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Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro
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When cellular cholesterol is elevated, the SCAP-SREBP2 complex cannot be transported to the Golgi and SREBP2 is sequestered at the ER membrane as an inactive precursor.
“When cellular cholesterol is elevated, the SCAP–SREBP2 complex cannot be transported to the Golgi and so SREBP2 is sequestered at the membrane of the endoplasmic reticulum (ER) as an inactive precursor [28,29].”
From Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation (2024) · cites this paper as [29]
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Metadata
- Authors
- Sun, L.-P., Li, L., Goldstein, J. L., & Brown, M. S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 280
- Issue
- 28
- Pages
- 26483-26490
- ISSN
- 0021-9258
- Cited by
- 223
- References
- 0
- Language
- en
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