Necessary Role for the Lag1p Motif in (Dihydro)ceramide Synthase Activity

Molecular Cloning: A Laboratory Manual

Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589

Molecular cloning: A laboratory manual

Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684

The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind

Hannun, Y. A., & Obeid, L. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200008200 · Cited by 913

Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane

Görlich, D. (1993) · Cell · doi:10.1016/0092-8674(93)90483-7 · Cited by 658

De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway

Merrill, A. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200009200 · Cited by 618

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

Bielawski, J., Szulc, Z. M., Hannun, Y. A., & Bielawska, A. E. (2006) · Methods · doi:10.1016/j.ymeth.2006.05.004 · Cited by 543

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Mizutani, Y., Kihara, A., & Igarashi, Y. (2005) · Biochemical Journal · doi:10.1042/bj20050291 · Cited by 376

A protein of the endoplasmic reticulum involved early in polypeptide translocation

Görlich, D., Hartmann, E., Prehn, S., & Rapoport, T. A. (1992) · Nature · doi:10.1038/357047a0 · Cited by 328

Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors

Riebeling, C., Allegood, J. C., Wang, E. L., Merrill, A. H., & Futerman, A. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307104200 · Cited by 292

Upstream of Growth and Differentiation Factor 1 (uog1), a Mammalian Homolog of the Yeast Longevity Assurance Gene 1 (LAG1), RegulatesN-Stearoyl-sphinganine (C18-(Dihydro)ceramide) Synthesis in a Fumonisin B1-independent Manner in Mammalian Cells

Venkataraman, K., Riebeling, C., Bodennec, J., Riezman, H., Allegood, J. C., Sullards, M. C., Merrill, A. H., & Futerman, A. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205211200 · Cited by 282

Accurate prediction of protein structures and interactions using a 3-track network

Baek, M., DiMaio, F., Anishchenko, I., Dauparas, J., Ovchinnikov, S., Lee, G. R., Wang, J., Cong, Q., Kinch, L. N., Schaeffer, R. D., et al. (2021) · doi:10.1101/2021.06.14.448402 · Cited by 5,549

Mammalian ceramide synthases

Levy, M., & Futerman, A. H. (2010) · IUBMB Life · doi:10.1002/iub.319 · Cited by 632

Ceramide synthases at the centre of sphingolipid metabolism and biology

Mullen, T. D., Hannun, Y. A., & Obeid, L. M. (2012) · Biochemical Journal · doi:10.1042/bj20111626 · Cited by 541

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

Sentelle, R. D., Senkal, C. E., Jiang, W., Ponnusamy, S., Gencer, S., Panneer Selvam, S., Ramshesh, V. K., Peterson, Y. K., Lemasters, J. J., Szulc, Z. M., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1059 · Cited by 539

Host-selective toxins produced by the plant pathogenic fungusAlternaria alternata

Tsuge, T., Harimoto, Y., Akimitsu, K., Ohtani, K., Kodama, M., Akagi, Y., Egusa, M., Yamamoto, M., & Otani, H. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2012.00350.x · Cited by 406

Sphingolipids and Cancer: Ceramide and Sphingosine-1-Phosphate in the Regulation of Cell Death and Drug Resistance

Ponnusamy, S., Meyers‐Needham, M., Senkal, C. E., Saddoughi, S. A., Sentelle, D., Selvam, S. P., Salas, A., & Öğretmen, B. (2010) · Future Oncology · doi:10.2217/fon.10.116 · Cited by 319

Loss of ceramide synthase 3 causes lethal skin barrier disruption

Jennemann, R., Rabionet, M., Gorgas, K., Epstein, S., Dalpke, A. H., Rothermel, U., Bayerle, A., van der Hoeven, F., Imgrund, S., Kirsch, J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr494 · Cited by 283

Replicative Aging in Yeast: The Means to the End

Steinkraus, K. A., Kaeberlein, M. R., & Kennedy, B. K. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123509 · Cited by 282

