CoChat
Sign Up
Cited by 299

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Phosphatidylinositol 3-phosphates—at the interface between cell signalling and membrane traffic

Marat, Andrea L, Haucke, Volker·2016·The EMBO Journal
DOI 10.15252/embj.201593564
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.15252/embj.201593564

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • PI(3)P is predominantly localized on early endosomes and functions by recruiting effectors that contain PX and FYVE domains.

    “PI(3)P is predominantly localized on early endosomes and functions by recruiting a variety of effectors that contain PI(3)P-binding domains, such as PX (Phox homology) and FYVE (Fab1, YOTB, Vac1, EEA1) domains”

    From PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity (2025) · cites this paper as Marat and Haucke, 2016

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 208

  1. Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y (2015) Phosphatidylinositol 3‐kinase class II α‐isoform PI3K‐C2α is required for transforming growth factor β‐induced Smad signaling in endothelial cells. J Biol Chem 290: 6086–6105 · DOI
  2. Al‐Qusairi L, Prokic I, Amoasii L, Kretz C, Messaddeq N, Mandel JL, Laporte J (2013) Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin‐proteasome pathways. FASEB J 27: 3384–3394 · DOI
  3. Arcaro A, Khanzada UK, Vanhaesebroeck B, Tetley TD, Waterfield MD, Seckl MJ (2002) Two distinct phosphoinositide 3‐kinases mediate polypeptide growth factor‐stimulated PKB activation. EMBO J 21: 5097–5108 · DOI
  4. Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, Griffiths G, Ktistakis NT (2008) Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3‐phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 182: 685–701 · DOI · Paper page
  5. Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR (2014) Characterization of VPS34‐IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3‐phosphate‐binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3‐kinase. Biochem J 463: 413–427 · DOI · Paper page
  6. Balderhaar HJ, Ungermann C (2013) CORVET and HOPS tethering complexes ‐ coordinators of endosome and lysosome fusion. J Cell Sci 126: 1307–1316 · DOI
  7. Balla T (2013) Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev 93: 1019–1137 · DOI · Paper page
  8. Barber DF, Alvarado‐Kristensson M, González‐García A, Pulido R, Carrera AC (2006) PTEN regulation, a novel function for the p85 subunit of phosphoinositide 3‐kinase. Sci STKE 2006: pe49 · DOI
  9. Baskaran S, Ragusa MJ, Boura E, Hurley JH (2012) Two‐site recognition of phosphatidylinositol 3‐phosphate by PROPPINs in autophagy. Mol Cell 47: 339–348 · DOI
  10. Baumeister MA, Martinu L, Rossman KL, Sondek J, Lemmon MA, Chou MM (2003) Loss of phosphatidylinositol 3‐phosphate binding by the C‐terminal Tiam‐1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J Biol Chem 278: 11457–11464 · DOI
  11. Baumeister MA, Rossman KL, Sondek J, Lemmon MA (2006) The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide‐exchange activity. Biochem J 400: 563–572 · DOI
  12. Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA (2003) Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot‐Marie‐Tooth syndrome. Mol Cell 12: 1391–1402 · DOI
  13. Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, Dixon JE (2006) Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci USA 103: 927–932 · DOI
  14. Berger P, Schaffitzel C, Berger I, Ban N, Suter U (2003) Membrane association of myotubularin‐related protein 2 is mediated by a pleckstrin homology‐GRAM domain and a coiled‐coil dimerization module. Proc Natl Acad Sci USA 100: 12177–12188 · DOI
  15. Biswas K, Yoshioka K, Asanuma K, Okamoto Y, Takuwa N, Sasaki T, Takuwa Y (2013) Essential role of class II phosphatidylinositol‐3‐kinase‐C2α in sphingosine 1‐phosphate receptor‐1‐mediated signaling and migration in endothelial cells. J Biol Chem 288: 2325–2339 · DOI
  16. Blondeau F, Laporte J, Bodin S, Superti‐Furga G, Payrastre B, Mandel JL (2000) Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3‐kinase and phosphatidylinositol 3‐phosphate pathway. Hum Mol Genet 9: 2223–2229 · DOI
  17. Botelho RJ (2009) Changing phosphoinositides “on the fly”: how trafficking vesicles avoid an identity crisis. BioEssays 31: 1127–1136 · DOI
  18. Böttcher RT, Stremmel C, Meves A, Meyer H, Widmaier M, Tseng HY, Fässler R (2012) Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1‐integrin tail. Nat Cell Biol 14: 584–592 · DOI · Paper page
  19. Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E (2015) PI3K‐C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling. Nat Commun 6: 7400 · DOI
