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Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

Follett, Jordan, Bugarcic, Andrea, Yang, Zhe, Ariotti, Nicholas, Norwood, Suzanne J., Collins, Brett M., Parton, Robert G., Teasdale, Rohan D.·2016·Journal of Biological Chemistry
DOI 10.1074/jbc.m115.703157
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  • The effect of R55 and R33 is primarily by restoring the function and localization of the retromer complex.

    “It is now believed that the effect of R55 and R33 is primarily by restoring the function and localization of the retromer complex [10].”

    From Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer’s disease mouse model (2025) · cites this paper as [10]

    The results on Vps35 mutant localization (Fig. 5) show that R55 increased endosomal localization and membrane recruitment of R524W-containing retromer, though it did not fully restore membrane levels. The Discussion suggests a possible mechanism for that effect, but our copy does not establish that restoring retromer function and localization is the primary mechanism of both agents; a search for R33 found no passage addressing it. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Dysfunctional retromer linked to neurodegenerative diseases is not primarily caused by loss of expression of Vps35 but by decreased endosomal association causing loss of function that can be mitigated by retromer stabilizing compounds such as R55 and R33.

    “Our results supports previous reports that dysfunctional retromer linked to neurodegenerative diseases is not primarily caused by loss of expression of Vps35 but by decreased endosomal association causing loss of function that can be mitigated by retromer stabilizing compounds such as R55 and R33 [10].”

    From Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer’s disease mouse model (2025) · cites this paper as [10]

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Research works printed but not linked: 51

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Metadata

Authors
Follett, J., Bugarcic, A., Yang, Z., Ariotti, N., Norwood, S. J., Collins, B. M., Parton, R. G., & Teasdale, R. D.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2016-08
Volume
291
Issue
35
Pages
18283-18298
ISSN
0021-9258
DOI
10.1074/jbc.m115.703157
Cited by
81
References
3
Language
en
Licence
Funders
  • National Health and Medical Research Council (APP1025538, APP1042082, APP1058734, APP1041929, APP1061574, APP1045092, APP1037320, APP1058565)
  • Australian Research Council (DP120103930, FT100100027)
  • Judith Jane Mason and Harold Stannett Williams Memorial Foundation
  • Australian Cancer Research Foundation

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