Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

Conserved role of intragenic DNA methylation in regulating alternative promoters

Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature · doi:10.1038/nature09165 · Cited by 1,743

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

Durand, C. M., Betancur, C., Boeckers, T. M., Bockmann, J., Chaste, P., Fauchereau, F., Nygren, G., Rastam, M., Gillberg, I. C., Anckarsäter, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1933 · Cited by 1,602

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

Peça, J., Feliciano, C., Ting, J. T., Wang, W., Wells, M. F., Venkatraman, T. N., Lascola, C. D., Fu, Z., & Feng, G. (2011) · Nature · doi:10.1038/nature09965 · Cited by 1,570

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349

Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins

Tu, J. C., Xiao, B., Naisbitt, S. R., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80810-7 · Cited by 1,079

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051

Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin

Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., & Sheng, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80809-0 · Cited by 1,009

Long-term depression in the CNS

Collingridge, G. L., Peineau, S., Howland, J. G., & Wang, Y. T. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2867 · Cited by 926

Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer

Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., Liu, G., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00339-7 · Cited by 716

Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder

Poleg, S., Kourieh, E., Ruban, A., Shapira, G., Shomron, N., Barak, B., & Offen, D. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01612-3 · Cited by 27

Gene dysregulation is restored in the Parkinson’s disease MPTP neurotoxic mice model upon treatment of the therapeutic drug CuII(atsm)

Cheng, L., Quek, C. Y. J., Hung, L. W., Sharples, R. A., Sherratt, N. A., Barnham, K. J., & Hill, A. F. (2016) · Scientific Reports · doi:10.1038/srep22398 · Cited by 24

Mutations of the synapse genes and intellectual disability syndromes

Verpelli, C., Montani, C., Vicidomini, C., Heise, C., & Sala, C. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.023 · Cited by 27

Behavioral phenotypes and neurobiological mechanisms in the Shank1 mouse model for autism spectrum disorder: A translational perspective

Sungur, A. Ö., Schwarting, R. K. W., & Wöhr, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.038 · Cited by 24

Shank3B mutant mice display pitch discrimination enhancements and learning deficits

Rendall, A. R., Perrino, P. A., Buscarello, A. N., & FITCH, R. H. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.10.003 · Cited by 25

Therapeutic approaches for shankopathies

Wang, X., Bey, A. L., Chung, L., Krystal, A. D., & Jiang, Y. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22084 · Cited by 23

Tandospirone, a Partial 5-HT1A Receptor Agonist, Administered Systemically or Into Anterior Cingulate Attenuates Repetitive Behaviors in Shank3B Mice

Dunn, J. T., Mroczek, J., Patel, H., & Ragozzino, M. E. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa047 · Cited by 23

Dissecting the 22q13 region to explore the genetic and phenotypic diversity of patients with Phelan-McDermid syndrome

Vitrac, A., Leblond, C. S., Rolland, T., Cliquet, F., Mathieu, A., Maruani, A., Delorme, R., Schön, M., Grabrucker, A. M., van Ravenswaaij‐Arts, C. M. A., et al. (2023) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2023.104732 · Cited by 22

Defective Synapse Maturation and Enhanced Synaptic Plasticity in Shank2 Δex7 –/– Mice

Wegener, S., Buschler, A., Stempel, A. V., Kang, S. J., Lim, C., Kaang, B., Shoichet, S. A., Manahan‐Vaughan, D., & Schmitz, D. (2018) · eNeuro · doi:10.1523/eneuro.0398-17.2018 · Cited by 25

Neural Stem Cells from Shank3-ko Mouse Model Autism Spectrum Disorders

Grasselli, C., Carbone, A., Panelli, P., Giambra, V., Bossi, M., Mazzoccoli, G., & Filippis, L. D. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01811-6 · Cited by 24

Phosphoproteome analysis of an early onset mouse model ( T g CRND 8) of A lzheimer's disease reveals temporal changes in neuronal and glia signaling pathways

Wang, F., Blanchard, A. P., Elisma, F., Granger, M. W., Xu, H., Bennett, S. A. L., Figeys, D., & Zou, H. (2013) · PROTEOMICS · doi:10.1002/pmic.201200415 · Cited by 20

mTOR-Dependent Spine Dynamics in Autism

Chaudry, S., & Vasudevan, N. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.877609 · Cited by 23

Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism

Patel, S., Roncaglia, P., & Lovering, R. C. (2015) · BMC Bioinformatics · doi:10.1186/s12859-015-0622-0 · Cited by 21

Advancing the discovery of medications for autism spectrum disorder using new technologies to reveal social brain circuitry in rodents

Kas, M. J., Modi, M. E., Saxe, M., & Smith, D. G. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3464-y · Cited by 19

Targeting Shank3 deficiency and paresthesia in autism spectrum disorder: A brief review

Huang, M., Qi, Q., & Xu, T. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1128974 · Cited by 21

Functional Relevance of Missense Mutations Affecting the N-Terminal Part of Shank3 Found in Autistic Patients

Nia, F. H., & Kreienkamp, H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00268 · Cited by 21

Defective AMPA-mediated synaptic transmission and morphology in human neurons with hemizygous SHANK3 deletion engrafted in mouse prefrontal cortex

Chiola, S., Napan, K. L., Wang, Y., Lazarenko, R. M., Armstrong, C. J., Cui, J., & Shcheglovitov, A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01023-2 · Cited by 20

Autism Spectrum Disorder Genes: Disease-Related Networks and Compensatory Strategies

Lim, H. K., Yoon, J. H., & Song, M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.922840 · Cited by 18

Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3+/∆c mutant mouse model

Li, C., Schaefer, M. L., Gray, C., Yang, Y., Furmanski, O., Liu, S., Worley, P. F., Mintz, C. D., Tao, F., & Johns, R. A. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.11.002 · Cited by 17

SHANK3 Antibody Validation: Differential Performance in Western Blotting, Immunocyto- and Immunohistochemistry

Lutz, A.-K., Bauer, H. F., Ioannidis, V., Schön, M., & Boeckers, T. M. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.890231 · Cited by 15

mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder

Gurgone, A., Pizzo, R., Raspanti, A., Chiantia, G., Devi, S., Comai, D., Morello, N., Pilotto, F., Gnavi, S., Lupori, L., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01412-3 · Cited by 16

Gene networks associated with non-syndromic intellectual disability

Lee, S., Rudd, S. A., Gratten, J., Visscher, P. M., Prins, J. B., & Dawson, P. A. (2017) · Journal of Neurogenetics · doi:10.1080/01677063.2017.1404058 · Cited by 20

Brain mGluR5 in Shank3B−/− Mice Studied With in vivo [18F]FPEB PET Imaging and ex vivo Immunoblotting

Cai, G., Wang, M., Wang, S., Liu, Y., Zhao, Y., Zhu, Y., Zhao, S., Zhang, M., Guo, B., Yao, H., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00038 · Cited by 16

Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium

Ioannidis, V., Pandey, R., Bauer, H. F., Schön, M., Bockmann, J., Boeckers, T. M., & Lutz, A.-K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02362-y · Cited by 18

Sex differences and hormonal regulation of metabotropic glutamate receptor synaptic plasticity

Fabian, C. B., Seney, M. L., & Joffe, M. E. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.10.002 · Cited by 14

The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons

Reim, D., Weis, T. M., Halbedl, S., Delling, J. P., Grabrucker, A. M., Boeckers, T. M., & Schmeißer, M. J. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00013 · Cited by 16

Apparent Genetic Rescue of AdultShank3Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments

Speed, H. E., Kouser, M., Xuan, Z., Liu, S., Duong, A. A., & Powell, C. M. (2019) · eNeuro · doi:10.1523/eneuro.0317-19.2019 · Cited by 14

The Physio-Pathological Role of Group I Metabotropic Glutamate Receptors Expressed by Microglia in Health and Disease with a Focus on Amyotrophic Lateral Sclerosis

Balbi, M., Bonanno, G., Bonifacino, T., & Milanese, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065240 · Cited by 14

Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models

Megagiannis, P., Suresh, R., Rouleau, G. A., & Zhou, Y. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114562 · Cited by 12

Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid

D’Antoni, S., Schiavi, S., Buzzelli, V., Giuffrida, S., Feo, A., Ascone, F., Busceti, C. L., Nicoletti, F., Trezza, V., & Catania, M. V. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06457-w · Cited by 11