  20. Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson KE, Butler PJ, Lavenir I, Perisic O, Hawkins PT, Stephens L, Williams RL (2001) The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3‐phosphate. Mol Cell 8: 829–839 · DOI
  21. Bridges D, Ma JT, Park S, Inoki K, Weisman LS, Saltiel AR (2012) Phosphatidylinositol 3,5‐bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol Biol Cell 23: 2955–2962 · DOI
  22. Brown RA, Domin J, Arcaro A, Waterfield MD, Shepherd PR (1999) Insulin activates the alpha isoform of class II phosphoinositide 3‐kinase. J Biol Chem 274: 14529–14532 · DOI
  23. Burd CG, Emr SD (1998) Phosphatidylinositol(3)‐phosphate signaling mediated by specific binding to RING FYVE domains. Mol Cell 2: 157–162 · DOI
  24. Byfield MP, Murray JT, Backer JM (2005) hVps34 is a nutrient‐regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 280: 33076–33082 · DOI
  25. Cabrera M, Nordmann M, Perz A, Schmedt D, Gerondopoulos A, Barr F, Piehler J, Engelbrecht‐Vandré S, Ungermann C (2014) The Mon1‐Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin‐fold‐Rab interface and association with PI3P‐positive membranes. J Cell Sci 127: 1043–1051
  26. Cao C, Laporte J, Backer JM, Wandinger‐Ness A, Stein MP (2007) Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic 8: 1052–1067 · DOI · Paper page
  27. Cao C, Backer JM, Laporte J, Bedrick EJ, Wandinger‐Ness A (2008) Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Mol Bio Cell 19: 3334–3346 · DOI
  28. Chagpar RB, Links PH, Pastor MC, Furber LA, Hawrysh AD, Chamberlain MD, Anderson DH (2010) Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3‐kinase. Proc Natl Acad Sci USA 107: 5471–5476 · DOI
  29. Chen YG, Wang Z, Ma J, Zhang L, Lu Z (2007) Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor‐beta signaling. J Biol Chem 282: 9688–9695 · DOI · Paper page
  30. Chiaruttini N, Redondo‐Morata L, Colom A, Humbert F, Lenz M, Scheuring S, Roux A (2015) Relaxation of loaded ESCRT‐III spiral springs drives membrane deformation. Cell 163: 866–879 · DOI
  31. Chow CY, Zhang Y, Dowling JJ, Jin N, Adamska M, Shiga K, Szigeti K, Shy ME, Li J, Zhang X, Lupski JR, Weisman LS, Meisler MH (2007) Mutation of Fig4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature 448: 68–72 · DOI
  32. Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Øvervatn A, Stenmark H, Bjørkøy G, Simonsen A, Johansen T (2010) p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy 6: 330–344 · DOI
  33. Cohen LA, Honda A, Varnai P, Brown FD, Balla T, Donaldson JG (2007) Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains. Mol Biol Cell 18: 2244–2253 · DOI
  34. Corbalan‐Garcia S, Gómez‐Fernández JC (2014) Signaling through C2 domains: more than one lipid target. Biochim Biophys Acta 1838: 1536–1547 · DOI
  35. Cullen PJ (2008) Endosomal sorting and signalling: an emerging role for sorting nexins. Nat Rev Mol Cell Biol 9: 574–582 · DOI · Paper page
  36. Daumke O, Roux A, Haucke V (2014) BAR domain scaffolds in dynamin‐mediated membrane fission. Cell 156: 882–892 · DOI
  37. Demetriades C, Doumpas N, Teleman AA (2014) Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell 156: 786–799 · DOI
  38. Devereaux K, Dall'Armi C, Alcazar‐Roman A, Ogasawara Y, Zhou X, Wang F, Yamamoto A, De Camilli P, Di Paolo G (2013) Regulation of mammalian autophagy by class II and III PI 3‐kinases through PI3P synthesis. PLoS ONE 8: e76405 · DOI · Paper page
  39. Di Cristofano A, Pesce B, Cordon‐Cardo C, Pandolfi PP (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet 19: 348–355 · DOI
  40. Di Paolo G, De Camilli P (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443: 651–657 · DOI · Paper page
  41. Dibble CC, Cantley LC (2015) Regulation of mTORC1 by PI3K signaling. Trends Cell Biol 25: 545–555 · DOI
  42. Doerks T, Strauss M, Brendel M, Bork P (2000) GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane‐associated proteins. Trends Biochem Sci 25: 483–485 · DOI
  43. Dooley HC, Razi M, Polson HE, Girardin SE, Wilson MI, Tooze SA (2014) WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12‐5‐16L1. Mol Cell 17: 238–252 · DOI
  44. Dooley HC, Wilson MI, Tooze SA (2015) WIPI2B links PtdIns3P to LC3 lipidation through binding ATG16L1. Autophagy 11: 190–191
  45. Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella‐Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF et al (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol 16: 1069–1070 · DOI · Paper page
  46. Duex JE, Nau JJ, Kauffman EJ, Weisman LS (2006a) Phosphoinositide 5‐phosphatase Fig4p is required for both acute rise and subsequent fall in stress‐induced phosphatidylinositol 3,5‐bisphosphate levels. Eukaryot Cell 5: 723–731 · DOI
