Cited by 25Sphingolipid Metabolism and SignalingLysosomal Storage Disorders ResearchLipid metabolism and biosynthesis

Ceramide synthases: Reflections on the impact of Dr. Lina M. Obeid

Kim, Jiyoon L., Mestre, Beatriz, Shin, Sun-Hye, Futerman, Anthony H.·2021·Cellular Signalling

Abstract

Sphingolipids are a family of lipids that are critical to cell function and survival. Much of the recent work done on sphingolipids has been performed by a closely-knit family of sphingolipid researchers, which including our colleague, Dr. Lina Obeid, who recently passed away. We now briefly review where the sphingolipid field stands today, focusing in particular on areas of sphingolipid research to which Dr. Obeid made valued contributions. These include the 'many-worlds' view of ceramides and the role of a key enzyme in the sphingolipid biosynthetic pathway, namely the ceramide synthases (CerS). The CerS contain a number of functional domains and also interact with a number of other proteins in lipid metabolic pathways, fulfilling Dr. Obeid's prophecy that ceramides, and the enzymes that generate ceramides, form the critical hub of the sphingolipid metabolic pathway.

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Crossref · 10.1016/j.cellsig.2021.109958

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  • The RoseTTAFold predicted structure of the ADAM33 prodomain has a lipocalin-like beta-barrel fold belonging to an extended superfamily that includes metalloprotease inhibitors (MPIs).

    “The RoseTTAFold predicted structure of the ADAM33 prodomain has a lipocalin-like beta-barrel fold (Fig. 3C) belonging to an extended superfamily that includes metalloprotease inhibitors (MPIs) (25).”

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Authors
Kim, J. L., Mestre, B., Shin, S.-H., & Futerman, A. H.
Affiliations
Weizmann Institute of Science (IL)
Corresponding author
Futerman, Anthony H.
Venue
Cellular Signalling
Publisher
Elsevier BV
Published
2021-06
Volume
82
Pages
109958
ISSN
0898-6568 (ISSN-L)
OpenAlex
W3130499490
Cited by
25
References
140
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 8
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Locations
  • Cellular Signalling (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
  • Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
ceramide synthase, ceramide, sphingolipids, sphingolipid biosynthesis, lipid metabolism, protein-protein interaction
MeSH terms
Ceramides, Sphingolipids, History, 20th Century, Sphingosine N-Acyltransferase

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