The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RhoA and ROCK Promote Migration by Limiting Membrane Protrusions
Open accessAbstract
Previously, we and others have shown that RhoA and ROCK signaling are required for negatively regulating integrin-mediated adhesion and for tail retraction of migrating leukocytes. This study continues our investigation into the molecular mechanisms underlying RhoA/ROCK-regulated integrin adhesion. We show that inhibition of ROCK up-regulates integrin-mediated adhesion, which is accompanied by both increased phosphotyrosine signaling through Pyk-2 and paxillin and inappropriate membrane protrusions. We provide evidence that inhibition of ROCK induces integrin adhesion by promoting remodeling of the actin cytoskeleton. Furthermore, we find that ROCK regulates membrane activity through a pathway involving cofilin. Inhibition of RhoA signaling allows the formation of multiple competing lamellipodia that disrupt productive migration of monocytes. Together, our results show that RhoA/ROCK signaling promotes migration by restricting integrin activity and membrane protrusions to the leading edge.
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Cites
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Cited by
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
ROCKs: multifunctional kinases in cell behaviour
Riento, K., & Ridley, A. J. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1128 · Cited by 1,941
Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,578
Self-citationPrespecification and plasticity: shifting mechanisms of cell migration
Friedl, P. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.11.001 · Cited by 667
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion
Narumiya, S., Tanji, M., & Ishizaki, T. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9170-7 · Cited by 530
Metadata
- Authors
- Worthylake, R. A., & Burridge, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 278
- Issue
- 15
- Pages
- 13578-13584
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2074349105
- Cited by
- 311
- References
- 1
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Worthylake, R. A., & Burridge, K. (2003). RhoA and ROCK Promote Migration by Limiting Membrane Protrusions. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m211584200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