  47. Duex JE, Tang F, Weisman LS (2006b) The Vac14p‐Fig4p complex acts independently of Vac7p and couples PI3, 5P2 synthesis and turnover. J Biol Chem 172: 693–704
  48. Dumas JJ, Merithew E, Sudharshan E, Rajamani D, Hayes S, Lawe D, Corvera S, Lambright DG (2001) Multivalent endosome targeting by homodimeric EEA1. Mol Cell 8: 947–958 · DOI
  49. Falasca M, Maffucci T (2012) Regulation and cellular functions of class II phosphoinositide 3‐kinases. Biochem J 443: 587–601 · DOI
  50. Feng S, Laketa V, Stein F, Rutkowska A, MacNamara A, Depner S, Klingmüller U, Saez‐Rodriguez J, Schultz C (2014) A rapidly reversible chemical dimerizer system to study lipid signaling in living cells. Angew Chem Int Ed Engl 53: 6720–6723 · DOI
  51. Ferguson SM (2015) Beyond indigestion: emerging roles for lysosome‐based signaling in human disease. Curr Opin Cell Biol 35: 59–68 · DOI
  52. Ferron M, Vacher J (2006) Characterization of the murine Inpp4b gene and identification of a novel isoform. Genes 376: 152–161
  53. Fili N, Calleja V, Woscholski R, Parker PJ, Larijani B (2006) Compartmental signal modulation: endosomal phosphatidylinositol 3‐phosphate controls endosome morphology and selective cargo sorting. Proc Natl Acad Sci USA 103: 15473–15478 · DOI
  54. Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia TJ, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A (2010) The selective macroautophagic degradation of aggregated proteins requires the PI3P‐binding protein Alfy. Mol Cell 38: 265–279 · DOI
  55. Fragoso R, Barata JT (2015) Kinases, tails and more: regulation of PTEN function by phosphorylation. Methods 77–78: 75–81 · DOI
  56. Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez‐Morga D, Boletta A, Merlo GR, Hirsch E (2014) PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function. Dev Cell 28: 647–658 · DOI
  57. Freitag A, Prajwal P, Shymanets A, Harteneck C, Nürnberg B, Schächtele C, Kubbutat M, Totzke F, Laufer SA (2015) Development of first lead structures for phosphoinositide 3‐kinase‐C2γ inhibitors. J Med Chem 58: 212–221 · DOI
  58. Funderburk SF, Wang QJ, Yue Z (2010) The Beclin 1‐VPS34 complex–at the crossroads of autophagy and beyond. Trends Cell Biol 20: 355–362 · DOI
  59. Galperin E, Sorkin A (2008) Endosomal targeting of MEK2 requires RAF, MEK kinase activity and clathrin‐dependent endocytosis. Traffic 9: 1776–1790 · DOI
  60. Grant BD, Donaldson JG (2009) Pathways and mechanisms of endocytic recycling. Nat Rev Mol Cell Biol 10: 597–608 · DOI · Paper page
  61. Guerrero‐Valero M, Ferrer‐Orta C, Querol‐Audí J, Marin‐Vicente C, Fita I, Gómez‐Fernández JC, Verdaguer N, Corbalán‐García S (2009) Structural and mechanistic insights into the association of PKCalpha‐C2 domain to PtdIns(4,5)P2. Proc Natl Acad Sci USA 106: 6603–6607 · DOI · Paper page
  62. Gulati P, Gaspers LD, Dann SG, Joaquin M, Nobukuni T, Natt F, Kozma SC, Thomas AP, Thomas G (2008) Amino acids activate mTOR complex 1 via Ca2 + /CaM signaling to hVps34. Cell Metab 7: 456–465 · DOI
  63. Hardie DG (2014) AMPK–sensing energy while talking to other signaling pathways. Cell Metab 20: 939–952 · DOI
  64. Hemmings BA, Restuccia DF (2012) PI3K‐PKB/Akt pathway. Cold Spring Harb Perspect Biol 4: a011189 · DOI
  65. Herman PK, Emr SD (1990) Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol Cell Biol 10: 6742–6754
  66. Hiles ID, Otsu M, Volinia S, Fry MJ, Gout I, Dhand R, Panayotou G, Ruiz‐Larrea F, Thompson A, Totty NF, Hsuan JJ, Courtneidge SA, Parker PJ, Waterfield MD (1992) Phosphatidylinositol 3‐kinase: structure and expression of the 110 kd catalytic subunit. Cell 70: 419–429 · DOI
  67. Hnia K, Vaccari I, Bolino A, Laporte J (2012) Myotubularin phosphoinositide phosphatases: cellular functions and disease pathophysiology. Trends Mol Med 18: 317–327 · DOI
  68. Hoepfner S, Severin F, Cabezas A, Habermann B, Runge A, Gillooly D, Stenmark H, Zerial M (2005) Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell 121: 437–450 · DOI
  69. Hsu F, Mao Y (2015) The structure of phosphoinositide phosphatases: insights into substrate specificity and catalysis. Biochim Biophys Acta 1851: 698–710 · DOI
  70. Idevall‐Hagren O, Dickson EJ, Hille B, Toomre DK, De Camilli P (2012) Optogenetic control of phosphoinositide metabolism. Proc Natl Acad Sci USA 109: E2316–E2323 · DOI
  71. Idevall‐Hagren O, De Camilli P (2015) Detection and manipulation of phosphoinositides. Biochim Biophys Acta 1851: 736–745 · DOI
  72. Ikonomov OC, Sbrissa D, Mlak K, Kanzaki M, Pessin J, Shisheva A (2002) Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5‐P2 production for endomembrane integrity. J Biol Chem 277: 9206–9211 · DOI
  73. Ikonomov OC, Sbrissa D, Fenner H, Shisheva A (2009) PIKfyve‐ArPIKfyve‐Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis. J Biol Chem 284: 35794–35806 · DOI
