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Cited by 136

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

SREBP-1 Mediates Activation of the Low Density Lipoprotein Receptor Promoter by Insulin and Insulin-like Growth Factor-I

Streicher, Rüdiger, Kotzka, Jörg, Müller-Wieland, Dirk, Siemeister, Gerhard, Munck, Martina, Avci, Haluk, Krone, Wilhelm·1996·Journal of Biological Chemistry
DOI 10.1074/jbc.271.12.7128
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Crossref · 10.1074/jbc.271.12.7128

Cites

2 of 2 references verified0 citation errors · 0 not checkable

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  • LDLR and PCSK9 are downstream genes of SREBPs.

    “LDLR and PCSK9 are downstream genes of SREBPs.”

    From Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression (2021) · cites this paper as [33]

    The Discussion concludes that SREBP-1 is involved in LDL receptor gene activation, supporting the LDLR part of the claim. Our copy does not address PCSK9, so it does not support the claim that PCSK9 is also downstream of SREBPs (searched: PCSK9, proprotein convertase subtilisin/kexin 9). (LLM, conf=0.89)

    Experimental — accuracy not yet measured

  • PCSK9 protein is a key mediator for LDLR degradation by ubiquitination.

    “The PCSK9 protein is a key mediator for LDLR degradation by ubiquitination, and its inhibitors have been applied to clinical trials for hypocholesterolemia (33, 34).”

    From Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression (2021) · cites this paper as [33]

    The introduction and Discussion describe SREBP-1 regulation of LDL receptor gene transcription, not degradation of the receptor protein. Searches for PCSK9, ubiquitination, and PCSK9 inhibitors found no passage addressing the attributed claim; page numbers were unavailable in our copy. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

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Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 23

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  11. Wade, 1989, Eur. J. Biochem., 181, 727, 10.1111/j.1432-1033.1989.tb14784.x · DOI
  12. Staels, 1990, J. Lipid Res., 31, 1211, 10.1016/S0022-2275(20)42629-X · DOI
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  18. Wang, 1994, Cell, 77, 53, 10.1016/0092-8674(94)90234-8 · DOI
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  20. O'Brien, 1991, Biochem. J., 278, 609, 10.1042/bj2780609 · DOI
  21. Maurer, 1987, Mol. Cell. Biol., 7, 4247
  22. Sheng, 1995, Proc. Natl. Acad. Sci. U. S. A., 92, 935, 10.1073/pnas.92.4.935 · DOI · Paper page
  23. Lloyd, 1995, J. Biol. Chem., 270, 25812, 10.1074/jbc.270.43.25812 · DOI

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Metadata

Authors
Streicher, R., Kotzka, J., Müller-Wieland, D., Siemeister, G., Munck, M., Avci, H., & Krone, W.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1996-03
Volume
271
Issue
12
Pages
7128-7133
ISSN
0021-9258
DOI
10.1074/jbc.271.12.7128
Cited by
136
References
2
Language
en
Licence

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