Endothelial cytosolic proteins bind to the 3′ untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha
Open accessAbstract
Changes in endothelial nitric oxide synthase (eNOS) expression may be involved in the endothelium-dependent vasorelaxation dysfunction associated with several vascular diseases. In the present work, we demonstrate that eNOS mRNA contains a previously undescribed cis element in the 3' untranslated region (3' UTR). A U+C-rich segment in the 3' UTR is critical in complex formation with bovine aortic endothelial cell cytosolic proteins. Tumor necrosis factor alpha (TNF-alpha), which destabilizes eNOS mRNA, increased the binding activity of the cytosolic proteins in a time-dependent manner. These data suggest that endothelial cytosolic proteins bind to the 3' UTR of eNOS mRNA. These proteins may play a role in TNF-alpha-induced eNOS mRNA destabilization.
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- Authors
- Alonso, J., Sánchez de Miguel, L., Montón, M., Casado, S., & López-Farré, A.
- Affiliations
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Nephrology, Hypertension and Cardiovascular Research Laboratory, Instituto de Investigaciones Médicas, Fundación Jiménez Díaz, Madrid, Spain
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1997-10-01
- Volume
- 17
- Issue
- 10
- Pages
- 5719-5726
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC232420
- OpenAlex
- W1886375502
- Cited by
- 146
- References
- 36
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 1 · 2012: 3
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- endothelial nitric oxide synthase, 3' untranslated region, cis-regulatory elements, TNF-α, mRNA destabilization, cytosolic proteins, RNA-protein interactions, endothelial cells
- MeSH terms
- Animals, Base Sequence, Cattle, Cells, Cultured, Cytosol, Endothelium, Vascular, Molecular Sequence Data, Polyribonucleotides, Regulatory Sequences, Nucleic Acid, RNA, Messenger, Tumor Necrosis Factor-alpha, RNA-Binding Proteins, Nitric Oxide Synthase
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