  74. Ikonomov OC, Sbrissa D, Delvecchio K, Xie Y, Jin JP, Rappolee D, Shisheva A (2011) The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve‐/‐ embryos but normality of PIKfyve+/‐ mice. J Biol Chem 286: 13404–13413 · DOI · Paper page
  75. Inoki K, Li Y, Zhu T, Wu J, Guan KL (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4: 648–657 · DOI · Paper page
  76. Itoh F, Divecha N, Brocks L, Oomen L, Janssen H, Calafat J, Itoh S, Pt DP (2002) The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF‐beta/Smad signalling. Genes Cells 7: 321–331 · DOI
  77. Jean S, Cox S, Schmidt EJ, Robinson FL, Kiger A (2012) Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Mol Biol Cell 23: 2723–2740 · DOI
  78. Jean S, Kiger AA (2012) Coordination between RAB GTPase and phosphoinositide regulation and functions. Nat Rev Mol Cell Biol 13: 463–470 · DOI
  79. Jean S, Kiger AA (2014) Classes of phosphoinositide 3‐kinases at a glance. J Cell Sci 127: 923–928 · DOI
  80. Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS (2008) VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J 27: 3221–3234 · DOI
  81. Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS (2014) Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell 25: 1171–1185 · DOI
  82. Jungmichel S, Sylvestersen KB, Choudhary C, Nguyen S, Mann M, Nielsen ML (2014) Specificity and commonality of the phosphoinositide‐binding proteome analysed by quantitative mass spectrometry. Cell Rep 6: 578–591 · DOI
  83. Kalaidzidis I, Miaczynska M, Brewińska‐Olchowik M, Hupalowska A, Ferguson C, Parton RG, Kalaidzidis Y, Zerial M (2015) APPL endosomes are not obligatory endocytic intermediates but act as stable cargo‐sorting compartments. J Cell Biol 211: 123–144 · DOI
  84. Ketel K, Krauss M, Nicot AS, Puchkov D, Wieffer M, Müller R, Subramanian D, Schultz C, Laporte J, Haucke V (2016) A phosphoinositide conversion mechanisms for exit from endosomes. Nature 529: 408–412 · DOI · Paper page
  85. Kim YM, Jung CH, Seo M, Kim EK, Park JM, Bae SS, Kim DH (2015) mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation. Mol Cell 57: 207–218 · DOI
  86. Knævelsrud H, Søreng K, Raiborg C, Håberg K, Rasmuson F, Brech A, Liestøl K, Rusten TE, Stenmark H, Neufeld TP, Carlsson SR, Simonsen A (2013) Membrane remodeling by the PX‐BAR protein SNX18 promotes autophagosome formation. J Cell Biol 202: 331–349 · DOI
  87. Kok K, Geering B, Vanhaesebroeck B (2009) Regulation of phosphoinositide 3‐kinase expression in health and disease. Trends Biochem Sci 34: 115–127 · DOI
  88. Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC (2011) Lysosomal positioning coordinates cellular nutrient response. Nat Cell Biol 13: 453–460 · DOI · Paper page
  89. Ktistakis NT, Manifava M, Schoenfelder P, Rotondo S (2012) How phosphoinositide 3‐phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal. Biochem Soc Trans 40: 37–43 · DOI
  90. Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T, Okamura Y (2012) 3′ Phosphatase activity toward phosphatidylinositol 3,4‐bisphosphate [PI(3,4)P2] by voltage‐sensing phosphatase (VSP). Proc Natl Acad Sci USA 109: 10089–10094 · DOI
  91. Kutateladze TG (2010) Translation of the phosphoinositide code by PI effectors. Nat Chem Biol 6: 507–513 · DOI
  92. Laketa V, Zarbakhsh S, Morbier E, Subramanian D, Dinkel C, Brumbaugh J, Zimmermann P, Pepperkok R, Schultz C (2009) Membrane‐permeant phosphoinositide derivatives as modulators of growth factor signaling and neurite outgrowth. Chem Biol 16: 1190–1196 · DOI
  93. Laketa V, Zarbakhsh S, Traynor‐Kaplan A, Macnamara A, Subramanian D, Putyrski M, Mueller R, Nadler A, Mentel M, Saez‐Rodriguez J, Pepperkok R, Schultz C (2014) PIP3 induces the recycling of receptor tyrosine kinases. Sci Signal 7: ra5 · DOI
  94. Laplante M, Sabatini DM (2012) mTOR Signaling. Cold Spring Harb Perspect Biol 4: a011593 · DOI
  95. Laporte J, Bedez F, Bolino A, Mandel JL (2003) Myotubularins, a large disease‐associated family of cooperating catalytically active and inactive phosphoinositides phosphatases. Hum Mol Genet 15: R285–R292 · DOI
  96. Lauffer BE, Melero C, Temkin P, Lei C, Hong W, Kortemme T, von Zastrow M (2010) SNX27 mediates PDZ‐directed sorting from endosomes to the plasma membrane. J Cell Biol 190: 565–574 · DOI · Paper page
  97. Leibiger B, Moede T, Uhles S, Barker CJ, Creveaux M, Domin J, Berggren PO, Leibiger IB (2010) Insulin‐feedback via PI3K‐C2alpha activated PKBalpha/Akt1 is required for glucose‐stimulated insulin secretion. FASEB J 24: 1824–1837 · DOI
  98. Lemmon MA (2003) Phosphoinositide recognition domains. Traffic 4: 201–213 · DOI
  99. Lemmon MA (2008) Membrane recognition by phospholipid‐binding domains. Nat Rev Mol Cell Biol 9: 99–111 · DOI · Paper page
