Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

Raingeaud, J., Whitmarsh, A. J., Barrett, T., Dérijard, B., & Davis, R. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1247 · Cited by 1,280

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704

Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis

Foster, D. O., & Frydman, M. L. (1979) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y79-039 · Cited by 518

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

Gälman, C., Lundåsen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafström, I., Dahlin, M., Åmark, P., Angelin, B., & Rudling, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.014 · Cited by 512

The hallmarks of protein and amino acid restriction in aging and longevity

Knopf, B. A., & Lamming, D. W. (2026) · Cell Press Blue · doi:10.1016/j.cpblue.2026.100079 · Cited by 4

Constitutive Serotonin Tone as a Modulator of Brown Adipose Tissue Thermogenesis: A Rat Study

Kesić, M., Baković, P., Farkaš, V., Bagarić, R., Kolarić, D., Štefulj, J., & Čičin‐Šain, L. (2023) · Life · doi:10.3390/life13071436 · Cited by 4

Protective Effects of Regular Physical Activity: Differential Expression of FGF21, GDF15, and Their Receptors in Trained and Untrained Individuals

Małkowska, P., Tomasiak, P., Tkacz, M., Zgutka, K., Tarnowski, M., Maciejewska, A., Buryta, R., Rosiński, Ł., & Sawczuk, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157115 · Cited by 4

Team players in the pathogenesis of metabolic dysfunctions-associated steatotic liver disease: The basis of development of pharmacotherapy

Habib, S. (2024) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v15.i4.93606 · Cited by 5

The hepatokine FGF21 stopped lipogenesis and reduced testosterone production in mLTC-1 Leydig Cell Line.

Bourdon, G., Chevaleyre, C., Estienne, A., Péchoux, C., Bourgeais, J., Hérault, O., Ba, M., Ramé, C., Dupont, J., Ducluzeau, P., et al. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112350 · Cited by 2

Traumatic brain injury from a peripheral axis perspective: Uncovering the roles of liver and adipose tissue in temperature regulation

Gómez‐Pinilla, F., & Myers, S. K. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102733 · Cited by 4

Saponins from Panax japonicus Enhance Lipolysis via Acting on FGF21-β-Klotho/FGFR1 in Obese Mice

Wang, T., Huang, Y., Hu, M., Huang, X., Yu, D., Jia, L., Zhi, W., Mu, Y., Zhou, Z., & Wang, J. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c01012 · Cited by 4

Simulated microgravity led to increased brown adipose tissue activity in rats

Chen, Y., Zhang, H., Ji, X., Yang, C., Wu, F., Lu, X. L., Chen, J., Li, K., Wang, H., Zhong, Y., et al. (2018) · Acta Astronautica · doi:10.1016/j.actaastro.2018.11.032 · Cited by 4

Impact du FGF21, une hormone du métabolisme énergétique, sur la reproduction

Bourdon, G., Froment, P., & Ducluzeau, P. (2021) · médecine/sciences · doi:10.1051/medsci/2021012 · Cited by 4

Characterization of Circulating Cold Shock Proteins FGF21 and RBM3 in a Multi-Center Study of Pediatric Cardiac Arrest

Herrmann, J. R., Fink, E. L., Fabio, A., Berger, R. P., Janesko‐Feldman, K. L., Gorse, K., Clark, R. S. B., Kochanek, P. M., Jackson, T. C., & Report, A. P. O. A. C. C. A. (2023) · Therapeutic Hypothermia and Temperature Management · doi:10.1089/ther.2023.0035 · Cited by 4

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González‐García, I., Milbank, E., Martínez-Ordóñez, A., Diéguez, C., López, M., & Contreras, C. (2019) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00719-y · Cited by 5

Blood Sampling for Arteriovenous Difference Measurements Across Interscapular Brown Adipose Tissue in Rat

Mestres‐Arenas, A., Cairó, M., Peyrou, M., & Villarroya, F. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2087-8_17 · Cited by 4

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Shen, Y., Liu, X., Dong, M., Lin, J., Zhao, Q., Lee, H.-J., & Jin, W. (2014) · Chinese Science Bulletin · doi:10.1007/s11434-014-0386-3 · Cited by 4

The Anti-Obesity Effect of Fish Oil in Diet-Induced Obese Mice Occurs via Both Decreased Food Intake and the Induction of Heat Production Genes in Brown but Not White Adipose Tissue

Obo, T., Hashiguchi, H., Matsuda, E., Kawade, S., Ogiso, K., Iwai, H., Ataka, K., Yasuda, O., Arimura, A., Deguchi, T., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010302 · Cited by 3

