Cited by 186Nitric Oxide and Endothelin EffectsNF-κB Signaling PathwaysCell Adhesion Molecules Research

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Tumor Necrosis Factor-α Inhibits Endothelial Nitric-oxide Synthase Gene Promoter Activity in Bovine Aortic Endothelial Cells

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Anderson, Hope D.I., Rahmutula, Dolkun, Gardner, David G.·2004·Journal of Biological Chemistry

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Abstract

Tumor necrosis factor-alpha (TNF-alpha) has been shown to reduce endothelial nitric-oxide synthase (eNOS) gene expression through post-transcriptional regulation of mRNA stability. The current study documented an independent effect of the cytokine on the eNOS gene promoter. TNF-alpha effected a time- and dose-dependent reduction in activity of a transiently transfected human -1197 eNOS-luciferase reporter. This reduction was inhibited by co-transfection of dominant negative IKKbeta as well as a nonphosphorylatable constitutively suppressive mutant of IkappaB implying involvement of the NFkappaB cascade in the inhibitory effect. The locus of the TNF-alpha-dependent inhibition was traced to two Sp1-binding sites positioned between -109 and -95 and -81 and -67 relative to the transcription start site. Electrophoretic mobility shift analysis and immunoperturbation studies showed evidence for Sp1 and Sp3 binding to each element. TNF-alpha treatment had no effect on the binding pattern to the downstream (-81 to -67) site but did suppress association of Sp1 and Sp3 to the upstream (-109 to -95) site. Collectively, these data indicate that TNF-alpha exerts transcriptional, as well as post-transcriptional, effects on eNOS gene expression and suggest a potential mechanism to account for the endothelial dysfunction that accompanies disorders such as diabetes mellitus and heart failure.