  100. Levin R, Grinstein S, Schlam D (2015) Phosphoinositides in phagocytosis and macropinocytosis. Biochim Biophys Acta 1851: 805–823 · DOI
  101. Liu L, Song X, He D, Komma C, Kita A, Virbasius JV, Huang G, Bellamy HD, Miki K, Czech MP, Zhou GW (2006) Crystal structure of the C2 domain of class II phosphatidylinositide 3‐kinase C2alpha. J Biol Chem 281: 4254–4260 · DOI
  102. Lorenzo O, Urbé S, Clague MJ (2005) Analysis of phosphoinositide binding domain properties within the myotubularin‐related protein MTMR3. J Cell Sci 118: 2005–2012 · DOI
  103. Lorenzo O, Urbé S, Clague MJ (2006) Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. J Cell Sci 119: 2953–2959 · DOI
  104. Maekawa M, Terasaka S, Mochizuki Y, Kawai K, Ikeda Y, Araki N, Skolnik EY, Taguchi T, Arai H (2014) Sequential breakdown of 3‐phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Proc Natl Acad Sci USA 111: E978–E987 · DOI
  105. Maekawa M, Fairn GD (2015) Molecular probes to visualize the location, organization and dynamics of lipids. J Cell Sci 127: 4801–4812
  106. Mak LH, Woscholski R (2015) Targeting PTEN using small molecule inhibitors. Methods 77–78: 63–68 · DOI
  107. Mayinger P (2012) Phosphoinositides and vesicular membrane traffic. Biochim Biophys Acta 1821: 1104–1113 · DOI
  108. McCartney AJ, Zhang Y, Weisman LS (2014) Phosphatidylinositol 3,5‐bisphosphate: low abundance, high significance. BioEssays 36: 52–64 · DOI
  109. Menezes MP, Waddell L, Lenk GM, Kaur S, MacArthur DG, Meisler MH, Clarke NF (2014) Whole exome sequencing identifies three recessive Fig4 mutations in an apparently dominant pedigree with Charcot‐Marie‐Tooth disease. Neuromuscul Disord 24: 666–670 · DOI
  110. Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD (2014) Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell 156: 771–785 · DOI · Paper page
  111. Mentel M, Laketa V, Subramanian D, Gillandt H, Schultz C (2011) Photoactivatable and cell‐membrane‐permeable phosphatidylinositol 3,4,5‐trisphosphate. Angew Chem Int Ed Engl 50: 3811–3814 · DOI
  112. Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler‐Joseph S, Habermann B, Wilm M, Parton RG, Zerial M (2004) APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 116: 445–456 · DOI
  113. Michell RH, Heath VL, Lemmon MA, Dove SK (2006) Phosphatidylinositol 3,5‐bisphosphate: metabolism and cellular functions. Trends Biochem Sci 31: 52–63 · DOI
  114. Mima J, Wickner W (2009) Phosphoinositides and SNARE chaperones synergistically assemble and remodel SNARE complexes for membrane fusion. Proc Natl Acad Sci USA 106: 16191–16196 · DOI
  115. Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai JI, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K (2000) Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol Cell Biol 20: 9346–9355 · DOI
  116. Munson MJ, Allen GF, Toth R, Campbell DG, Lucocq JM, Ganley IG (2015) mTOR activates the VPS34‐UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J 34: 2272–2290 · DOI
  117. Naga Prasad SV, Laporte SA, Chamberlain D, Caron MG, Barak L, Rockman HA (2002) Phosphoinositide 3‐kinase regulates beta2‐adrenergic receptor endocytosis by AP‐2 recruitment to the receptor/beta‐arrestin complex. J Cell Biol 158: 563–575 · DOI
  118. Naguib A, Bencze G, Cho H, Zheng W, Tocilj A, Elkayam E, Faehnle CR, Jaber N, Pratt CP, Chen M, Zong WX, Marks MS, Joshua‐Tor L, Pappin DJ, Trotman LC (2015) PTEN functions by recruitment to cytoplasmic vesicles. Mol Cell 58: 255–268 · DOI
  119. Nair U, Cao Y, Xie Z, Klionsky DJ (2010) Roles of the lipid‐binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy. J Biol Chem 285: 11476–11488 · DOI
  120. Naughtin MJ, Sheffield DA, Rahman P, Hughes WE, Gurung R, Stow JL, Nandurkar HH, Dyson JM, Mitchell CA (2010) The myotubularin phosphatase MTMR4 regulates sorting from early endosomes. J Cell Sci 123: 3071–3083 · DOI
  121. Nicot AS, Laporte J (2008) Endosomal phosphoinositides and human diseases. Traffic 9: 1240–1249 · DOI
  122. Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G (2005) Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH‐kinase. Proc Natl Acad Sci USA 102: 14238–14243 · DOI
  123. Nordmann M, Cabrera M, Perz A, Bröcker C, Ostrowicz C, Engelbrecht‐Vandré S, Ungermann C (2010) The Mon1‐Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7. Curr Biol 20: 1654–1659 · DOI
  124. O'Farrell F, Rusten TE, Stenmark H (2013) Phosphoinositide 3‐kinases as accelerators and brakes of autophagy. FEBS J 280: 6322–6337 · DOI
  125. Parachoniak CA, Park M (2012) Dynamics of receptor trafficking in tumorigenicity. Trends Cell Biol 22: 231–240 · DOI
