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Cited by 300Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice

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McConlogue, Lisa, Buttini, Manuel, Anderson, John P., Brigham, Elizabeth F., Chen, Karen S., Freedman, Stephen B., Games, Dora, Johnson-Wood, Kelly, Lee, Michael, Zeller, Michelle, Liu, Weiqun, Motter, Ruth, Sinha, Sukanto·2007·Journal of Biological Chemistry
DOI 10.1074/jbc.m611687200
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Abstract

The aspartyl protease beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates processing of amyloid precursor protein (APP) into amyloid beta (Abeta) peptide, the major component of Alzheimer disease (AD) plaques. To determine the role that BACE1 plays in the development of Abeta-driven AD-like pathology, we have crossed PDAPP mice, a transgenic mouse model of AD overexpressing human mutated APP, onto mice with either a homozygous or heterozygous BACE1 gene knockout. Analysis of PDAPP/BACE(-/-) mice demonstrated that BACE1 is absolutely required for both Abeta generation and the development of age-associated plaque pathology. Furthermore, synaptic deficits, a neurodegenerative pathology characteristic of AD, were also reversed in the bigenic mice. To determine the extent of BACE1 reduction required to significantly inhibit pathology, PDAPP mice having a heterozygous BACE1 gene knock-out were evaluated for Abeta generation and for the development of pathology. Although the 50% reduction in BACE1 enzyme levels caused only a 12% decrease in Abeta levels in young mice, it nonetheless resulted in a dramatic reduction in Abeta plaques, neuritic burden, and synaptic deficits in older mice. Quantitative analyses indicate that brain Abeta levels in young APP transgenic mice are not the sole determinant for the changes in plaque pathology mediated by reduced BACE1. These observations demonstrate that partial reductions of BACE1 enzyme activity and concomitant Abeta leve…

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Metadata

Authors
McConlogue, L., Buttini, M., Anderson, J. P., Brigham, E. F., Chen, K. S., Freedman, S. B., Games, D., Johnson-Wood, K., Lee, M., Zeller, M., Liu, W., Motter, R., & Sinha, S.
Affiliations
Elan Pharmaceuticals, Inc. (Ireland) (IE)
Corresponding author
McConlogue, Lisa
ORCID
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2007-09
Volume
282
Issue
36
Pages
26326-26334
ISSN
0021-9258 (ISSN-L)
DOI
10.1074/jbc.m611687200
OpenAlex
W2000536660
Cited by
300
References
56
Citations by year
2026: 4 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 18 · 2019: 16 · 2018: 13 · 2017: 17 · 2016: 18 · 2015: 24 · 2014: 24 · 2013: 17 · 2012: 23
FWCI
14.91
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
BACE1, Alzheimer's disease, amyloid-beta, amyloid plaques, APP transgenic mice, PDAPP mice, synaptic deficits, neuritic plaques, therapeutic target
MeSH terms
Aging, Alzheimer Disease, Animals, Disease Models, Animal, Enzyme Activation, Humans, Synaptic Membranes, Aspartic Acid Endopeptidases, Neurites, Amyloid beta-Protein Precursor, Mice, Knockout, Mice, Amyloid Precursor Protein Secretases

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