The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
p53-dependent Induction of PVT1 and miR-1204
Open accessAbstract
p53 is a tumor suppressor protein that acts as a transcription factor to regulate (either positively or negatively) a plethora of downstream target genes. Although its ability to induce protein coding genes is well documented, recent studies have implicated p53 in the regulation of non-coding RNAs, including both microRNAs (e.g. miR-34a) and long non-coding RNAs (e.g. lincRNA-p21). We have identified the non-protein coding locus PVT1 as a p53-inducible target gene. PVT1, a very large (>300 kb) locus located downstream of c-myc on chromosome 8q24, produces a wide variety of spliced non-coding RNAs as well as a cluster of six annotated microRNAs: miR-1204, miR-1205, miR-1206, miR-1207-5p, miR-1207-3p, and miR-1208. Chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA), and luciferase assays reveal that p53 binds and activates a canonical response element within the vicinity of miR-1204. Consistently, we demonstrate the p53-dependent induction of endogenous PVT1 transcripts and consequent up-regulation of mature miR-1204. Finally, we have shown that ectopic expression of miR-1204 leads to increased p53 levels and causes cell death in a partially p53-dependent manner.
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Cites
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
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Blinded by the Light: The Growing Complexity of p53
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Self-citationRequirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
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A microRNA component of the p53 tumour suppressor network
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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
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“p53 is a tumor suppressor protein whose function is inactivated (bymutations or by othermeans)with a high frequency in a wide spectrum of human cancers (1, 2).”
BackgroundRadiation-induced cell cycle arrest compromised by p21 deficiency
Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., & Hannon, G. J. (1995) · Nature · doi:10.1038/377552a0 · Cited by 1,242
The miR-34 family in cancer and apoptosis
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A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
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Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23
MacPherson, D., Kim, J., Kim, T., Rhee, B. K., van Oostrom, C. T., DiTullio, R. A., Venere, M., Halazonetis, T. D., Bronson, R., de Vries, A., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600363 · Cited by 124
Cited by
p53 in ferroptosis regulation: The new weapon for the old guardian
Liu, Y., & Gu, W. (2022) · Cell Death & Differentiation · doi:10.1038/s41418-022-00943-y · Cited by 540
Wang, F., Yuan, J.-H., Wang, S.-B., Yang, F., Yuan, S.-X., Ye, C., Yang, N., Zhou, W.-P., Li, W.-L., Li, W., et al. (2014) · Hepatology · doi:10.1002/hep.27239 · Cited by 440
Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage
Younger, S. T., Kenzelmann-Broz, D., Jung, H., Attardi, L. D., & Rinn, J. L. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv284 · Cited by 99
Expanding the p53 regulatory network: LncRNAs take up the challenge
Grossi, E., Sánchez, Y., & Huarte, M. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.07.011 · Cited by 78
The emerging functions of the p53-miRNA network in stem cell biology
Lin, C.-P., Choi, Y. J., Hicks, G. G., & He, L. (2012) · Cell Cycle · doi:10.4161/cc.20207 · Cited by 38
Metadata
- Authors
- Barsotti, A. M., Beckerman, R., Laptenko, O., Huppi, K., Caplen, N. J., & Prives, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 287
- Issue
- 4
- Pages
- 2509-2519
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2068348383
- Cited by
- 186
- References
- 10
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Barsotti, A. M., Beckerman, R., Laptenko, O., Huppi, K., Caplen, N. J., & Prives, C. (2012). p53-dependent Induction of PVT1 and miR-1204. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m111.322875
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