  126. Pearce LR, Komander D, Alessi DR (2010) The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol 11: 9–22 · DOI · Paper page
  127. Peter BJ, Kent HM, Mills IG, Vallis Y, Butler PJ, Evans PR, McMahon HT (2004) BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science 303: 495–499 · DOI · Paper page
  128. Pirruccello M, De Camilli P (2012) Inositol 5‐phosphatases: insights from the Lowe syndrome protein OCRL. Trends Biochem Sci 37: 134–143 · DOI
  129. Platta HW, Stenmark H (2011) Endocytosis and signaling. Curr Opin Cell Biol 23: 393–403 · DOI
  130. Polson HE, de Lartigue J, Rigden DJ, Reedijk M, Urbé S, Clague MJ, Tooze SA (2010) Mammalian Atg18 (WIPI2) localizes to omegasome‐anchored phagophores and positively regulates LC3 lipidation. Autophagy 6: 506–522 · DOI · Paper page
  131. Posor Y, Eichhorn‐Gruenig M, Puchkov D, Schöneberg J, Ullrich A, Lampe A, Müller R, Zarbakhsh S, Gulluni F, Hirsch E, Krauss M, Schultz C, Schmoranzer J, Noé F, Haucke V (2013) Spatiotemporal control of endocytosis by phosphatidylinositol‐3,4‐bisphosphate. Nature 499: 233–237 · DOI
  132. Poteryaev D, Datta S, Ackema K, Zerial M, Spang A (2010) Identification of the switch in early‐to‐late endosome transition. Cell 141: 497–508 · DOI · Paper page
  133. Proikas‐Cezanne T, Takacs Z, Dönnes P, Kohlbacher O (2015) WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome. J Cell Sci 128: 207–217
  134. Rabinovsky R, Pochanard P, McNear C, Brachmann SM, Duke‐Cohan JS, Garraway LA, Sellers WR (2009) p85 Associates with unphosphorylated PTEN and the PTEN‐associated complex. Mol Cell Biol 29: 5377–5388 · DOI
  135. Raiborg C, Bremnes B, Mehlum A, Gillooly DJ, D'Arrigo A, Stang E, Stenmark H (2001) FYVE and coiled‐coil domains determine the specific localisation of Hrs to early endosomes. J Cell Sci 114: 2255–2263 · DOI
  136. Raiborg C, Bache KG, Gillooly DJ, Madshus IH, Stang E, Stenmark H (2002) Hrs sorts ubiquitinated proteins into clathrin‐coated microdomains of early endosomes. Nat Cell Biol 4: 394–398 · DOI · Paper page
  137. Raiborg C, Stenmark H (2009) The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 458: 445–452 · DOI · Paper page
  138. Raiborg C, Schink KO, Stenmark H (2013) Class III phosphatidylinositol 3‐kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic. FEBS J 280: 2730–2742 · DOI
  139. Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia‐Arencibia M, Green‐Thompson ZW, Jimenez‐Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Moreau K, Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow AR, Rubinsztein DC (2010) Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 90: 1383–1435 · DOI
  140. Razidlo GL, Katafiasz D, Taylor GS (2011) Myotubularin regulates Akt‐dependent survival signaling via phosphatidylinositol 3‐phosphate. J Biol Chem 286: 20005–20019 · DOI
  141. Reis CR, Chen PH, Srinivasan S, Aguet F, Mettlen M, Schmid SL (2015) Crosstalk between Akt/GSK3β signaling and dynamin‐1 regulates clathrin‐mediated endocytosis. EMBO J 34: 2132–2146 · DOI
  142. Reversi A, Loeser E, Subramanian D, Schultz C, De Renzis S (2014) Plasma membrane phosphoinositide balance regulates cell shape during Drosophila embryo morphogenesis. J Cell Biol 205: 395–408 · DOI
  143. Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J (2002) A crystallographic view of interactions between Dbs and Cdc42: PH domain‐assisted guanine nucleotide exchange. EMBO J 21: 1315–1326 · DOI · Paper page
  144. Rostislavleva K, Soler N, Ohashi Y, Zhang L, Pardon E, Burke JE, Masson GR, Johnson C, Steyaert J, Ktistakis NT, Williams RL (2015) Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Science 350: aac7365 · DOI · Paper page
  145. Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL (2013) ULK1 induces autophagy by phosphorylating Beclin‐1 and activating VPS34 lipid kinase. Nat Cell Biol 15: 741–750 · DOI · Paper page
  146. Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H (2010) PtdIns(3)P controls cytokinesis through KIF13A‐mediated recruitment of FYVE‐CENT to the midbody. Nat Cell Biol 12: 362–371 · DOI
  147. Salmena L, Carracedo A, Pandolfi PP (2008) Tenets of PTEN tumor suppression. Cell 133: 403–414 · DOI
  148. Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar‐Peled L, Sabatini DM (2008) The Rag GTPases bind raptor and mediate amino acid signalling to mTORC1. Science 320: 1496–1501 · DOI · Paper page
  149. Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A (2009) Mammalian phosphoinositide kinases and phosphatases. Prog Lipid Res 48: 307–343 · DOI
  150. Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T (2010) The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature 465: 497–501 · DOI
