Cited by 252Fibroblast Growth Factor ResearchAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21

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Chartoumpekis, Dionysius V, Habeos, Ioannis G, Ziros, Panos G, Psyrogiannis, Agathoklis I, Kyriazopoulou, Venetsana E, Papavassiliou, Athanasios G·2011·Molecular Medicine

Abstract

Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver and adipose tissue. Brown adipose tissue (BAT) is responsible for cold-induced thermogenesis in rodents. The role of FGF21 in BAT biology has not been investigated. In the present study, wild-type C57BL/6J mice as well as a brown adipocyte cell line were used to explore the potential role of cold exposure and β3-adrenergic stimulation in the expression of FGF21 in BAT. Our results demonstrate that short-term exposure to cold, as well as β3-adrenergic stimulation, causes a significant induction of FGF21 mRNA levels in BAT, without a concomitant increase in FGF21 plasma levels. This finding opens new routes for the potential use of pharmaceuticals that could induce FGF21 and, hence, activate BAT thermogenesis.

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Crossref · 10.2119/molmed.2011.00075

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Authors
Chartoumpekis, D. V., Habeos, I. G., Ziros, P. G., Psyrogiannis, A. I., Kyriazopoulou, V. E., & Papavassiliou, A. G.
Affiliations
  • University of Patras (GR)
  • National and Kapodistrian University of Athens (GR)
Corresponding author
Papavassiliou, Athanasios G
Venue
Molecular Medicine
Published
2011-02-25
Volume
17
Issue
7-8
Pages
736-740
ISSN
  • 1076-1551 (ISSN-L)
  • 1528-3658
OpenAlex
W31735925
Cited by
252
References
32
Citations by year
2026: 5 · 2025: 5 · 2024: 11 · 2023: 12 · 2022: 19 · 2021: 14 · 2020: 23 · 2019: 21 · 2018: 21 · 2017: 23 · 2016: 16 · 2015: 26 · 2014: 20 · 2013: 16 · 2012: 18
FWCI
7.28
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Molecular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
brown adipose tissue, FGF21, cold exposure, thermogenesis, brown adipocytes, energy homeostasis
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adrenergic beta-Agonists, Animals, Adipose Tissue, Brown, Cell Line, Transformed, Cold Temperature, Dioxoles, Fibroblast Growth Factors, Male, Mice, Inbred C57BL, Oxazoles, RNA, Messenger, Transcription Factors, Tyrosine, Transcriptional Activation, Trans-Activators, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Receptors, Adrenergic, beta-3, Thermogenesis, PPAR alpha, Mice

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