SUMO-1 Modification of the C-terminal KVEKVD of Axin Is Required for JNK Activation but Has No Effect on Wnt Signaling

Wnt signaling and cancer

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Functional interaction of β-catenin with the transcription factor LEF-1

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β‐catenin is a target for the ubiquitin–proteasome pathway

Aberle, H., Bauer, A., Stappert, J., Kispert, A., & Kemler, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3797 · Cited by 2,533 · see citing works

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,066 · see citing works

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,017 · see citing works

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

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A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

Mahajan, R. K., Delphin, C., Guan, T., Gerace, L., & Melchior, F. (1997) · Cell · doi:10.1016/s0092-8674(00)81862-0 · Cited by 1,258 · see citing works

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

Behrens, J., Jerchow, B., Würtele, M., Grimm, J., Asbrand, C., Wirtz, R. M., Kühl, M., Wedlich, D., & Birchmeier, W. (1998) · Science · doi:10.1126/science.280.5363.596 · Cited by 1,255 · see citing works

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., & Kikuchi, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1371 · Cited by 1,248 · see citing works

SUMO-1 Modification of IκBα Inhibits NF-κB Activation

Desterro, J. M. P., Rodríguez, M. S., & Hay, R. T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80133-1 · Cited by 1,048 · see citing works

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Satoh, S., Daigo, Y., Furukawa, Y., Kato, T., Miwa, N., Nishiwaki, T., Kawasoe, T., Ishiguro, H., Fujita, M., Tokino, T., et al. (2000) · Nature Genetics · doi:10.1038/73448 · Cited by 960 · see citing works

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitroPreprint

Winston, J. T., Strack, P. R., Beer‐Romero, P., Chu, C. Y., Elledge, S. J., & Harper, J. W. (1999) · Genes & Development · doi:10.1101/gad.13.3.270 · Cited by 949 · see citing works

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M., & Costantini, F. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80324-4 · Cited by 907 · see citing works

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · see citing works

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity

Pichler, A., Gast, A., Seeler, J.-S., Dejean, A., & Melchior, F. (2002) · Cell · doi:10.1016/s0092-8674(01)00633-x · Cited by 817 · see citing works

Inhibition of Stat1-mediated gene activation by PIAS1

Liu, B., Liao, J., Rao, X., Kushner, S. A., Chung, C. D., Chang, D. D., & Shuai, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10626 · Cited by 765 · see citing works

Sumo, ubiquitin's mysterious cousin

Müller, S. P., Hoege, C., Pyrowolakis, G., & Jentsch, S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056591 · Cited by 765 · see citing works

SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting

Rodríguez, M. S., Dargemont, C., & Hay, R. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009476200 · Cited by 753 · see citing works

Conjugation with the ubiquitin‐related modifier SUMO‐1 regulates the partitioning of PML within the nucleus

Müller, S. P., Matunis, M. J., & Dejean, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.61 · Cited by 683 · see citing works

The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

Hart, M. J., Concordet, J., Lassot, I., Albert, I., Santos, R., Durand, H., Perret, C., Rubinfeld, B., Margottin-Goguet, F., Bénarous, R., et al. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80091-8 · Cited by 670 · see citing works

An E3-like Factor that Promotes SUMO Conjugation to the Yeast Septins

Johnson, E. S., & Gupta, A. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00491-3 · Cited by 641 · see citing works

SUMO‐1 modification activates the transcriptional response of p53

Rodríguez, M. S., Desterro, J. M. P., Laı́n, S., Midgley, C., Lane, D. P., & Hay, R. T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6455 · Cited by 639 · see citing works

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodiesPreprint

Sachdev, S., Bruhn, L., Sieber, H., Pichler, A., Melchior, F., & Grosschedl, R. (2001) · Genes & Development · doi:10.1101/gad.944801 · Cited by 549 · see citing works

An F‐box protein, FWD1, mediates ubiquitin‐dependent proteolysis of β‐catenin

Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K.-I., & Nakayama, K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2401 · Cited by 529 · see citing works

Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

Kishida, S., Yamamoto, H., Ikeda, S., Kishida, M., Sakamoto, I., Koyama, S., & Kikuchi, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10823 · Cited by 491 · see citing works

Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53

Kahyo, T., Nishida, T., & Yasuda, H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00349-5 · Cited by 449 · see citing works

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

Schmidt, D., & Müller, S. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052559499 · Cited by 449 · see citing works

PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

Kotaja, N., Karvonen, U., Jänne, O. A., & Palvimo, J. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5222-5234.2002 · Cited by 426 · see citing works

Modulation of STAT signaling by STAT-interacting proteins

Shuai, K. (2000) · Oncogene · doi:10.1038/sj.onc.1203522 · Cited by 379 · see citing works

Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability

Yamamoto, H., Kishida, S., Kishida, M., Ikeda, S., Takada, S., & Kikuchi, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10681 · Cited by 364 · see citing works

Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complexPreprint

Willert, K., Shibamoto, S., & Nusse, R. (1999) · Genes & Development · doi:10.1101/gad.13.14.1768 · Cited by 337 · see citing works

SP-RING for SUMO

Hochstrasser, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00519-0 · Cited by 281 · see citing works

Identification of a Domain of Axin That Binds to the Serine/Threonine Protein Phosphatase 2A and a Self-binding Domain

Hsu, W., Zeng, L., & Costantini, F. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3439 · Cited by 262 · see citing works

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligasesPreprint

Jackson, P. K. (2001) · Genes & Development · doi:10.1101/gad.955501 · Cited by 244 · see citing works

Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex

Gao, Z.-H., Seeling, J. M., Hill, V., Yochum, A., & Virshup, D. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032468199 · Cited by 225 · see citing works

Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1

Kim, Y. H., Choi, C. Y., & Kim, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12350 · Cited by 161 · see citing works

Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice

Hsu, W., Shakya, R., & Costantini, F. (2001) · Journal of Cell Biology · doi:10.1083/jcb.200107066 · Cited by 137 · see citing works

Axin Forms a Complex with MEKK1 and Activates c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase through Domains Distinct from Wnt Signaling

Zhang, Y., Neo, S. Y., Wang, X., Han, J., & Lin, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.35247 · Cited by 132 · see citing works

Functional analysis and intracellular localization of p53 modified by SUMO-1

Kwek, S. S., Derry, J. J., Tyner, A. L., Shen, Z., & Gudkov, A. V. (2001) · Oncogene · doi:10.1038/sj.onc.1204362 · Cited by 130 · see citing works

Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iε

Kishida, M., Hino, S.-I., Michiue, T., Yamamoto, H., Kishida, S., Fukui, A., Asashima, M., & Kikuchi, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103555200 · Cited by 119 · see citing works

Characterization of a Novel Mammalian SUMO-1/Smt3-specific Isopeptidase, a Homologue of Rat Axam, Which Is an Axin-binding Protein Promoting β-Catenin Degradation

Nishida, T., Kaneko, F., Kitagawa, M., & Yasuda, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103955200 · Cited by 103 · see citing works

Desumoylation Activity of Axam, a Novel Axin-Binding Protein, Is Involved in Downregulation of β-Catenin

Kadoya, T., Yamamoto, H., Suzuki, T., Yukita, A., Fukui, A., Michiue, T., Asahara, T., Tanaka, K., Asashima, M., & Kikuchi, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3803-3819.2002 · Cited by 71 · see citing works

Inhibition of Wnt Signaling Pathway by a Novel Axin-binding Protein

Kadoya, T., Kishida, S., Fukui, A., Hinoi, T., Michiue, T., Asashima, M., & Kikuchi, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005984200 · Cited by 58 · see citing works

RGS16 Attenuates Gαq-dependent p38 Mitogen-activated Protein Kinase Activation by Platelet-activating Factor

Zhang, Y., Neo, S. Y., Han, J., Yaw, L. P., & Lin, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2851 · Cited by 52 · see citing works

