In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

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Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

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Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

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Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

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Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives

Dubey, S., Kallubai, M., & Subramanyam, R. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.01.094 · Cited by 29

Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid β-Derived Neurotoxins

Lambert, M., Velasco, P., Viola, K., & Klein, W. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787601876 · Cited by 29

Immunoreactivity of Phage Library-derived Human Single-Chain Antibodies to Amyloid Beta Conformers In Vitro

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Amyloid‐β Aggregation with Gold Nanoparticles on Brain Lipid Bilayer

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A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3

Li, Y., Lu, J. N., Cao, X., Zhao, H., Gao, L., Xia, P., & Pei, G. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7698560 · Cited by 29

Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation

Hettmann, T., Gillies, S. D., Kleinschmidt, M., Piechotta, A., Makioka, K., Lemere, C. A., Schilling, S., Rahfeld, J., & Lues, I. (2020) · Scientific Reports · doi:10.1038/s41598-020-60319-5 · Cited by 29

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo

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The Modulating Effect of Mechanical Changes in Lipid Bilayers Caused by ApoE-Containing Lipoproteins on Aβ Induced Membrane Disruption

Legleiter, J. A., Fryer, J. D., Holtzman, D. M., & Kowalewski, T. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn2000475 · Cited by 28

N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly

Liao, M.-C., Hoos, M. D., Aucoin, D., Ahmed, M., Davis, J., Smith, S. O., & Nostrand, W. E. V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169599 · Cited by 29

Different Fates of Alzheimer’s Disease Amyloid-β Fibrils Remodeled by Biocompatible Small Molecules

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‘Click peptide’: a novel ‘O‐acyl isopeptide method’ for peptide synthesis and chemical biology‐oriented synthesis of amyloid β peptide analogues

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Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid

Asam, K. R., Staniszewski, A., Zhang, H., Melideo, S. L., Mazzeo, A., Voronkov, M. V., Huber, K. L., Pérez, E., Stock, M. B., Stock, J. B., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189413 · Cited by 28

A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ 42 and tau‐induced pathophysiological effects on long‐term potentiation

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Acute amnestic encephalopathy in amyloid-β oligomer–injected mice is due to their widespread diffusion in vivo

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A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-β

Reinke, A. A., Seh, H. Y., & Gestwicki, J. E. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.07.082 · Cited by 26

Signal loss due to oligomerization in ELISA analysis of amyloid-beta can be recovered by a novel sample pre-treatment method

Janssen, L., Sobott, F., Deyn, P. P. D., & Dam, D. V. (2015) · MethodsX · doi:10.1016/j.mex.2015.02.011 · Cited by 27

Monitoring the earliest amyloid-β oligomers via quantized photobleaching of dye-labeled peptides

Dukes, K. D., Rodenberg, C. F., & Lammi, R. K. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2008.07.011 · Cited by 27

Nitration of Tyrosine Residue Y10 of Aβ1–42 Significantly Inhibits Its Aggregation and Cytotoxicity

Zhao, J. J., Wu, J., Yang, Z., Li, H., & Gao, Z. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00447 · Cited by 28

Pyk2 overexpression in postsynaptic neurons blocks amyloid β1–42-induced synaptotoxicity in microfluidic co-cultures

Kilinc, D., Vreulx, A.-C., Mendes, T., Flaig, A., Coelho, D. M., Verschoore, M., Demiautte, F., Amouyel, P., Bank, N.-C. B., Eysert, F., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa139 · Cited by 34

Prophylaxis and Treatment of Alzheimer's Disease by Delivery of an Adeno-Associated Virus Encoding a Monoclonal Antibody Targeting the Amyloid Beta Protein

Shimada, M., Abe, S., Takahashi, T., Shiozaki, K., Okuda, M., Mizukami, H., Klinman, D. M., Ozawa, K., & Okuda, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057606 · Cited by 27

Role of Small Oligomers on the Amyloidogenic Aggregation Free-Energy Landscape

He, X., Giurleo, J. T., & Talaga, D. S. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.10.019 · Cited by 26

Differential Regulation of N-Methyl-D-Aspartate Receptor Subunits is An Early Event in the Actions of Soluble Amyloid-β1-40 Oligomers on Hippocampal Neurons

Chang, L., Zhang, Y., Liu, J., Song, Y., Lv, A., Li, Y., Zhou, W., Yan, Z., Almeida, O. F. X., & Wu, Y. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150942 · Cited by 27

Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis

Alecki, C., Rizwan, J., Le, P., Jacob‐Tomas, S., Comaduran, M. F., Verbrugghe, M., Xu, J. M. S., Minotti, S., Lynch, J., Biswas, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-55055-7 · Cited by 26

Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein Conformational Diseases

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Amyloid A β 42 , a promoter of magnetite nanoparticle formation in Alzheimer’s disease

Tahirbegi, I. B., Pardo, W. A., Alvira, M., Mir, M., & Samitier, J. (2016) · Nanotechnology · doi:10.1088/0957-4484/27/46/465102 · Cited by 26

Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes

Hayden, E. Y., Conovaloff, J., Mason, A. J., Bitan, G., & Teplow, D. B. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.10.026 · Cited by 26

Preparation Protocols of Aβ(1–40) Promote the Formation of Polymorphic Aggregates and Altered Interactions with Lipid Bilayers

Yates, E. A., & Legleiter, J. A. (2014) · Biochemistry · doi:10.1021/bi500792f · Cited by 26

Dependence of the Formation of Tau and Aβ Peptide Mixed Aggregates on the Secondary Structure of the N-Terminal Region of Aβ

Rojas, A. V., Maisuradze, G. G., & Scheraga, H. A. (2018) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b04647 · Cited by 28

An excellent electrochemical aptasensor for amyloid-β oligomers based on a triple-helix aptamer switch via target-triggered signal transduction DNA displacement events

Wang, X., Gu, X., Li, L., Yu, B., Lv, L., Chen, Q., & Xu, M. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03319-2 · Cited by 26

Effects of Tissue Transglutaminase on β -Amyloid1-42-Induced Apoptosis

Wakshlag, J. J., Antonyak, M. A., Boehm, J. E., Boehm, K., & Cerione, R. A. (2006) · The Protein Journal · doi:10.1007/s10930-006-0009-1 · Cited by 26

Detection of Alzheimer’s amyloid beta aggregation by capturing molecular trails of individual assemblies

Vestergaard, M. C. M., Hamada, T., Saito, M., Yajima, Y., Kudou, M., Tamiya, E., & Takagi, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.072 · Cited by 26

Aβ20–29 peptide blocking apoE/Aβ interaction reduces full-length Aβ42/40 fibril formation and cytotoxicity in vitro

Hao, J., Zhang, W., Zhang, P., Liu, R., Liu, L., Lei, G., Su, C., Miao, J., & Li, Z. (2010) · Neuropeptides · doi:10.1016/j.npep.2010.03.001 · Cited by 26

Monitoring Insulin Aggregation via Capillary Electrophoresis

Pryor, E. N., Kotarek, J. A., Moss, M. A., & Hestekin, C. N. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12129369 · Cited by 28

New Insights into the Spontaneous Human Alzheimer’s Disease-Like Model Octodon degus : Unraveling Amyloid-β Peptide Aggregation and Age-Related Amyloid Pathology

Cisternas, P., Zolezzi, J. M., Lindsay, C. B., Rivera, D. S., Martinez, A. N., Bozinovic, F., & Inestrosa, N. C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180729 · Cited by 27

Near-Infrared Responsive Dopamine/Melatonin-Derived Nanocomposites Abrogating in Situ Amyloid β Nucleation, Propagation, and Ameliorate Neuronal Functions

Srivastava, A. K., Choudhury, S. R., & Karmakar, S. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b22214 · Cited by 26

A 13 kDa carboxy‐terminal fragment of ApoE stabilizes Abeta hexamers

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Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric‐Aβ mediates pathology maturation

Darricau, M., Dou, C., Kinet, R., Zhu, T., Zhou, L., Li, X., Bedel, A., Claverol, S., Tokarski, C., Katsinelos, T., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13604 · Cited by 30

Discovery of Proteoforms Associated With Alzheimer's Disease Through Quantitative Top-Down Proteomics

Fulcher, J. M., Ives, A. N., Tasaki, S., Kelly, S. S., Williams, S., Fillmore, T., Zhou, M., Moore, R., Qian, W., Paša‐Tolić, L., et al. (2025) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2025.100983 · Cited by 25

Kinetic Insights into Zn2+-Induced Amyloid β-Protein Aggregation Revealed by Stopped-Flow Fluorescence Spectroscopy

