The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Two Functional but Noncomplementing Drosophila Tyrosine Decarboxylase Genes
Open accessAbstract
The trace biogenic amine tyramine is present in the nervous systems of animals ranging in complexity from nematodes to mammals. Tyramine is synthesized from tyrosine by the enzyme tyrosine decarboxylase (TDC), a member of the aromatic amino acid family, but this enzyme has not been identified in Drosophila or in higher animals. To further clarify the roles of tyramine and its metabolite octopamine, we have cloned two TDC genes from Drosophila melanogaster, dTdc1 and dTdc2. Although both gene products have TDC activity in vivo, dTdc1 is expressed nonneurally, whereas dTdc2 is expressed neurally. Flies with a mutation in dTdc2 lack neural tyramine and octopamine and are female sterile due to egg retention. Although other Drosophila mutants that lack octopamine retain eggs completely within the ovaries, dTdc2 mutants release eggs into the oviducts but are unable to deposit them. This specific sterility phenotype can be partially rescued by driving the expression of dTdc2 in a dTdc2-specific pattern, whereas driving the expression of dTdc1 in the same pattern results in a complete rescue. The disparity in rescue efficiencies between the ectopically expressed Tdc genes may reflect the differential activities of these gene products. The egg retention phenotype of the dTdc2 mutant and the phenotypes associated with ectopic dTdc expression contribute to a model in which octopamine and tyramine have distinct and separable neural activities.
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Cites
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
Brand, A. H., & Perrimon, N. (1993) · Development · doi:10.1242/dev.118.2.401 · Cited by 9,612
Genetic Transformation of Drosophila with Transposable Element Vectors
Rubin, G. M., & Spradling, A. C. (1982) · Science · doi:10.1126/science.6289436 · Cited by 3,014
Lee, T., & Luo, L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80701-1 · Cited by 2,571
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
Oldendorf, W. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.6.1629 · Cited by 1,683
Trace amines: Identification of a family of mammalian G protein-coupled receptors
Borowsky, B., Adham, N., Jones, K. A., Raddatz, R., Artymyshyn, R., Ogozalek, K. L., Durkin, M. M., Lakhlani, P. P., Bonini, J. A., Pathirana, S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151105198 · Cited by 906
A unique central tryptophan hydroxylase isoform
Walther, D. J., & Bader, M. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00556-2 · Cited by 751
Analysis of P transposable element functions in drosophila
Karess, R. E., & Rubin, G. M. (1984) · Cell · doi:10.1016/0092-8674(84)90534-8 · Cited by 722
Bunzow, J. R., Sonders, M. S., Arttamangkul, S., Harrison, L. M., Zhang, G., Quigley, D. I., Darland, T., Suchland, K. L., Pasumamula, S., Kennedy, J. L., et al. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.6.1181 · Cited by 648
Roeder, T. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00016-7 · Cited by 602
Tetrahydropterin-Dependent Amino Acid Hydroxylases
Fitzpatrick, P. F. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.355 · Cited by 513
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Metadata
- Authors
- Cole, S. H., Carney, G. E., McClung, C. A., Willard, S. S., Taylor, B. J., & Hirsh, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 280
- Issue
- 15
- Pages
- 14948-14955
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2039528431
- Cited by
- 344
- References
- 32
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cole, S. H., Carney, G. E., McClung, C. A., Willard, S. S., Taylor, B. J., & Hirsh, J. (2005). Two Functional but Noncomplementing Drosophila Tyrosine Decarboxylase Genes. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m414197200
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