The Basal Proton Conductance of Skeletal Muscle Mitochondria from Transgenic Mice Overexpressing or Lacking Uncoupling Protein-3

Cadenas, Susana; Echtay, Karim S.; Harper, James A.; Jekabsons, Mika B.; Buckingham, Julie A.; Grau, Evelyn; Abuin, Alejandro; Chapman, Helen; Clapham, John C.; Brand, Martin D.

doi:10.1074/jbc.m109736200

The Basal Proton Conductance of Skeletal Muscle Mitochondria from Transgenic Mice Overexpressing or Lacking Uncoupling Protein-3

The ability of native uncoupling protein-3 (UCP3) to uncouple mitochondrial oxidative phosphorylation is controversial. We measured the expression level of UCP3 and the proton conductance of skeletal muscle mitochondria isolated from transgenic mice overexpressing human UCP3 (UCP3-tg) and from UC…