CoChat
Sign Up
Cited by 38

The DOI matches its Crossref record.

Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses

Papadopoulos, Theofilos, Rhee, Hong Jun, Subramanian, Devaraj, Paraskevopoulou, Foteini, Mueller, Rainer, Schultz, Carsten, Brose, Nils, Rhee, Jeong-Seop, Betz, Heinrich·2017·Journal of Biological Chemistry
DOI 10.1074/jbc.m116.771592
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1074/jbc.m116.771592

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 60

  1. Balla, 2013, Phosphoinositides: tiny lipids with giant impact on cell regulation, Physiol. Rev., 93, 1019, 10.1152/physrev.00028.2012 · DOI · Paper page
  2. Raiborg, 2013, Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic, FEBS J., 280, 2730, 10.1111/febs.12116 · DOI
  3. Roth, 2004, Phosphoinositides in constitutive membrane traffic, Physiol. Rev., 84, 699, 10.1152/physrev.00033.2003 · DOI
  4. Wenk, 2004, Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals, Proc. Natl. Acad. Sci. U.S.A., 101, 8262, 10.1073/pnas.0401874101 · DOI
  5. Luscher, 2011, GABAA receptor trafficking-mediated plasticity of inhibitory synapses, Neuron., 70, 385, 10.1016/j.neuron.2011.03.024 · DOI
  6. Papadopoulos, 2011, The role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions, Front. Cell. Neurosci., 5, 11, 10.3389/fncel.2011.00011 · DOI
  7. Poulopoulos, 2009, Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin, Neuron., 63, 628, 10.1016/j.neuron.2009.08.023 · DOI
  8. Mayer, 2013, Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission, Proc. Natl. Acad. Sci. U.S.A., 110, 20795, 10.1073/pnas.1309078110 · DOI
  9. Soykan, 2014, A conformational switch in collybistin determines the differentiation of inhibitory postsynapses, EMBO J., 33, 2113, 10.15252/embj.201488143 · DOI
  10. Kalscheuer, 2009, A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation, Hum. Mutat., 30, 61, 10.1002/humu.20814 · DOI
  11. Reddy-Alla, 2010, PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering, Eur. J. Neurosci., 31, 1173, 10.1111/j.1460-9568.2010.07149.x · DOI
  12. Ludolphs, 2016, Specificity of collybistin-phosphoinositide interactions: impact of the individual protein domains, J. Biol. Chem., 291, 244, 10.1074/jbc.M115.673400 · DOI
  13. Long, 2015, Missense mutation R338W in ARHGEF9 in a family with X-linked intellectual disability with variable macrocephaly and macro-orchidism, Front. Mol. Neurosci., 8, 83
  14. Harvey, 2004, The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering, J. Neurosci., 24, 5816, 10.1523/JNEUROSCI.1184-04.2004 · DOI
  15. Papadopoulos, 2015, Lipid binding defects and perturbed synaptogenic activity of a collybistin R290H mutant that causes epilepsy and intellectual disability, J. Biol. Chem., 290, 8256, 10.1074/jbc.M114.633024 · DOI
  16. Gillooly, 2000, Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells, EMBO J., 19, 4577, 10.1093/emboj/19.17.4577 · DOI · Paper page
  17. Schu, 1993, Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting, Science., 260, 88, 10.1126/science.8385367 · DOI · Paper page
  18. Marat, 2016, Phosphatidylinositol 3-phosphates–at the interface between cell signalling and membrane traffic, EMBO J., 35, 561, 10.15252/embj.201593564 · DOI · Paper page
  19. Brown, 1999, Insulin activates the α isoform of class II phosphoinositide 3-kinase, J. Biol. Chem., 274, 14529, 10.1074/jbc.274.21.14529 · DOI
  20. Ktori, 2003, TNF-α and leptin activate the α-isoform of class II phosphoinositide 3-kinase, Biochem. Biophys. Res. Commun., 306, 139, 10.1016/S0006-291X(03)00933-1 · DOI
  21. Subramanian, 2010, Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells, Nat. Chem. Biol., 6, 324, 10.1038/nchembio.348 · DOI
  22. Papadopoulos, 2007, Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice, EMBO J., 26, 3888, 10.1038/sj.emboj.7601819 · DOI
  23. Ketel, 2016, A phosphoinositide conversion mechanism for exit from endosomes, Nature., 529, 408, 10.1038/nature16516 · DOI · Paper page
  24. Mentel, 2011, Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate, Angew. Chem. Int. Ed. Engl., 50, 3811, 10.1002/anie.201007796 · DOI
  25. Stenmark, 1996, Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger, J. Biol. Chem., 271, 24048, 10.1074/jbc.271.39.24048 · DOI
  26. Meyer, 1995, Identification of a gephyrin binding motif on the glycine receptor β subunit, Neuron., 15, 563, 10.1016/0896-6273(95)90145-0 · DOI
  27. Kirsch, 1995, The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton, J. Neurosci., 15, 4148, 10.1523/JNEUROSCI.15-06-04148.1995 · DOI
  28. Seitanidou, 1992, Partial glycinergic denervation induces transient changes in the distribution of a glycine receptor-associated protein in a central neuron, J. Neurosci., 12, 116, 10.1523/JNEUROSCI.12-01-00116.1992 · DOI
  29. Essrich, 1998, Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin, Nat. Neurosci., 1, 563, 10.1038/2798 · DOI
  30. Kneussel, 1999, Loss of postsynaptic GABAA receptor clustering in gephyrin-deficient mice, J. Neurosci., 19, 9289, 10.1523/JNEUROSCI.19-21-09289.1999 · DOI
