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TRPM7 Regulates Cell Adhesion by Controlling the Calcium-dependent Protease Calpain
Open accessAbstract
m-Calpain is a protease implicated in the control of cell adhesion through focal adhesion disassembly. The mechanism by which the enzyme is spatially and temporally controlled is not well understood, particularly because the dependence of calpain on calcium exceeds the submicromolar concentrations normally observed in cells. Here we show that the channel kinase TRPM7 localizes to peripheral adhesion complexes with m-calpain, where it regulates cell adhesion by controlling the activity of the protease. Our research revealed that overexpression of TRPM7 in cells caused cell rounding with a concomitant loss of cell adhesion that is dependent upon the channel of the protein but not its kinase activities. Knockdown of m-calpain blocked TRPM7-induced cell rounding and cell detachment. Silencing of TRPM7 by RNA interference, however, strengthened cell adhesion and increased the number of peripheral adhesion complexes in the cells. Together, our results suggest that the ion channel TRPM7 regulates cell adhesion through m-calpain by mediating the local influx of calcium into peripheral adhesion complexes.
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Cites
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Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
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Sebbagh, M., Renvoizé, C., Hamelin, J., Riché, N., Bertoglio, J., & Bréard, J. (2001) · Nature Cell Biology · doi:10.1038/35070019 · Cited by 915
Regulation of Cell Migration by the Calcium-dependent Protease Calpain
Huttenlocher, A., Palecek, S. P., Lu, Q., Zhang, W., Mellgren, R. L., Lauffenburger, D. A., Ginsberg, M. H., & Horwitz, A. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32719 · Cited by 390
Glading, A., Bodnar, R. J., Reynolds, I. J., Shiraha, H., Satish, L., Potter, D. A., Blair, H. C., & Wells, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2499-2512.2004 · Cited by 271
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Romani, A. M. P. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.05.010 · Cited by 531
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Role of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Cells move when ions and water flow
Schwab, A., Nechyporuk-Zloy, V., Fabian, A., & Stock, C. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0138-6 · Cited by 176
Metadata
- Authors
- Su, L.-T., Agapito, M. A., Li, M., Simonson, W. T. N., Huttenlocher, A., Habas, R., Yue, L., & Runnels, L. W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 281
- Issue
- 16
- Pages
- 11260-11270
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2113304856
- Cited by
- 229
- References
- 4
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Su, L.-T., Agapito, M. A., Li, M., Simonson, W. T. N., Huttenlocher, A., Habas, R., Yue, L., & Runnels, L. W. (2006). TRPM7 Regulates Cell Adhesion by Controlling the Calcium-dependent Protease Calpain. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m512885200
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