Photocrosslinkable Chitosan Quaternary Ammonium Salt-Based Ternary Hydrogel with Fibroblast Growth Factor 21 for Diabetic Wound Healing

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Gut microbiota and their relationship with circulating adipokines in an acute hepatic encephalopathy mouse model induced by surgical bile duct ligation

Lee, B., Jo, D., Park, J., Kim, O. Y., & Song, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38534 · Cited by 3

Identification of candidate nsSNPs of the human FNDC5 gene and their structural and functional consequences using in silico analysis

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Fibroblast Growth Factor 21 is a Regulator of Energy Metabolism in the Liver and Adipose Tissue

Matikainen, N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407869-7.00039-8 · Cited by 3

FGF21 Levels in Pheochromocytoma/Functional Paraganglioma

Klímová, J., Zelinka, T., Rosa, J., Štrauch, B., Haluzíková, D., Haluzı́k, M., Holaj, R., Krátká, Z., Kvasnička, J., Ďurovcová, V., et al. (2019) · Cancers · doi:10.3390/cancers11040485 · Cited by 3

Fibroblast Growth Factor 21 (FGF21) creates sugar-specific taste aversion to fructose through action in the brain in micePreprint

Stevanović, D., Hebert, A. J., Desai, B. N., Singhal, G., Adams, A. C., Flier, J. S., & Maratos–Flier, E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.27.921361 · Cited by 3

The secretome of brown adipose tissue

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Impact of cold exposure on shift working seafood handlers in Northern Norway: a comparative analysis across work shifts

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Adipose tissue as a humoral–neuronal hub in metabolic regulation

Tsuji, T., & Tseng, Y. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-026-01265-6 · Cited by 5

Receptor Tyrosine Kinases and the Insulin Signaling System

White, M. F. (2018) · Endocrinology · doi:10.1007/978-3-319-44675-2_7 · Cited by 2

Fibroblast Growth Factor 21 as a Regulator of Energy Metabolism in the Liver and Adipose Tissue

Matikainen, N., & Söderlund, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816093-0.00013-6 · Cited by 2

Pinuseldarone, a Clerodane-Type Diterpene from Pinus eldarica Needles and Phytochemicals as Novel Agents for Regulating Brown Adipogenesis and Thermogenesis

Cho, Y. R., Lee, S., Kim, H., Park, E. C., Jeong, S. Y., Hamishehkar, H., Jung, S. M., & Kim, K. H. (2023) · Journal of Natural Products · doi:10.1021/acs.jnatprod.3c00779 · Cited by 2

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Pellegrinelli, V., Vidal‐Puig, A., & Carobbio, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-40116-9_23 · Cited by 2

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Chondronikola, M., & Sidossis, L. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-52031-5_6 · Cited by 2

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Ding, H., & Chris, R. B. (2011) · InTech eBooks · doi:10.5772/24862 · Cited by 2

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Sartini, L., & Frontini, A. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2015.983474 · Cited by 2

Adipose Structure (White, Brown, Beige)

Peirce, V. J., Pellegrinelli, V., & Vidal‐Puig, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_23-1 · Cited by 3

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Freemark, M., & Collins, S. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-68192-4_7 · Cited by 2

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CCE and EODF as two distinct non-shivering thermogenesis models inducing weight loss

Xu, T., Wang, J., Shi, H., Wei, X., Zhang, H., Ji, Y., Lu, S., Yan, Y., Yu, X., Luo, X., et al. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02827-7 · Cited by 2

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Li, X., Shen, H., Zhou, T., Cao, X., Chen, Y., Liang, Y., Lu, T., He, J., Dou, Z., Liu, C., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-349444/v1 · Cited by 2

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Obi, P. O., Souza, T. F. G., Lao, Y., McManus, K. J., Gordon, J. W., LeDuc, R. D., Zahedi, R. P., & Saleem, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.09.612156 · Cited by 2

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Yang, Y., Song, A., Gong, F., Jiang, Y., Li, M., Xia, W., Xing, X., Wang, O., & Pan, H. (2023) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-023-02979-w · Cited by 1

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Zhang, C., Wang, X., Feng, C., Zheng, H., Leng, S., Jiang, Y., Sun, Q., Li, X., Zhang, T., Zhang, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66305-7 · Cited by 1

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Chakarov, S., & Xu, H. (2026) · Nature Immunology · doi:10.1038/s41590-026-02593-5 · Cited by 3

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Wang, D., Li, M., Lu, T., Matsushita, M., Sakai, J., Saito, M., Yoneshiro, T., & Kajimura, S. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.06.020 · Cited by 1

Can having fun protect you from obesity and its cancer risk?