  151. Sbrissa D, Ikonomov OC, Shisheva A (1999) PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5‐phosphoinositides. Effect of insulin. J Biol Chem 274: 21589–21597 · DOI
  152. Schenck A, Goto‐Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M (2008) The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 133: 486–497 · DOI
  153. Schmees C, Villaseñor R, Zheng W, Ma H, Zerial M, Heldin CH, Hellberg C (2012) Macropinocytosis of the PDGF β‐receptor promotes fibroblast transformation by H‐RasG12V. Mol Biol Cell 23: 2571–2582 · DOI
  154. Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD (1993) Phosphatidylinositol 3‐kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260: 88–91 · DOI · Paper page
  155. Seet LF, Hong W (2006) The Phox (PX) domain proteins and membrane traffic. Biochim Biophys Acta 1761: 878–896 · DOI
  156. Sheppard K, Kinross KM, Solomon B, Pearson RB, Phillips WA (2012) Targeting PI3 kinase/AKT/mTOR signaling in cancer. Crit Rev Oncog 17: 69–95 · DOI
  157. Simonsen A, Lippé R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H (1998) EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394: 494–498 · DOI · Paper page
  158. Simonsen A, Birkeland HC, Gillooly DJ, Mizushima N, Kuma A, Yoshimori T, Slagsvold T, Brech A, Stenmark H (2004) Alfy, a novel FYVE‐domain‐containing protein associated with protein granules and autophagic membranes. J Cell Sci 117: 4239–4251 · DOI
  159. Slagsvold T, Aasland R, Hirano S, Bache KG, Raiborg C, Trambaiolo D, Wakatsuki S, Stenmark H (2005) Eap45 in mammalian ESCRT‐II binds ubiquitin via a phosphoinositide‐interacting GLUE domain. J Biol Chem 280: 19600–19606 · DOI
  160. Slessareva JE, Routt SM, Temple B, Bankaitis VA, Dohlman HG (2006) Activation of the phosphatidylinositol 3‐kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126: 191–203 · DOI
  161. Snyder JT, Rossman KL, Baumeister MA, Pruitt WM, Siderovski DP, Der CJ, Lemmon MA, Sondek J (2001) Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins. J Biol Chem 276: 45868–45875 · DOI
  162. Solinger JA, Spang A (2013) Tethering complexes in the endocytic pathway: CORVET and HOPS. FEBS J 280: 2743–2757 · DOI
  163. Sorkin A, Goh LK (2009) Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res 315: 683–696 · DOI
  164. Sorkin A, von Zastrow M (2009) Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol 10: 609–622 · DOI · Paper page
  165. Spinelli L, Lindsay YE, Leslie NR (2015) PTEN inhibitors: an evaluation of current compounds. Adv Biol Regul 57: 102–111 · DOI
  166. Stanley RE, Ragusa MJ, Hurley JH (2014) The beginning of the end: how scaffolds nucleate autophagosome biogenesis. Trends Cell Biol 24: 73–81 · DOI
  167. Stenmark H, Aasland R, Toh BH, D'Arrigo A (1996) Endosomal localization of the autoantigen EEA1 is mediated by a zinc‐binding FYVE finger. J Biol Chem 271: 24048–24054 · DOI
  168. Stephens L, Smrcka A, Cooke FT, Jackson TR, Sternweis PC, Hawkins PT (1994) A novel phosphoinositide 3 kinase activity in myeloid‐derived cells is activated by G protein βγ subunits. Cell 77: 83–93 · DOI
  169. Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebroeck B, Dhand R, Nirnberg B, Gierschik P, Seedorf K, Hsuan JJ, Waterfield MD, Wetzker R (1995) Cloning and characterization of a G protein‐activated human phosphoinositide‐3 kinase. Science 269: 690–693 · DOI
  170. Strømhaug PE, Reggiori F, Guan J, Wang CW, Klionsky DJ (2004) Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol Biol Cell 15: 3553–3566 · DOI
  171. Subramanian D, Laketa V, Müller R, Tischer C, Zarbakhsh S, Pepperkok R, Schultz C (2010) Activation of membrane‐permeant caged PtdIns(3)P induces endosomal fusion in cells. Nat Chem Biol 6: 324–326 · DOI
  172. Taguchi‐Atarashi N, Hamasaki M, Matsunaga K, Omori H, Ktistakis NT, Yoshimori T, Noda T (2010) Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy. Traffic 11: 468–478 · DOI
  173. Taylor GS, Maehama T, Dixon JE (2000) Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3‐phosphate. Proc Natl Acad Sci USA 97: 8910–8915 · DOI
  174. Teasdale RD, Collins BM (2012) Insights into the PX (phox‐homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease. Biochem J 441: 39–59 · DOI · Paper page
  175. Teo H, Gill DJ, Sun J, Perisic O, Veprintsev DB, Vallis Y, Emr SD, Williams RL (2006) ESCRT‐I core and ESCRT‐II GLUE domain structures reveal role for GLUE in linking to ESCRT‐I and membranes. Cell 125: 99–111 · DOI · Paper page
  176. Thomas CC, Deak M, Alessi DR, van Aalten DM (2002) High‐resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)‐trisphosphate. Curr Biol 23: 1256–1262 · DOI
  177. Toettcher JE, Gong D, Lim WA, Weiner OD (2011) Light‐based feedback for controlling intracellular signaling dynamics. Nat Methods 8: 837–839 · DOI