A blueprint for research on Shankopathies: A view from research on autism spectrum disorder

Carbonetto, S. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22150 · Cited by 13

Neurogranin in the nucleus accumbens regulates NMDA receptor tolerance and motivation for ethanol seeking

Reker, A. N., Oliveros, A., Sullivan, J. M., Nahar, L., Hinton, D. J., Kim, T. H., Bruner, R. C., Choi, D., Goeders, N. E., & Nam, H. W. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.008 · Cited by 12

Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice

Chung, M., Imanaka, K., Huang, Z., Watarai, A., Wang, M., Tao, K., Ejima, H., Aida, T., Feng, G., & Okuyama, T. (2024) · Nature Communications · doi:10.1038/s41467-024-48430-x · Cited by 12

Clinical, developmental and serotonemia phenotyping of a sample of 70 Italian patients with Phelan-McDermid Syndrome

Asta, L., Ricciardello, A., Cucinotta, F., Turriziani, L., Boncoddo, M., Bellomo, F., Angelini, J. M., Gnazzo, M., Scandolo, G., Pisanò, G., et al. (2024) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-024-09572-7 · Cited by 14

Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3 ‐Deficient Rats

Barbier, M., Rajamani, K. T., Netser, S., Wagner, S., & Harony‐Nicolas, H. (2025) · Advanced Science · doi:10.1002/advs.202414813 · Cited by 12

Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome

Giona, F., Beretta, S., Zippo, A. G., Stefanoni, A., Tomasoni, Z., Vicidomini, C., Ponzoni, L., Sala, M., Jones, C. K., Conn, P. J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02947-9 · Cited by 12

Activity Deprivation Modulates the Shank3/Homer1/mGluR5 Signaling Pathway to Enable Synaptic Upscaling

Guerrero, A. A., & Turrigiano, G. G. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0807-25.2025 · Cited by 12

Mining and modeling human genetics for autism therapeutics

Smith, D. G., & Ehlers, M. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.03.004 · Cited by 10

A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging

Falkovich, R., Danielson, E., de Arce, K. P., Wamhoff, E., Strother, J., Lapteva, A. P., Sheng, M., Cottrell, J. R., & Bathe, M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112430 · Cited by 10

Electrophysiological- and Neuropharmacological-Based Benchmarking of Human Induced Pluripotent Stem Cell-Derived and Primary Rodent Neurons

Jezierski, A., Baumann, E., Aylsworth, A., Costain, W. J., Corluka, S., Banderali, U., Sodja, C., Ribecco‐Lutkiewicz, M., Alasmar, S., Martina, M., et al. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10263-2 · Cited by 10

Deciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO Mouse

Yang, J., Ma, G., Du, X., Xie, J., Wang, M., Wang, W., Guo, B., & Wu, S. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01330-y · Cited by 10

Effects of Kynurenic Acid on the Rat Aorta Ischemia—Reperfusion Model: Pharmacological Characterization and Proteomic Profiling

Lima, V. S. S., Mariano, D. O. C., Vigerelli, H., Janussi, S., Vanalli, T., Claudino, M. A., Pimenta, D. C., & Sciani, J. M. (2021) · Molecules · doi:10.3390/molecules26102845 · Cited by 9

Clustering of Ca V 1 .3 L‐type calcium channels by Shank3

Yang, Q., Perfitt, T. L., Quay, J., Hu, L., Lawson‐Qureshi, D., & Colbran, R. J. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15880 · Cited by 8

Enhanced Glutamatergic Currents at Birth in Shank3 KO Mice

Chiesa, M., Nardou, R., Lozovaya, N., Eftekhari, S., Tyzio, R., Guimond, D., Ferrari, D. C., & Ben‐Ari, Y. (2019) · Neural Plasticity · doi:10.1155/2019/2382639 · Cited by 9

Hypersynchronous iPSC-derived SHANK2 neuronal networks are rescued by mGluR5 agonism

McCready, F. P., Pradeepan, K. S., Khaki, M., Wei, W., Guevara‐Ferrer, M., Matusiak, N., Feng, B., Piekna, A., Martínez-Trujillo, J., & Ellis, J. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102718 · Cited by 7

Hypoxic Preconditioned Neural Stem Cell-Derived Extracellular Vesicles Contain Distinct Protein Cargo from Their Normal Counterparts