Axin-Induced Apoptosis Depends on the Extent of Its JNK Activation and Its Ability to Down-Regulate β-Catenin Levels

Neo, S. Y., Zhang, Y., Yaw, L. P., Li, P., & Lin, S. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2751 · Cited by 51 · see citing works

Casein Kinase I and Casein Kinase II Differentially Regulate Axin Function in Wnt and JNK Pathways

Zhang, Y., Qiu, W.-J., Chan, S. C., Han, J., He, X., & Lin, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111982200 · Cited by 49 · see citing works

Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase

Zhang, Y., Neo, S. Y., Lin, S., & Han, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002491200 · Cited by 47 · see citing works

Differential Molecular Assemblies Underlie the Dual Function of Axin in Modulating the Wnt and JNK Pathways

Zhang, Y., Qiu, W.-J., Liu, D., Neo, S. Y., He, X., & Lin, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104451200 · Cited by 43 · see citing works

Induction of Apoptosis by Protein Inhibitor of Activated Stat1 through c-Jun NH2-terminal Kinase Activation

Liu, B., & Shuai, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101085200 · Cited by 41 · see citing works

Protein Modification by SUMO

Johnson, E. S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074118 · Cited by 1,675 · see citing works

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works

Sequential Modification of NEMO/IKKγ by SUMO-1 and Ubiquitin Mediates NF-κB Activation by Genotoxic Stress

Huang, T. T., Wuerzberger‐Davis, S. M., Wu, Z., & Miyamoto, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00895-x · Cited by 560 · see citing works

Intrinsic disorder in scaffold proteins: Getting more from less

Cortese, M. S., Uversky, V. N., & Dunker, A. K. (2008) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2008.05.007 · Cited by 292 · see citing works

SUMO protein modification

Dohmen, R. J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.09.021 · Cited by 270 · see citing works

Regulation of Wnt/β-catenin signaling by posttranslational modifications

Gao, C., Xiao, G., & Hu, J. (2014) · Cell & Bioscience · doi:10.1186/2045-3701-4-13 · Cited by 226 · see citing works

Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction

Martin, S., Wilkinson, K. A., Nishimune, A., & Henley, J. M. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2276 · Cited by 205 · see citing works

Down-Regulation of c-Fos/c-Jun AP-1 Dimer Activity by Sumoylation

Bossis, G., Malnou, C. E., Farrás, R., Andermarcher, E., Hipskind, R. A., Rodríguez, M. S., Schmidt, D., Müller, S. P., Jariel‐Encontre, I., & Piechaczyk, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.6964-6979.2005 · Cited by 195 · see citing works

Axin is a scaffold protein in TGF‐β signaling that promotes degradation of Smad7 by Arkadia

Liu, W., Rui, H., Wang, J., Lin, S., He, Y., Chen, M., Li, Q., Ye, Z., Chan, S. C., Chan, S. C., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601057 · Cited by 193 · see citing works

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of β-catenin

Cong, F., & VARMUS, H. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307344101 · Cited by 189 · see citing works

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

Rui, Y., Xu, Z., Lin, S., Li, Q., Rui, H., Luo, W., Hai‐Meng, Z. H. O. U., Cheung, P., Wu, Z., Ye, Z., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600475 · Cited by 189 · see citing works

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia

Comerford, K. M., Leonard, M. O., Karhausen, J., Carey, R., Colgan, S. P., & Taylor, C. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337412100 · Cited by 185 · see citing works

SUMO and transcriptional regulation

Girdwood, D., Tatham, M. H., & Hay, R. T. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2003.12.001 · Cited by 165 · see citing works

Mammalian RGS proteins: Multifunctional regulators of cellular signalling

Willars, G. B. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.03.005 · Cited by 163 · see citing works

Axin: A Master Scaffold for Multiple Signaling Pathways

Luo, W., & Lin, S. (2004) · Neurosignals · doi:10.1159/000076563 · Cited by 154 · see citing works

