In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

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Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

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Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

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Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

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Middle-aged dogs with low and high Aβ CSF concentrations show differences in energy and stress related metabolic profiles in CSF

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Trehalose, but not other sugars, protects HT22 cells against amyloid-beta toxicity

Xu, Y., Singh, K., Beazely, M. A., & Leonenko, Z. (2025) · Brain Organoid and Systems Neuroscience Journal · doi:10.1016/j.bosn.2025.04.005 · Cited by 1

Impedimetric Detection of Amyloid Beta (1–42) on Curcumin‐Copper Complex Electropolymerized Graphite Electrode

Sayar, P., Maral, M., Yildiz, E., & Erdem, A. (2025) · Electroanalysis · doi:10.1002/elan.12049 · Cited by 1

Intravenously injected hPSC-derived pericytes for Alzheimer disease: Neuroprotection and vascular repair via extracellular vesicles

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Nitration of Tyrosine Residue Y10 of Aβ 1‐42 Ameliorates Aβ 1‐42 ‐Induced Neurotoxicity and Memory Impairment In Vitro and In Vivo

Zhao, J., Chen, J., Lu, J., Shi, Q., Wang, Q., Gao, Z., Zeng, L., & Liu, Q. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70218 · Cited by 1

Microbial metabolites alleviate Aß-induced alterations of intestinal epithelial barrier and enteric nervous system connectivity

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Astrocytic TPK1 mitigates amyloid pathology via TFEB-mediated endocytosis

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Recent advances in small molecules for amyloid fibril inhibition: chemical strategies and molecular mechanistic insights from lysozyme and insulin models

Kumar, V., Tom, M., Santhosini, R. M., Begam, R., Jayashree, S., & Jaimohan, S. M. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109539 · Cited by 2

Unmasking the hidden catalyst: How infections trigger Alzheimer's disease

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Pyk2 plays a critical role in synaptic dysfunction during the early stages of Alzheimer’s disease

Rodriguez, Q., Payet, F., Vargas-Baron, K., Borel, E., Lanté, F., Boisseau, S., Blot, B., Girault, J., & Buisson, A. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00021-4 · Cited by 1

Neurotoxicity of the Alzheimer’s β-Amyloid Peptide

Howlett, D. R. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-888-5_6 · Cited by 1

Transition from physiological to pathophysiological indices as exemplified by amyloidosis in periodic disease, non-insulin-dependent diabetes mellitus, and Alzheimer’s disease

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BASP1 – an Axon Terminal Protein Forming Amyloid-Like Oligomers

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Fibrillogenesis in ADan peptides is inhibited by biphenyl ethers

Surolia, I., Chhibber, M., Sarkar, D. P., & Sinha, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.015 · Cited by 1

Amyloid β-protein oligomers and Alzheimer's

Hayden, E. Y., & Teplow, D. B. (2013) · Cited by 1

Understanding mechanistic details of neuroinflammatory pathways stimulated by the Alzheimer's disease amyloid-beta protein

Usery, S. E. (2014) · IRL - University of Missouri, St. Louis (University of Missouri–St. Louis) · Cited by 1

Analogue and conformational studies on peptides, hormones and other biologically active peptides

Penke, B., Tóth, G. K., & Váradi, G. (2007) · Royal Society of Chemistry eBooks · doi:10.1039/b710350f · Cited by 1

Beneficial Effects of Citrus Flavonoids Against Aβ Pathology in Alzheimer’s Disease

Javed, H., Ojha, S. K., & Jamali, M. C. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_19 · Cited by 1

TRPM2 in the Central Nervous System: Physiological Role and Critical Regulatory Pathways

Belrose, J. C. (2012) · Scholarship@Western (Western University) · Cited by 1

Amyloid-β As a Biologically Active Peptide in CNS

Gamkrelidze, G. N., Yun, S. H., & Trommer, B. L. (2006) · Springer eBooks · doi:10.1007/0-387-25443-9_30 · Cited by 1