  31. Bekkers, 1991, Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture, Proc. Natl. Acad. Sci. U.S.A., 88, 7834, 10.1073/pnas.88.17.7834 · DOI
  32. Wucherpfennig, 2003, Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release, J. Cell Biol., 161, 609, 10.1083/jcb.200211087 · DOI
  33. Rosenmund, 1996, Definition of the readily releasable pool of vesicles at hippocampal synapses, Neuron., 16, 1197, 10.1016/S0896-6273(00)80146-4 · DOI
  34. Jockusch, 2007, CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins, Cell., 131, 796, 10.1016/j.cell.2007.11.002 · DOI
  35. Nair, 2013, Neurobeachin regulates neurotransmitter receptor trafficking to synapses, J. Cell Biol., 200, 61, 10.1083/jcb.201207113 · DOI
  36. Maffucci, 2003, Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation, EMBO J., 22, 4178, 10.1093/emboj/cdg402 · DOI
  37. Maffucci, 2005, Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration, J. Cell Biol., 169, 789, 10.1083/jcb.200408005 · DOI
  38. Posor, 2013, Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate, Nature., 499, 233, 10.1038/nature12360 · DOI
  39. El Sheikh, 2003, Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation, BMC Clin. Pathol., 3, 4, 10.1186/1472-6890-3-4 · DOI
  40. Traer, 2006, Are class II phosphoinositide 3-kinases potential targets for anticancer therapies?, Bull. Cancer., 93, E53
  41. Kong, 2006, Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane, Mol. Cell. Biol., 26, 6065, 10.1128/MCB.00203-06 · DOI
  42. Petiot, 2003, PI3P signaling regulates receptor sorting but not transport in the endosomal pathway, J. Cell Biol., 162, 971, 10.1083/jcb.200303018 · DOI
  43. Kins, 2000, Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin, Nat. Neurosci., 3, 22, 10.1038/71096 · DOI
  44. Hoon, 2011, Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina, Proc. Natl. Acad. Sci. U.S.A., 108, 3053, 10.1073/pnas.1006946108 · DOI
  45. Park, 2012, Controlling synaptotagmin activity by electrostatic screening, Nat. Struct. Mol. Biol., 19, 991, 10.1038/nsmb.2375 · DOI
  46. Brown, 2001, Growth factor regulation of the novel class II phosphoinositide 3-kinases, Biochem. Soc. Trans., 29, 535, 10.1042/bst0290535 · DOI
  47. Wuchter, 2012, A comprehensive small interfering RNA screen identifies signaling pathways required for gephyrin clustering, J. Neurosci., 32, 14821, 10.1523/JNEUROSCI.1261-12.2012 · DOI
  48. Inoue, 2003, The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin, Nature., 422, 629, 10.1038/nature01533 · DOI
  49. Chiou, 2011, Differential regulation of the postsynaptic clustering of γ-aminobutyric acid type A (GABAA) receptors by collybistin isoforms, J. Biol. Chem., 286, 22456, 10.1074/jbc.M111.236190 · DOI
  50. Tyagarajan, 2011, Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses, J. Cell Sci., 124, 2786, 10.1242/jcs.086199 · DOI
  51. Brünig, 2002, Intact sorting, targeting, and clustering of γ-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro, J. Comp. Neurol., 443, 43, 10.1002/cne.10102 · DOI
  52. Stopkova, 2004, Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia, Biol. Psychiatry., 55, 981, 10.1016/j.biopsych.2004.01.014 · DOI
  53. Lionel, 2013, Rare exonic deletions implicate the synaptic organizer gephyrin (GPHN) in risk for autism, schizophrenia and seizures, Hum. Mol. Gen., 22, 2055, 10.1093/hmg/ddt056 · DOI
  54. Tyagarajan, 2011, Regulation of GABAergic synapse formation and plasticity by GSK3β-dependent phosphorylation of gephyrin, Proc. Natl. Acad. Sci. U.S.A., 108, 379, 10.1073/pnas.1011824108 · DOI
  55. Kneussel, 2000, Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model, Trends Neurosci., 23, 429, 10.1016/S0166-2236(00)01627-1 · DOI
  56. Fuhrmann, 2002, Gephyrin interacts with dynein light chains 1 and 2, components of motor protein complexes, J. Neurosci., 22, 5393, 10.1523/JNEUROSCI.22-13-05393.2002 · DOI
  57. Maas, 2006, Neuronal cotransport of glycine receptor and the scaffold protein gephyrin, J. Cell Biol., 172, 441, 10.1083/jcb.200506066 · DOI
  58. Burgalossi, 2012, Analysis of neurotransmitter release mechanisms by photolysis of caged Ca2+ in an autaptic neuron culture system, Nat. Protoc., 7, 1351, 10.1038/nprot.2012.074 · DOI
  59. Saiepour, 2010, Complex role of collybistin and gephyrin in GABAA receptor clustering, J. Biol. Chem., 285, 29623, 10.1074/jbc.M110.121368 · DOI
  60. Kittler, 2004, Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating γaminobutyric acid type A receptor membrane trafficking, Proc. Natl. Acad. Sci. U.S.A., 101, 12736, 10.1073/pnas.0401860101 · DOI

Cited by

Sorted by citations

Metadata

Authors
Papadopoulos, T., Rhee, H. J., Subramanian, D., Paraskevopoulou, F., Mueller, R., Schultz, C., Brose, N., Rhee, J.-S., & Betz, H.
ORCID
Papadopoulos, Theofilos
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2017-01
Volume
292
Issue
4
Pages
1160-1177
ISSN
0021-9258
DOI
10.1074/jbc.m116.771592
Cited by
38
References
0
Language
en
Licence
Funders
Deutsche Forschungsgemeinschaft (PA 2087/1–3, SFB1190/P10, TRR83)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review