acid Inhibits Invasiveness in Bladder Cancer but Not in Prostate Cancer Cells

Chen, C., Sung, J., Cohen, M. J., Chowdhury, W. H., Sachs, M. D., Li, Y., Lakshmanan, Y., Yung, B. Y., Lupold, S. E., & Rodríguez, R. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.106658 · Cited by 44 · see citing works

HDAC inhibitors: Magic bullets, dirty drugs or just another targeted therapy

Witt, O., & Lindemann, R. K. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.038 · Cited by 41 · see citing works

Nerve growth factor modulates the expression and secretion of β‐amyloid precursor protein through different mechanisms in PC12 cells

Villa, A., Latasa, M. J., & Pascual, A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00315.x · Cited by 38 · see citing works

Induction of β-amyloid precursor protein isoform mRNAs by bFGF in astrocytes

Gray, C. W., & Patel, A. J. (1993) · Neuroreport · doi:10.1097/00001756-199306000-00054 · Cited by 38 · see citing works

Induction of Terminal Differentiation in Melanoma Cells on Downregulation of β-Amyloid Precursor Protein

Caarls, M. B., Wang, X., Arndt‐Jovin, D. J., Becker, D., & Jovin, T. M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.296 · Cited by 36 · see citing works

Glucose regulation of GRP78 gene expression

Mote, P. L., Tillman, J. B., & Spindler, S. R. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00064-5 · Cited by 35 · see citing works

Membrane inserted APP fragments containing the βA4 sequence of Alzheimer's disease do not aggregate

Dyrks, T., Dyrks, E., Masters, C. L., & Beyreuther, K. T. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80730-5 · Cited by 34 · see citing works

High-dose tizanidine abuse.

ZULLINO, D. F., Eskenasy, A. C., & Beeson, J. (2003) · PubMed · Cited by 31 · see citing works

Characterization of a Bioengineered Chimeric Na+-Nucleoside Transporter

Wang, J., & Giacomini, K. M. (1999) · Molecular Pharmacology · doi:10.1124/mol.55.2.234 · Cited by 31 · see citing works

High sensitivity to carcinogens in the brain of a mouse model of Alzheimer's disease

Serrano, J., Fernández, A. P., Martínez‐Murillo, R., & Martı́nez, A. (2010) · Oncogene · doi:10.1038/onc.2009.503 · Cited by 28 · see citing works

Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition

Shi, Y., Gerritsma, D. A., Bowes, A. J., Capretta, A. A., & Werstuck, G. H. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.06.006 · Cited by 27 · see citing works

Expression of neutral endopeptidase (NEP/CD10) on pancreatic tumor cell lines, pancreatitis and pancreatic tumor tissues

Erhuma, M., Köbel, M., Mustafa, T., Wulfänger, J., Dralle, H., Hoang‐Vu, C., Langner, J., Seliger, B., & Kehlen, A. (2007) · International Journal of Cancer · doi:10.1002/ijc.22252 · Cited by 26 · see citing works

A gene trap insertion reveals that amyloid precursor protein expression is a very early event in murine embryogenesis

M.-O., O., & Bullock, S. L. (2001) · Development Genes and Evolution · doi:10.1007/s004270100158 · Cited by 22 · see citing works

Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference

Sakai, T., & Hohjoh, H. (2006) · Cell Biology International · doi:10.1016/j.cellbi.2006.06.018 · Cited by 13 · see citing works

Altered cholesterol metabolism in APP695-transfected neuroblastoma cells

Wirths, O., Thelen, K., Lütjohann, D., Falkai, P., & Bayer, T. A. (2007) · Brain Research · doi:10.1016/j.brainres.2007.03.029 · Cited by 8 · see citing works

Stimuli-Responsive Therapeutic Metallodrugs

Wang, X., Wang, X., Jin, S., Nafees, M., & Guo, Z. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00209 · Cited by 651 · see citing works

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Vizioli, M. G., Liu, T., Miller, K. N., Robertson, N. A., Gilroy, K., Lagnado, A. B., Perez-Garcia, A., Kiourtis, C., Dasgupta, N., Lei, X., et al. (2020) · Genes &amp; Development · doi:10.1101/gad.331272.119 · Cited by 359 · see citing works

Biology and pathophysiology of the amyloid precursor protein

Zheng, H., & Koo, E. H. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-27 · Cited by 346 · see citing works