Gharbi, T., Liu, C., Khan, H. L., Zhang, Z., Yang, G., & Tang, Y. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45030127 · Cited by 7

Structural and Functional Organization of the Postsynaptic Density

Verpelli, C., Heise, C., & Sala, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418675-0.00004-3 · Cited by 7

Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder

Lee, I., Walker, D. I., Lin, Y., Smith, M. R., Mandl, K. D., Jones, D. P., & Kong, S. W. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104746 · Cited by 7

SHANK Mutations in Intellectual Disability and Autism Spectrum Disorder

Schmeißer, M. J., & Verpelli, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00010-8 · Cited by 7

Regulation of Dendrite and Dendritic Spine Formation by TCF20

Vinci, E., Beretta, S., Colombo, V., Zippo, A. G., Catanese, A., Wiegreffe, C., Britsch, S., Boeckers, T. M., Verpelli, C., & Sala, C. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.16297 · Cited by 6

Altered Structural Plasticity Mediated by mGlu and NMDA Receptors and Impaired Cognition in a Genetic ASD Model (Shank3 +/− Mice)

Perera-Murcia, G. R., Prior-González, M., Gutiérrez-Vera, B., López-Huerta, V. G., Cecilia, G.-M., Contreras-López, R., Tenorio-Hernández, L., & Cortés, Y. R. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.0791-25.2025 · Cited by 6

Autism-associated Shank3 is essential for homeostatic plasticity and neuronal circuit stabilityPreprint

Tatavarty, V., Pacheco, A. T., Lin, H. K., Miska, N. J., Hengen, K. B., Wagner, F. F., & Turrigiano, G. G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/365445 · Cited by 6

The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling

Woike, D., Tibbe, D., Nia, F. H., Martens, V., Wang, E. Q., Barsukov, I., & Kreienkamp, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03611-5 · Cited by 8

Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens

Nam, H. W., Grant, C. A., Jorgensen, A. N., Heppelmann, C. J. H., Trutschl, M., & Cvek, U. (2019) · PROTEOMICS · doi:10.1002/pmic.201900266 · Cited by 5

Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism

Naples, A. J., Yang, Y., Gravel, P., Toyonaga, T., Sadabad, F. E., Koohsari, S., Pittman, B. P., Gallezot, J., Pisani, L., Finn, C., et al. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20241084 · Cited by 4

Implication of mGlu5 receptor in the enhancement of morphine-induced hyperlocomotion under chronic treatment with zolpidem

Shibasaki, M., Ishii, K., Masukawa, D., Ando, K., Ikekubo, Y., Ishikawa, Y., Shibasaki, Y., Mori, T., & Suzuki, T. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.001 · Cited by 4

Shank3 contributes to neuropathic pain by facilitating the SNI-dependent increase of HCN2 and the expression of PSD95

Zhang, X., Li, X., Wang, H., Xie, X., Li, Y., Xu, X., Su, S., Zhao, H., Li, J., Ke, C., et al. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.05.010 · Cited by 4

Disrupted Development of the mPFC-Thalamic Circuit in Shank3–/– mice, an autism-associated model

Devienne, G. F., Vantomme, G., & Huguenard, J. R. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03390-6 · Cited by 3

Expression of SH3 and Multiple Ankyrin Repeat Domains Protein 3 in Mouse Retina

Xu, Y., Wang, Y., Tong, G., Li, L., Cheng, J., Zhang, L., Xu, Q., Wang, L., & Zhang, P. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.795668 · Cited by 3

SHANK Mutations May Disorder Brain Development

Poot, M. (2014) · Molecular Syndromology · doi:10.1159/000368949 · Cited by 3

The Shank3Venus/Venus knock in mouse enables isoform-specific functional studies of Shank3a

Bouquier, N., Sakkaki, S., Raynaud, F., Hemonnot-Girard, A.-L., Seube, V., Compan, V., Bertaso, F., Perroy, J., & Moutin, E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1081010 · Cited by 3

SHANK2 and SHANK3 Mutations Implicate Glutamate Signaling Abnormalities in Autism Spectrum Disorders

Harony‐Nicolas, H., Bozdagi-Gunal, O., & Buxbaum, J. D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391924-3.00032-6 · Cited by 2