Amyloid Fibril Formation of Natively Unfolded Proteins

Uversky, V. N., & Fink, A. L. (2008) · Wiley eBooks · doi:10.1002/9783527610754.md15 · Cited by 1

Development of molecular recognition by rational and combinatorial engineering

Jonsson, A. (2009) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1

Interaction of Alzheimer Amyloid Peptide with Cell Surfaces and Artificial Membranes

Bateman, D. A., & Chakrabartty, A. (2011) · Wiley eBooks · doi:10.1002/9783527634323.ch11 · Cited by 1

Sum frequency generation spectroscopy of amyloid fibrils and oligomers at air/water interface

Niaura, G., Budvytytė, R., Kuprionis, Z., & Valinčius, G. (2010) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.871042 · Cited by 2

Apolipoprotein E: Structural and Functional Interactions with Amyloid β

Stine, W. B., & LaDu, M. J. (2005) · Wiley eBooks · doi:10.1002/9783527619344.ch10 · Cited by 1

Yeast as a Model for Studying Aβ Aggregation, Toxicity and Clearance

Bharadwaj, P. (2011) · Australasian Journal of Paramedicine · Cited by 1

Characterization of Interactions Between Misfolding Proteins and Molecular Chaperones by NMR Spectroscopy

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Macropinocytosis of aggregated amyloid-beta and tau requires Arf6 and the RhoGTPases Rac1, Cdc42 and RhoAPreprint

Krupa, J. M., Medapati, M. R., Tsang, A. R., Seah, C., & Pasternak, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.02.641073 · Cited by 1

Excess Met1-ubiquitination leads to solid aggregate formationPreprint

Kaypee, S., Miyasaka, M., NAKAJIMA, T., Nishimura, H., Sakamaki, J.-I., Komatsu, M., & Ikeda, F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.20.700516 · Cited by 1

The dynamic nature of amyloid-beta protein aggregation and its association to Alzheimer’s disease

Vilaprinyó-Pascual, S. (2015) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)

Reporters of Amyloid Structure

LeVine, H. (2006) · Springer eBooks · doi:10.1007/0-387-25919-8_14

Development and Application of Mass Spectrometry-Based Biophysical Approaches

Zhang, Y. (2014) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7154f6v

Local Surface Plasmon Resonance and Electrochemical Biosensing Systems for Analyzing Functional Peptides

Saito, M., & Tamiya, E. (2011) · doi:10.1002/9783527631841.ch6

Small Molecule Interactions with Self-Assembling Peptides

Seh, H. Y. (2011) · Deep Blue (University of Michigan)

Formation of abnormally large-sized tubular amyloid β aggregates on a nanostructured gold surface

Lee, J., Park, J., Kwak, B. K., Choi, I., Kim, Y., Choi, K., & Yi, J. (2010) · Korean Journal of Chemical Engineering · doi:10.1007/s11814-010-0314-4

The involvement of degradation pathways and neuron-to-neuron transmission in Alzheimer’s disease

Agholme, L. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Affibody molecules for proteomic and therapeutic applications

Grönwall, C. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.

Östner, G. (2013) · Lund University Publications (Lund University)

Synergistic effect of N-terminal pyroglutamyl amyloid ß protein in Alzheimer's disease and in normal aging

Wang, Y.-C., Huang, R., Wu, S.-D., & Shan, C. (2009)

AFM detection of an Alzheimer marker: Different stages of amyloid beta peptide on a mica substrate

Lee, J., Jeong, H., Bubar, C. T., BUSNAINA, A. A., & Lee, H. (2015) · Journal of the Korean Physical Society · doi:10.3938/jkps.67.1957

Pathological Consequences of Aβ From Extracellular to Intraneuronal

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Chaperone DnaK and its Influence on Multiple Steps of Formation of Amyloid beta Structural Species Results in Differential Effects on Amyloid Beta Oligomer Formation and Concomitant Cytotoxicity