An Acetylation/Deacetylation-SUMOylation Switch through a Phylogenetically Conserved ψKXEP Motif in the Tumor Suppressor HIC1 Regulates Transcriptional Repression Activity

Stankovic‐Valentin, N., Deltour, S., Seeler, J.-S., Pinte, S., Vergoten, G., Guérardel, C., Dejean, A., & Leprince, D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01098-06 · Cited by 153 · see citing works

A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice

Maupin, K. A., Droscha, C. J., & Williams, B. O. (2013) · Bone Research · doi:10.4248/br201301004 · Cited by 133 · see citing works

Targets and consequences of protein SUMOylation in neurons

Wilkinson, K. A., Nakamura, Y., & Henley, J. M. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.04.002 · Cited by 130 · see citing works

Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

Du, L., Li, Y., Fakih, M., Wiatrek, R. L., Duldulao, M. P., Chen, Z., Chu, P. G., García‐Aguilar, J., & Chen, Y. (2016) · Nature Communications · doi:10.1038/ncomms12326 · Cited by 121 · see citing works

SUMO-Specific Protease 2 Is Essential for Modulating p53-Mdm2 in Development of Trophoblast Stem Cell Niches and Lineages

Chiu, S.-Y., Asai, N., Costantini, F. D., & Hsu, W. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060310 · Cited by 121 · see citing works

MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression

Johnson, G. L., Dohlman, H. G., & Graves, L. M. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.04.004 · Cited by 119 · see citing works

Sumoylation in neurodegenerative diseases

Krumova, P., & Weishaupt, J. H. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1158-3 · Cited by 116 · see citing works

PIAS1-mediated Sumoylation of Focal Adhesion Kinase Activates Its Autophosphorylationn

Kadaré, G., Toutant, M., Formstecher, É., Corvol, J., Carnaud, M., Boutterin, M., & Girault, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308562200 · Cited by 108 · see citing works

New insights into the regulation of Axin function in canonical Wnt signaling pathway

Song, X., Wang, S., & Li, L. (2014) · Protein & Cell · doi:10.1007/s13238-014-0019-2 · Cited by 102 · see citing works

SUMO and Alzheimer’s Disease

Lee, L., Sakurai, M., Matsuzaki, S., Arancio, O., & Fraser, P. E. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8257-7 · Cited by 89 · see citing works

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

Pan, C. Q., Sudol, M., Sheetz, M. P., & Low, B. C. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.06.002 · Cited by 84 · see citing works

Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling

Cha, B., Kim, W., Kim, Y., Hwang, B. N., Park, S. Y., Yoon, J., Park, W. S., Cho, J. W., Bedford, M. T., & Jho, E. (2011) · Oncogene · doi:10.1038/onc.2010.610 · Cited by 85 · see citing works

Role for SUMO Modification in Facilitating Transcriptional Repression by BKLF

Perdomo, J., Verger, A., Turner, J. J. O., & Crossley, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1549-1559.2005 · Cited by 84 · see citing works

The carboxy-terminus, a key regulator of protein function

Sharma, S., & Schiller, M. R. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1586828 · Cited by 80 · see citing works

Sumoylation Delimits KLF8 Transcriptional Activity Associated with the Cell Cycle Regulation

Wei, H., Wang, X., Gan, B., Urvalek, A. M., Melkoumian, Z. K., Guan, J., & Zhao, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513135200 · Cited by 79 · see citing works

Axin Utilizes Distinct Regions for Competitive MEKK1 and MEKK4 Binding and JNK Activation

Luo, W., Ng, W. W., Jin, L., Ye, Z., Han, J., & Lin, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305277200 · Cited by 75 · see citing works

Interactions between PIAS Proteins and SOX9 Result in an Increase in the Cellular Concentrations of SOX9

Hattori, T., Eberspaecher, H., Lu, J., Zhang, R., Nishida, T., Kahyo, T., Yasuda, H., & Crombrugghe, B. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511330200 · Cited by 70 · see citing works