Epigenetics and Pervasive Developmental Disorders

Gropman, A. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00019-x · Cited by 2

The specific role of zinc in autism spectrum disorders

Grabrucker, A. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821132-8.00008-2 · Cited by 1

Multimodal bioinformatic analyses of the neurodegenerative disease-associated TECPR2 gene reveal its diverse roles

Shalev, I., Somekh, J., & Eran, A. (2021) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2021-108193 · Cited by 1

Patients with granuloma annulare treated with Jak inhibitors show Cutibacterium acnes expansion: A clue to the mechanism underlying acneiform eruptions seen with Jak inhibitors

Wang, Y., Hernandez, E., Junejo, M. H., & Damsky, W. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.10.600 · Cited by 2

Large-Scale Proteome and Phosphoproteome Quantification by Using Dimethylation Isotope Labeling

Wang, F. (2013) · Springer theses · doi:10.1007/978-3-642-42008-5_4 · Cited by 1

Molecular Mechanisms of Synaptic Plasticity and Memory and Their Dysfunction in Alzheimer's Disease ☆

Stephens, G. S., You, J. C., Fu, C.-H., & Chin, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21126-7 · Cited by 1

Epigenetics and pervasive developmental disorders

Gropman, A. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00011-8 · Cited by 1

Shank3 related muscular hypotonia is accompanied by increased intracellular calcium concentrations and ion channel dysregulation in striated muscle tissue

Yildiz, B., Schiedt, L., Mulaw, M. A., Bockmann, J., Jesse, S., Lutz, A.-K., & Boeckers, T. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1243299 · Cited by 2

A Neurodevelopmental Perspective for Autism-Associated Gene Function

Poquérusse, J., & Luikart, B. W. (2017) · OBM Neurobiology · doi:10.21926/obm.neurobiol.1702004 · Cited by 1

Structural and Functional Organization of the Postsynaptic Density☆

Verpelli, C., Heise, C., & Sala, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02403-2 · Cited by 1

Patent Highlights

Mucke, H. A. (2012) · Pharmaceutical Patent Analyst · doi:10.4155/ppa.12.79 · Cited by 1

Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of Shank3B −/− micePreprint

Shih, Y.-C., Nelson, L., Janeček, M., & Peixoto, R. T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.23.568500 · Cited by 3

Molecular Pathways in Autistic Spectrum Disorders

Gallagher, L., Shen, S., & Anney, R. (2015) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000363593

The K + -Cl − Cotransporter KCC2 and Zolpidem

Shibasaki, M., Mori, T., & Suzuki, T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800634-4.00031-7

Applications of Monolithic Column and Isotope Dimethylation Labeling in Shotgun Proteome Analysis

Wang, F. (2013) · Springer theses · doi:10.1007/978-3-642-42008-5

Role of CaMKII and the GluN2B subunit of the NMDAR in dorsal striatal glutamatergic synaptic transmission, MSN morphology and striatal-based behaviors

Klug, J. R. (2012)

LossofPredominantShank3IsoformsResultsin Hippocampus-DependentImpairmentsinBehaviorand SynapticTransmission

Reimers, J. M., Widman, A. J., & Jaramillo, T. C. (2013)

Convergent Signaling Pathways Suggest Potential Therapeutic Targets in Autism

Lin, Y. (2016) · International Journal of Clinical Pharmacology & Pharmacotherapy · doi:10.15344/2456-3501/2016/119

Neurodevelopment is Particular Vulnerable in Neonatal Male Rats Subjected to Maternal Separation

Yang, C. (2020) · Archives in Neurology & Neuroscience · doi:10.33552/ann.2020.06.000643

Case Study and Literature Review of Phelan-McDermid Syndrome Caused By a Pathogenic Mutation in The SHANK3 GenePreprint

Xu, Q., Wang, S., Wang, Y., Wang, C., Zhang, Y., Wang, J., Luo, J., & Chen, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-800787/v1

"Primaverano" pictórico / teatral

Simón, A. (2010) · La Ratonera: Revista asturiana de teatro

Glutamate-based preclinical and clinical dysfunction and treatment in bipolar disorder

Decker, A., Bacalzo, B., & Niciu, M. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821398-8.00020-5

Perturbations of a causal synaptic molecular network in autism and schizophrenia revealed with multiplexed imagingPreprint

