Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

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Adiponectin and Adiponectin Receptors

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AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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Adiponectin and development of type 2 diabetes in the Pima Indian population

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Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

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AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

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Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

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APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

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Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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A Rapamycin-Sensitive Pathway Down-Regulates Insulin Signaling via Phosphorylation and Proteasomal Degradation of Insulin Receptor Substrate-1

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AMP-Activated Protein Kinase as a Drug Target

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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1

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Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

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Growth suppression by Lkb1 is mediated by a G 1 cell cycle arrest

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Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302

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Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway

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Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signalingPreprint

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TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

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Adiponectin: a relevant player in PPARγ-agonist-mediated improvements in hepatic insulin sensitivity?

Bouskila, M., Pajvani, U. B., & Scherer, P. E. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802908 · Cited by 149

Keynote review: The adipocyte as a drug discovery target

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Identification of Dominant Negative Mutants of Rheb GTPase and Their Use to Implicate the Involvement of Human Rheb in the Activation of p70S6K

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Nutrient-dependent and Insulin-stimulated Phosphorylation of Insulin Receptor Substrate-1 on Serine 302 Correlates with Increased Insulin Signaling

Giraud, J., Leshan, R. L., Lee, Y.-H., & White, M. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308631200 · Cited by 100

Attenuation of Insulin-stimulated Insulin Receptor Substrate-1 Serine 307 Phosphorylation in Insulin Resistance of Type 2 Diabetes

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Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin increases chemosensitivity of CaSki cells to paclitaxel

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Asymmetric p38 Activation in Zebrafish

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Functional consequences of progressive cone dystrophy-associated mutations in the human cone photoreceptor cyclic nucleotide-gated channel CNGA3 subunit

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Potentiation of insulin-stimulated glucose transport by the AMP-activated protein kinase

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AMPK in Health and Disease

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Adipose tissue as an endocrine organ

Galić, S., Oakhill, J. S., & Steinberg, G. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.018 · Cited by 1,654

Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1

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LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644

The Role of Adiponectin in Cancer: A Review of Current Evidence

Dalamaga, Μ., Diakopoulos, K. N., & Mantzoros, C. S. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1015 · Cited by 653

Globular adiponectin activates Akt in cultured myocytes

Sattar, A. A., & Sattar, R. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.027 · Cited by 8

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

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Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin

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Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2

Liu, X., Yang, Y., Shao, H., Liu, S., Niu, Y., & Fu, L. (2022) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2022.08.001 · Cited by 16

Adiponectin deletion impairs insulin signaling in insulin-sensitive but not insulin-resistant 3T3-L1 adipocytes

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