Merlin, J. L. P. (2013) · Journal of the Chosun Natural Science · doi:10.13160/ricns.2013.6.4.220

MatrixMetalloproteinasesExpressedbyAstrocytesMediate ExtracellularAmyloid-PeptideCatabolism

Cirrito, J. R. (2006)

Studying Amyloid b-Protein Assembly

Maji, S. K., Lazo, N. D., Fradinger, E. A., & Teplow, D. B. (2004) · CRC Press eBooks · doi:10.1201/9780203492185.ch7

Intraneuronal Amyloid and Plaque Formation

D’Andrea, M. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804256-4.00005-x

Plasma decontamination of surfaces

Kong, M. G., & Laroussi, M. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511902598.010

Identifying the mechanism of Aβ42 inhibition of PDGF-BB signalling

Saffi, G. T. (2014) · UWSpace (University of Waterloo)

Neuron-to-neuron propagation of neurodegenerative proteins; relation to degradative systems

Domert, J. (2017) · Linköping University medical dissertations · doi:10.3384/diss.diva-134667

Detection and conformational characterization of misfolded proteins in neurodegenerative diseases

Morozova, O. A. (2016) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/yt52-dk03

Nitrate Chimeras: A New Class of Disease Modifying Agents for the Treatment of Alzheimer's Disease

VandeVrede, L. A. (2014) · Figshare

In Vitro Characterization of Unmodified and Pyroglutamylated Alzheimer's Amyloid beta peptide

Matos, J. O. (2014) · Journal of International Crisis and Risk Communication Research

Electroanalysis of α-Synuclein Aggregation Related to Parkinson's Disease

Chan, T. (2011) · TSpace (University of Toronto)

Neuroprotective Effects of Selective Estrogen Receptor Modulators Against Amyloid Beta Toxicity and the Pathways That Provide Protection

Rose, M. K. (2019) · doi:10.15760/honors.768

Direct Visualization of Single Molecule Amyloid Beta Peptides in Action by High-Speed Atomic Force Microscopy

Feng, L. (2019) · Research Online (University of Wollongong)

Effects of anle138b treatment on amyloid-β neurotoxicity

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Aβ promotes amyloidogenic processing of APP through a Go/Gβγ signalingPreprint

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Engineering Sciences (Mechanical Engineering)

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Biophysical Analysis of the Structure and Aggregation of Amyloid beta Peptide

Abedin, F. (2021) · Journal of International Crisis and Risk Communication Research

Enhanced Glycolysis in Astrocytes Impairs Synaptic Plasticity and Accelerates the Aβ Aggregation in Early Alzheimer's Disease ModelsPreprint

Yang, X., Chen, Y.-H., Liu, L., Gu, Z., You, Y., Hao, J., Sun, N., & Gao, C. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4527346

Additional file 2 of Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

de Dios, C., Abadin, X., Agujetas, V. R., Jiménez-Martínez, M., Morales, A., Trullás, R., Marı́, M., & Colell, A. (2023) · Figshare · doi:10.6084/m9.figshare.22626457

Altered T cell reactivity to β-amyloid-related antigens in early Alzheimer’s diseasePreprint

Rickenbach, C., Mallone, A., Häusle, L., Frei, L., Seiter, S., Sparano, C., Kirabali, T., Blennow, K., Zetterberg, H., Ferretti, M. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.04.597424

Convergent effects of synthetic glucocorticoid dexamethasone and amyloid beta in human olfactory neurosphere‐derived cells

Farnum, Z., Mani, R., Bindoff, A. D., Wilson, R., Fiotakis, A., Stephens, J., Cho, H., Mackay‐Sim, A., & Sinclair, D. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16263

Simulation study of solvent effect on competitive degradation of aggregation of homo- and hetero- amyloid-β dimers

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Preparation and NMR characterization of Aβ peptides at pathological pH