Collins, S. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00937.x · Cited by 1

Comparison of Swarm Optimization and Genetic Algorithm for Mobile Robot Navigation

Ćurković, P., Jerbić, B., & Stipanĉić, T. (2010) · InTech eBooks · doi:10.5772/8601 · Cited by 1

Lipid Response to Amino Acid Starvation in Fat Cells: Role of FGF21

Pérez‐Martí, A., Marrero, P. F., Haro, D., & Relat, J. (2019) · Springer eBooks · doi:10.1007/978-3-319-55387-0_15 · Cited by 1

Adipose Structure (White, Brown, Beige)

Pellegrinelli, V., Vidal‐Puig, A., & Carobbio, S. (2023) · Springer eBooks · doi:10.1007/978-3-319-12125-3_23-2 · Cited by 1

Obesity: A Multi Perspective of Physiology and Neurobiology Energy Regulation

Meiliana, A., Dewi, N. M., & Wijaya, A. (2024) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v16i1.2840 · Cited by 1

Fibroblast growth factor 21 in patients with mild autonomic cortisol secretion and non-functioning adrenal incidentalomas

Siemińśka, L., Siemińska, K., Dittfeld, A., & Kotecka-Blicharz, A. (2024) · Endokrynologia Polska · doi:10.5603/ep.102598 · Cited by 1

Controlling Thermogenesis: Understanding the Role of PRDM16 in the Development and Function of Brown Fat

Harms, M. (2015) · Scholarly Commons (University of Pennsylvania) · Cited by 1

Papel del tejido adiposo marrón y perivascular en las complicaciones vasculares asociadas a la obesidad

Gómez‐Hernández, A., Perdomo, L., Escribano, Ó., & Benito, M. (2013) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2012.11.002 · Cited by 1

FGF21 Conducts a Metabolic Orchestra and Fat Is a Key Player

Whittle, A. J. (2016) · Endocrinology · doi:10.1210/en.2016-1193 · Cited by 1

Pathophysiology and Pharmacology of FGFs

Li, X. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-816142-5.00004-7 · Cited by 1

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Xu, Y., & Pan, J. (2020) · Obesity Medicine · doi:10.1016/j.obmed.2020.100252 · Cited by 1

Batokines : les hormones du tissu adipeux brun

Fève, B. (2022) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2022.09.008 · Cited by 1

Paralysed hemidiaphragm and shingles.

(1970) · BMJ · doi:10.1136/bmj.1.5693.382 · Cited by 1

Influência de dieta desbalanceada hipoproteica na imunidade tecido-específica da mucosa intestinal

Santos, J. M. (2020) · doi:10.11606/d.42.2020.tde-19042022-163334 · Cited by 1

FGF21 Counteracts Adipose Tissue Wasting in Cancer-Associated CachexiaPreprint

Österreicher, T., Kührer, K., Höbler, A.-L., Berghoff, A. S., Gottmann, L., Udonta, F., Körbelin, J., Pollak, D. D., Hengstschläger, M., Loges, S., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4896832 · Cited by 1

The role of metabolic hormone Fibroblast Growth Factor 21 (FGF21) in mammalian hibernation using transgenic ground squirrels

Nelson, B. T. (2012) · University of Minnesota Digital Conservancy (University of Minnesota)

Metabolic signaling under nutrient deprivation

Coelho, D. S., & Luisa, A. (2012) · TDX (Tesis Doctorals en Xarxa)

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Nelson, B. T. (2012)

© 2012 Landes Bioscience. Do not distribute. Brown adipose tissue Recent insights into development, metabolic function and therapeutic potential

Townsend, K. L., & Tseng, Y. (2012)

Keystone Symposia, Genetic and Molecular Basis of Obesity and Body Weight Regulation (J7) , Pathogenesis of Diabetes (J8)に参加して

Community, S. F. (2012)

Potensi Terapeutik Fibroblast Growth Factor 21 terhadap Resistensi Insulin

Kurniasari, K., & Arozal, W. (2015) · eJournal Kedokteran Indonesia · doi:10.23886/ejki.3.5049

Receptor Tyrosine Kinases and the Insulin Signaling System

White, M. F. (2017) · Endocrinology · doi:10.1007/978-3-319-27318-1_7-1

Lipid Response to Amino Acid Starvation in Fat Cells: Role of FGF21

Pérez‐Martí, A., Marrero, P. F., Haro, D., & Relat, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-40007-5_15-1

Novel approaches to white adipose browning and beige adipose activation for the treatment of obesity

Goh, T. (2017) · OpenBU (Boston University)

INDUCTION OF BROWN ADIPOSE TISSUE: A REVIEW

Romauld, S. I., Akilashree, S., & Devi, P. B. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i5.22646

Fibroblast Growth Factor 21 is a Novel Protein Sensor in Pregnancy

Sutton, E. F. (2017) · doi:10.31390/gradschool_dissertations.4263

Investigação do potencial termogênico e metabólico da planta Camellia sinensis em camundongos obesos - repercussão sistêmica do fenótipo bege.