Role of lncRNA LUCAT1 in cancer

Xing, C., Sun, S., Yue, Z.-Q., & Bai, F. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111158 · Cited by 328 · see citing works

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

Nalivaeva, N. N., & Turner, A. J. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.05.010 · Cited by 271 · see citing works

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

Ricobaraza, A., Cuadrado‐Tejedor, M., Marco, S., Pérez‐Otaño, I., & García‐Osta, A. (2012) · Hippocampus · doi:10.1002/hipo.20883 · Cited by 239 · see citing works

Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1–Dependent M1 Microglial Polarization

Wang, J., Zhao, H., Fan, Z., Li, G., Ma, Q., Tao, Z., Wang, R., Feng, J., & Luo, Y. (2017) · Stroke · doi:10.1161/strokeaha.117.017387 · Cited by 239 · see citing works

Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response

Huan, L., Guo, T., Wu, Y., Xu, L., Huang, S., Xu, Y., Liang, L., & He, X. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1122-z · Cited by 177 · see citing works

Glucose regulated protein 78: A critical link between tumor microenvironment and cancer hallmarks

Li, Z., & Li, Z. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.02.001 · Cited by 144 · see citing works

Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression

Song, C., Zhu, S., Wu, C., & Kang, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.498758 · Cited by 133 · see citing works

The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Salvador, M. A., Wicinski, J., Cabaud, O., Toiron, Y., Finetti, P., Josselin, E., Lelièvre, H., Kraus‐Berthier, L., Depil, S., Bertucci, F., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0877 · Cited by 133 · see citing works

Oral Administration of Histone Deacetylase Inhibitor MS-275 Ameliorates Neuroinflammation and Cerebral Amyloidosis and Improves Behavior in a Mouse Model

Zhang, Z., & Schluesener, H. J. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318283114a · Cited by 125 · see citing works

Conjugate of Pt(IV)–Histone Deacetylase Inhibitor as a Prodrug for Cancer Chemotherapy

Yang, J. J., Sun, X., Mao, W., Sui, M., Tang, J., & Shen, Y. (2012) · Molecular Pharmaceutics · doi:10.1021/mp200597r · Cited by 125 · see citing works

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Pandey, P., Sliker, B. H., Peters, H. L., Tuli, A., Herskovitz, J., Smits, K., Purohit, A., Singh, R. K., Dong, J., Batra, S. K., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7103 · Cited by 108 · see citing works

Scriptaid, a Novel Histone Deacetylase Inhibitor, Protects Against Traumatic Brain Injury via Modulation of PTEN and AKT Pathway

Wang, G., Jiang, X., Pu, H., Zhang, W., An, C., Hu, X., Liou, A. K. F., Leak, R. K., Gao, Y., & Chen, J. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0157-2 · Cited by 100 · see citing works

Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer

Lim, S., Yoo, B. K., Kim, H.-S., Gilmore, H. L., Lee, Y., Lee, H.-P., Kim, S.-J., Letterio, J., & Lee, H.-G. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-928 · Cited by 100 · see citing works

Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy

Fourcade, S., Ruíz, M., Guilera, C., Hahnen, E., Brichta, L., Naudí, A., Portero‐Otín, M., Dacremont, G., Cartier, N., Wanders, R. J. A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq082 · Cited by 100 · see citing works

Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia–reperfusion injury

Zhang, Z., Tong, N., Gong, Y., Qiu, Q., Yin, L., Lv, X.-H., & Wu, X. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.09.003 · Cited by 95 · see citing works

Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H‐Ferritin

Venkataramani, V., Doeppner, T. R., Willkommen, D., Cahill, C. M., Xin, Y., Ye, G., Liu, Y., Southon, A. G., Aron, A. T., Au‐Yeung, H. Y., et al. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14580 · Cited by 85 · see citing works

Effect of Sodium Valproate Administration on Brain Neprilysin Expression and Memory in Rats

Nalivaeva, N. N., Belyaev, N. D., Lewis, D. I., Pickles, A. R., Makova, N. Z., Bagrova, D. I., Dubrovskaya, N. M., Plesneva, S. A., Zhuravin, I. A., & Turner, A. J. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9644-x · Cited by 87 · see citing works

HDAC 9 exacerbates endothelial injury in cerebral ischaemia/reperfusion injury

Shi, W., Wei, X., Wang, Z., Han, H., Fu, Y., Liu, J., Zhang, Y., Guo, J., Dong, C., Zhou, D., et al. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12803 · Cited by 83 · see citing works

Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain

Morris, M. J., Karra, A. S., & Monteggia, L. M. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833c20c0 · Cited by 82 · see citing works

Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis

Closa, A., Cordero, D., Pamplona, R. S., Solé, X., Crous‐Bou, M., Paré, L., Berenguer, A., Guinó, E., López‐Doriga, A., Guardiola, J., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu092 · Cited by 79 · see citing works

Pharmacological intervention of histone deacetylase enzymes in the neurodegenerative disorders

Gupta, R. V., Ambasta, R. K., & Kumar, P. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117278 · Cited by 79 · see citing works

HDAC 4/5‐ HMGB 1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury

He, M. Y., Zhang, B., Wei, X., Wang, Z., Fan, B., Du, P., Zhang, Y., Jian, W., Chen, L., Wang, L., et al. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12040 · Cited by 74 · see citing works

Epigenetics of colorectal cancer

Migheli, F., & Migliore, L. (2012) · Clinical Genetics · doi:10.1111/j.1399-0004.2011.01829.x · Cited by 67 · see citing works

Epilepsy in the cancer patient

Kargiotis, O., Markoula, S., & Kyritsis, A. P. (2011) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-011-1569-0 · Cited by 65 · see citing works

Inhibition of Enveloped Virus Infection of Cultured Cells by Valproic Acid

Vázquez-Calvo, Á., Sáiz, J., Sobrino, F., & Martín-Acebes, M. A. (2010) · Journal of Virology · doi:10.1128/jvi.01717-10 · Cited by 60 · see citing works

Identification of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics Analysis

Zhang, H., Liu, J., Fu, X., & Yang, A. (2017) · Medical Science Monitor · doi:10.12659/msm.905035 · Cited by 59 · see citing works

Identification of head and neck squamous cell carcinoma biomarker candidates through proteomic analysis of cancer cell secretome

Marimuthu, A., Chavan, S., Sathe, G. J., Sahasrabuddhe, N. A., Manda, S. S., Renuse, S., Ahmad, S., Radhakrishnan, A., Barbhuiya, M. A., Kumar, R. V., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.04.029 · Cited by 58 · see citing works

Machine Learning-Assisted Network Inference Approach to Identify a New Class of Genes that Coordinate the Functionality of Cancer Networks

Bari, M. G., Ung, C. Y., Zhang, C., Zhu, S., & Li, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-07481-5 · Cited by 56 · see citing works

β-Amyloid precursor protein (APP) and the human diseases

Nguyen, K. V. (2019) · AIMS neuroscience · doi:10.3934/neuroscience.2019.4.273 · Cited by 53 · see citing works

CD31 Expression Determines Redox Status and Chemoresistance in Human Angiosarcomas

Venkataramani, V., Küffer, S., Cheung, K. C. P., Jiang, X., Trümper, L., Wulf, G. G., & Ströbel, P. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1778 · Cited by 50 · see citing works

Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma

Gu, S., Tian, Y., Chlenski, A., Salwen, H. R., Lu, Z., Raj, J. U., & Yang, Q. (2012) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32835739dd · Cited by 49 · see citing works

A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity

Rogers, J. T., Venkataramani, V., Washburn, C., Liu, Y., Tummala, V., Jiang, H. F., Smith, A., & Cahill, C. M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13671 · Cited by 47 · see citing works

Epigenetic Treatment of Neurological Disease

Gray, S. G. (2011) · Epigenomics · doi:10.2217/epi.11.67 · Cited by 45 · see citing works

Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling

Woods, N. K., Trevino, J., Coppola, D., Chellappan, S., Yang, S., & Padmanabhan, J. (2015) · Oncotarget · doi:10.18632/oncotarget.5933 · Cited by 45 · see citing works

Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex

Aydin, D., Filippov, M. A., Tschäpe, J., Gretz, N., Prinz, M., Eils, R., Brors, B., & Müller, U. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-160 · Cited by 45 · see citing works

Inhibition of Amyloid Precursor Protein Processing Enhances Gemcitabine-mediated Cytotoxicity in Pancreatic Cancer Cells

Woods, N. K., & Padmanabhan, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.459255 · Cited by 44 · see citing works

Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling

Gupta, A. K., Schulze, T. G., Nagarajan, V., Akula, N., Corona, W., Jiang, X.-Y., Hunter, N., McMahon, F. J., & Detera-Wadleigh, S. D. (2011) · The Pharmacogenomics Journal · doi:10.1038/tpj.2011.9 · Cited by 42 · see citing works

Age-dependent effects of valproic acid in Alzheimer’s disease (AD) mice are associated with nerve growth factor (NGF) regulation

Noh, H., & Seo, H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.012 · Cited by 41 · see citing works

(−)-Epigallocatechin-3-gallate induces cancer cell apoptosis via acetylation of amyloid precursor protein

Hu, Q., Chang, X., Yan, R., Rong, C., Yang, C., Cheng, S., Gu, X., Yao, H., Hou, X., Mo, Y., et al. (2014) · Medical Oncology · doi:10.1007/s12032-014-0390-0 · Cited by 40 · see citing works

Valproic acid exerts specific cellular and molecular anti-inflammatory effects in post-operative conjunctiva

Seet, L., Toh, L. Z., Finger, S. N., Chu, S. W. L., & Wong, T. T. L. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1722-x · Cited by 40 · see citing works

Trichostatin A increases the levels of plasma gelsolin and amyloid beta-protein in a transgenic mouse model of Alzheimer's disease

Yang, W., Chauhan, A., Mehta, S. P., Mehta, P. D., Gu, F., & Chauhan, V. P. S. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.01.064 · Cited by 38 · see citing works

Valproic acid inhibits the proliferation of cancer cells by re-expressing cyclin D2

Witt, D., Burfeind, P., Hardenberg, S. V., Opitz, L., Salinas, G., Bremmer, F., Schweyer, S., Thelen, P., Neesen, J., & Kaulfuß, S. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt019 · Cited by 37 · see citing works

Key Disease Mechanisms Linked to Alzheimer’s Disease in the Entorhinal Cortex

Bottero, V., Powers, D., Yalamanchi, A., Quinn, J. P., & Potashkin, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083915 · Cited by 35 · see citing works

Silencing ADAM10 inhibits the in vitro and in vivo growth of hepatocellular carcinoma cancer cells

Liu, S., Zhang, W., Liu, K., Ji, B., & Wang, G. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2652 · Cited by 34 · see citing works

Prospects for repurposing CNS drugs for cancer treatment

Abdelaleem, M., Ezzat, H., Osama, M., Megahed, A. A., Alaa, W., Gaber, A. I., Shafei, A., & Refaat, A. (2019) · Oncology Reviews · doi:10.4081/oncol.2019.411 · Cited by 34 · see citing works

Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid

Vázquez-Calvo, Á., Martín-Acebes, M. A., Sáiz, J., Ngo, N., Sobrino, F., & de la Torre, J. C. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.05.012 · Cited by 33 · see citing works

ADAM10 is overexpressed in human hepatocellular carcinoma and contributes to the proliferation, invasion and migration of HepG2 cells

Shao, Y., LEI, S., & Wu, S. (2013) · Oncology Reports · doi:10.3892/or.2013.2650 · Cited by 33 · see citing works

Synopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases

Jabir, N. R., Firoz, C. K., Baeesa, S. S., Ashraf, G. M., Akhtar, S., Kamal, W., Kamal, M. A., & Tabrez, S. S. M. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12344 · Cited by 31 · see citing works

Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells

Peters, H. L., Tuli, A., Wang, X., Liu, C., Pan, Z., Ouellette, M. M., Hollingsworth, M. A., MacDonald, R. G., & Solheim, J. C. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1553 · Cited by 29 · see citing works

Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells

Chen, J., Lee, I., Huang, C., Wu, Y., Chung, C., Lee, M., Lin, M. H., & Yang, J. (2019) · BMC Cancer · doi:10.1186/s12885-019-5843-6 · Cited by 29 · see citing works

Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies

Wen, Q., O’Reilly, P. G., Dunne, P. D., Lawler, M., Schaeybroeck, S. V., Salto‐Tellez, M., Hamilton, P., & Zhang, S. (2015) · BMC Systems Biology · doi:10.1186/1752-0509-9-s5-s4 · Cited by 28 · see citing works

A Synthetic Peptide with the Putative Iron Binding Motif of Amyloid Precursor Protein (APP) Does Not Catalytically Oxidize Iron

Ebrahimi, K. H., Hagedoorn, P., & Hagen, W. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040287 · Cited by 28 · see citing works

SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells

Bu, Q., Cui, L., Li, J., Du, X., Zou, W., Ding, K., & Pan, J. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.28931 · Cited by 27 · see citing works

Trichostatin A increases BDNF protein expression by improving XBP-1s/ATF6/GRP78 axis in Schwann cells of diabetic peripheral neuropathy

An, J., Zhang, X., Jia, K., Zhang, C., Zhu, L., Cheng, M., Li, F., Song, Z., & Hao, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111062 · Cited by 26 · see citing works

Histone Deacetylases and their Inhibitors as Potential Therapeutic Drugs for cholangiocarcinoma - Cell Line findings

Sriraksa, R., & Limpaiboon, T. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.4.2503 · Cited by 26 · see citing works

Characterizing the pocketome of Mycobacterium tuberculosis and application in rationalizing polypharmacological target selection

Anand, P., & Chandra, N. R. (2014) · Scientific Reports · doi:10.1038/srep06356 · Cited by 26 · see citing works

Transition Metal-Based Prodrugs for Anticancer Drug Delivery

Phillips, A. M. F., & Pombeiro, A. J. L. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867326666181203141122 · Cited by 26 · see citing works

Valproic acid decreases the proliferation of telencephalic cells in zebrafish larvae

Lee, Y., Kim, Y., Yun, J.-S., & Lee, C. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.07.004 · Cited by 25 · see citing works

Drug Repurposing in the Development of Anticancer Agents

Ölgen, S., & Kotra, L. P. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867325666180713155702 · Cited by 24 · see citing works

Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes. Update 2014

Froestl, W., Muhs, A., & Pfeifer, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140402 · Cited by 23 · see citing works

Role of Glucose-regulated Protein 78 in Embryonic Development and Neurological Disorders

Weng, W., Lee, W., Hsu, W., Chang, B., & Lee, H. (2011) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(11)60064-8 · Cited by 24 · see citing works

Secretome proteins as candidate biomarkers for aggressive thyroid carcinomas

Chaker, S., Kashat, L., Voisin, S. N., Kaur, J., Kak, I., MacMillan, C., Özçelik, H., Siu, K. W. M., Ralhan, R., & Walfish, P. G. (2013) · PROTEOMICS · doi:10.1002/pmic.201200356 · Cited by 23 · see citing works

NO-HDAC dual inhibitors

Omidkhah, N., & Ghodsi, R. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113934 · Cited by 22 · see citing works

Gene Expression Profile and Functional Analysis of Alzheimer’s Disease

Chen, F., Guan, Q., Nie, Z.-Y., & Jin, L.-J. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317513500838 · Cited by 22 · see citing works

Valproic Acid-Induced CCN1 Promotes Osteogenic Differentiation by Increasing CCN1 Protein Stability through HDAC1 Inhibition in Tonsil-Derived Mesenchymal Stem Cells

Yu, Y., Oh, S.-Y., Kim, H. Y., Choi, J.-Y., Jo, S. A., & Jo, I. (2022) · Cells · doi:10.3390/cells11030534 · Cited by 22 · see citing works

Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference

Xu, Q., Liu, X., Chen, W., & Zhang, Z. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-136 · Cited by 21 · see citing works

Amyloid-β Protein Precursor Regulates Phosphorylation and Cellular Compartmentalization of Microtubule Associated Protein Tau

Nizzari, M., Barbieri, F., Gentile, M. T., Passarella, D., Caorsi, C., Diaspro, A., Taglialatela, M., Pagano, A., Colucci-D'Amato, L., Florio, T., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-101590 · Cited by 21 · see citing works

Correction of Niemann-Pick type C1 trafficking and activity with the histone deacetylase inhibitor valproic acid

Subramanian, K., Hutt, D. M., Scott, S. M., Gupta, V. R., Mao, S., & Balch, W. E. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010524 · Cited by 21 · see citing works

Evaluation of Toxicogenomics Approaches for Assessing the Risk of Nongenotoxic Carcinogenicity in Rat Liver

Eichner, J., Wrzodek, C., Römer, M., Ellinger-Ziegelbauer, H. C., & Zell, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097678 · Cited by 20 · see citing works

Synthesis, Characterization, and In Vitro Drug Delivery Capabilities of (Zn, Al)-Based Layered Double Hydroxide Nanoparticles

Nagaraj, V. J., Sun, X., Mehta, J., Martin, M., Ngo, T., & Dey, S. K. (2015) · Journal of Nanotechnology · doi:10.1155/2015/350370 · Cited by 20 · see citing works