He, X., Ma, Y., Zhang, N., & Zhou, C. (2025) · Protein Expression and Purification · doi:10.1016/j.pep.2025.106704

Dietary docosahexaenoic acid and dihydrocaffeic acid, a chlorogenic acid derivative, confer additive neuroprotection against β-amyloid in SH-SY5Y cells

Reza-Zaldívar, E. E., Faccinetto-Beltrán, P., & Jacobo‐Velázquez, D. A. (2025) · CyTA - Journal of Food · doi:10.1080/19476337.2025.2526636

Amyloid beta aggregation promoted by iron leads to neuronal loss in an ex vivo model of Alzheimer’s diseasePreprint

Sunkara, S., Krishnamoorthy, R., Radulović, S., Leoni, M., Patz, S., Goessler, W., Kaufmann, W. A., Birkl-Toeglhofer, A. M., Haybaeck, J., & Leitinger, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.664035

Mangiferin and norathyriol acting on Alzheimer’s disease biomarkers: acetylcholinesterase, β-secretase (BACE-1), and amyloid β-peptide

de Oliveira, T. B., Galeriani, A. C. B., de Souza, J. R. R., Kawano, D. F., Trevisan, M. T. S., & Almeida, W. P. (2025) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaf055

Etude de la dynamique de tau dans le compartiment synaptique dans un contexte physiologique et pathologique exemple de la maladie d'Alzheimer

Frandemiche, M. (2013) · theses.fr (ABES) · doi:10.70675/260ed9c4zd958z47e0za418z0f324a1b102b

Lack of neuroprotective effects by platelet-derived growth factor against beta-amyloid induced toxicity uncovers a novel hypothesis of Alzheimer's disease pathology

Liu, H. (2012) · UWSpace (University of Waterloo)

Additional file 1 of NMDAR-dependent somatic potentiation of synaptic inputs is correlated with β amyloid-mediated neuronal hyperactivity

Bao, Y., Yang, X., Fu, Y., Zhengyan, L., Gong, R., & Lu, W. (2021) · Figshare · doi:10.6084/m9.figshare.16590459

Additional file 5 of Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage

Dou, Y., Xie, J., Tan, Y., Zhang, M., Zhao, Y., & Liu, X. (2021) · Figshare · doi:10.6084/m9.figshare.16821559

Additional file 6 of Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage

Dou, Y., Xie, J., Tan, Y., Zhang, M., Zhao, Y., & Liu, X. (2021) · Figshare · doi:10.6084/m9.figshare.16821562

Additional file 7 of Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage

Dou, Y., Xie, J., Tan, Y., Zhang, M., Zhao, Y., & Liu, X. (2021) · Figshare · doi:10.6084/m9.figshare.16821565

Additional file 1 of Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage

Dou, Y., Xie, J., Tan, Y., Zhang, M., Zhao, Y., & Liu, X. (2021) · Figshare · doi:10.6084/m9.figshare.16821547

Association of nonfribrillar amyloid oligomers with drusen of aging and age-related macular degeneration

Luibl, V. (2006) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.5701

Additional file 2 of Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage

Dou, Y., Xie, J., Tan, Y., Zhang, M., Zhao, Y., & Liu, X. (2021) · Figshare · doi:10.6084/m9.figshare.16821550

Additional file 1 of Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

de Dios, C., Abadin, X., Agujetas, V. R., Jiménez-Martínez, M., Morales, A., Trullás, R., Mari, M., & Colell, A. (2023) · Figshare · doi:10.6084/m9.figshare.22626454

Additional file 3 of Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage

Dou, Y., Xie, J., Tan, Y., Zhang, M., Zhao, Y., & Liu, X. (2021) · Figshare · doi:10.6084/m9.figshare.16821553

Additional file 4 of Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage

Dou, Y., Xie, J., Tan, Y., Zhang, M., Zhao, Y., & Liu, X. (2021) · Figshare · doi:10.6084/m9.figshare.16821556

