Ceramide synthases: Reflections on the impact of Dr. Lina M. Obeid
Abstract
Sphingolipids are a family of lipids that are critical to cell function and survival. Much of the recent work done on sphingolipids has been performed by a closely-knit family of sphingolipid researchers, which including our colleague, Dr. Lina Obeid, who recently passed away. We now briefly review where the sphingolipid field stands today, focusing in particular on areas of sphingolipid research to which Dr. Obeid made valued contributions. These include the 'many-worlds' view of ceramides and the role of a key enzyme in the sphingolipid biosynthetic pathway, namely the ceramide synthases (CerS). The CerS contain a number of functional domains and also interact with a number of other proteins in lipid metabolic pathways, fulfilling Dr. Obeid's prophecy that ceramides, and the enzymes that generate ceramides, form the critical hub of the sphingolipid metabolic pathway.
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The RoseTTAFold predicted structure of the ADAM33 prodomain has a lipocalin-like beta-barrel fold belonging to an extended superfamily that includes metalloprotease inhibitors (MPIs).
“The RoseTTAFold predicted structure of the ADAM33 prodomain has a lipocalin-like beta-barrel fold (Fig. 3C) belonging to an extended superfamily that includes metalloprotease inhibitors (MPIs) (25).”
From Accurate prediction of protein structures and interactions using a 3-track network (2021) · cites this paper as [25]
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Self-citationA New Functional Motif in Hox Domain-containing Ceramide Synthases
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Self-citationMechanisms of Ceramide-Mediated Apoptosis
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A Handbook of Transcription Factors
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Ceramide synthase 1 is regulated by proteasomal mediated turnover
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Self-citationHou, Q., Jin, J., Zhou, H., Novgorodov, S. A., Bielawska, A. E., Szulc, Z. M., Hannun, Y. A., Obeid, L. M., & Hsu, Y. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m012161 · Cited by 48 · see citing works
Lipid Metabolism: Ceramide Transfer Protein Adds a New Dimension
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Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity
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Self-citationRegulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein
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Self-citationGenome-wide DNA methylation analysis in blood cells from patients with Werner syndrome
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Ganglioside Metabolism and Its Inherited Diseases
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Sphingosine Kinases as Druggable Targets
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Self-citationGangliosides: methods and protocols
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A novel C-terminal DxRSDxE motif in ceramide synthases involved in dimer formation
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Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis
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- Authors
- Kim, J. L., Mestre, B., Shin, S.-H., & Futerman, A. H.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Futerman, Anthony H.
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 82
- Pages
- 109958
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W3130499490
- Cited by
- 25
- References
- 140
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 8
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- ceramide synthase, ceramide, sphingolipids, sphingolipid biosynthesis, lipid metabolism, protein-protein interaction
- MeSH terms
- Ceramides, Sphingolipids, History, 20th Century, Sphingosine N-Acyltransferase
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