ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing
Open accessAbstract
The ATP-binding cassette transporter A7 (ABCA7) has been identified as a susceptibility factor of late onset Alzheimer disease in genome-wide association studies. ABCA7 has been shown to mediate phagocytosis and affect membrane trafficking. The current study examined the impact of ABCA7 loss of function on amyloid precursor protein (APP) processing and generation of amyloid-β (Aβ). Suppression of endogenous ABCA7 in several different cell lines resulted in increased β-secretase cleavage and elevated Aβ. ABCA7 knock-out mice displayed an increased production of endogenous murine amyloid Aβ42 species. Crossing ABCA7-deficient animals to an APP transgenic model resulted in significant increases in the soluble Aβ as compared with mice expressing normal levels of ABCA7. Only modest changes in the amount of insoluble Aβ and amyloid plaque densities were observed once the amyloid pathology was well developed, whereas Aβ deposition was enhanced in younger animals. In vitro studies indicated a more rapid endocytosis of APP in ABCA7 knock-out cells that is mechanistically consistent with the increased Aβ production. These in vitro and in vivo findings indicate a direct role of ABCA7 in amyloid processing that may be associated with its primary biological function to regulate endocytic pathways. Several potential loss-of-function ABCA7 mutations and deletions linked to Alzheimer disease that in some instances have a greater impact than apoE allelic variants have recently been identified. A reduction in ABCA7 expression or loss of function would be predicted to increase amyloid production and that may be a contributing factor in the associated Alzheimer disease susceptibility.
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ABCA7 underexpression induces faster APP endocytosis, increases Aβ production in vitro, and accelerates amyloid pathology in young transgenic mice.
“ABCA7 underexpression induced faster APP endocytosis, consistent with increased Aβ production in vitro and accelerated the amyloid pathology in young transgenic mice [111].”
From The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? (2019) · cites this paper as [111]
ABCA7 is involved in endocytosis and intracellular trafficking of APP.
“ABCA7, an ATP-binding cassette transporter protein, is known to be involved in endocytosis and intracellular trafficking of APP [151].”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [151]
Suppression of ABCA7 led to increased β-secretase-mediated processing of APP and subsequent elevation of Aβ species.
“Suppression of ABCA7 led to increased β-secretase-mediated processing of APP and subsequent elevation of Aβ species [151].”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [151]
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- Authors
- Satoh, K., Abe-Dohmae, S., Yokoyama, S., St George-Hyslop, P., & Fraser, P. E.
- Affiliations
- University of Toronto (CA)
- Nagoya City University (JP)
- Chubu University (JP)
- Corresponding author
- Satoh, Kanayo
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 290
- Issue
- 40
- Pages
- 24152-24165
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC4591804
- OpenAlex
- W2194393752
- Cited by
- 128
- References
- 65
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 12 · 2023: 9 · 2022: 18 · 2021: 10 · 2020: 14 · 2019: 7 · 2018: 10 · 2017: 16 · 2016: 13 · 2015: 1
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP-115056)
- Japan Society for the Promotion of Science (21591164, 25461375)
- Japan Health Sciences Foundation
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- ABCA7, ABC transporters, Alzheimer's disease, amyloid-beta, APP processing, endocytosis, APP transgenic mice, amyloid plaques, loss-of-function mutations
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Female, Gene Expression Regulation, HeLa Cells, Humans, Male, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Endosomes, Risk Factors, Amyloid beta-Peptides, Gene Deletion, Mice, Knockout, Disease Progression, ATP-Binding Cassette Transporters, RNA Interference, Cell Line, Tumor, Mice, Amyloid Precursor Protein Secretases, HEK293 Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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