Riluzole shifts glial responses to protect synapses and memory in Aβ oligomer–treated ratsPreprint

Wint-Mon, M.-K., Kida, H., Kimura, R., & Mitsushima, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.26.696626

Systemic Amyloid-β Metabolism in Alzheimer’s Disease

Dong-yu, F., Wang, J., Gu, B. J., Masters, C. L., & Wang, Y. (2026) · Springer eBooks · doi:10.1007/978-981-95-5222-1_7

APP NL-F knock-in Alzheimer’s Disease model mice reveal etiological convergence of aging and amyloidosisPreprint

Prieur, M., Hemonnot-Girard, A.-L., Beck, V., Garcia, V., Phuadraksa, T., Linck, N., Leportier, M., Vignon, A., Séverac, D., Perrier, V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.28.702259

Targeting of Itch by clomipramine or gene therapy improves cognitive defects related to Alzheimer’s disease

Chauhan, M., Singh, K. P., & Sharma, P. (2026) · iScience · doi:10.1016/j.isci.2026.115181

Collagène auto-assemblé en support 3D biomimétique fonctionnalisé pour la différenciation de cellules nerveuses

Labour, M.-N. (2012) · doi:10.70675/6afca839za213z4543z9342z239dd2fbdfdd

Etude préclinique et clinique de la phase précoce de la maladie d'Alzheimer

Epelbaum, S. (2015) · theses.fr (ABES) · doi:10.70675/ea81e5c2z5032z4474z9f96z59f62125a629

Fluorinated Peptidomimetics : Synthesis, Conformational Studies and Evaluation as Amyloid Proteins Aggregation Modulators

Xu, Y. (2016) · theses.fr (ABES) · doi:10.70675/39ceb0d5zfd48z4e4fz84f0z597eb08381d7

Implication des recepteurs nicotiniques α7 dans les deficits mnesiques induits par des injections intra-hippocampiques de peptides amyloïdes-beta (1-42) chez la souris

Faucher, P. (2015) · theses.fr (ABES) · doi:10.70675/32388e8eze91bz48c8z8d7fzbc873b067cfd

Coupling Laser with Mass Spectrometry for Biomolecules Characterization : From Peptides towards Protein Fibrils

Halim, M. A. (2017) · theses.fr (ABES) · doi:10.70675/1987b0d6z615ez491dz9468z6cb2816294cf

Contribution à l’étude des anticorps dirigés contre le peptide Aβ et de leur implication dans l’angiopathie amyloïde cérébrale

Chantran, Y. (2020) · theses.fr (ABES) · doi:10.70675/85da59a6z44afz49ecz8d9bz231a28465826

Exploring the role of CHRFAM7A in the early stages of Alzheimer's disease : in vitro studies and development of a novel humanized mouse model

Pou, M. L. (2023) · theses.fr (ABES) · doi:10.70675/0424309azddeaz4545z8176z8df20cea5e8f

Using β-strand and β-hairpin peptidomimetics induced by constrained amino acids to modulate the aggregation of the microtubule associated protein Tau : design, synthesis and evaluation

Lorenzo, D. D. (2023) · theses.fr (ABES) · doi:10.70675/0bdac871z5f25z4b5az9467z96a6d16ffb34

JMJD6 Inhibits the Ferroptosis of Neurons in Alzheimer's Disease through Driving H4R3 Symmetrical Dimethylation of GPX4

Gu, L., Sun, D., Sun, L., Ma, T., Wang, Q., Hou, X., & Cheng, H. (2026) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2026064685

Nicotinamide nucleotide transhydrogenase deficiency impairs neuronal function via energy metabolism dysregulation in Alzheimer's disease

Wan, X., Lu, W., Liu, S., Zhao, Y., Hu, J., Ding, X., Gu, P., Zou, Y., Jiang, B., & Yang, Y. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.341

The PDE5 inhibitor vardenafil enhances glutamatergic transmission through amyloid-beta and cellular prion protein

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