Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21
Open accessAbstract
Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver and adipose tissue. Brown adipose tissue (BAT) is responsible for cold-induced thermogenesis in rodents. The role of FGF21 in BAT biology has not been investigated. In the present study, wild-type C57BL/6J mice as well as a brown adipocyte cell line were used to explore the potential role of cold exposure and β3-adrenergic stimulation in the expression of FGF21 in BAT. Our results demonstrate that short-term exposure to cold, as well as β3-adrenergic stimulation, causes a significant induction of FGF21 mRNA levels in BAT, without a concomitant increase in FGF21 plasma levels. This finding opens new routes for the potential use of pharmaceuticals that could induce FGF21 and, hence, activate BAT thermogenesis.
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In response to cold, Fgf21 mRNA expression is upregulated in both WAT and BAT.
“Fgf21 mRNA expression is upregulated in both WAT (36, 52) and BAT (15, 36, 49, 52) in response to cold.”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [15]
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- Authors
- Chartoumpekis, D. V., Habeos, I. G., Ziros, P. G., Psyrogiannis, A. I., Kyriazopoulou, V. E., & Papavassiliou, A. G.
- Affiliations
- University of Patras (GR)
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Papavassiliou, Athanasios G
- Venue
- Molecular Medicine
- Published
- 2011-02-25
- Volume
- 17
- Issue
- 7-8
- Pages
- 736-740
- ISSN
- 1076-1551 (ISSN-L)
- 1528-3658
- PMC
- PMC3146611
- OpenAlex
- W31735925
- Cited by
- 252
- References
- 32
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 11 · 2023: 12 · 2022: 19 · 2021: 14 · 2020: 23 · 2019: 21 · 2018: 21 · 2017: 23 · 2016: 16 · 2015: 26 · 2014: 20 · 2013: 16 · 2012: 18
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- brown adipose tissue, FGF21, cold exposure, thermogenesis, brown adipocytes, energy homeostasis
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adrenergic beta-Agonists, Animals, Adipose Tissue, Brown, Cell Line, Transformed, Cold Temperature, Dioxoles, Fibroblast Growth Factors, Male, Mice, Inbred C57BL, Oxazoles, RNA, Messenger, Transcription Factors, Tyrosine, Transcriptional Activation, Trans-Activators, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Receptors, Adrenergic, beta-3, Thermogenesis, PPAR alpha, Mice
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