  178. Traer CJ, Rutherford AC, Palmer KJ, Wassmer T, Oakley J, Attar N, Carlton JG, Kremerskothen J, Stephens DJ, Cullen PJ (2007) SNX4 coordinates endosomal sorting of TfnR with dynein‐mediated transport into the endocytic recycling compartment. Nat Cell Biol 9: 1370–1380 · DOI · Paper page
  179. Tseng HY, Thorausch N, Ziegler T, Meves A, Fässler R, Böttcher RT (2014) Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability. J Mol Biol 426: 3180–3194 · DOI
  180. Tsujita K, Itoh T, Ijuin T, Yamamoto A, Shisheva A, Laporte J, Takenawa T (2004) Myotubularin regulates the function of the late endosome through the gram domain‐phosphatidylinositol 3,5‐bisphosphate interaction. J Biol Chem 279: 13817–13824 · DOI
  181. Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (1998) SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 95: 779–791 · DOI
  182. Vaccari I, Carbone A, Previtali SC, Mironova YA, Alberizzi V, Noseda R, Rivellini C, Bianchi F, Del Carro U, D'Antonio M, Lenk GM, Wrabetz L, Giger RJ, Meisler MH, Bolino A (2015) Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy. Hum Mol Genet 24: 383–396 · DOI · Paper page
  183. Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (2007) Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9: 316–323 · DOI
  184. Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (1997) P110delta, a novel phosphoinositide 3‐kinase in leukocytes. Proc Natl Acad Sci USA 94: 4330–4335 · DOI
  185. Venkateswarlu K, Oatey PB, Tavaré JM, Cullen PJ (1998) Insulin‐dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3‐kinase. Curr Biol 8: 463–466 · DOI
  186. Venkateswarlu K, Brandom KG, Lawrence JL (2004) Centaurin‐alpha1 is an in vivo phosphatidylinositol 3,4,5‐trisphosphate‐dependent GTPase‐activating protein for ARF6 that is involved in actin cytoskeleton organization. J Biol Chem 279: 6205–6208 · DOI
  187. Vanhaesebroeck B, Guillermet‐Guibert J, Graupera M, Bilanges B (2010a) The emerging mechanisms of isoform‐specific PI3K signalling. Nat Rev Mol Cell Biol 11: 329–341 · DOI · Paper page
  188. Vanhaesebroeck B, Vogt PK, Rommel C (2010b) PI3K: from the bench to the clinic and back. Curr Top Microbiol Immunol 347: 1–19
  189. Vicinanza M, Korolchuk VI, Ashkenazi A, Puri C, Menzies FM, Clarke JH, Rubinsztein DC (2015) PI(5)P regulates autophagosome biogenesis. Mol Cell 57: 219–234 · DOI
  190. Vitale N, Patton WA, Moss J, Vaughan M, Lefkowitz RJ, Premont RT (2000) GIT proteins, A novel family of phosphatidylinositol 3,4, 5‐trisphosphate‐stimulated GTPase‐activating proteins for ARF6. J Biol Chem 275: 13901–13906 · DOI
  191. Walker SM, Downes CP, Leslie NR (2001) TPIP: a novel phosphoinositide 3‐phosphatase. Biochem J 360: 277–283 · DOI
  192. Watt SA, Kimber WA, Fleming IN, Leslie NR, Downes CP, Lucocq JM (2004) Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4‐bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy. Biochem J 377: 653–663 · DOI
  193. van Weering JR, Cullen PJ (2014) Membrane‐associated cargo recycling by tubule‐based endosomal sorting. Semin Cell Dev Biol 31: 40–47 · DOI
  194. Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument‐Bromage H, Tempst P, Hawkins PT, Stephens LR (2002) P‐Rex1, a PtdIns(3,4,5)P3‐ and Gbetagamma‐regulated guanine‐nucleotide exchange factor for Rac. Cell 108: 809–821 · DOI
  195. Woolley JF, Dzneladze I, Salmena L (2015) Phosphoinositide signaling in cancer: INPP4B Akt(s) out. Trends Mol Med 21: 530–532 · DOI
  196. Wu Y, Cheng S, Zhao H, Zou W, Yoshina S, Mitani S, Zhang H, Wang X (2014) PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. EMBO Rep 15: 973–981 · DOI
  197. Xu H, Wickner W (2010) Phosphoinositides function asymmetrically for membrane fusion, promoting tethering and 3Q‐SNARE subcomplex assembly. J Biol Chem 285: 39359–39365 · DOI
  198. Xu J, Fotouhi M, McPherson PS (2015) Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy. EMBO Rep 16: 709–718 · DOI
  199. Yoon MS, Du G, Backer JM, Frohman MA, Chen J (2011) Class III PI‐3‐kinase activates phospholipase D in an amino acid‐sensing mTORC1 pathway. J Cell Biol 195: 435–447 · DOI
  200. Yoon MS, Rosenberger CL, Wu C, Truong N, Sweedler JV, Chen J (2015) Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid. Mol Cell 58: 549–556 · DOI

200 of 208 shown

Cited by

Sorted by citations

Metadata

Authors
Marat, A. L., & Haucke, V.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2016-02-17
Volume
35
Issue
6
Pages
561-579
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.15252/embj.201593564
Cited by
299
References
14
Language
en
Licence
Funders
  • Alexander von Humboldt Foundation
  • Banting Postdoctoral Fellowships
  • German Research Foundation (SFB740/C08)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review