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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,036
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Tumor necrosis factor signaling
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,422
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M. S., Mann, M., Manning, A. M., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,042
Signal transduction by tumor necrosis factor and its relatives.
Baud, V., & Karin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02064-5 · Cited by 1,741
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.Preprint
Chen, Z., Hagler, J., Palombella, V. J., Melandri, F. D., Scherer, D. C., Ballard, D. W., & Maniatis, T. (1995) · Genes & Development · doi:10.1101/gad.9.13.1586 · Cited by 1,270
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., Hartmann, M., Skatchkov, M. P., Thaiss, F., Stahl, R. A. K., Warnholtz, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.2.e14 · Cited by 1,191
IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK
Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., & Goeddel, D. V. (1997) · Science · doi:10.1126/science.278.5339.866 · Cited by 1,183
Cellular and molecular mechanisms of endothelial cell dysfunction.
Harrison, D. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119751 · Cited by 1,059
Adipose tissue as an endocrine and paracrine organ
Mohamed‐Ali, V., Pinkney, J. H., & Coppack, S. W. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800770 · Cited by 1,016
The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
Karin, M., & Delhase, M. (2000) · Seminars in Immunology · doi:10.1006/smim.2000.0210 · Cited by 973
IKK-γ is an essential regulatory subunit of the IκB kinase complex
Rothwarf, D. M., Zandi, E., Natoli, G., & Karin, M. (1998) · Nature · doi:10.1038/26261 · Cited by 958
Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase
Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T. J., Ellisman, M. H., Johnson, R. S., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.316 · Cited by 822
The role of TNFα and TNF receptors in obesity and insulin resistance
Hotamisligil, G. S. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00490.x · Cited by 780
Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life
Yoshizumi, M., Perrella, M. A., Burnett, J. C., & Lee, M. E. (1993) · Circulation Research · doi:10.1161/01.res.73.1.205 · Cited by 771
Superoxide Generation from Endothelial Nitric-oxide Synthase
Xia, Y., Tsai, A.-L., Berka, V., & Zweier, J. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25804 · Cited by 705
Regulation of Endothelial Constitutive Nitric Oxide Synthase Gene Expression in Endothelial Cells and In Vivo
Kuboki, K., Jiang, Z. Y., Takahara, N., Ha, S. W., Igarashi, M., Yamauchi, T., Feener, E. P., Herbert, T. P., Rhodes, C. J., & King, G. L. (2000) · Circulation · doi:10.1161/01.cir.101.6.676 · Cited by 642
The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus
Rothwarf, D., & Karin, M. (1999) · Science's STKE · doi:10.1126/stke.1999.5.re1 · Cited by 553
Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
Nakano, H., Shindo, M., Komazawa‐Sakon, S., Nishinaka, S., Mihara, M., Yagita∥, H., & Okumura, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3537 · Cited by 518
Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate
Zandi, E., Chen, Y., & Karin, M. (1998) · Science · doi:10.1126/science.281.5381.1360 · Cited by 451
The essential role of MEKK3 in TNF-induced NF-κB activation
Yang, J., Lin, Y., Guo, Z., Cheng, J., Huang, J. H., Deng, L., Liao, W. S. ‐., Chen, Z. J., Liu, Z. G., & Su, B. (2001) · Nature Immunology · doi:10.1038/89769 · Cited by 396
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF‐κB‐dependent gene transcription
Bonnard, M., Mirtsos, C., Suzuki, S., Graham, K., Huang, J., Ng, M., Itié, A., Wakeham, A., Shahinian, A., Henzel, W. J., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.18.4976 · Cited by 381
NAK is an IκB kinase-activating kinase
Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatakeyama, S., Nakayama, K. I., Kaneko, Y. S., Nimura, Y., Motoyama, N., Ikeda, K., et al. (2000) · Nature · doi:10.1038/35008109 · Cited by 375
Rapid Reactive Oxygen Species Production by Mitochondria in Endothelial Cells Exposed to Tumor Necrosis Factor-α Is Mediated by Ceramide
Corda, S., Laplace, C., Vicaut, É., & Duranteau, J. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.6.4228 · Cited by 352
Effects of free fatty acids (FFA) on glucose metabolism: Significance for insulin resistance and type 2 diabetes
Boden, G. (2003) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2003-39781 · Cited by 348
IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex
Mercurio, F., Murray, B. W., Shevchenko, A., Bennett, B. L., Young, D. B., Li, J. W., Pascual, G., Motiwala, A., Zhu, H., Mann, M., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1526 · Cited by 325
EDRF coordinates the behaviour of vascular resistance vessels
Griffith, T. M., Edwards, D. H., Davies, R. L., Harrison, T. J., & Evans, K. T. (1987) · Nature · doi:10.1038/329442a0 · Cited by 317
Structural Alterations in Subcutaneous Small Arteries of Normotensive and Hypertensive Patients With Non–Insulin-Dependent Diabetes Mellitus
Rizzoni, D., Porteri, E., Guelfi, D., Muiesan, M. L., Valentini, U., Cimino, A., Girelli, A., Rodella, L. F., Bianchi, R., Sleiman, I., et al. (2001) · Circulation · doi:10.1161/01.cir.103.9.1238 · Cited by 302
Mitogen-activated Protein Kinase/ERK Kinase Kinases 2 and 3 Activate Nuclear Factor-κB through IκB Kinase-α and IκB Kinase-β
Zhao, Q., & Lee, F. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8355 · Cited by 276
Oral Administration of Tetrahydrobiopterin Prevents Endothelial Dysfunction and Vascular Oxidative Stress in the Aortas of Insulin-Resistant Rats
Shinozaki, K., Nishio, Y., Okamura, T., Yoshida, Y., Maegawa, H., Kojima, H., Masada, M., Toda, N., Kikkawa, R., & Kashiwagi, A. (2000) · Circulation Research · doi:10.1161/01.res.87.7.566 · Cited by 242
Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products.
Chakravarthy, U., Hayes, R., Stitt, A. W., McAuley, E., & Archer, D. B. (1998) · Diabetes · doi:10.2337/diabetes.47.6.945 · Cited by 237
Serum From Patients With Severe Heart Failure Downregulates eNOS and Is Proapoptotic
Agnoletti, L., Curello, S., Bachetti, T., Malacarne, F., Gaia, G., Comini, L., Volterrani, M., Bonetti, P., Parrinello, G., Cadei, M., et al. (1999) · Circulation · doi:10.1161/01.cir.100.19.1983 · Cited by 236