Negative Modulation of RXRα Transcriptional Activity by Small Ubiquitin-related Modifier (SUMO) Modification and Its Reversal by SUMO-specific Protease SUSP1

Choi, S. J., Chung, S. S., Rho, E. J., Lee, H. W., Lee, M. H., Choi, H., Seol, J. H., Baek, S. H., Bang, O. S., & Chung, C. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604033200 · Cited by 69 · see citing works

Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) C-Terminal-Activating Region 3 Contributes to LMP1-Mediated Cellular Migration via Its Interaction with Ubc9

Bentz, G. L., Whitehurst, C. B., & Pagano, J. S. (2011) · Journal of Virology · doi:10.1128/jvi.05035-11 · Cited by 69 · see citing works

Detection of point mutations of the Axin1 gene in colorectal cancers

Jin, L., Shao, Q., Luo, W., Ye, Z., Li, Q., & Lin, S. (2003) · International Journal of Cancer · doi:10.1002/ijc.11435 · Cited by 68 · see citing works

SUMO: a (Oxidative) Stressed Protein

Feligioni, M., & Nisticò, R. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8266-6 · Cited by 62 · see citing works

The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death

Leitao, B., Jones, M. C., & Brosens, J. (2011) · The FASEB Journal · doi:10.1096/fj.11-186346 · Cited by 67 · see citing works

A β-Catenin-Independent Dorsalization Pathway Activated by Axin/JNK Signaling and Antagonized by Aida

Rui, Y., Xu, Z., Xiong, B., Cao, Y., Lin, S., Zhang, M., Chan, S.-C., Luo, W., Han, Y., Ye, Z., et al. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.07.006 · Cited by 58 · see citing works

Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model

Park, J.-Y., Kim, Y.-H., Im, J. A., & Lee, H. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0709-1 · Cited by 57 · see citing works

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

Kim, M. J., Chia, I. V., & Costantini, F. D. (2008) · The FASEB Journal · doi:10.1096/fj.08-113910 · Cited by 56 · see citing works

LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1

Bentz, G. L., Moss, C. R., Whitehurst, C. B., Moody, C. A., & Pagano, J. S. (2015) · Journal of Virology · doi:10.1128/jvi.00711-15 · Cited by 51 · see citing works

Proteins of the PIAS family enhance the sumoylation of the papillomavirus E1 protein

Rosas-Acosta, G., Langereis, M. A., Deyrieux, A. F., & Wilson, V. G. (2004) · Virology · doi:10.1016/j.virol.2004.10.025 · Cited by 45 · see citing works

Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene

Lalonde, S., Codina-Fauteux, V.-A., de Bellefon, S. M., Leblanc, F., Beaudoin, M., Simon, M.-M., Dali, R., Kwan, T., Lo, K. S., Pastinen, T., et al. (2019) · Genome biology · doi:10.1186/s13059-019-1749-5 · Cited by 44 · see citing works

PIASy represses TRIF‐induced ISRE and NF‐κB activation but not apoptosis

Zhang, J., Xu, L., Han, K.-J., Wei, X., & Shu, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.081 · Cited by 44 · see citing works

The DIX Domain Protein Coiled-coil-DIX1 Inhibits c-Jun N-terminal Kinase Activation by Axin and Dishevelled through Distinct Mechanisms

Wong, C. K., Luo, W., Deng, Y., Zou, H., Ye, Z., & Lin, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404598200 · Cited by 44 · see citing works

The scaffold protein AXIN1: gene ontology, signal network, and physiological function

Qiu, L., Sun, Y., Ning, H., Chen, G., Zhao, W., & Gao, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01482-4 · Cited by 43 · see citing works

The role of SUMOylation in cerebral hypoxia and ischemia

Peters, M., Wielsch, B., & Boltze, J. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.03.011 · Cited by 35 · see citing works

Covalent modification by SUMO is required for efficient disruption of PML oncogenic domains by Kaposi's sarcoma-associated herpesvirus latent protein LANA2