Bolin, A. P. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2018.tde-13062018-151546

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Fischer, C. (2019) · Figshare

Is ursodeoxycholic acid therapy due to pregnant intrahepatic cholestasis change the adiponectin and fibroblast growth factor‐21 levels?—Pilot study

Kierach, R., Dąbrowski, K., Grabarek, B. O., Kojs‐Mrożkiewicz, M., & Boroń, D. (2020) · Dermatologic Therapy · doi:10.1111/dth.13296

Rôle des hépatokines dans le dialogue inter-organes en physiologie et physiopathologie

Pacheco, A., & Postic, C. (2020) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2020.04.008

Molecular description of fibroblast growth factor and mechanisms by which fibroblast growth factor-21 mediating biological actions and acting as a biologic biomarker of cardiovascular diseases

Melaku, L. S., & Debela, N. (2020) · Indian Journal of Health Sciences and Biomedical Research (KLEU) · doi:10.4103/kleuhsj.kleuhsj_92_20

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Alcalá, M., Herrero, L., Serra, D., & Viana, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-53370-0_4

MiR-21-3p regulation FGFR1/FGF21/PPARγ pathway induces atrial fibrosis by targeting FGFR1 in diabetesPreprint

Gu, J. F., Pan, J., Yu, J., Lin, H., Zhang, H., Zhang, J., & Wang, C. (2020) · doi:10.21203/rs.3.rs-20602/v1

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Darcy, J., Fang, Y., McFadden, S., Hascup, K. N., Hascup, E. R., & Bartke, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00007-x

Metabolic and Electrophysiological Effects of Fibroblast Growth Factor 19 in the Dorsal Vagal Complex

Wean, J. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.383

Paracrine role for endothelial IGF-1 receptor in white adipocyte beigingPreprint

Haywood, N. J., Bridge, K., Luk, C., Warmke, N., Simmons, K. J., Drozd, M., Moran, A., Straw, S., Scragg, J. L., Smith, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.01.470734

PPARs as Modulators of Cardiac Metabolism and Inflammation

Planavila, A., & van Bilsen, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-800039-7.00011-6

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(2012) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3283566807

MiR-21-3p regulation FGFR1/FGF21/PPARγ pathway induces atrial fibrosis by targeting FGFR1 in diabetesPreprint

Pan, J., Lin, H., Yu, J., Zhang, H., Zhang, J., Wang, C., & Gu, J. (2020) · doi:10.21203/rs.3.rs-20602/v2

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Carrière, A., Jeanson, Y., & Casteilla, L. (2014) · Obésité · doi:10.1007/s11690-014-0460-7

Faculty Opinions recommendation of p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.

Silke, J. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733590239.793575595

CO as a Protective Mediator of Liver Injury

Joe, Y., Park, J., Do, M., Ryter, S. W., Surh, Y., Kim, U., & Chung, A. H. T. (2022) · doi:10.1002/9781119783435.ch22

Establishing and Validating Methods to Assess the Influence of Exercise on Circulating Exosome Profiles in Sedentary Older Adults

Quiriarte, H. D. (2021) · Louisiana State University · doi:10.31390/gradschool_theses.5265

Glycolysis in adipose tissue-dependent thermogenesis

Topete, M., Pereira, S. S., Andrade, S., Oliveira, S. B., & Monteiro, M. P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91704-9.00019-7

The anti-obesity effect of fish oil in diet-induced obese mice occurs via the induction of heat production in brown but not white adipose tissuePreprint

Obo, T., Hashiguchi, H., Matsuda, E., Kawade, S., Ogiso, K., Iwai, H., Ataka, K., Yasuda, O., Arimura, A., Deguchi, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.19.563064

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Li, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15793-6.00000-7

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Li, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15793-6.00007-x

Fish oil induces thermogenesis in diet-induced obese mice in brown adipose tissue, but not in white adipose tissue.Preprint

Obo, T., Hashiguchi, H., Matsuda, E., Kawade, S., Ogiso, K., Iwai, H., Ataka, K., Yasuda, O., Arimura, A., Deguchi, T., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3919360/v1

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