Gene Structure, Polymorphism and Mapping of the Human Endothelial Nitric Oxide Synthase Gene
Nadaud, S., Bonnardeaux, A., Lathrop, M. G., & Soubrier, F. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1146 · Cited by 226
Mechanical strain activates BNP gene transcription through a p38/NF-κB–dependent mechanism
Liang, F., & Gardner, D. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7362 · Cited by 212
Characterization of the Human Endothelial Nitric-oxide Synthase Promoter
Karantzoulis-Fegaras, F., Antoniou, H., Lai, S.-L. M., Kulkarni, G., D'Abreo, C., Wong, G. K. T., Miller, T. L., Chan, Y., Atkins, J., Wang, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.3076 · Cited by 211
Length, force, and Ca(2+)-troponin C affinity in cardiac and slow skeletal muscle
Wang, Y. P., & Fuchs, F. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.4.c1077 · Cited by 205
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency
Meininger, C. J., MARINOS, R. S., Hatakeyama, K., Martı́nez–Zaguilán, R., Rojas, J. D., Kelly, K. A., & Wu, G. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490353 · Cited by 186
Insulin-Like Growth Factor-1 Enhances Inflammatory Responses in Endothelial Cells
Che, W., Lerner‐Marmarosh, N., Huang, Q., Osawa, M., Ohta, S., Yoshizumi, M., Glassman, M., Lee, J.-D., Chen, Y., Berk, B. C., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000021127.83364.7d · Cited by 183
Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors.
Channon, K. M., & Guzik, T. J. (2002) · PubMed · Cited by 175
Functional Interference of Sp1 and NF-κB through the Same DNA Binding Site
Hirano, F., Tanaka, H., Hirano, Y., Hiramoto, M., Handa, H., Makino, I., & Scheidereit, C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1266 · Cited by 157
Tumor Necrosis Factor Antagonism With Etanercept Improves Systemic Endothelial Vasoreactivity in Patients With Advanced Heart Failure
Fichtlscherer, S., Rössig, L., Breuer, S., Vasa‐Nicotera, M., Dimmeler, S., & Zeiher, A. M. (2001) · Circulation · doi:10.1161/hc5001.101749 · Cited by 147
Endothelial cytosolic proteins bind to the 3′ untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha
Alonso, J., Sánchez de Miguel, L., Montón, M., Casado, S., & López-Farré, A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.5719 · Cited by 146
Proliferating Arterial Smooth Muscle Cells After Balloon Injury Express TNF-α but Not Interleukin-1 or Basic Fibroblast Growth Factor
Tanaka, H., Sukhova, G. K., Schwartz, D., & Libby, P. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.1.12 · Cited by 131
cGMP-Mediated Negative-Feedback Regulation of Endothelial Nitric Oxide Synthase Expression by Nitric Oxide
Vaziri, N. D., & Wang, X. Q. (1999) · Hypertension · doi:10.1161/01.hyp.34.6.1237 · Cited by 106
Elevated serum TNF‐α level as a link between endothelial dysfunction and insulin resistance in normotensive obese patients
Winkler, G., Lakatos, P. L., Salamon, F., Nagy, Z., Speer, G., Kovács, M., Harmos, G., Dworak, O., & Cseh, K. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00052.x · Cited by 101
Atorvastatin inhibition of cytokine‐inducible nitric oxide synthase expression in native endothelial cellsin situ
Wagner, A. H., Schwabe, O., & Hecker, M. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704678 · Cited by 98
Evidence for altered sensitivity of the nitric oxide/cGMP signalling cascade in insulin-resistant skeletal muscle
YOUNG, E. M., & Leighton, B. (1998) · Biochemical Journal · doi:10.1042/bj3290073 · Cited by 92
Proinflammatory cytokines downregulate gene expression and activity of constitutive nitric oxide synthase in porcine pulmonary artery endothelial cells.
Zhang, J., Patel, J. M., Li, Y. D., & Block, E. R. (1997) · PubMed · Cited by 88
Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries
Muzaffar, S. (2003) · Thorax · doi:10.1136/thorax.58.7.598 · Cited by 87
Lack of Role for Nitric Oxide (NO) in the Selective Destabilization of Endothelial NO Synthase mRNA by Tumor Necrosis Factor–α
Mohamed, F., Monge, J. C., Gordon, A. E., Černáček, P., Blais, D., & Stewart, D. J. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.1.52 · Cited by 80
NO upregulation of a cyclic nucleotide-gated channel contributes to calcium elevation in endothelial cells
Zhang, J., Xia, S., Block, E. R., & Patel, J. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00048.2002 · Cited by 78
Recombinant IκB Kinases α and β Are Direct Kinases of IκBα
Li, J., Peet, G. W., Pullen, S. S., Schembri-King, J., Warren, T. C., Marcu, K. B., Kehry, M. R., Barton, R. W., & Jakes, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30736 · Cited by 73
Circulating Tumor Necrosis Factor α is Elevated in Male but Not in Female Patients With Type II Diabetes Mellitus
Pfeiffer, A. F. H., Janott, J., Möhlig, M., Ristow, M., Rochlitz, H. J., Busch, K., Schatz, H., & Schifferdecker, E. (1997) · Hormone and Metabolic Research · doi:10.1055/s-2007-979001 · Cited by 61
NF-κB induced by IL-1β inhibits elastin transcription and myofibroblast phenotype
Kuang, P., Berk, J. L., Rishikof, D. C., Foster, J. A., Humphries, D. E., Ricupero, D. A., & Goldstein, R. H. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00314.2001 · Cited by 55
Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication
Beauparlant, P., Kwon, H., Clarke, M., Lin, R., Sonenberg, N., Wainberg, M. A., & Hiscott, J. B. (1996) · Journal of Virology · doi:10.1128/jvi.70.9.5777-5785.1996 · Cited by 51
In Vivo Blockade of Tumor Necrosis Factor-α Accelerates Functional Endothelial Recovery After Balloon Angioplasty
Krasinski, K. L., Spyridopoulos, I., Kearney, M., & Losordo, D. W. (2001) · Circulation · doi:10.1161/hc4001.098046 · Cited by 47
Endothelin Inhibits NPR-A and Stimulates eNOS Gene Expression in Rat IMCD Cells
Ye, Q., Chen, S., & Gardner, D. G. (2003) · Hypertension · doi:10.1161/01.hyp.0000047204.72286.34 · Cited by 45
Molecular cloning of constitutive endothelial nitric oxide synthase: evidence for a family of related genes
Michel, T., & Lamas, S. (1992) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199204002-00014 · Cited by 24
Effect of Chylomicrons on the Fibrinolytic Activity of Normal Human Plasma in Vitro
Merigan, T. C., Farquhar, J. W., Williams, J. H., & Sokolow, M. (1959) · Circulation Research · doi:10.1161/01.res.7.2.205 · Cited by 19
Comparative Study of Induction of iNOS mRNA Expression in Vascular Cells of Different Species
Wen, J., & Han, M. (2000) · Biochemistry (Moscow) · doi:10.1023/a:1002848705637 · Cited by 13