Marcos-Villar, L., Campagna, M., Lopitz‐Otsoa, F., Gallego, P., González, J., Gonzalez, D., Rodríguez, M. S., & Rivas, C. (2010) · Journal of General Virology · doi:10.1099/vir.0.024984-0 · Cited by 35 · see citing works

Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus

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Influenza Virus A/Beijing/501/2009(H1N1) NS1 Interacts with β-Tubulin and Induces Disruption of the Microtubule Network and Apoptosis on A549 Cells

Xue-qing, H., Li, Z., Chen, H., Wang, H., Mei, L., Wu, S., Zhang, T., Liu, B., & Lin, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048340 · Cited by 32 · see citing works

SUMO-Conjugating Enzyme E2 UBC9 Mediates Viral Immediate-Early Protein SUMOylation in Crayfish To Facilitate Reproduction of White Spot Syndrome Virus

Chen, A., Gao, L., Wang, X., Zhao, X., & Wang, J. (2012) · Journal of Virology · doi:10.1128/jvi.01671-12 · Cited by 31 · see citing works

Axin1 Prevents Salmonella Invasiveness and Inflammatory Response in Intestinal Epithelial Cells

Zhang, Y., Wu, S., Xia, Y., Chen, D., Petrof, E. O., Claud, E. C., Hsu, W., & Sun, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034942 · Cited by 30 · see citing works

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC

Tacchelly‐Benites, O., Wang, Z., Yang, E., Benchabane, H., Tian, A., Randall, M. P., & Ahmed, Y. F. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007178 · Cited by 29 · see citing works

Novel SUMO-Protease SENP7S Regulates β-catenin Signaling and Mammary Epithelial Cell Transformation

Karami, S., Lin, F., Kumar, S., Bahnassy, S., Thangavel, H., Quttina, M., Li, Y., Ren, J. F., & Bawa‐Khalfe, T. (2017) · Scientific Reports · doi:10.1038/srep46477 · Cited by 27 · see citing works

The Spindle Positioning Protein Kar9p Interacts With the Sumoylation Machinery in Saccharomyces cerevisiae

Meednu, N., Hoops, H. J., D’Silva, S., Pogorzala, L., Wood, S., Farkas, D., Sorrentino, M., Sia, E. A., Meluh, P. B., & Miller, R. K. (2008) · Genetics · doi:10.1534/genetics.108.095042 · Cited by 26 · see citing works

Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins

Zou, H., Li, Q., Lin, S., Wu, Z., Han, J., & Ye, Z. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.12.012 · Cited by 23 · see citing works

Diversity of axin in signaling pathways and its relation to colorectal cancer

Parveen, N., Hussain, M. U., Pandith, A. A., & Mudassar, S. (2010) · Medical Oncology · doi:10.1007/s12032-010-9722-x · Cited by 20 · see citing works

Axin Family of Scaffolding Proteins in Development: Lessons from C. elegans

Mallick, A., Taylor, S. K. B., Ranawade, A., & Gupta, B. P. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7040020 · Cited by 20 · see citing works

Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis

Chia, I. V., Kim, M. J., Itoh, K., Sokol, S. Y., & Costantini, F. D. (2009) · Genetics · doi:10.1534/genetics.109.101055 · Cited by 20 · see citing works

SUMOylation modulates transcriptional repression by TRPS1

Kaiser, F. J., Lüdecke, H., & Weger, S. (2007) · Biological Chemistry · doi:10.1515/bc.2007.051 · Cited by 19 · see citing works

SUMO E3 Ligase PIASy Mediates High Glucose-Induced Activation of NF-κB Inflammatory Signaling in Rat Mesangial Cells

Huang, W. G., Liang, Y., Dong, J., Zhou, L., Gao, C., Jiang, C., Chen, M., Long, Y., & Xu, Y. (2017) · Mediators of Inflammation · doi:10.1155/2017/1685194 · Cited by 16 · see citing works