Falkovich, R., Danielson, E., de Arce, K. P., Wamhoff, E., Cottrell, J. R., Sheng, M., & Bathe, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.11.499330

Living on the edge

Scheefhals, N. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1224

Decreased expression of ribosomal protein Rpl3 contributes to behavioral deficits caused by Shank3 deficiencyPreprint

Verpelli, C., Giona, F., Beretta, S., Zippo, A. G., Vicidomini, C., Ponzoni, L., Sala, M., Jones, C. K., Conn, P. J., Böckers, T. M., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2812308/v1

Role of Gut Microbiota in the Developmental Regression of AutismPreprint

Cui, J. J., Li, H., Hu, C., Wu, D., Li, H., Luo, X., & Hao, Y. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4627113

Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memoryPreprint

Chung, M., Imanaka, K., Huang, Z., Watarai, A., Wang, M., Tao, K., Ejima, H., Aida, T., Feng, G., & Okuyama, T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.22.576000

Disrupted Development of the mPFC-Thalamic Circuit in the Mouse Shank3 −/− model of AutismPreprint

Devienne, G. F., Vantomme, G., & Huguenard, J. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.09.612160

A reciprocal interplay between 5-HT 2A and mGlu 5 receptors underlies neuroplasticityPreprint

del Olmo, T., Decourcelle, M., Sevéno, M., Bockaert, J., Marin, P., & Bécamel, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.23.666382

Identification of neuronal alterations induced by Shank3 mutations using iPS cells from Phelan-McDermid Patients' Fibroblasts

Martins, M. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Caractérisation de la co-organisation nanoscopique des récepteurs glutamatergiques à l'état basal et dans un modèle d'autisme

Goncalves, J. (2018) · theses.fr (ABES) · doi:10.70675/5d689799zebb1z4bf3z8372zfda0a5c8dab0

Influence de la concentration du glutamate sur la liaison du 18F-FPEB au récepteur métabotropique du glutamate de sous-type 5 : une étude translationnelle

Dupont, A.-C. (2021) · theses.fr (ABES) · doi:10.70675/9da10e15z280dz4047z9093z4f5619da60b7

SHANK3-anchored reverse phenotyping identifies a rare-variant-enriched cognitive-motor subgroup of autismPreprint

Udeshi, A., Smout, S., Caballero, M., Rapp, A., Kolevzon, A. L., Mahjani, B., & Jung, S. (2026) · medRxiv · doi:10.64898/2026.05.07.26352644

Autism-associated Shank3B deletion drives widespread dorsal cortical hyperactivity, amplified sensory responses and accelerated propagationPreprint

Chan, A., Yu, Z., Ma, Y., Zahacy, R., & Winship, I. R. (2026) · Research Square · doi:10.21203/rs.3.rs-10732790/v1

SHANK3 regulates nuclear hnRNP K and oxidative stress-associated DNA damage signaling in neurons

Chen, Y., Pagano, J., Lutz, A.-K., Bauer, H. F., & Boeckers, T. M. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107634

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

Vicidomini, C., Ponzoni, L., Lim, D., Schmeißer, M. J., Reim, D., Morello, N., Orellana, D. I., Tozzi, A., Durante, V., Scalmani, P., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.30 · Cited by 147

POSITIVE MODULATION OF MGLU5 REVERSES ASD-LIKE BEHAVIORS FOUND IN SHANK3 KNOCK-OUT MICE

Vicidomini, C. (2016) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/c-vicidomini_phd2016-01-12

Autism‐associated Shank3 mutations alter mGluR expression and mGluR‐dependent but not NMDA receptor‐dependent long‐term depression

Lee, K., Vyas, Y., Garner, C. C., & Montgomery, J. M. (2019) · Synapse · doi:10.1002/syn.22097 · Cited by 28

Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5

Scheefhals, N., Catsburg, L. A. E., Westerveld, M. L., Blanpied, T. A., Hoogenraad, C. C., & MacGillavry, H. D. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.102 · Cited by 32

Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome

Giona, F., Beretta, S., Zippo, A. G., Stefanoni, A., Tomasoni, Z., Vicidomini, C., Ponzoni, L., Sala, M., Jones, C. K., Conn, P. J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02947-9 · Cited by 12