Alternaria Toxins: Potential Virulence Factors and Genes Related to Pathogenesis

Meena, M., Gupta, S. K., Swapnil, P., Zehra, A., Dubey, M. K., & Upadhyay, R. S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01451 · Cited by 260

Antiapoptotic roles of ceramide‐synthase‐6‐generated C 16 ‐ceramide via selective regulation of the ATF6/ CHOP arm of ER‐stress‐response pathways

Senkal, C. E., Ponnusamy, S., Bielawski, J., Hannun, Y. A., & Öğretmen, B. (2009) · The FASEB Journal · doi:10.1096/fj.09-135087 · Cited by 254

Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics

Saddoughi, S. A., Song, P., & Öğretmen, B. (2008) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-8831-5_16 · Cited by 245

Ceramide synthases as potential targets for therapeutic intervention in human diseases

Park, J., Park, W., & Futerman, A. H. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.08.019 · Cited by 237

Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans

Deng, X., Yin, X., Allan, R., Lu, D. D., Maurer, C. W., Haimovitz‐Friedman, A., FUKS, Z. Y., Shaham, S., & Kolesnick, R. N. (2008) · Science · doi:10.1126/science.1158111 · Cited by 206

Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase

Menuz, V., Howell, K. S., Gentina, S., Epstein, S., Riezman, I., Fornallaz-Mulhauser, M., Hengartner, M. O., Gomez, M., Riezman, H., & Martinou, J. (2009) · Science · doi:10.1126/science.1168532 · Cited by 168

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

Zhao, L., Spassieva, S. D., Jucius, T. J., Shultz, L. D., Shick, H. E., Macklin, W. B., Hannun, Y. A., Obeid, L. M., & Ackerman, S. L. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002063 · Cited by 167

Impaired Epidermal Ceramide Synthesis Causes Autosomal Recessive Congenital Ichthyosis and Reveals the Importance of Ceramide Acyl Chain Length

Eckl, K., Tidhar, R., Thiele, H., Oji, V., Haußer, I., Brodesser, S., Preil, M., Önal-Akan, A., Stock, F., Müller, D., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.153 · Cited by 162

JNK3 Signaling Pathway Activates Ceramide Synthase Leading to Mitochondrial Dysfunction

Yu, J., Novgorodov, S. A., Chudakova, D. A., Zhu, H., Bielawska, A. E., Bielawski, J., Obeid, L. M., Kindy, M. S., & Gudz, T. I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701812200 · Cited by 157

Accurate prediction of protein structures and interactions using a three-track neural network

Baek, M., DiMaio, F., Anishchenko, I. V., Dauparas, J., Ovchinnikov, S., Lee, G. R., Wang, J., Cong, Q., Kinch, L. N., Schaeffer, R. D., et al. (2022) · Yearbook of pediatric endocrinology · doi:10.1530/ey.19.15.15 · Cited by 199

Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes

Ginkel, C., Hartmann, D., Dorp, K. V., Zlomuzica, A., Farwanah, H., Eckhardt, M., Sandhoff, R., Degen, J., Rabionet, M., Dere, E., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.413500 · Cited by 135

An RNAi Screen Reveals Intestinal Regulators of Branching Morphogenesis, Differentiation, and Stem Cell Proliferation in Planarians

Forsthoefel, D. J., James, N., Escobar, D., Stary, J. M., Vieira, A. P., Waters, F. A., & Newmark, P. A. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.09.008 · Cited by 136

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

Spassieva, S. D., Mullen, T. D., Townsend, D. M., & Obeid, L. M. (2009) · Biochemical Journal · doi:10.1042/bj20090699 · Cited by 133

The enigma of ceramide synthase regulation in mammalian cells

Wegner, M.-S., Schiffmann, S., Parnham, M. J., Geißlinger, G., & Grösch, S. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.03.006 · Cited by 135