14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia

Mancini, M., Leo, E., Takemaru, K., Campi, V., Castagnetti, F., Soverini, S., Benedittis, C. D., Rosti, G., Cavo, M., Santucci, M. A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131074 · Cited by 15 · see citing works

XSENP1, a novel sumo‐specific protease in Xenopus, inhibits normal head formation by down‐regulation of Wnt/β‐catenin signalling

Yukita, A., Michiue, T., Fukui, A., Sakurai, K., Yamamoto, H., Ihara, M., Kikuchi, A., & Asashima, M. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00757.x · Cited by 12 · see citing works

The PIAS Protein Family and TC-PTP

Liu, B., & Shuai, K. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_6 · Cited by 10 · see citing works

Regulation of SUMOylation Targets Associated With Wnt/β-Catenin Pathway

Fan, L., Yang, X., Zheng, M., Yang, X., Ning, Y., Gao, M., & Zhang, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.943683 · Cited by 10 · see citing works

Sumoylation in Craniofacial Disorders

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Novel Interaction Between Nuclear Coactivator CBP and the Protein Inhibitor of Activated Stat1 (PIAS1)

Yin, X., Warner, D. R., Roberts, E. A., Pisano, M. M., & Greene, R. M. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.321 · Cited by 8 · see citing works

Sumoylation differentially regulates Goosecoid-mediated transcriptional repression

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The role of SUMOylation in epithelial-mesenchymal transition

Li, S., Yu, X.-M., Liang, L., & Zheng, Y. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02568-3 · Cited by 4 · see citing works

Possible Role of Proto-Oncogenes in Colorectal Cancer — A Population Based Study

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Sumoylation in Craniofacial Disorders

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Probing Septin Function Through Interaction Screens: Identification of Novel Septins and Possible Regulatory Mechanisms

Steels, J. D. (2008) · TSpace (University of Toronto) · Cited by 1 · see citing works

From membrane to nucleus: New roles and functions of SUMOylated IGF-1R and EGFR

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Members of the T-Cell Factor Family of DNA-Binding Proteins and Their Roles in Tumorigenesis

Hecht, A. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18932-6_5

A Role for AXIN2 in Oncogenesis.

Mazzoni, S. M. (2014) · Deep Blue (University of Michigan)

The Role of Protein SUMOylation in Neuronal Function

Wilkinson, K. A., & Henley, J. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7061-9_9

Role of Axin1 scaffold protein in regulating the c-myc onocoprotein

Krishnamoorthy, A. K. (2012) · doi:10.6083/m4m906nh

The Sumoylation Pathway Modulates JNK Signaling in Drosophila*

Huang, H. Y., Zhu, N., & Jiao, R. (2011) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2011.00254

Novel mechanisms of transcriptional repression by the paired- like homeodomain transcription factor Goosecoid.

Izzi, L. (2008) · TSpace (University of Toronto)

Axin

Song, X., & Li, L. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101525

Ubc9

Wrighton, K. H., & Feng, X. (2008) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a002350.01

Axin

Song, X., & Li, L. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101525-1

SUMOylation modulates α-synuclein toxicity and fibril formation

Krumova, P. (2010) · doi:10.53846/goediss-3286

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

Kim, M. J., Chia, I. V., & Costantini, F. D. (2008) · The FASEB Journal · doi:10.1096/fj.08-113910 · Cited by 56 · see citing works

Axin Forms a Complex with MEKK1 and Activates c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase through Domains Distinct from Wnt Signaling

Zhang, Y., Neo, S. Y., Wang, X., Han, J., & Lin, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.35247 · Cited by 132 · see citing works

Desumoylation Regulates Wnt Signaling

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Axin Utilizes Distinct Regions for Competitive MEKK1 and MEKK4 Binding and JNK Activation

Luo, W., Ng, W. W., Jin, L., Ye, Z., Han, J., & Lin, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305277200 · Cited by 75 · see citing works

Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase

Zhang, Y., Neo, S. Y., Lin, S., & Han, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002491200 · Cited by 47 · see citing works