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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
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The hepatic phenotype of LKO largely phenocopies that of liver-specific transgenic mice that produce a constitutively-active SREBP1c form.
“This could explain why both the precursor and mature (i.e. nuclear) forms of SREBP1 are elevated upon MARCHF6 ablation, and that the hepatic phenotype of LKO largely phenocopies that of liver-specific transgenic mice that produce a constitutively-active SREBP1c form [55].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [55]
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- Ericsson, J., S.M. Jackson, B.C. Lee, and P.A. Edwards. 1996. Sterol reg- ulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. Proc. Natl. Acad. Sci. USA. 93:945-950.
- Hua, X., C. Yokoyama, J. Wu, M.R. Briggs, M.S. Brown, J.L. Goldstein, and X. Wang. 1993. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. USA. 90:11603-11607.
- Yieh, L., H.B. Sanchez, and T.F. Osborne. 1995. Domains of transcrip- tion factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter. Proc. Natl. Acad. Sci. USA. 92:6102-6106.
- Sheng, Z., H. Otani, M.S. Brown, and J.L. Goldstein. 1995. Independent regulation of sterol regulatory element binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA. 92:935-938.
- Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York.
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Metadata
- Authors
- Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S., & Goldstein, J. L.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-03-01
- Volume
- 99
- Issue
- 5
- Pages
- 846-854
- ISSN
- 0021-9738
- Cited by
- 730
- References
- 0
- Language
- en
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