Identification of a β-Secretase Activity, Which Truncates Amyloid β-Peptide after Its Presenilin-dependent Generation

Fluhrer, Regina; Multhaup, Gerd; Schlicksupp, Andrea; Okochi, Masayasu; Takeda, Masatoshi; Lammich, Sven; Willem, Michael; Westmeyer, Gil; Bode, Wolfram; Walter, Jochen; Haass, Christian

doi:10.1074/jbc.m211485200

Cited by 64

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Identification of a β-Secretase Activity, Which Truncates Amyloid β-Peptide after Its Presenilin-dependent Generation

Fluhrer, Regina, Multhaup, Gerd, Schlicksupp, Andrea, Okochi, Masayasu, Takeda, Masatoshi, Lammich, Sven, Willem, Michael, Westmeyer, Gil, Bode, Wolfram, Walter, Jochen, Haass, Christian·2003·Journal of Biological Chemistry

DOI 10.1074/jbc.m211485200

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BACE-1 is a prominent Aβ-generating enzyme but also an occasional Aβ-degrading enzyme under some circumstances.
“Together, these data confirm early studies (Fluhrer et al., 2003; Shi et al., 2003), placing BACE-1 as a prominent Aβ-generating, but also as an occasional Aβ-“degrading” enzyme under some circumstances.”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Fluhrer et al., 2003

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE
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Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) · Nature · doi:10.1038/359322a0 · Cited by 1,921
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Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757
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Control of Peripheral Nerve Myelination by the ß-Secretase BACE1
Willem, M., Garratt, A. N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P., Birchmeier, C., & Haass, C. (2006) · Science · doi:10.1126/science.1132341 · Cited by 703
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Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP
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Authors: Fluhrer, R., Multhaup, G., Schlicksupp, A., Okochi, M., Takeda, M., Lammich, S., Willem, M., Westmeyer, G., Bode, W., Walter, J., & Haass, C.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2003-02
Volume: 278
Issue: 8
Pages: 5531-5538
ISSN: 0021-9258
DOI: 10.1074/jbc.m211485200
Cited by: 64
References: 5
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6461 d)

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Identification of a β-Secretase Activity, Which Truncates Amyloid β-Peptide after Its Presenilin-dependent Generation

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