Guo, J., Yu, L., Sun, Y. P., & Dong, X. (2017) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6b12187 · Cited by 25

Fullerenemalonates inhibit amyloid beta aggregation, in vitro and in silico evaluation

Martínez‐Herrera, M., Figueroa-Gerstenmaier, S., García‐Sierra, F., Beltrán, H. I., Rivera-Fernández, N., Romero, J. A. L., López-Camacho, P. Y., & Basurto‐Islas, G. (2018) · RSC Advances · doi:10.1039/c8ra07643j · Cited by 27

Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway

Zheng, M., Liu, Z., Mana, L., Qin, G., Huang, S., Gong, Z., Tian, M., He, Y., & Wang, P. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114264 · Cited by 25

Charged surfactants induce a non‐fibrillar aggregation pathway of amyloid‐beta peptide

Loureiro, J., Rocha, S., & Pereira, M. D. C. (2013) · Journal of Peptide Science · doi:10.1002/psc.2535 · Cited by 24

Towards Ratiometric Sensing of Amyloid Fibrils In Vitro

Freire, S., Rodríguez‐Prieto, F., Rodríguez, M. C. R., Penedo, J. C., Al‐Soufi, W., & Novo, M. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201406110 · Cited by 25

C-Terminal Threonine Reduces Aβ43 Amyloidogenicity Compared with Aβ42

Chemuru, S., Kodali, R. B., & Wetzel, R. B. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.008 · Cited by 25

Role of Intramolecular Aromatic π–π Interactions in the Self‐Assembly of Di‐ l ‐Phenylalanine Dipeptide Driven by Intermolecular Interactions: Effect of Alanine Substitution

Reddy, S. M. M., & Shanmugam, G. (2016) · ChemPhysChem · doi:10.1002/cphc.201600364 · Cited by 25

Id1 and Sonic Hedgehog Mediate Cell Cycle Reentry and Apoptosis Induced by Amyloid Beta-Peptide in Post-mitotic Cortical Neurons

Chao, A., Chen, C.-H., Chang, S.-H., Huang, C.-T., Hwang, W., & Yang, D. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1098-5 · Cited by 25

Effects of estrogen on beta-amyloid-induced cholinergic cell death in the nucleus basalis magnocellularis

Szegő, É. M., Csorba, A., Janáky, T., Kékesi, K. A., Ábrahám, I. M., Mórotz, G. M., Penke, B., Palkovits, M., Murvai, Ü., Kellermayer, M. S. Z., et al. (2011) · Neuroendocrinology · doi:10.1159/000321119 · Cited by 24

Δ133p53α Protects Human Astrocytes from Amyloid-beta Induced Senescence and Neurotoxicity

Ungerleider, K., Beck, J. A., Lissa, D., Joruiz, S. M., Horikawa, I., & Harris, C. C. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.004 · Cited by 24

Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer’s disease

Wan, L., Yang, F., Yin, A., Luo, Y., Yi, L. I. U., Liu, F., Wang, J., Liu, R., & Wang, X. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01448-0 · Cited by 26

Exogenous Aβ1-42 monomers improve synaptic and cognitive function in Alzheimer's disease model mice

Duan, Y., Lv, J., Zhang, Z., Chen, Z., Wu, H., Chen, J., Chen, Z., Yang, J., Wang, D., Liu, Y., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109002 · Cited by 24

N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer’s pathophysiology

Rostagno, A. A., Cabrera, E., Lashley, T., & Ghiso, J. A. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00303-3 · Cited by 23

A sensitive colorimetric strategy for monitoring cerebral β-amyloid peptides in AD based on dual-functionalized gold nanoplasmonic particles

Yu, Y., Zhang, L., Sun, X., Li, C., Qiu, Y., Sun, H.-P., Tang, D., Liu, Y., & Yin, X. (2015) · Chemical Communications · doi:10.1039/c5cc01855b · Cited by 24

A New Amyloid-Like β-Aggregate with Amyloid Characteristics, Except Fibril Morphology

Chang, E. S. ‐., Liao, T., Lim, T., Fann, W. S., & Chen, R. P. ‐. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.11.009 · Cited by 24

Acetylcholinesterase inhibitory activity and neuroprotection in vitro , molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice

Liu, Y.-H., Lee, C., Chen, L., Lee, T.-L., Hsieh, Y.-Y., Han, C.-H., Yang, C.-H., Huang, W., & Hou, W. (2020) · Food & Function · doi:10.1039/c9fo02339a · Cited by 26

Formation of amyloid-β oligomers in brain vascular smooth muscle cells transiently exposed to iron-induced oxidative stress

Frackowiak, J., Potempska, A., & Mazur‐Kolecka, B. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0497-0 · Cited by 24

Glossopharyngeal and vagal neuralgia secondary to vascular compression of the nerves.