Drug Repurposing Strategies for Non-cancer to Cancer Therapeutics

Singhal, S., Maheshwari, P., Krishnamurthy, P. T., & Patil, V. M. (2022) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520622666220317140557 · Cited by 18 · see citing works

Association between single nucleotide polymorphisms and sexual precocity in Nellore heifers

Regatieri, I. C., Boligon, A. A., Costa, R. B., de Souza, F. R. P., Baldi, F. S., Takada, L., Venturini, G. C., de Camargo, G. M. F., Fernandes, G. A., Tonhati, H., et al. (2016) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2016.12.009 · Cited by 19 · see citing works

Effects of Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes

Wang, S.-H., Wu, C., Tsai, C., Chen, T.-Y., Tsai, K.-J., Hung, C., Hsu, C., Wu, C., & Hsieh, T. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44050142 · Cited by 17 · see citing works

Repurposed Drugs in Gastric Cancer

de Araújo, D. T. L., Ribeiro, E., Amorim, I., & Vale, N. (2022) · Molecules · doi:10.3390/molecules28010319 · Cited by 17 · see citing works

Valproic acid ameliorates olfactory dysfunction in APP/PS1 transgenic mice of Alzheimer's disease: Ameliorations from the olfactory epithelium to the olfactory bulb

Yao, Z., Jing, H., Wang, D., Lv, B., Li, J., Liu, F.-F., Fan, H., Sun, X., Qin, Y., & Zhao, M. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.02.012 · Cited by 16 · see citing works

HDAC4 degradation by combined TRAIL and valproic acid treatment induces apoptotic cell death of TRAIL-resistant head and neck cancer cells

Lee, B., Kim, Y. S., Kim, H., Kim, D.-H., Won, H.-R., Kim, Y., & Kim, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-31039-8 · Cited by 16 · see citing works

Histone deacetylase inhibitors as a novel therapeutic approach for pheochromocytomas and paragangliomas

Manta, A., Kazanas, S., Karamaroudis, S., Gogas, H. J., & Ziogas, D. C. (2022) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2022.026913 · Cited by 16 · see citing works

Overexpression of Histone Deacetylase and Amyloid Precursor Protein in Hepatocellular Carcinoma

Zhao, L., He, D., Jiao, M., Kong, L., Shao, C., Chen, J., Fang, Z., Ma, X., Chen, H., Li, L., et al. (2016) · Technology in Cancer Research & Treatment · doi:10.1177/1533034616661664 · Cited by 15 · see citing works

Evaluation of the Effects of Valproic Acid Treatment on Cell Survival and Epithelial-Mesenchymal Transition-Related Features of Human Gastric Cancer Cells

Jahani, M., Khanahmad, H., & Nikpour, P. (2020) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-019-00332-8 · Cited by 15 · see citing works

Effects of Chard (Beta Vulgaris L. Var. Cicla) on Cardiac Damage in Valproic Acid-Induced Toxicity

Üstündağ, Ü. V., Tunalı, S., Alev, B., İpekçi, H., Emekli‐Alturfan, E., Akbay, T. T., Yanardağ, R., & Yarat, A. (2015) · Journal of Food Biochemistry · doi:10.1111/jfbc.12202 · Cited by 15 · see citing works

Spectroscopic analysis of the interaction of valproic acid with histone H1 in solution and in chromatin structure

Sargolzaei, J., Rabbani‐Chadegani, A., Mollaei, H., & Deezagi, A. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.02.098 · Cited by 16 · see citing works

Immune-related gene expression signatures in colorectal cancer

Sun, Z., Xia, W., Lyu, Y., Song, Y., Wang, M., Zhang, R., Sui, G.-D., Li, Z., Song, L., Wu, C., et al. (2021) · Oncology Letters · doi:10.3892/ol.2021.12804 · Cited by 14 · see citing works

New findings concerning vertebrate porin II — On the relevance of glycine motifs of type-1 VDAC

THINNES, F. P. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.01.008 · Cited by 14 · see citing works

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Venkataramani, V., Thiele, K., Behnes, C. L., Wulf, G. G., Thelen, P., Opitz, L., Salinas-Riester, G., Wirths, O., Bayer, T. A., & Schweyer, S. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.12.015 · Cited by 14 · see citing works

