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Cited by 29

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Leukotriene B4 BLT Receptor Signaling Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of Ras/Raf/ERK/p42 AUF1 Pathway

Zhai, Beibei, Yang, Huiqing, Mancini, Arturo, He, QingWen, Antoniou, John, Di Battista, John A.·2010·Journal of Biological Chemistry
DOI 10.1074/jbc.m110.107623
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Abstract

Recent studies suggest that active resolution of the inflammatory response in animal models of arthritis may involve leukotriene B(4) (LTB(4))-dependent stimulation of "intermediate" prostaglandin production, which in turn favors the synthesis of "downstream" anti-inflammatory and pro-resolving lipoxins, resolvins, and protectins. We explored a putative mechanism involving LTB(4)-dependent control of cyclooxygenase-2 (COX-2) expression, the rate-limiting step in inflammatory prostaglandin biosynthesis. Indeed, LTB(4) potently up-regulated/stabilized interleukin-1beta-induced COX-2 mRNA and protein expression under conditions of COX-2 inhibitor-dependent blockade of PGE(2) release in human synovial fibroblasts (EC(50) = 16.5 + or - 1.7 nm for mRNA; 19 + or - 2.4 nm for protein, n = 4). The latter response was pertussis toxin-sensitive, and semi-quantitative reverse transcription-PCR confirmed the quantitative predominance of the BLT2 receptor. Transfection experiments, using human COX-2 promoter plasmids and chimeric luciferase-COX-2 mRNA 3'-untranslated region (3'-UTR) reporter constructs, revealed that LTB(4) exerted its stabilizing effect at the post-transcriptional level through a 116-bp adenylate/uridylate-rich sequence in the proximal region of the COX-2 3'-UTR. Using luciferase-COX-2 mRNA 3'-UTR reporter constructs and Ras/c-Raf expression and mutant constructs, we showed that the Ras/c-Raf/MEK1/2/ERK1/2 signaling pathway mediated LTB(4)-dependent COX-2 mRNA stabilizati…

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Crossref · 10.1074/jbc.m110.107623

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Citations

Cites

Research works printed but not linked: 4

  1. He, 2002, J. Rheumatol., 29, 546
  2. Kamohara, 2000, J. Biol. Chem., 275, 27000, 10.1016/S0021-9258(19)61471-7 · DOI
  3. Hashimoto, 2003, J. Rheumatol., 30, 1712
  4. Mancini, 2007, Inflamm. Res., 56, S374

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Metadata

Authors
Zhai, B., Yang, H., Mancini, A., He, Q., Antoniou, J., & Di Battista, J. A.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2010-07
Volume
285
Issue
31
Pages
23568-23580
ISSN
0021-9258
DOI
10.1074/jbc.m110.107623
Cited by
29
References
50
Language
en
Licence

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.