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Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs

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Copper Ion Uptake by Chitosan in the Presence of Amyloid-β and Histidine

Mahl, C. R. A., Taketa, T. B., Neto, J. B. M. R., Almeida, W. P., & Beppu, M. M. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-03120-z · Cited by 23

Cu(II) disrupts autophagy-mediated lysosomal degradation of oligomeric Aβ in microglia via mTOR-TFEB pathway

Tan, X., Guan, H., Yang, Y., Luo, S., Hou, L., Chen, H., & Li, J. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115090 · Cited by 23

Inhibiting amyloid beta (1–42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex

Olajide, O. J., Rue, C. L., Bergdahl, A., & Chapman, C. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.960314 · Cited by 24

Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons

Chen, S., Wu, C., Lin, T., Chuang, Y., & Yang, D. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.05.012 · Cited by 23

How Ionic Strength Affects the Conformational Behavior of Human and Rat Beta Amyloids – A Computational Study

Křı́ž, Z., Klusák, J., Krištofíková, Z., & Koča, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062914 · Cited by 23

Structural, Dynamic Properties of Key Residues in Aβ Amyloidogenesis: Implications of an Important Role of Nanosecond Timescale Dynamics

Lim, K. H., Henderson, G. L., Jha, A., & Louhivuori, M. (2007) · ChemBioChem · doi:10.1002/cbic.200700194 · Cited by 23

Designed Fluorescent Probes Reveal Interactions between Amyloid-β(1–40) Peptides and GM1 Gangliosides in Micelles and Lipid Vesicles

Mikhalyov, I. I., Olofsson, A., Gröbner, G., & Johansson, L. B. ‐. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.06.043 · Cited by 23

Oxidative stress and mitochondria-mediated cell death mechanisms triggered by the familial Danish dementia ADan amyloid

Todd, K. L., Ghiso, J. A., & Rostagno, A. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.10.003 · Cited by 22

Pramlintide Antagonizes Beta Amyloid (Aβ)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation

Kimura, R., MacTavish, D., Yang, J., Westaway, D. A., & Jhamandas, J. H. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9684-x · Cited by 24

Vitamin D 3 protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis

Pierucci, F., Garcia‐Gil, M., Frati, A., Bini, F., Martinesi, M., Vannini, E., Mainardi, M., Luzzati, F., Peretto, P. M., Caleo, M., et al. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.003 · Cited by 24

Abeta Peptide Toxicity is Reduced After Treatments Decreasing Phosphatidylethanolamine Content in Differentiated Neuroblastoma Cells

Cazzaniga, E., Bulbarelli, A., Lonati, E., Orlando, A., Re, F., Gregori, M., & Masserini, M. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0415-4 · Cited by 23

Cholinergic Homeostatic Synaptic Plasticity Drives the Progression of Aβ-Induced Changes in Neural Activity

Hahm, E.-T., Nagaraja, R. Y., Waro, G., & Tsunoda, S. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.029 · Cited by 24

A Method for Evaluating the Level of Soluble β‐Amyloid(1–40/1–42) in Alzheimer’s Disease Based on the Binding of Gelsolin to β‐Amyloid Peptides

Yu, Y., Zhang, L., Li, C., Sun, X., Tang, D., & Shi, G. (2014) · Angewandte Chemie · doi:10.1002/ange.201405001 · Cited by 23

Cholesterol seco‐Sterol‐Induced Aggregation of Methylated Amyloid‐β Peptides—Insights into Aldehyde‐Initiated Fibrillization of Amyloid‐β

Scheinost, J. C., Wang, H., Boldt, G. E., Offer, J., & Wentworth, P. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200705922 · Cited by 23

Globular and Protofibrillar Aβ Aggregates Impair Neurotransmission by Different Mechanisms

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Synthesis and biological evaluation of 2′-Aminochalcone: A multi-target approach to find drug candidates to treat Alzheimer’s disease

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