The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.
Identification and Characterization of E2F7, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation
Open accessAbstract
The mammalian E2F family of transcription factors plays a crucial role in the regulation of cellular proliferation, apoptosis, and differentiation. Consistent with its biological role in a number of important cellular processes, E2F regulates the expression of genes involved in cell cycle, DNA replication, DNA repair, and mitosis. It has proven difficult, however, to determine the specific roles played by the various known family members in these cellular processes. The work presented here now extends the complexity of this family even further by the identification of a novel E2F family member, which we now term E2F7. Like the expression of the known E2F activators, E2F1, E2F2, and E2F3, the expression of E2F7 is growth-regulated, at least in part, through E2F binding elements on its promoter, and its protein product is localized to the nucleus and associates with DNA E2F recognition sites with high affinity. A number of salient features, however, make this member unique among the E2F family. First, the E2F7 gene encodes a protein that possesses two distinct DNA-binding domains and that lacks a dimerization domain as well as a transcriptional activation and a retinoblastoma-binding domain. In contrast to the E2F activators, E2F7 can block the E2F-dependent activation of a subset of E2F target genes as well as mitigate cellular proliferation of mouse embryo fibroblasts. These findings identify E2F7 as a novel member of the mammalian E2F transcription factor family that has properties of a transcriptional repressor capable of negatively influencing cellular proliferation.
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“Acting as mutually redundant transcriptional repressors, E2F7 and E2F8 inhibit the expression of many genes, including Aurka/b, Ccnb1, and Plk1, which encode proteins that act during mitotic progression (7, 8, 11).”
From Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade (2022) · cites this paper as [11]
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Cites
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Sibling rivalry in the E2F family
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A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G 0 Cells
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The E2F1–3 transcription factors are essential for cellular proliferation
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Self-citationAnalysis of Chromatin Structure byin VivoFormaldehyde Cross-Linking
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Toward an understanding of the functional complexity of the E2F and retinoblastoma families.
Nevins, J. R. (1998) · PubMed · Cited by 514
E2F3 activity is regulated during the cell cycle and is required for the induction of S phasePreprint
Leone, G. W., DeGregori, J. V., Yan, Z., Jakoi, L., Ishida, S., Williams, R. S., & Nevins, J. R. (1998) · Genes & Development · doi:10.1101/gad.12.14.2120 · Cited by 400
Self-citationEmerging roles for E2F: Beyond the G1/S transition and DNA replication
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Research works printed but not linked: 1
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Control of cell cycle transcription during G1 and S phases
Bertoli, C., Skotheim, J. M., & de Bruin, R. A. M. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3629 · Cited by 1,567
Cell Cycle Regulation in Plant Development
Inzé, D., & Veylder, L. D. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090431 · Cited by 907
The broken cycle: E2F dysfunction in cancer
Kent, L. N., & Leone, G. W. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0143-7 · Cited by 807
Self-citationThe E2F transcriptional network: old acquaintances with new faces
Dimova, D. K., & Dyson, N. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208612 · Cited by 715
E2F target genes: unraveling the biology
Bracken, A. P., Cirò, M., Cocito, A., & Helin, K. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.06.006 · Cited by 608
Metadata
- Authors
- de Bruin, A., Maiti, B., Jakoi, L., Timmers, C., Buerki, R., & Leone, G.
- Affiliations
- The Ohio State University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Leone, Gustavo
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 278
- Issue
- 43
- Pages
- 42041-42049
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2122511750
- Cited by
- 221
- References
- 20
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 2 · 2013: 9 · 2012: 6
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- E2F7, E2F transcription factors, transcriptional repressor, cell proliferation, growth inhibition, DNA-binding domain, E2F target genes, mouse embryonic fibroblasts, cell cycle regulation
- MeSH terms
- Animals, Binding Sites, Cell Division, Cloning, Molecular, DNA, Embryo, Mammalian, Fibroblasts, Gene Expression Regulation, Promoter Regions, Genetic, Repressor Proteins, Transfection, Protein Structure, Tertiary, DNA, Complementary, Response Elements, Peptide Elongation Factor 2, E2F7 Transcription Factor, Mice
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