Research works printed but not linked: 7

Furchgott, 1987, Blood Vessels., 24, 145
Channon, 2002, J. Physiol. Pharmacol., 53, 515
Meininger, 2000, Biochem. J., 349, 353, 10.1042/bj3490353 · DOI
Ding, 2000, Am. J. Physiol., 279, E11
Tickerhoof, 2003, Am. J. Physiol., 285, H2694
Johnson, 1994, Am. J. Physiol., 267, L318
Zhang, 1997, Res. Commun. Mol. Pathol. Pharmacol., 96, 71

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Authors: Anderson, H. D. I., Rahmutula, D., & Gardner, D. G.
Affiliations: University of California, San Francisco (US)
Corresponding author: Gardner, David G.
ORCID: Anderson, Hope D.I.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2004-01
Volume: 279
Issue: 2
Pages: 963-969
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m309552200
OpenAlex: W1984870795
Cited by: 186
References: 69
Citations by year: 2026: 6 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 11 · 2015: 2 · 2014: 10 · 2013: 8 · 2012: 10
FWCI: 8.43
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6145 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-45637, R01HL045637)
National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-63720, P30DK063720)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: TNF-α, endothelial nitric oxide synthase, transcriptional regulation, Sp1 binding site, Sp3, NF-κB signaling, IκB, IKKβ, endothelial dysfunction, bovine aortic endothelial cells, luciferase reporter
MeSH terms: NF-KappaB Inhibitor alpha, Animals, Aorta, Cattle, Cell Nucleus, DNA-Binding Proteins, Dose-Response Relationship, Drug, Endothelium, Vascular, Genes, Dominant, Humans, Luciferases, Mutation, Phosphorylation, Plasmids, Promoter Regions, Genetic, Protein Binding, RNA Processing, Post-Transcriptional, RNA, Messenger, Time Factors, Transcription Factors, Transfection, Tumor Necrosis Factor-alpha, Blotting, Western, Sp1 Transcription Factor, Protein Serine-Threonine Kinases, Genes, Reporter, Nitric Oxide Synthase, I-kappa B Proteins, Endothelial Cells, I-kappa B Kinase, Sp3 Transcription Factor, Nitric Oxide Synthase Type III

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Tumor Necrosis Factor-α Inhibits Endothelial Nitric-oxide Synthase Gene Promoter Activity in Bovine Aortic Endothelial Cells

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