The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus
Open accessAbstract
DNA (cytosine-5) methylation represents one of the most widely used mechanisms of enduring cellular memory. Stable patterns of DNA methylation are established during development, resulting in creation of persisting cellular phenotypes. There is growing evidence that the nervous system has co-opted a number of cellular mechanisms used during development to subserve the formation of long term memory. In this study, we examined the role DNA (cytosine-5) methyltransferase (DNMT) activity might play in regulating the induction of synaptic plasticity. We found that the DNA within promoters for reelin and brain-derived neurotrophic factor, genes implicated in the induction of synaptic plasticity in the adult hippocampus, exhibited rapid and dramatic changes in cytosine methylation when DNMT activity was inhibited. Moreover, zebularine and 5-aza-2-deoxycytidine, inhibitors of DNMT activity, blocked the induction of long term potentiation at Schaffer collateral synapses. Activation of protein kinase C in the hippocampus decreased reelin promoter methylation and increased DNMT3A gene expression. Interestingly, DNMT activity is required for protein kinase C-induced increases in histone H3 acetylation. Considered together, these results suggest that DNMT activity is dynamically regulated in the adult nervous system and that DNMT may play a role in regulating the induction of synaptic plasticity in the mature CNS.
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Cites
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Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
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Self-citationCBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation
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Epigenetic mechanisms in memory formation
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Self-citationDNA methylation and chromatin modification
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Cited by
DNA methylation and its basic function
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Global epigenomic reconfiguration during mammalian brain development
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Epigenetic regulation in psychiatric disorders
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Epigenetic transmission of the impact of early stress across generations
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Metadata
- Authors
- Levenson, J. M., Roth, T. L., Lubin, F. D., Miller, C. A., Huang, I.-C., Desai, P., Malone, L. M., & Sweatt, J. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 281
- Issue
- 23
- Pages
- 15763-15773
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2031379951
- Cited by
- 618
- References
- 10
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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