Sodium Valproate Modulates the Methylation Status of Lysine Residues 4, 9 and 27 in Histone H3 of HeLa Cells

Mello, M. L. S., Rocha, M. A., & Vidal, B. D. C. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220316110405 · Cited by 13 · see citing works

Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2

Peters, H. L., Tuli, A., Sharma, M., Naslavsky, N., Caplan, S., MacDonald, R. G., & Solheim, J. C. (2011) · Immunologic Research · doi:10.1007/s12026-011-8238-6 · Cited by 13 · see citing works

Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors

Hasibeder, A., Venkataramani, V., Thelen, P., Radzun, H., & Schweyer, S. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2060 · Cited by 12 · see citing works

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Hu, S., Qin, J., Ding, M., Gao, R. C., Xiao, Q., Lou, J., Chen, Y., Wang, S., & Pan, Y. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167535 · Cited by 10 · see citing works

Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitro

Strey, C. W., SCHAMELL, L., Oppermann, E., Haferkamp, A., Bechstein, W. O., & Blaheta, R. A. (2011) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2011.202 · Cited by 10 · see citing works

Methanolic extract of Costus pictus D. DON induces cytotoxicity in liver hepatocellular carcinoma cells mediated by histone deacetylase inhibition

Jayasri, M., Neethu, P., & Suthindhiran, K. (2017) · Pharmacognosy Magazine · doi:10.4103/pm.pm_524_16 · Cited by 9 · see citing works

Genome-Wide Analysis of microRNA and mRNA Expression in Colorectal Intramucosal Neoplasia and Colorectal Cancer With a Microsatellite-Stable Phenotype Based on Adenoma-Carcinoma Sequences

Sugai, T., Osakabe, M., Niinuma, T., Sugimoto, R., Eizuka, M., Tanaka, Y., Yanagawa, N., Otsuka, K., Sasaki, A., Matsumoto, T., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.831100 · Cited by 8 · see citing works

Neuroprotective Strategies and Cell-Based Biomarkers for Manganese-Induced Toxicity in Human Neuroblastoma (SH-SY5Y) Cells

Cahill, C. M., Sarang, S. S., Bakshi, R., Xia, N., Lahiri, D. K., & Rogers, J. T. (2024) · Biomolecules · doi:10.3390/biom14060647 · Cited by 8 · see citing works

Clinical Significance of Amyloid Precursor Protein in Patients with Testicular Germ Cell Tumor

Yamada, Y., Fujimura, T., Takahashi, S., Takayama, K., Urano, T., Murata, T., Obinata, D., Ouchi, Y., Homma, Y., & Inoue, S. (2013) · Advances in Urology · doi:10.1155/2013/348438 · Cited by 8 · see citing works

Valproic acid decreases cell proliferation and migration in the cerebellum of zebrafish larvae

Lee, Y., Lee, B., & Lee, C. (2014) · Animal Cells and Systems · doi:10.1080/19768354.2014.905491 · Cited by 8 · see citing works

Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook

Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7 · see citing works

Beyond epilepsy: The expanding role of valproic acid in Alzheimer disease therapy – a review

Markowicz-Piasecka, M., Miłkowska, Z., Adla, S. K., Huttunen, K. M., & Pietrzak, B. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103658 · Cited by 8 · see citing works

Therapeutic uses of antiepileptic drugs in non-epileptic disorders

Moch, S. L. (2010) · Pharmacy management · Cited by 7 · see citing works

Die Funktionsanalyse und Pharmakomodulation des Amyloid-Vorläufer-Proteins (APP) in vitro und in vivo - Eine neue Zielstruktur zur Behandlung maligner Tumore

Venkataramani, V. (2012) · doi:10.53846/goediss-1184

Untersuchung der Wirkung von HDAC-Inhibitoren auf das Amyloid-Vorläufer-Protein (APP) in Tumorzellen

Hensen, B. (2013) · doi:10.53846/goediss-3989

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Jones (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000022 · Cited by 22 · see citing works

Alteration of Alzheimer Amyloid Precursor Protein after Treatment with Carbamazepine in Colon Cancer

Akbarzadeh, L., Zanjani, T. M., Sabetkasaei, M., & Khazaei, Y. (2017) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.43780 · Cited by 1 · see citing works

Profound Inhibitory and Apoptotic Effects of Histone Deacetylase Inhibitor Valproic Acid on Different Cancers

Sanaei, M., & Kavoosi, F. (2019) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 2 · see citing works