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Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence
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BACE-1 can catalyze amyloidolytic processing by cleavage between Tyr10 and Glu11 of the Aβ sequence, the β'-cleavage site.
“BACE-1 can also catalyze amyloidolytic processing by cleavage between Tyr10 and Glu11 of the Aβ sequence (Huse et al., 2002; Liu et al., 2002; Kimura et al., 2016), the so-called β’-cleavage site (Figure 1).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Kimura et al., 2016
β'-cleavage is favored in the neuroprotective Icelandic APP mutation while canonical β-cleavage at Asp1 is reduced.
“Interestingly, β’-cleavage is favored in the neuroprotective Icelandic APP mutation while the canonic β-cleavage at Asp1 is reduced (Kimura et al., 2016).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Kimura et al., 2016
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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
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Metadata
- Authors
- Kimura, A., Hata, S., & Suzuki, T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 291
- Issue
- 46
- Pages
- 24041-24053
- ISSN
- 0021-9258
- Cited by
- 95
- References
- 7
- Language
- en
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