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

Mullen, T. D., Spassieva, S. D., Jenkins, R. W., Kitatani, K., Bielawski, J., Hannun, Y. A., & Obeid, L. M. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009142 · Cited by 130

Ceramide induced mitophagy and tumor suppression

Dany, M., & Öğretmen, B. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.12.039 · Cited by 130

The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis

Siskind, L. J., Mullen, T. D., Rosales, K. R., Clarke, C. J., Hernandez‐Corbacho, M. J., Edinger, A. L., & Obeid, L. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078121 · Cited by 125

Modulation of Ceramide Synthase Activity via Dimerization

Laviad, E. L., Kelly, S. L., Merrill, A. H., & Futerman, A. H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363580 · Cited by 126

Autophagy paradox and ceramide

Jiang, W., & Öğretmen, B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.005 · Cited by 123

(Dihydro)ceramide Synthase 1–Regulated Sensitivity to Cisplatin Is Associated with the Activation of p38 Mitogen-Activated Protein Kinase and Is Abrogated by Sphingosine Kinase 1

Min, J., Mesika, A., Sivaguru, M., Veldhoven, P. P. V., Alexander, H., Futerman, A. H., & Alexander, S. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0100 · Cited by 115

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells

Jin, J., Mullen, T. D., Hou, Q., Bielawski, J., Bielawska, A. E., Zhang, X., Obeid, L. M., Hannun, Y. A., & Hsu, Y. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900119-jlr200 · Cited by 108

Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death

Mullen, T. D., Jenkins, R. W., Clarke, C. J., Bielawski, J., Hannun, Y. A., & Obeid, L. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.230870 · Cited by 99

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+ Loading Capacity and Promotes Apoptosis

Novgorodov, S. A., Chudakova, D. A., Wheeler, B. W., Bielawski, J., Kindy, M. S., Obeid, L. M., & Gudz, T. I. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.164392 · Cited by 97

Impairment of ceramide synthesis causes a novel progressive myoclonus epilepsy

Vanni, N., Fruscione, F., Ferlazzo, E., Striano, P., Robbiano, A., Traverso, M., Sander, T., Falace, A., Gazzerro, E., Bramanti, P., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24170 · Cited by 94

Ceramide and Mitochondria in Ischemia/Reperfusion

Novgorodov, S. A., & Gudz, T. I. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31819b52d5 · Cited by 96

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila

Bauer, R., Voelzmann, A., Breiden, B., Schepers, U., Farwanah, H., Hahn, I., Eckardt, F., Sandhoff, K., & Hoch, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.305 · Cited by 94

SIRT3 Deacetylates Ceramide Synthases

Novgorodov, S. A., Riley, C. L., Keffler, J. A., Yu, J., Kindy, M. S., Macklin, W. B., Lombard, D. B., & Gudz, T. I. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.668228 · Cited by 86

Inactivation of Ceramide Synthase 6 in Mice Results in an Altered Sphingolipid Metabolism and Behavioral Abnormalities

Ebel, P., Dorp, K. V., Petrasch‐Parwez, E., Zlomuzica, A., Kinugawa, K., Mariani, J., Minich, D. J., Ginkel, C., Welcker, J., Degen, J., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.479907 · Cited by 83

Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells

Jin, J., Hou, Q., Mullen, T. D., Zeidan, Y. H., Bielawski, J., Kraveka, J. M., Bielawska, A. E., Obeid, L. M., Hannun, Y. A., & Hsu, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801597200 · Cited by 83

Kinetic characterization of mammalian ceramide synthases: Determination of K m values towards sphinganine

Lahiri, S., Lee, H., Mesicek, J., FUKS, Z. Y., Haimovitz‐Friedman, A., Kolesnick, R., & Futerman, A. H. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.018 · Cited by 79

Convergent evolution of bacterial ceramide synthesis

Stankeviciute, G., Tang, P., Ashley, B., Chamberlain, J. D., Hansen, M. E. B., Coleman, A., D’Emilia, R., Fu, L., Mohan, E. C., Nguyen, H. X., et al. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00948-7 · Cited by 76

Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans

Mosbech, M., Kruse, R., Harvald, E. B., Olsen, A. S. B., Gallego, S. F., Hannibal‐Bach, H. K., Ejsing, C. S., & Færgeman, N. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070087 · Cited by 76

Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia

Ebel, P., Imgrund, S., Dorp, K. V., Hofmann, K., Maier, H., Drake, H., Degen, J., Dörmann, P., Eckhardt, M., Franz, T., et al. (2014) · Biochemical Journal · doi:10.1042/bj20131242 · Cited by 74

Eleven residues determine the acyl chain specificity of ceramide synthases

Tidhar, R., Zelnik, I. D., Volpert, G., Ben‐Dor, S., Kelly, S. L., Merrill, A. H., & Futerman, A. H. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.001936 · Cited by 71

Mechanisms of ceramide‐mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

Wooten, L. G., Song, P., Senkal, C. E., & Öğretmen, B. (2007) · The FASEB Journal · doi:10.1096/fj.07-8621com · Cited by 69

Acyl Chain Specificity of Ceramide Synthases Is Determined within a Region of 150 Residues in the Tram-Lag-CLN8 (TLC) Domain

Tidhar, R., Ben‐Dor, S., Wang, E. L., Kelly, S. L., Merrill, A. H., & Futerman, A. H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.280271 · Cited by 69

Alteration of Sphingolipids in Biofluids: Implications for Neurodegenerative Diseases

Pujol-Lereis, L. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143564 · Cited by 69

Concerted functions of HDAC1 and microRNA‐574‐5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells

Meyers‐Needham, M., Ponnusamy, S., Gencer, S., Jiang, W., Thomas, R. J., Senkal, C. E., & Öğretmen, B. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100189 · Cited by 67

Alternaria host-selective toxins: determinant factors of plant disease

Akimitsu, K., Tsuge, T., Kodama, M., Yamamoto, M., & Otani, H. (2013) · Journal of General Plant Pathology · doi:10.1007/s10327-013-0498-7 · Cited by 65

A New Functional Motif in Hox Domain-containing Ceramide Synthases

Mesika, A., Ben‐Dor, S., Laviad, E. L., & Futerman, A. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703487200 · Cited by 67

Ceramide and mitochondria in ischemic brain injury.

Novgorodov, S. A., & Gudz, T. I. (2011) · Europe PMC (PubMed Central) · Cited by 62

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements

Sociale, M., Wulf, A., Breiden, B., Klee, K., Thielisch, M., Eckardt, F., Sellin, J., Bülow, M. H., Loebbert, S., Weinstock, N., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.090 · Cited by 63

CLN 5 and CLN 8 protein association with ceramide synthase: B iochemical and proteomic approaches

Haddad, S. E., Khoury, M., Daoud, M., Kantar, R. S., Harati, H., Mousallem, T. I., Álzate, Ó., Meyer, B. F., & Boustany, R. (2012) · Electrophoresis · doi:10.1002/elps.201200472 · Cited by 60

Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis

Pathak, D., Mehendale, N., Singh, S., Mallik, R., & Kamat, S. S. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00438 · Cited by 60

A Stroll Down the CerS Lane

Zelnik, I. D., Rozman, B., Rosenfeld-Gur, E., Ben‐Dor, S., & Futerman, A. H. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21162-2_4 · Cited by 55

Ceramide synthase 1 is regulated by proteasomal mediated turnover

Sridevi, P., Alexander, H., Laviad, E. L., Pewzner‐Jung, Y., Hannink, M., Futerman, A. H., & Alexander, S. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.04.006 · Cited by 53

Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction

Hernandez‐Corbacho, M. J., Jenkins, R. W., Clarke, C. J., Hannun, Y. A., Obeid, L. M., Snider, A. J., & Siskind, L. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020411 · Cited by 47

Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing

Sridevi, P., Alexander, H., Laviad, E. L., Min, J., Mesika, A., Hannink, M., Futerman, A. H., & Alexander, S. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.09.027 · Cited by 50

Off-Target Function of the Sonic Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Nitric Oxide–Dependent Neutral Sphingomyelinase 2/Ceramide Induction

Meyers‐Needham, M., Lewis, J. A., Gencer, S., Sentelle, R. D., Saddoughi, S. A., Clarke, C. J., Hannun, Y. A., Norell, H., da Palma, T. M., Nishimura, M. I., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0705 · Cited by 45

The longevity assurance homologue of yeast lag1 (Lass) gene family (Review)

Teufel (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000110 · Cited by 42

Metabolomics Analysis Identifies Sphingolipids as Key Signaling Moieties in Appressorium Morphogenesis and Function in Magnaporthe oryzae

Liu, X., Liang, S., Wei, Y., Zhu, X., Li, L., Liu, P., Zheng, Q., Zhou, H., Zhang, Y., Mao, L.-J., et al. (2019) · mBio · doi:10.1128/mbio.01467-19 · Cited by 42

Distinct roles of two ceramide synthases, CaLag1p and CaLac1p, in the morphogenesis of Candida albicans

Cheon, S. A., Bal, J., Song, Y., Hwang, H., Kim, A. R., Kang, W. K., Kang, H. A., Hannibal‐Bach, H. K., Knudsen, J., Ejsing, C. S., et al. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07961.x · Cited by 39

Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype

Pani, T., Rajput, K., Kar, A., Sharma, H., Basak, R., Medatwal, N., Saha, S., Dev, G., Kumar, S., Gupta, S., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03436-x · Cited by 35

Combination of C17 Sphingoid Base Homologues and Mass Spectrometry Analysis as a New Approach to Study Sphingolipid Metabolism

Spassieva, S. D., Bielawski, J., Anelli, V., & Obeid, L. M. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)34012-3 · Cited by 34

Sphingolipids: major regulators of lipid metabolism

Worgall, T. S. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328028fda3 · Cited by 32

The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway

Santos, T. C. B., Dingjan, T., & Futerman, A. H. (2022) · FEBS Letters · doi:10.1002/1873-3468.14457 · Cited by 27

Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases

Zelnik, I. D., Mestre, B., Weinstein, J. J., Dingjan, T., Izrailov, S., Ben‐Dor, S., Fleishman, S. J., & Futerman, A. H. (2023) · Nature Communications · doi:10.1038/s41467-023-38047-x · Cited by 28

Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1

Tedesco, P. M., Jiang, J. C., Wang, J., Jazwinski, S. M., & Johnson, T. E. (2008) · AGE · doi:10.1007/s11357-008-9046-3 · Cited by 28

A rapid ceramide synthase activity using NBD-sphinganine and solid phase extraction

Tidhar, R., Sims, K. H., Rosenfeld-Gur, E., Shaw, W., & Futerman, A. H. (2014) · Journal of Lipid Research · doi:10.1194/jlr.d052001 · Cited by 29

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Mina, J. G., & Denny, P. W. (2017) · Parasitology · doi:10.1017/s0031182017001081 · Cited by 26

Hydrogel-mediated delivery of celastrol and doxorubicin induces a synergistic effect on tumor regression via upregulation of ceramides

Medatwal, N., Ansari, M. N., Kumar, S., Pal, S., Jha, S. K., Verma, P., Rana, K., Dasgupta, U., & Bajaj, A. (2020) · Nanoscale · doi:10.1039/d0nr01066a · Cited by 27

Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry

Snider, J. M., Snider, A. J., Obeid, L. M., Luberto, C., & Hannun, Y. A. (2018) · Journal of Lipid Research · doi:10.1194/jlr.d081646 · Cited by 26

Ceramide synthases: Reflections on the impact of Dr. Lina M. Obeid

Kim, J. L., Mestre, B., Shin, S.-H., & Futerman, A. H. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109958 · Cited by 25

Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division

Bickert, A., Kern, P., van Uelft, M., Herresthal, S., Ulas, T., Gutbrod, K., Breiden, B., Degen, J., Sandhoff, K., Schultze, J. L., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.04.006 · Cited by 24

Lead genetic studies in Dictyostelium discoideum and translational studies in human cells demonstrate that sphingolipids are key regulators of sensitivity to cisplatin and other anticancer drugs

Alexander, S., & Alexander, H. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.10.005 · Cited by 23

NuclearDrosophilaCerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif

Voelzmann, A., Wulf, A., Eckardt, F., Thielisch, M., Brondolin, M., Pesch, Y., Sociale, M., Bauer, R., & Hoch, M. (2016) · FEBS Letters · doi:10.1002/1873-3468.12125 · Cited by 22

Structure and mechanism of a eukaryotic ceramide synthase complex

Xie, T., Fang, Q., Zhang, Z., Wang, Y., Dong, F., & Gong, X. (2023) · The EMBO Journal · doi:10.15252/embj.2023114889 · Cited by 24

Regulation of lipid metabolism by sphingolipids

Worgall, T. S. (2008) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-8830-8_14 · Cited by 20

Structural basis of the mechanism and inhibition of a human ceramide synthase

Pascoa, T. C., Pike, A. C. W., Tautermann, C. S., Chi, G., Traub, M., Quigley, A., Chalk, R., Štefanić, S., Thamm, S., Pautsch, A., et al. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01414-3 · Cited by 25

Insight into tomato plant immunity to necrotrophic fungi

Pandey, A. K., Dinesh, K., Nirmala, N. S., Kumar, A., Chakraborti, D., & Bhattacharyya, A. (2023) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2023.100144 · Cited by 19

Alterations of lipid‐mediated mitophagy result in aging‐dependent sensorimotor defects

Oleinik, N., Albayram, O., Kassir, M. F., Atilgan, F. C., Walton, C., Karakaya, E., Kurtz, J., Alekseyenko, A., Alsudani, H., Sheridan, M., et al. (2023) · Aging Cell · doi:10.1111/acel.13954 · Cited by 18

Sphingoid bases and their involvement in neurodegenerative diseases

Goins, L., & Spassieva, S. D. (2018) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.10.004 · Cited by 16

Sphingolipids and Response to Chemotherapy

Dimanche‐Boitrel, M., & Rébillard, A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-7091-1511-4_4 · Cited by 19

Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations

Yamamoto, M., Sassa, T., Kyono, Y., Uemura, H., Kugo, M., Hayashi, H., Imai, Y., Yamanishi, K., & Kihara, A. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.15725 · Cited by 18

Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid

Velazquez, F. N., Hernandez‐Corbacho, M. J., Trayssac, M., Stith, J. L., Bonica, J., Jean, B., Pulkoski‐Gross, M. J., Carroll, B. L., Salama, M., Hannun, Y. A., et al. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109875 · Cited by 16

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Zhou, Y., & Reynolds, T. B. (2024) · Journal of Fungi · doi:10.3390/jof10030171 · Cited by 18

Ceramide synthases in mammalians, worms, and insects: emerging schemes

Voelzmann, A., & Bauer, R. (2010) · BioMolecular Concepts · doi:10.1515/bmc.2010.028 · Cited by 15

siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.

Šeparović, D., Breen, P., Joseph, N., Bielawski, J., Pierce, J. S., Buren, E. C. V., & Gudz, T. I. (2012) · PubMed · Cited by 14

Following the flux of long-chain bases through the sphingolipid pathway in vivo using mass spectrometry

Martínez-Montañés, F., & Schneiter, R. (2016) · Journal of Lipid Research · doi:10.1194/jlr.d066472 · Cited by 14

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Kretzschmar, T., Wu, J. M. F., & Schulze, P. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031498 · Cited by 15

Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi

Figueiredo, J. M., Rodrigues, D. C., Silva, R. C. M. C., Koeller, C. M., Jiang, J. C., Jazwinski, S. M., Previato, J. O., Mendonça‐Previato, L., Ürményi, T. P., & Heise, N. (2011) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2011.12.006 · Cited by 14

Ceramide Synthases: Reexamining Longevity

Park, J., & Pewzner‐Jung, Y. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-7091-1368-4_5 · Cited by 13

Hyphenation of supercritical fluid chromatography and trapped ion mobility-mass spectrometry for quantitative lipidomics

Scholz, J., Rudt, E., Gremme, A., Gaßmöller, C. M., Bornhorst, J., & Hayen, H. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342913 · Cited by 13

Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS

Voelzmann, A., & Bauer, R. (2011) · Gene Expression Patterns · doi:10.1016/j.gep.2011.08.006 · Cited by 11

Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution

Holmes, R. S., Barron, K. A., & Krupenko, N. I. (2018) · Biomolecules · doi:10.3390/biom8040111 · Cited by 11

Structure of the yeast ceramide synthase

Schäfer, J.-H., Clausmeyer, L., Körner, C., Esch, B. M., Wolf, V. N., Sapia, J., Ahmed, Y., Walter, S., Vanni, S., Januliene, D., et al. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01415-2 · Cited by 10

De novo synthesis of sphingolipids plays an important role during in vitro encystment of Entamoeba invadens

Jáuregui-Wade, J. M., Valdés, J., Ayala-Sumuano, J. T., Ávila-García, R., & Cerbón-Solórzano, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.005 · Cited by 10

Phosphorylated LASS2 inhibits prostate carcinogenesis via negative regulation of Wnt/β‐catenin signaling

Zhang, K., Wu, R., Mei, F., Zhou, Y., He, L., Liu, Y., Zhao, X., You, J., Liu, B., Meng, Q., et al. (2021) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29926 · Cited by 10

Identification and Expression Analysis of the Zebrafish Homologs of the ceramide synthase Gene Family

Brondolin, M., Berger, S., Reinke, M., Tanaka, H., Ohshima, T., Fuβ, B., & Hoch, M. (2012) · Developmental Dynamics · doi:10.1002/dvdy.23913 · Cited by 9

A mass spectrometry-based method for the assay of ceramide synthase substrate specificity

Luttgeharm, K. D., Cahoon, E. B., & Markham, J. E. (2015) · Analytical Biochemistry · doi:10.1016/j.ab.2015.02.016 · Cited by 10

Ylpex5 mutation partially suppresses the defective hyphal growth of a Yarrowia lipolytica ceramide synthase mutant, Yllac1, by recovering lipid raft polarization and vacuole morphogenesis

Bal, J., Lee, H., Cheon, S. A., Lee, K. J., Oh, D., & Kim, J. (2012) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2012.11.003 · Cited by 9

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Wang, G., Zhang, X., Chen, B., & Peng, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c05535 · Cited by 8

Human Homologues of LAG1 Reconstitute Acyl-CoA-dependent Ceramide Synthesis in Yeast

Guillas, I., Jiang, J. C., Vionnet, C., Roubaty, C., Uldry, D., Chuard, R., Wang, J., Jazwinski, S. M., & Conzelmann, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307554200 · Cited by 101

Transmembrane topology of ceramide synthase in yeast

Kageyama‐Yahara, N., & Riezman, H. (2006) · Biochemical Journal · doi:10.1042/bj20060697 · Cited by 87

LASS5 Is a Bona Fide Dihydroceramide Synthase That Selectively Utilizes Palmitoyl-CoA as Acyl Donor

Lahiri, S., & Futerman, A. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506485200 · Cited by 123

Lip1p: a novel subunit of acyl‐CoA ceramide synthase

Vallée, B., & Riezman, H. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600562 · Cited by 152

Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction inSaccharomyces cerevisae

Schorling, S., Vallée, B., Barz, W. P., Riezman, H., & Oesterhelt, D. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3417 · Cited by 276